$249 Find Cheap Flights from Gainesville to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Gainesville to South Carolina departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Gainesville to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Gainesville to South Carolina, as well as popular online travel agencies
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Cheap Flights from Gainesville to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Myrtle Beach
Myrtle Beach1 stop$367
Greenville
Greenville1 stop$387
Charlotte
Charlottenonstop$404
Myrtle Beach
Myrtle Beach1 stop$367
Greenville
Greenville1 stop$387
Charlotte
Charlottenonstop$404

Book Cheap Gainesville to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Gainesville to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Gainesville to South Carolina

Tue, May 19 - Tue, May 26
Delta Logo
6:38 am - 10:39 am
GNV
-
MYR
4h 01m
1 stop
Delta Logo
6:00 am - 12:22 pm
MYR
-
GNV
6h 22m
1 stop
$367Delta
Tue, May 19 - Tue, May 26
American Airlines Logo
6:05 am - 11:29 am
GNV
-
MYR
5h 24m
1 stop
American Airlines Logo
4:43 pm - 11:59 pm
MYR
-
GNV
7h 16m
2 stops
$382American Airlines
Fri, Apr 24 - Sun, Apr 26
Delta Logo
7:03 pm - 11:56 pm
GNV
-
GSP
4h 53m
1 stop
Delta Logo
5:40 am - 9:24 am
GSP
-
GNV
3h 44m
1 stop
$387Delta
Tue, Apr 21 - Sun, Apr 26
American Airlines Logo
6:49 pm - 8:40 pm
GNV
-
CLT
1h 51mnonstop
American Airlines Logo
12:59 pm - 2:41 pm
CLT
-
GNV
1h 42mnonstop
$404American Airlines
Fri, Apr 24 - Sun, Apr 26
American Airlines Logo
7:59 pm - 11:57 pm
GNV
-
GSP
3h 58m
1 stop
American Airlines Logo
5:20 am - 10:57 am
GSP
-
GNV
5h 37m
1 stop
$407American Airlines
Wed, Apr 15 - Sat, May 2
Delta Logo
10:10 am - 1:43 pm
GNV
-
CLT
3h 33m
1 stop
Delta Logo
5:30 am - 9:24 am
CLT
-
GNV
3h 54m
1 stop
$413Delta
Tue, Apr 21 - Sun, Apr 26
American Airlines Logo
6:25 am - 1:44 pm
GNV
-
CLT
7h 19m
1 stop
American Airlines Logo
5:51 pm - 7:33 pm
CLT
-
GNV
1h 42mnonstop
$414American Airlines
Tue, Apr 21 - Sun, Apr 26
American Airlines Logo
6:25 am - 1:44 pm
GNV
-
CLT
7h 19m
1 stop
American Airlines Logo
6:35 pm - 11:59 pm
CLT
-
GNV
5h 24m
1 stop
$424American Airlines
Thu, May 7 - Sun, May 10
Delta Logo
7:05 pm - 11:43 pm
GNV
-
GSP
4h 38m
1 stop
Delta Logo
8:45 am - 2:55 pm
GSP
-
GNV
6h 10m
1 stop
$433Delta
Wed, Apr 15 - Sat, May 2
American Airlines Logo
5:47 pm - 7:35 pm
GNV
-
CLT
1h 48mnonstop
American Airlines Logo
9:10 am - 10:57 am
CLT
-
GNV
1h 47mnonstop
$433American Airlines
Booking Insights

KAYAK's insights & trends for Gainesville to South Carolina flights

Get data-powered insights and trends into flights from Gainesville to South Carolina to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Gainesville to South Carolina?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Gainesville to South Carolina were found on Delta ($367) and American Airlines ($404).

Good to know

Low seasonJuly
Cheapest flight$249
Best time to beat the crowds with an average 13% drop in price.
Most popular time to fly and prices are also 13% lower on average.
Flight from Gainesville to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Gainesville to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Gainesville to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Gainesville to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Gainesville to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Gainesville to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Gainesville to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Gainesville to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Gainesville to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Gainesville to the following destinations at these prices or less: Charlotte $307 one-way - $436 round-trip

Reviews of the top airline flying from Gainesville to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Gainesville to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Gainesville to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8288 reviews
7.9Comfort
8.1Boarding
7.8Entertainment
8.5Crew
7.2Food
Airline reviews

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

10.0 ExcellentDebra, Mar 2026
PBI - ATL
Read more Delta reviews

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

Loved flying First Class. Very comfortable. The seat was amazing. Enjoyed a movie and was able to relax so much better than in coach.

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

An awesome flight crew. FC seat cushion just doesn’t cut it for a 3+ hour flight.

The landing was the worst I’ve experienced with a flight.

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Totally worth the miles to upgrade to Delta Comfort. Plenty of legroom.

This was my first time flying Delta ever and I had a great experience!

The flight was great as well as the airline staff

Comfort seating was on the tight side. Maybe it was a smaller plane(?)

Everything you need to know for your flight from Gainesville to South Carolina

Information on your arrival and departure airports