$83 Find Cheap Flights from Detroit to South Carolina - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Detroit to South Carolina departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Cheap Flights from Detroit to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$175
Myrtle Beach
Myrtle Beach1 stop$216
Greenville
Greenville1 stop$208
Columbia
Columbia1 stop$309
Florence
Florence1 stop$541
Charlotte
Charlotte2 stops$319
Charleston
Charleston1 stop$175
Myrtle Beach
Myrtle Beach1 stop$216
Greenville
Greenville1 stop$208
Columbia
Columbia1 stop$309
Florence
Florence1 stop$541
Charlotte
Charlotte2 stops$319

Book Cheap Detroit to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Detroit to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Detroit to South Carolina

Tue, Aug 25 - Mon, Aug 31
Multiple Airlines Logo
1:40 pm - 3:28 pm
DTW
-
CHS
25h 48m
1 stop
Multiple Airlines Logo
9:44 pm - 12:44 pm
CHS
-
DTW
15h 00m
1 stop
$175Multiple Airlines
Wed, Sep 2 - Sat, Sep 5
Multiple Airlines Logo
10:18 am - 5:55 pm
DTW
-
SAV
7h 37m
1 stop
Multiple Airlines Logo
12:19 pm - 12:55 pm
SAV
-
DTW
24h 36m
1 stop
$192Multiple Airlines
Wed, Sep 2 - Wed, Sep 9
Multiple Airlines Logo
10:18 am - 5:55 pm
DTW
-
SAV
7h 37m
1 stop
Multiple Airlines Logo
12:23 pm - 1:07 pm
SAV
-
DTW
24h 44m
1 stop
$197Multiple Airlines
Wed, Jul 22 - Sat, Jul 25
American Airlines Logo
6:00 am - 10:44 am
DTW
-
CAE
4h 44m
1 stop
American Airlines Logo
4:10 pm - 10:34 pm
CAE
-
DTW
6h 24m
1 stop
$309American Airlines
Wed, Jul 29 - Wed, Aug 5
United Airlines Logo
8:50 am - 2:21 pm
DTW
-
HHH
5h 31m
1 stop
United Airlines Logo
3:05 pm - 8:22 pm
HHH
-
DTW
5h 17m
1 stop
$309United Airlines
Thu, Aug 20 - Tue, Aug 25
United Airlines Logo
7:30 am - 2:03 pm
DTW
-
HHH
6h 33m
1 stop
United Airlines Logo
2:58 pm - 8:29 pm
HHH
-
DTW
5h 31m
1 stop
$312United Airlines
Sat, Oct 3 - Tue, Oct 6
Delta Logo
8:05 pm - 9:52 pm
DTW
-
CLT
1h 47mnonstop
Delta Logo
5:00 pm - 6:50 pm
CLT
-
DTW
1h 50mnonstop
$323Delta
Wed, Jul 15 - Fri, Jul 24
Delta Logo
5:20 am - 9:22 am
DTW
-
CAE
4h 02m
1 stop
Delta Logo
7:39 pm - 12:59 am
CAE
-
DTW
5h 20m
1 stop
$324Delta
Wed, Jul 29 - Tue, Aug 11
Southwest Logo
7:05 am - 3:40 pm
DTW
-
CLT
8h 35m
2 stops
Southwest Logo
11:10 am - 9:15 pm
CLT
-
DTW
10h 05m
2 stops
$324Southwest
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
7:15 am - 2:20 pm
DTW
-
HHH
7h 05m
1 stop
American Airlines Logo
5:15 pm - 9:38 pm
HHH
-
DTW
4h 23m
1 stop
$337American Airlines
Booking Insights

KAYAK's insights & trends for Detroit to South Carolina flights

Get data-powered insights and trends into flights from Detroit to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Detroit Metropolitan Wayne County Airport to South Carolina?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Detroit Metropolitan Wayne County Airport to South Carolina departing in August.

What is the cheapest Detroit Metropolitan Wayne County Airport to South Carolina flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to South Carolina from Detroit Metropolitan Wayne County Airport found in the last 5 days was to Myrtle Beach, at $299 round-trip. The most popular route is from Detroit Metropolitan Wayne County Airport (DTW) to Myrtle Beach (MYR), and the cheapest round-trip airline ticket found on this route in the last 5 days was $299.

What is the cheapest time of day to fly to South Carolina?

The average price for all round-trip flights from Detroit Metropolitan Wayne County Airport to South Carolina depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to South Carolina is generally in the afternoon, when round-trip flights cost $299 on average. Morning departures are around 5% cheaper than evening flights, on average. The most expensive time of day to fly to South Carolina is generally at night, which is peak travel time and where the average cost of a ticket is $408.

Can I save money by flying with a layover from Detroit Metropolitan Wayne County Airport to South Carolina?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $440 on average.

What is the cheapest month to fly from Detroit Metropolitan Wayne County Airport to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Detroit Metropolitan Wayne County Airport to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Detroit Metropolitan Wayne County Airport to South Carolina is August, when tickets cost $45 (return) on average. On the other hand, the most expensive months are May and March, when the average cost of round-trip tickets is $218 and $203 respectively.

What’s the cheapest day of the week to fly from Detroit to South Carolina?

The average price of all round-trip flights from Detroit Metropolitan Wayne County Airport to South Carolina clicked on KAYAK for each day over the last 12 months.

When flying from Detroit to South Carolina, you should consider leaving on a Tuesday and avoid Thursdays if you are looking for the best rates. For your return to Detroit, you’ll find the best rates on Fridays and the most expensive ones on Sundays.

How far in advance should I book a flight from Detroit Metropolitan Wayne County Airport to South Carolina?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Detroit Metropolitan Wayne County Airport to South Carolina, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Detroit Metropolitan Wayne County Airport to South Carolina, you should book around 3 weeks before departure, which saves you about 32% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 13 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$83
Best time to beat the crowds but there is an average 13% increase in price.
Most popular time to fly and prices are also 17% lower on average.
Flight from Detroit to Charleston

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Detroit to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Detroit to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Detroit to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Detroit to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Detroit to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Detroit to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Detroit to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Detroit to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Detroit to the following destinations at these prices or less: Charlotte $221 one-way - $368 round-trip

Reviews of the top 4 airlines serving from Detroit to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Detroit to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Detroit to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4250 reviews
8.0Comfort
8.6Crew
7.5Entertainment
7.0Food
8.1Boarding
Airline reviews

My experience will Southwest was good. I wish there was more entertainment and the boarding process was slow at time but other than that my experience was great definitely will be flying with SouthWest again.

8.0 ExcellentAnonymous, Jul 2026
PHL - BNA
Read more Southwest reviews

My experience will Southwest was good. I wish there was more entertainment and the boarding process was slow at time but other than that my experience was great definitely will be flying with SouthWest again.

Flight was delayed by 2 hours, meaning that a flight to Dwnver which should have arrived at 11pm came into the airport at 1 am. Made for a very long day.

I think Southwest is the number one airline that anyone can fly I have flown for the first time Frontier and what a joke and their customer service United was a very strange experience I'm only sticking to Southwest from here on out for sure

Great job! My family doesnt fly often but we felt safe 100%

Great job Southwest! My family doesn't fly often but we felt safe the whole time.

SW can't get their wifi right. I upgrade to insure wifi service but the last two trips had intermittent service. Not worth the extra costs.

I'm glad it wasn't only 75% full because I could get a good seat

Check-in, Boarding and flight were smooth. All the employees and crew was very nice and funny. They gave the kids crayons and workbooks to keep them occupied which was a big win. I’ve flown Southwest many times and that’s the first time I’ve seen that and it is a great addition.

Southwest's seats are the least comfortable I have ever sat in.

Southwest is a discount airline. I get it. You take the (usually) good pricing with the bad (cramped). But Southwest is becoming more and more like the cut-rate airlines *cough* Spirit *cough*. It used to actually be a fun experience. e.g. paying for WiFi is bad enough - having to pay for it on each leg of a flight is ridiculous. Yes, I've seen your numbers that it only "impacts a small percentage", but you and I both know that is misleading at best. While I used to try to fly SW exclusively when flying domestically, now I'll look elsewhere very frequently and price being equal (or close) I'm going to the other carriers.

Everything about this flight was good except for the very end when I reached my destination. Everyone from the tune to the wheelchair escorts were great with the case were great but I miss you with people at the check in this at the very end. I need help from the chicken desk because I forgot my pillow on the plane The female worker at the chicken desk said that they found my pillow and she was going to retrieve it for me. She left a 30 minutes without any update and her so she saw me walking back and forth waiting for her and they didn't even bother calling her or radioing her for any updates. They were busy because they were behind schedule and they were overwhelmed but thanks because at least glanced me and try to give me an update just a quick radio check or phone call. I don't care about the pillow but if you tell me to wait, I waited for at least half an hour before I said something and I just left because they wouldn't bother talking to me so I could, so everything's going in the review. I took pictures of the two men that were left working at the check-in counter. The totally ignored me despite the signals I've been giving them. I don't see any offers in the kayak review to add pictures or screenshots so I'm going to post another review I don't know their name but I'm pretty sure Delta will find other names when they see the review. Google with pictures. There was another guy at the chicken counter bring an orange workers vest who finally left after telling me that the girl that was retrieving my pillow is working the gates now. That would have been if they just told me that's what happened. But I had no update. Make me wait for nothing. Thank you Delta airlines!

Crew was real good, flight was smooth and came in early.

Should never have had to go to Detroit from Orlando back to Tennessee!

Free & relatively fast Wi-Fi. Would've liked a wider drink selection.

Smooth flight. Left on time, and got in 15 minutes early. Onboard video was great

Everything went smoothly, although the usual gripes about airline travel were still present: the boarding process is inefficient, the snack selection is limited, and so on. Since there was extra space on the flight, the gate agent rearranged many people's seats to put people on the aisles and windows, leaving the middle seats empty, as much as possible, which was pretty great.

Miserable. This entire round trip was miserable. I booked evening flights to and from Detroit on consecutive days that should have had me at my destination by 10:30. Instead I arrived after 3am on my flight to Detroit and after midnight on my return. Multiple unforced errors like awaiting bags to get put on the plane for almost an hour in Detroit and a 20 minute delay to pull up to the gate in Atlanta has me rethinking my assumption that delta is the best and most reliable airline

2+hrs delay without any reason provided and a cramped flight

Flight was delayed and no reasons provided. After the passengers were boarded, the crew made announcement that the captain has jot arrived and he would take another 15 mins. All passengers patiently sat until the captain came and started. Terrible experience!

Flight delay was frustrating, also you cannot checkin online without delta app, web browser check-in throw errors

The flight was delayed by a hour and I wish they had communicated it sooner. No issues on the plane, it did take a while for food to come.

Know that the movies that you are going to be offered are the oldest be rated movies they could possibly get. They may have one or two new movies that they keep advertising but when you’re flying 15 hours, there is nothing to see past the first new movie.

This flight is a quick way to get to Chicago, but a bit expensive.

Awful. No counter attendants. No dinner offered due to delays.

We got delayed three hours and nobody thought to have the bathroom fixed while we were sitting waiting to board? took a full hour to have maintenance come and check it off. Had to shut the bathroom down twice so that the pilots could go to the bathroom. Everyone missed their connections.

Not good - outbound flight was delayed and missed my connection even though I got to the gate after running through the airport - the agent would not let me on because the door was closed (flight had not left). There was no notification from United - overall experience was very disappointing. Additionally, I was downgraded from first class to coach on the alternative flight

I liked that the flight was nonstop from ORD to CIU for $200 round trip.

Some sort of compensation for missing work because of a cancelled flight that was United’s fault

I was told we'd have a hot breakfast option in first class, so I chose not get a hot breakfast. It was a very strange meal, but the fresh fruit was very good quality. Service was excellent from ORD to ELP. No service from MBS to ORD, not even water. However, when flying American from FNT to ORD, which is a shorter flight, they at least pass out snacks and offer water.

Staff friendly and app worked really well. Modest delays were frustrating

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

The passenger in front of of me reclined their seat back all the way the entire flight. Their headrest was in my face the entire flight! I barely had room for the little plastic cup of water to fit on my tray table; can you make the seats and space between the rows any smaller??? You can’t even get up to use the restroom! Worst flight I’ve had in a very long time!

I was on a small regional flight from Detroit to Philadelphia. When we landed the outside cruise needed to turn something off with the engine, which took quite a long time. Then, when they allowed us to get off the plane it was outside. They took their time, unloading all the luggage and waited till they unloaded all the luggage before they brought it over to us. It was 9 o’clock at night freezing cold out, and there was no proactive hustle to try to get people their luggage. It was really one of the worst experiences I think I’ve ever had with American until a manager came over. I don’t think they were going to even consider pulling the luggage over to the people that had been waiting outside for at least 10 minutes in the freezing cold.

It was a good trip. Flight Attendants were friendly and responsive.

Poor seat in rear of aircraft Food at Admiral’s Club Terminal D at DFW inedible

The trip was very smooth and they provided great customer service

It was on time, which is always a good thing. There wasn’t any food hence my okay rating.

It was a crazy day with a lot of delays and gate changes. Not a huge fan of the Charlotte hub at all.

We have been delayed and postponed 2days and nights…and still do not have our flight until tomorrow..

American Airlines is awful!! Will never fly with them again. Connection flight left early leaving 22 people in Charlotte with no way to get to Key West for 24 hours. Would not provide hotel or any other accommodations. Bags were delayed two days.

Everything you need to know for your flight from Detroit to South Carolina

Information on your arrival and departure airports