$457 Find Cheap Flights from Fort Myers to Panama - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Price, demand and travel trends for Fort Myers to Panama flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

What are the cheapest fares from Fort Myers to Panama right now?

The cheapest fare from Fort Myers to Panama in the last week was $700 round-trip, to Panama City Tocumen Intl (PTY).

Which airport in Panama is the cheapest to fly to from Fort Myers?

All flights from Fort Myers to Panama arrive at Panama City Tocumen Intl (PTY). On average, round-trip fares are around $787.

What's the cheapest time of day to fly from Fort Myers to Panama?

Data from the past 12 months shows it's cheapest to fly to Panama during the afternoon with average prices of $645. The morning is the most expensive time to fly, with average prices of $967.

Key details for Fort Myers to Panama flights

Cheapest flight

$457
The most popular month to fly with an average 9% increase in travelers.
One-way flight from Fort Myers to Panama City

Your Fort Myers to Panama flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • Is now a good time to book a flight from Fort Myers to Panama?

    Fares from Fort Myers to Panama are around their usual level right now. A round-trip under $699 is considered a good deal, so it's worth keeping an eye out, or setting a Price Alert to catch price changes.

  • How much should I budget for a flight from Fort Myers to Panama?

    Over the past 12 months, round-trip fares from Fort Myers to Panama have ranged from $699 to $1,028.

  • Which cabin classes are available on flights from Fort Myers to Panama?

    On flights from Fort Myers to Panama you can only book Economy Class.

  • What are some popular landmarks in Panama?

    KAYAK travelers' favorite landmarks in Panama include:

    • ATLAPA Conventions Center
    • Panama Old Cathedral
    • Veneto Casino
    • Ancon Hill

Your guide to booking Fort Myers to Panama flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your travel dates are flexible, book your trip for March when flights are typically cheapest and avoid May when prices are at their highest.
  • Flying on Tuesday is usually the cheapest. Flights on Thursday cost about 48% more on average, so being flexible with your travel dates could help you save.
  • Start your trip in Panama City, which is the most popular destination in Panama. From there, it's easy to continue on to other popular destinations such as Bocas del Toro, Río Hato and Boquete.

Reviews of the top airline flying from Fort Myers to Panama

 
Need help choosing which airline to fly with from Fort Myers to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8678 reviews
8.5Crew
7.2Food
8.1Boarding
7.8Entertainment
7.8Comfort
Airline reviews

I think in the future I cannot fly anything less than Comfort plus. The seats vary depending on the plane. The people are extremely nice and funny. I try to only fly Delta if I can help it.

8.0 ExcellentCrystal, Oct 2026
Read more Delta reviews

I think in the future I cannot fly anything less than Comfort plus. The seats vary depending on the plane. The people are extremely nice and funny. I try to only fly Delta if I can help it.

Great flight. Thank you for the upgrade to first class.

Everything was great. The only thing that wasn’t was the breakfast calzone which was basically warm bread. It was very tasteless and wasn’t good at all

I usually like delta. However this is my second flight that the wifi does not work

Both legs on the way were smaller planes, each had a mechanical issue causing a delay

Delayed flight. Dirty seats, dirty seat belts with food stuck on it from previous passengers maybe. No one cleaned the seats or flight.

Connection through Atlanta was difficult. Mechanical issue on plane caused a two hour delay. New gate was a mile away.

Newer plane, relatively easy boarding, not a full flight and was told that we could not be moved up because of weight and balance issues. Otherwise, a very good experience.

Great - This was the last flight before hurricane closures and did a quick turnaround to get the plane heading north. Much appreciated.

Crew was great! I need wheelchair assistance and they knew who I was and updated me that my chair was on its way and to just hang tight. There was some turbulence but the captain announced we would be going thru it and he handled the plane well. Landing was soft and his.

More options for your flight from Fort Myers to Panama

Complete your trip to Panama with a hotel stay or car rental