$106 Find Cheap Flights from Knoxville to Missouri - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Missouri departing on 7/20. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Missouri

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Missouri, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Missouri, as well as popular online travel agencies
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Cheap Flights from Knoxville to Missouri

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
St. Louis
St. Louis1 stop$248
Kansas City
Kansas City2 stops$271
Springfield
Springfield1 stop$317
Joplin
Joplin1 stop$384
St. Louis
St. Louis1 stop$248
Kansas City
Kansas City2 stops$271
Springfield
Springfield1 stop$317
Joplin
Joplin1 stop$384

Book Cheap Knoxville to Missouri Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Missouri that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Missouri

Thu, Dec 10 - Tue, Dec 15
Delta Logo
5:57 pm - 8:49 pm
TYS
-
STL
3h 52m
1 stop
Delta Logo
11:51 am - 5:18 pm
STL
-
TYS
4h 27m
1 stop
$248Delta
Thu, Dec 10 - Tue, Dec 15
Southwest Logo
7:00 am - 1:10 pm
TYS
-
STL
7h 10m
2 stops
Southwest Logo
12:40 pm - 7:50 pm
STL
-
TYS
6h 10m
1 stop
$253Southwest
Wed, Jul 29 - Sat, Aug 1
Southwest Logo
6:55 pm - 11:05 pm
TYS
-
STL
5h 10m
1 stop
Southwest Logo
2:30 pm - 9:25 pm
STL
-
TYS
5h 55m
1 stop
$258Southwest
Fri, Jul 24 - Thu, Aug 20
Multiple Airlines Logo
12:40 pm - 8:57 am
TYS
-
STL
21h 17m
2 stops
Multiple Airlines Logo
6:45 pm - 9:46 pm
STL
-
TYS
26h 01m
1 stop
$266Multiple Airlines
Tue, Aug 25 - Sat, Aug 29
American Airlines Logo
6:03 am - 10:30 am
TYS
-
MCI
5h 27m
1 stop
American Airlines Logo
3:47 pm - 11:53 pm
MCI
-
TYS
7h 06m
1 stop
$279American Airlines
Tue, Sep 1 - Wed, Sep 2
United Airlines Logo
6:02 pm - 10:00 pm
TYS
-
STL
4h 58m
1 stop
United Airlines Logo
8:50 am - 4:58 pm
STL
-
TYS
7h 08m
1 stop
$281United Airlines
Sat, Aug 15 - Mon, Aug 17
American Airlines Logo
6:03 am - 10:30 am
TYS
-
MCI
5h 27m
1 stop
American Airlines Logo
6:20 am - 12:56 pm
MCI
-
TYS
5h 36m
1 stop
$285American Airlines
Sat, Aug 15 - Mon, Aug 17
United Airlines Logo
5:45 am - 12:20 pm
TYS
-
MCI
7h 35m
2 stops
United Airlines Logo
5:39 pm - 11:59 pm
MCI
-
TYS
5h 20m
1 stop
$312United Airlines
Thu, Jul 9 - Mon, Jul 13
Allegiant Air Logo
3:54 pm - 9:30 am
TYS
-
SGF
18h 36m
1 stop
Allegiant Air Logo
8:51 am - 11:19 pm
SGF
-
TYS
13h 28m
1 stop
$317Allegiant Air
Thu, Aug 6 - Sat, Aug 8
Allegiant Air Logo
8:15 am - 7:14 pm
TYS
-
SGF
11h 59m
1 stop
Allegiant Air Logo
4:05 pm - 12:31 pm
SGF
-
TYS
19h 26m
1 stop
$335Allegiant Air
Booking Insights

KAYAK's insights & trends for Knoxville to Missouri flights

Get data-powered insights and trends into flights from Knoxville to Missouri to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Knoxville to Missouri?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Knoxville to Missouri departing in July.

What is the cheapest month to fly from Knoxville to Missouri?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Missouri, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Missouri is September, when tickets cost $150 (return) on average. On the other hand, the most expensive months are June and May, when the average cost of round-trip tickets is $278 and $270 respectively.

Good to know

Low seasonFebruary
Cheapest flight$106
Best time to beat the crowds but there is an average 16% increase in price.
Most popular time to fly and prices are also 12% lower on average.
Flight from Knoxville to St. Louis

FAQs - booking Missouri flights

  • How does KAYAK find such low prices on flights from Knoxville to Missouri?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Missouri.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Missouri?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to Missouri is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Missouri?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to Missouri with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Missouri?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to Missouri up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Knoxville to Missouri

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Missouri. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4246 reviews
7.5Entertainment
8.6Crew
8.1Boarding
7.0Food
8.0Comfort
Airline reviews

Communication about the delayed flight was poor. We were told to move gates three times but that was bad information. We went from gate 128 to gate 126 and then to gate 123 and back to gate 126. Communication about the delay was bad. Ended up being 1 1/2 hour late getting home.

2.0 MediocreDavid, Apr 2026
MCO - MCI
Read more Southwest reviews

Communication about the delayed flight was poor. We were told to move gates three times but that was bad information. We went from gate 128 to gate 126 and then to gate 123 and back to gate 126. Communication about the delay was bad. Ended up being 1 1/2 hour late getting home.

I have roller bag with food and medication told me I couldn't bring on my 2nd flight today. 15 years flying with SW never an issue with that bag.

I have not flown Southwest in awhile and had a very pleasant experience. From ticketing to boarding to the flight. The flight left on time and landed ahead of schedule. It won't be so long next time!!

Everything went smoothly and we even arrived a little bit early.

Boarded on time but once we were ready for take off, the crew determined that, although every seat was taken, somehow someone was on the wrong flight. Delay, delay delay, announcements and ended up with one person checking EVERY ID against their passenger Manifest only to figure out it was a "clerical error." We departed 54 minutes late causing me to run in the St. Louis Airport to make my connection and lose the priority boarding spot I had paid for. Unnecessary delay.

Flight was delayed due to plane not passing inspection And one of the crew had to time out and we had to wait for another one A 3 hour delay

Southwest's seats are the least comfortable I have ever sat in.

It was one and half hour late... Not sure if any other experience matters.

For my birthday trip this was my second time ever flying, this trip was the best.

Everything went smoothly and the plane wasn’t full. It was delayed though. .

I was in Comfort and we didn’t get any drinks, chips or anything! First Class got full service on the flight and Comfort got nothing. Seat was horrible and uncomfortable

Short trip, no food and therefore no expectation for much interaction with staff who were pleasant and professional. My critique is on comfort of the seats. Exit rows and comfort seats do not provide enough personal space for 3 side-by-side seats, especially when in the middle row. Some passengers are not considerate of the middle seat and there should be signs that state something to the effect of: "please consider giving middle seats use of the armrests."

We departed early and made up time in the air allowing us to arrive 30 minutes early. Capt was incredibly genuine and thanked every passenger for flying with Delta. Completely humble and professional!

The boarding process needs to be refined. Sometimes the gate crew calls out the zones and then flip to showing the.zones boarding on the gate monitor display. So, unless you are huddled around the gate lanes watching the monitor, you could miss your boarding zone. Suggest the zones be announced each time a new zone is allowed to board.

This route with Delta always has delays or is cancelled. Aircrafts seem smaller and older. I fly Delta quite a bit - haven’t had issues with the international flights. But this route has always been the troublesome one

From Atlanta to Cabo I would have hoped on a plane that size I would have been able to breathe and wiggle my feet a little! The leg room in that plane is non existent and I am only 5”4’. And the air vent either wasn’t working very well or just could not blow air from the ceiling to the seat area as I was suffocating through the entire flight! And please don’t say I would have been more comfortable in first class because I cannot afford those rates and have always travelled Main Cabin without issues !

On 2 different flights the wifi was horrible and there was no drink or snack service.

There was no FREE wi-fi nor entertainment screens at all.

Great, on time departure, friendly and accommodating crew, great leg room, Smith flight

As we lined up to board they gave our plane to a flight going to Newark. So then we got delayed until they could find another plane. Flight crew was ok. I’m assuming since it’s a shorter flight they only offered water and coffee.

Flight was 3 hours delayed. They gave our plan to two other routes. Need to knock that off.

We called Kayak for a change due to the TSA situation in Atlanta. What we got was a canceled return flight (in error) and we had to find the mistake. Not happy with Kayak who blamed it on AA.

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

Small plane, poor meal choices for first class, bad terminal and boarding experience at LAX

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

I didn’t like anything, being platinum pro get you absolutely nowhere and does not increase the customer service treatment whatsoever anymore. My flight was canceled and they put me on a flight eight hours later that would’ve got me back in the middle of the night. They could’ve easily move me up to an hour Prior on an earlier flight. My second flight was unreasonable to take, the third flight was also canceled due to mechanical issues like the first flight. I don’t know what’s going on with American, but they are falling apart, after seven flight changes I finally got home, Unreasonable.

This was a horrible American Airlines experience, and it discourages me from flying with them again. It may have stemmed from a mechanical delay, but it appeared that the team was unprepared to respond to the delay. After boarding, we waited an hour before finally taking off. After landing at our destination, we waited an additional hour on the tarmac waiting for a gate (at 8:00pm) to be assigned and cleared. The flight crew did their best, but they were clearly tired and also ready to be done for the day. Because of the delay, I missed a connecting flight. It was a very poor experience.

Fantastic! If it had not been for a check-in agent in Knoxville I may have not gotten my passes on British Airways. I couldn’t check-in online because British Airways had messed us the info on my tickets to London & Inverness. AA’s was great! British Airways was a continuous series of delays and frustrations.

Wheelchair was waiting for me,changed to a better seat which was great as it's hard for me to walk

Everything you need to know for your flight from Knoxville to Missouri

Information on your arrival and departure airports