$135 Find Cheap Flights from Knoxville to Missouri

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Missouri departing on 3/8. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Missouri

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Missouri, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Missouri, as well as popular online travel agencies
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Cheap Flights from Knoxville to Missouri

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
St. Louis
St. Louis1 stop$233
Kansas City
Kansas City1 stop$267
Springfield
Springfield1 stop$269
Joplin
Joplin1 stop$905
St. Louis
St. Louis1 stop$233
Kansas City
Kansas City1 stop$267
Springfield
Springfield1 stop$269
Joplin
Joplin1 stop$905

Book Cheap Knoxville to Missouri Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Missouri that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Missouri

Tue, Mar 24 - Tue, Mar 31
Southwest Logo
12:30 pm - 4:35 pm
TYS
-
STL
5h 05m
1 stop
Southwest Logo
7:30 am - 11:50 am
STL
-
TYS
3h 20m
1 stop
$233Southwest
Tue, Mar 24 - Tue, Mar 31
Southwest Logo
6:35 am - 2:40 pm
TYS
-
STL
9h 05m
2 stops
Southwest Logo
2:25 pm - 8:05 pm
STL
-
TYS
4h 40m
1 stop
$238Southwest
Thu, Mar 5 - Tue, Mar 10
American Airlines Logo
5:40 am - 11:01 am
TYS
-
STL
6h 21m
1 stop
American Airlines Logo
9:21 am - 4:31 pm
STL
-
TYS
6h 10m
1 stop
$245American Airlines
Thu, Mar 5 - Tue, Mar 10
American Airlines Logo
12:21 pm - 5:13 pm
TYS
-
STL
5h 52m
1 stop
American Airlines Logo
9:59 am - 4:31 pm
STL
-
TYS
5h 32m
1 stop
$254American Airlines
Wed, May 6 - Tue, May 12
Delta Logo
4:38 pm - 10:11 pm
TYS
-
MCI
6h 33m
1 stop
Delta Logo
5:40 am - 1:07 pm
MCI
-
TYS
6h 27m
1 stop
$267Delta
Sat, May 2 - Tue, May 5
United Airlines Logo
7:00 am - 10:36 am
TYS
-
SGF
4h 36m
1 stop
United Airlines Logo
3:00 pm - 11:44 pm
SGF
-
TYS
7h 44m
1 stop
$269United Airlines
Wed, Mar 4 - Sun, Mar 8
Multiple Airlines Logo
2:05 pm - 10:27 pm
TYS
-
STL
9h 22m
1 stop
Multiple Airlines Logo
7:52 am - 9:50 pm
STL
-
TYS
12h 58m
1 stop
$270Multiple Airlines
Sat, May 2 - Tue, May 5
United Airlines Logo
7:00 am - 10:36 am
TYS
-
SGF
4h 36m
1 stop
United Airlines Logo
6:00 am - 2:34 pm
SGF
-
TYS
7h 34m
2 stops
$274United Airlines
Tue, Feb 24 - Sat, Feb 28
Delta Logo
5:35 am - 11:20 am
TYS
-
SGF
6h 45m
1 stop
Delta Logo
6:00 am - 11:08 am
SGF
-
TYS
4h 08m
1 stop
$279Delta
Thu, Feb 19 - Mon, Feb 23
Multiple Airlines Logo
7:00 am - 5:13 pm
TYS
-
MCI
11h 13m
1 stop
Multiple Airlines Logo
10:55 am - 10:06 am
MCI
-
TYS
46h 11m
2 stops
$291Multiple Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Missouri flights

Get data-powered insights and trends into flights from Knoxville to Missouri to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Knoxville to Missouri?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Knoxville to Missouri were found on Southwest ($233) and Delta ($267).

Good to know

Low seasonJanuary
Cheapest flight$135
Best time to beat the crowds with an average 9% drop in price.
Most popular time to fly and prices are also 9% lower on average.
Flight from Knoxville to St. Louis

FAQs - booking Missouri flights

  • How does KAYAK find such low prices on flights from Knoxville to Missouri?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Missouri.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Missouri?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to Missouri is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Missouri?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to Missouri with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Missouri?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to Missouri up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Knoxville to Missouri

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Missouri. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8178 reviews
7.9Comfort
8.1Boarding
7.2Food
8.5Crew
7.8Entertainment
Airline reviews

Was forced to check in my small carry on, even though I informed the crew it has very fragile items inside

2.0 MediocreJaspreet, Feb 2026
SEA - SMF
Read more Delta reviews

Was forced to check in my small carry on, even though I informed the crew it has very fragile items inside

This was one of the worst flights I’ve been on in years. I upgraded to comfort and had such an uncomfortable experience. The person next to me was oversized - which I understand - however, they took up their space and mine. I could only use about 50% of my seat space to not be physically touching this person the entire flight and there was no spatial awareness. I also could not use the seat outlet because their body was obstructing it. It was very inconvenient. Their body kept touching me repeatedly during the flight and I felt very uncomfortable. To pay more for an upgraded space and then not even being able to use it was highly disappointing.

No wheel chair as requested at Atlanta arrival on first flight.

Only freetext wifi was available in flight; browsing WiFi required payment. Since the seats had no in flight entertainment, Delta should revisit this policy on this longer flight.

Only water, tea or coffee served midflight, even to comfort seating. Man next to me needed two seats and took up a portion of my seat and Delta did nothing.

The flight was great as well as the airline staff

First class and monitors weren’t working for mine & my husbands. Eventually fixed, but quite annoyed as we bought first class. Also, No foot rests.

Prior to takeoff, the pilot told us there was a possibility of not being able to land and going to Portland. Well that happened, we took off and then did 8 loops around Spokane before the pilot told us we ran out of fuel and had to go to Portland. So for a 35 minute flight we have now been on the plane for 3 hours (boarded at 6:50 am and landed in Portland at 10:30). Then, we just sat in Portland's airport with no updates of when we can start heading back. All of a sudden, our pilots and crew just left, leaving us stranded in a different city and state. We continued to sit in Portland until we finally got a new crew assigned and boarded the plane (This was from 10:30-2). We then sat on the plane for an additional hour before take off because they had to count us multiple times. We finally landed in Spokane at 3:55 PM. So a flight that should have taken at max an hour took us 10 hours and we missed the majority of the recruiting event we went for.

It was delayed but other than that it was great.

Got on the plane and sat there for an hour before departure.

Everything was on time Will use united again for sure

Plane outlets in my row not working to charge phone. Staff response was, well it should be. Plug into seed for volume not working well. Had to find the sweet spot for plug in or it would shut off and on.

Fine not above and beyond as I had a connection that was delayed due to maintenance

The power at the seat didn't work and the seat itself was difficult to adjust - this was a business class seat. Flight attendant gave me miles to compensate. The attendant was very professional and on top of his game the entire flight.

I upgraded my seat and was promised it would be next to the emergency door for extra leg room and they said it was premium plus but it was at the back of the plane...same thing happened from Newark to Dubai

Everything except the food and entertainment. It was a great experience though

Bad food, bad service, cold cabin with no additional blankets when asked for (they told me they don’t provide additional blankets). I’m a frequent traveler and this is one of the worst companies I traveled with (by the way I thought that I booked my ticket with Lufthansa but I didn’t see that the flights were handled by United).

United Airlines is my preferred airlines and I am thankful for Gary who also help support me on the phone to switch my flight literally last min.

Not being stranded in Chicago for her airport to 11:30 tomorrow morning the 3rd

the whole trip was smooth, and as comfortable as flying is these days. flight crew was friendly and very courteous and helpful.

One day, I do so hope for a gluten free snack! Seems like with the rest of the world FINALLY figuring out what gluten free is, American Airlines would too. Fingers crossed!!

The flight was significantly delayed for 6.5 hours because of snow. There was no communication once the plane returned to the gate regarding when the flight would resume. Other flights were departing while our flight was being unloaded for reasons unknown. Our flight also seemed out of the queue regarding further deicing, refueling, and waiting to Taxi to the runway.

Flight was on time and the meal and service were good.

Flight was delayed for 2 hours, then last minute the change to on time. The satélite location is far and a nightmare to get to.

This was a horrible experience. I’ve experienced several delays at this point and still not home. I was supposed to be home by 8:30 last night and here I sit at 7 am on a plane STILL unable to go home because of American Airlines.

Generally good. Flight left on time and the seats are comfortable. Plenty of space in front if you in you choose a comfort plus seat, completely worth spending the extra money given the amount of hours the flight lasts. The food tastes good but I would say it’s a the amount is too little. The crew was friendly and efficient. There was a some turbulence at different points into the flight. American Airlines has good deals to NZ if you book with plenty of time before you plan on going.

the plane was so hot!! the air-conditioning was barely blowing. The flight was delayed, and we had to sit on the hot plane before take off for an extended amount of time, waiting on international passengers. Would not have been so bad if it was not so hot. They said it would get better after take off, but it did not.

They are always late and seats was also not having working charger

We flew in first class. The crew did not offer drinks before the flight took off, but they treated us well during the flight. The food was excellent. There was actually too much food served, but it was nice to have all the options.

did not have enough meal for first class passengers so offer us snack

Everything you need to know for your flight from Knoxville to Missouri

Information on your arrival and departure airports