$116 Find Cheap Flights from Detroit to South Carolina - Compare and Save

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Cheap Flights from Detroit to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 5 days
Charleston
Charleston1 stop$214
Myrtle Beach
Myrtle Beach1 stop$233
Greenville
Greenville1 stop$226
Columbia
Columbia1 stop$339
Florence
Florence1 stop$489
Charlotte
Charlotte2 stops$363
Charleston
Charleston1 stop$214
Myrtle Beach
Myrtle Beach1 stop$233
Greenville
Greenville1 stop$226
Columbia
Columbia1 stop$339
Florence
Florence1 stop$489
Charlotte
Charlotte2 stops$363
Booking Insights

KAYAK's insights & trends for Detroit to South Carolina flights

Get data-powered insights and trends into flights from Detroit to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Detroit Metropolitan Wayne County Airport to South Carolina?

Flight prices are below average for this route right now.

Flights to South Carolina from Detroit Metropolitan Wayne County Airport usually cost between $394 and $609 in December.
The lowest price found in the past 5 days was $214 on Multiple Airlines (Dec 7-Dec 14).

What is the cheapest Detroit Metropolitan Wayne County Airport to South Carolina flight route?

The cheapest ticket to South Carolina from Detroit Metropolitan Wayne County Airport found in the last 5 days was to Myrtle Beach, at $323 round-trip. The most popular route is from Detroit Metropolitan Wayne County Airport (DTW) to Myrtle Beach (MYR), and the cheapest round-trip airline ticket found on this route in the last 5 days was $323.

What is the cheapest time of day to fly to South Carolina?

The cheapest time of day to fly to South Carolina is generally at night, when round-trip flights cost $419 on average. Morning departures are around 4% more expensive than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the morning, which is peak travel time and where the average cost of a ticket is $456.

Can I save money by flying with a layover from Detroit Metropolitan Wayne County Airport to South Carolina?

No, with an average price for the route of $440, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Detroit Metropolitan Wayne County Airport to South Carolina?

The cheapest month for flights from Detroit Metropolitan Wayne County Airport to South Carolina is January, when tickets cost $333 (return) on average. On the other hand, the most expensive months are November and March, when the average cost of round-trip tickets is $479 and $469 respectively.

What’s the cheapest day of the week to fly from Detroit to South Carolina?

When flying from Detroit to South Carolina, you should consider leaving on a Tuesday and avoid Thursdays if you are looking for the best rates. For your return to Detroit, you’ll find the best rates on Fridays and the most expensive ones on Sundays.

How far in advance should I book a flight from Detroit Metropolitan Wayne County Airport to South Carolina?

To get a below average price on the flight from Detroit Metropolitan Wayne County Airport to South Carolina, you should book around 3 weeks before departure, which saves you about 51% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 24 weeks before departure.

Good to know

Low season

January

Cheapest flight

$116
Best time to beat the crowds with an average 3% drop in price.
Most popular time to fly with an average 6% increase in price.
Flight from Detroit to Charleston

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Detroit to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Detroit to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Detroit to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Detroit to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Detroit to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Detroit to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Detroit to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Detroit to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Detroit to the following destinations at these prices or less: Charlotte $273 one-way - $453 round-trip

Reviews of the top 4 airlines serving from Detroit to South Carolina

 
Need help choosing which airline to fly with from Detroit to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4224 reviews
8.0Comfort
7.0Food
8.6Crew
8.1Boarding
7.4Entertainment
Airline reviews

the flight was significantly delayed. Not much was done by the airline to compensate passengers

2.0 MediocreChristopher Ryan, Oct 2026
Read more Southwest reviews

the flight was significantly delayed. Not much was done by the airline to compensate passengers

the flight itself was totally fine. The crew were great and very helpful. The flight was delayed, however, over an hour without a lot of information as to why.

Had to walk back and forth between concourses to figure out which gate I was supposed to be at. The app and the flight board in the airport had different gates listed. Was told numerous times to check bags only to get on the plane and find that there was plenty of room for bags. The flight was over an hour late which had me landing after the last train departed. WiFi was unusable

My experience was okay I changed my returning flight and I was charged extra money which I dont think should be the case, especially because I experienced small delays from my going flight. And many flights were either canceled or delayed after my original flight time. I believe some customers should have the ability to change flights due to certain situations

Nice managed … it was a smaller plane, so the seating wasn’t as comfortable.

Fairly good - the seats seemed more comfortable on this flight. The staff out of Detroit were quite friendly. But they directed us to the wrong carousel for luggage. :(

I'm glad it wasn't only 75% full because I could get a good seat

Check-in, Boarding and flight were smooth. All the employees and crew was very nice and funny. They gave the kids crayons and workbooks to keep them occupied which was a big win. I’ve flown Southwest many times and that’s the first time I’ve seen that and it is a great addition.

Southwest's seats are the least comfortable I have ever sat in.

Southwest is a discount airline. I get it. You take the (usually) good pricing with the bad (cramped). But Southwest is becoming more and more like the cut-rate airlines *cough* Spirit *cough*. It used to actually be a fun experience. e.g. paying for WiFi is bad enough - having to pay for it on each leg of a flight is ridiculous. Yes, I've seen your numbers that it only "impacts a small percentage", but you and I both know that is misleading at best. While I used to try to fly SW exclusively when flying domestically, now I'll look elsewhere very frequently and price being equal (or close) I'm going to the other carriers.

attendents were rude and the boarding was disjointed and poor

Great quik boarding, friendly gate agent and crew. Let early

We sat at the gate for over 30 minutes, with no indication as to why

All was fine. Small plane so no food or entertainment.

Very aggressive at the boarding area of only allowing one person passed a line/ sign

Delayed 7 hours Crew and employees were nice Extra long flight but at least we got in

I love how the flight crews are now saying what the weather will be like, when we can expect to be able to get up and use the restrooms etc. I have to say also that our flight crews this trip were incredible - fast and courteous - and somehow managed to do the service even on these short flights with a few bumps. The only reason for an ok rating on entertainment was because these short flights are on planes without seatback displays but that's ok because I just download shows on my iPhone beforehand.

Our flight from Detroit to LaGuardia on Thursday 8/20 was delayed from 555 to 910 due to storms and a ground stop at LGA. It’s never fun to be stuck at the airport but I thought the desk crew and captain handled it well and kept us informed. I especially liked how they referred to us as their “LaGuardia family.” I am a loyal delta customer and this is one of the reasons why.

The meal tray was not usable it was completely uneven

Chaotic boarding at these gates, multiple gates squeezed in at the very end of a concourse, behind a restaurant. Agents gave up on boarding by individual zones. Flight itself was uneventful, which is all we hope for any more.

Seats needs to be wirer and food is very poor

Phx - ORD was nice 737 with starlink and the ORD - grr was ancient bare bones airbus with not even a power port lol

This flight is a quick way to get to Chicago, but a bit expensive.

Awful. No counter attendants. No dinner offered due to delays.

We got delayed three hours and nobody thought to have the bathroom fixed while we were sitting waiting to board? took a full hour to have maintenance come and check it off. Had to shut the bathroom down twice so that the pilots could go to the bathroom. Everyone missed their connections.

Not good - outbound flight was delayed and missed my connection even though I got to the gate after running through the airport - the agent would not let me on because the door was closed (flight had not left). There was no notification from United - overall experience was very disappointing. Additionally, I was downgraded from first class to coach on the alternative flight

I liked that the flight was nonstop from ORD to CIU for $200 round trip.

Some sort of compensation for missing work because of a cancelled flight that was United’s fault

I was told we'd have a hot breakfast option in first class, so I chose not get a hot breakfast. It was a very strange meal, but the fresh fruit was very good quality. Service was excellent from ORD to ELP. No service from MBS to ORD, not even water. However, when flying American from FNT to ORD, which is a shorter flight, they at least pass out snacks and offer water.

Staff friendly and app worked really well. Modest delays were frustrating

First class snacks - stewardess gave out multiples to everyone until there was almost no selection left when she got back to me last in first class cabin. Nothing left that I would eat.

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

The passenger in front of of me reclined their seat back all the way the entire flight. Their headrest was in my face the entire flight! I barely had room for the little plastic cup of water to fit on my tray table; can you make the seats and space between the rows any smaller??? You can’t even get up to use the restroom! Worst flight I’ve had in a very long time!

I was on a small regional flight from Detroit to Philadelphia. When we landed the outside cruise needed to turn something off with the engine, which took quite a long time. Then, when they allowed us to get off the plane it was outside. They took their time, unloading all the luggage and waited till they unloaded all the luggage before they brought it over to us. It was 9 o’clock at night freezing cold out, and there was no proactive hustle to try to get people their luggage. It was really one of the worst experiences I think I’ve ever had with American until a manager came over. I don’t think they were going to even consider pulling the luggage over to the people that had been waiting outside for at least 10 minutes in the freezing cold.

It was a good trip. Flight Attendants were friendly and responsive.

The trip was very smooth and they provided great customer service

It was on time, which is always a good thing. There wasn’t any food hence my okay rating.

It was a crazy day with a lot of delays and gate changes. Not a huge fan of the Charlotte hub at all.

We have been delayed and postponed 2days and nights…and still do not have our flight until tomorrow..

American Airlines is awful!! Will never fly with them again. Connection flight left early leaving 22 people in Charlotte with no way to get to Key West for 24 hours. Would not provide hotel or any other accommodations. Bags were delayed two days.

More options for your flight from Detroit to South Carolina

Complete your trip to South Carolina with a hotel stay or car rental