$72 Find Cheap Flights from Detroit to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Detroit to South Carolina departing on 6/9. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Detroit to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Detroit to South Carolina, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Detroit to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston2 stops$260
Myrtle Beach
Myrtle Beach2 stops$268
Greenville
Greenville1 stop$282
Columbia
Columbia1 stop$305
Florence
Florence2 stops$471
Charlotte
Charlotte1 stop$238
Charleston
Charleston2 stops$260
Myrtle Beach
Myrtle Beach2 stops$268
Greenville
Greenville1 stop$282
Columbia
Columbia1 stop$305
Florence
Florence2 stops$471
Charlotte
Charlotte1 stop$238

Book Cheap Detroit to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Detroit to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Detroit to South Carolina

Thu, Jun 4 - Sun, Jun 7
Frontier Logo
8:52 am - 4:00 pm
DTW
-
CLT
7h 08m
1 stop
Frontier Logo
5:58 pm - 6:43 pm
CLT
-
DTW
24h 45m
1 stop
$238Frontier
Tue, Jun 2 - Wed, Jun 3
Frontier Logo
12:44 pm - 12:05 pm
DTW
-
CLT
23h 21m
1 stop
Frontier Logo
7:58 pm - 12:00 pm
CLT
-
DTW
16h 02m
1 stop
$240Frontier
Thu, Jul 2 - Tue, Jul 7
Multiple Airlines Logo
2:02 pm - 8:41 pm
DTW
-
CHS
30h 39m
2 stops
Multiple Airlines Logo
11:15 am - 1:07 pm
CHS
-
DTW
25h 52m
1 stop
$260Multiple Airlines
Sat, Aug 15 - Sat, Aug 22
Multiple Airlines Logo
2:54 pm - 5:37 pm
DTW
-
CHS
26h 43m
2 stops
Multiple Airlines Logo
8:56 pm - 5:58 pm
CHS
-
DTW
21h 02m
1 stop
$266Multiple Airlines
Sat, Jul 25 - Wed, Jul 29
American Airlines Logo
7:58 pm - 12:10 am
DTW
-
CAE
4h 12m
1 stop
American Airlines Logo
6:03 pm - 12:41 am
CAE
-
DTW
6h 38m
1 stop
$305American Airlines
Sat, Jun 6 - Sat, Jun 13
American Airlines Logo
6:00 am - 12:02 pm
DTW
-
CAE
6h 02m
1 stop
American Airlines Logo
6:39 pm - 11:57 pm
CAE
-
DTW
5h 18m
1 stop
$307American Airlines
Thu, Jun 4 - Mon, Jun 8
Delta Logo
6:15 am - 1:14 pm
DTW
-
CAE
6h 59m
1 stop
Delta Logo
7:41 pm - 12:59 am
CAE
-
DTW
5h 18m
1 stop
$324Delta
Wed, Nov 11 - Sun, Nov 15
Delta Logo
1:45 pm - 5:57 pm
DTW
-
CAE
4h 12m
1 stop
Delta Logo
6:50 pm - 11:47 pm
CAE
-
DTW
4h 57m
1 stop
$332Delta
Wed, Jun 10 - Fri, Jun 12
Southwest Logo
5:35 am - 10:10 am
DTW
-
SAV
4h 35m
1 stop
Southwest Logo
7:55 pm - 12:15 am
SAV
-
DTW
4h 20m
1 stop
$369Southwest
Thu, Jun 25 - Mon, Jun 29
Southwest Logo
6:55 am - 3:15 pm
DTW
-
SAV
8h 20m
1 stop
Southwest Logo
5:25 pm - 12:05 am
SAV
-
DTW
6h 40m
2 stops
$370Southwest
Booking Insights

KAYAK's insights & trends for Detroit to South Carolina flights

Get data-powered insights and trends into flights from Detroit to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Detroit Metropolitan Wayne County Airport to South Carolina?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Detroit Metropolitan Wayne County Airport to South Carolina departing in July.

What is the cheapest Detroit Metropolitan Wayne County Airport to South Carolina flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to South Carolina from Detroit Metropolitan Wayne County Airport found in the last 72 hours was to Myrtle Beach, at $339 round-trip. The most popular route is from Detroit Metropolitan Wayne County Airport (DTW) to Myrtle Beach (MYR), and the cheapest round-trip airline ticket found on this route in the last 72 hours was $339.

What is the cheapest time of day to fly to South Carolina?

The average price for all round-trip flights from Detroit Metropolitan Wayne County Airport to South Carolina depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to South Carolina is generally in the afternoon, when round-trip flights cost $299 on average. Morning departures are around 21% cheaper than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the evening, which is peak travel time and where the average cost of a ticket is $387.

Can I save money by flying with a layover from Detroit Metropolitan Wayne County Airport to South Carolina?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $401 on average.

What is the cheapest month to fly from Detroit Metropolitan Wayne County Airport to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Detroit Metropolitan Wayne County Airport to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Detroit Metropolitan Wayne County Airport to South Carolina is May, when tickets cost $32 (return) on average. On the other hand, the most expensive months are March and December, when the average cost of round-trip tickets is $203 and $115 respectively.

What’s the cheapest day of the week to fly from Detroit to South Carolina?

The average price of all round-trip flights from Detroit Metropolitan Wayne County Airport to South Carolina clicked on KAYAK for each day over the last 12 months.

When flying from Detroit to South Carolina, you should consider leaving on a Monday and avoid Thursdays if you are looking for the best rates. For your return to Detroit, you’ll find the best rates on Fridays and the most expensive ones on Tuesdays.

How far in advance should I book a flight from Detroit Metropolitan Wayne County Airport to South Carolina?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Detroit Metropolitan Wayne County Airport to South Carolina, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Detroit Metropolitan Wayne County Airport to South Carolina, you should book around 4 weeks before departure, which saves you about 53% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 13 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$72
Best time to beat the crowds but there is an average 10% increase in price.
Most popular time to fly and prices are also 6% lower on average.
Flight from Detroit to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Detroit to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Detroit to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Detroit to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Detroit to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Detroit to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Detroit to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Detroit to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Detroit to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Detroit to the following destinations at these prices or less: Charlotte $172 one-way - $361 round-trip

Reviews of the top 4 airlines serving from Detroit to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Detroit to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Detroit to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4292 reviews
8.1Boarding
7.5Entertainment
8.6Crew
8.0Comfort
7.0Food
Airline reviews

The checking experience in Orlando was terrible, almost missed the flight. Too many travelers and Southwest completely understaffed.

2.0 MediocreAnonymous, May 2026
MCO - MDW
Read more Southwest reviews

The checking experience in Orlando was terrible, almost missed the flight. Too many travelers and Southwest completely understaffed.

I'm glad it wasn't only 75% full because I could get a good seat

if I was good. Not happy that I have to pay extra money to get the seat I need for lake room, but I guess that’s a sign of the times.

Seats were very comfortable. They tilted back. Drinks and snacks were free and served 3 times. Attendants were awesome.

Plane was clean and comfortable. Flight attendants and gate staff were professional, friendly and efficient. Boarding and deplaning were orderly and efficient. All in all, the typical excellent Southwest experience.

Truly terrible. Will never willingly fly southwest again. Seats are worse than before they switched to assigned seating. One flight attendant was the opposite of helpful (rude, unhelpful, dismissive, and as my stranger seatmate said unprompted: a total prick). This caused me, 15 minutes into the flight, to book an alternate return flight home on a competing airline (first class 1.2k purchase instead of my existing planned flight) just so I would not have to ever be on that aircraft, with that terrible service person, with those horrific seats ever again.

Not having a five hour delay with little notice! The crew was very kind, though, and just as tired as we passengers were. The flight didn't depart until nearly 1 am...and no reason was ever given.

The entire experience from boarding to landing was amazing! The crew were very friendly. Will definitely be back.

no service at all due to turbulence. they should've at least given us snacks, there were only 10 people on the entire flight.

First time I've had to use the disabled accommodations. And I could not have had a better experience with Southwest, i was having trouble getting from one terminal to another due to my heart failure. And the next thing I know a Southwest agent had made sure. I had a wheelchair at all my flights. Can't thank them enough.

Enjoyed it very much. Especially liked the free WiFi that Delta offers.

Smooth flight. Left on time, and got in 15 minutes early. Onboard video was great

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

WiFi didn’t work on two of four planes. Flight attendants were not overly friendly or welcoming. Planes were extremely slow to board and deplane.

Delta does a great job with entertainment and free wifi. I can still be in touch with my colleagues while in the air.

Aside from a completely packed plane, I really have no complaints.

Bus to plane was delayed for no apparent reason and our luggage was still on the belt when they shut it off. Took about 20 minutes to turn it back on to get our luggage.

It was a pleasant surprise to have complimentary Wi-Fi on the flight

Much better than Latam, the worse airline company ever. I hope I don't have the need to fly Latam ever in my life again.

Seats in Delta Main are unbelievably close to the seat in front of. Hard to get a backpack under the seat.

Fine. Nothing to write home about. The plane left on time, and arrived on time.

I was downgraded from first class to coach due to an airplane change. They pulled me out of line and I was the very last person to board the plane stuck in the middle seat with no overhead place to put my carry-.on. Very poor customer service.

Seat comfort was poor (no lumbar or lower back support).

The airplane seats were spacious and comfortable, and the flight attendants were friendly and attentive. The food was delicious like never before. The blankets and toiletries were thoughtfully provided. The captain's navigation was steady and reliable. In short, having flown with Starlux, I won't consider any other airline next time.

STOP MAKING THE SEATING SO CRAMPED. WE NEED A PASSENGER BILL OF RIGHTS!

The passenger in front of of me reclined their seat back all the way the entire flight. Their headrest was in my face the entire flight! I barely had room for the little plastic cup of water to fit on my tray table; can you make the seats and space between the rows any smaller??? You can’t even get up to use the restroom! Worst flight I’ve had in a very long time!

We had several flights and they were all on-time and flawless

My Frequent Flyer nber wasn't put on as I was told it was..... This resulted in a last group boarding and no priority tags on My bags.

Terrible steward... Plane was quite empty... I asked to move "back" in the plane and the steward said no... Unnecessary power trip of mediocre people.

The small flights with Valet Luggage has a poor service

Everyone was nice but it's budget. There's nothing free and no entertainment

Broke my bag and offered no support or solution afterwards

Always Good ,… Spirit customers are high class Delta customers are self proclaimed elites and American crews you can hear them complain about everything (they’re loud)

The ticket price are reasonable, however, they can do better with the price on the luggage. Overall, I will continue using spirit.

Flight was delayed more than 3 hours, and the metro had stopped running by the time we got to the terminal well past midnight, so I was stranded, alone, with no way to get home until the metro started up the next morning.

Flight was delayed due to waiting for crew! Flight attendants did not offer us food or drinks. Did not communicate with them at all other than at boarding and leaving the plane.

Crew was very nice. Take off and landing were great. Economy seats are not comfortable. Extra cost for snacks.

They cancelled my flight last minute, forcing me to rebook with another airline.

Flight has been canceled 10 minutes before the departure time and no explanation was given. What a joke of a company

Everything was OK, the deicing took a long time, our connections were almost missed.

Everything you need to know for your flight from Detroit to South Carolina

Information on your arrival and departure airports