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Cheap Flights from Knoxville to Missouri

Cheapest round-trip prices found by our users on KAYAK in the last 5 days
Sort by: Cheapest
St. Louis
3h 39m2 stops
from $277per person
Kansas City
4h 08m2 stops
from $319per person
Columbia
Columbia
4h 45m2 stops
from $334per person
Springfield
4h 12m2 stops
from $369per person
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Booking Insights

Price, demand and travel trends for Knoxville to Missouri flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

What are the cheapest fares from Knoxville to Missouri recently?

Here are the cheapest round-trip fares from Knoxville to Missouri on KAYAK in the last week:

• Lambert-St Louis (STL) from $277
• Kansas City (MCI) from $324
• Columbia Regional (COU) from $334

How do fares into airports in Missouri compare?

According to KAYAK data from the last 12 months, the cheapest airports to fly into Missouri from Knoxville are:

• Lambert-St Louis (STL) (avg. price $328)
• Columbia Regional (COU) (avg. price $386)
• Kansas City (MCI) (avg. price $400)

What's the cheapest month to fly from Knoxville to Missouri?

January is typically the cheapest month to fly from Knoxville to Missouri, with round-trip fares averaging $342. November and April are usually the most expensive, averaging $504 and $423, respectively.

How do fares from Knoxville to Missouri vary by day of the week?

On average, Wednesday is the cheapest day to fly from Knoxville to Missouri and Tuesday is the most expensive. Looking at the past 12 months of KAYAK data, it's 68% more expensive to fly on a Tuesday compared to Wednesday.

What's the best time of day to fly from Knoxville to Missouri?

It's cheapest to fly to Missouri in the afternoon with average prices of $387. The evening is the most expensive time to fly, with average prices of $436.

Key details for Knoxville to Missouri flights

Low season

May

Cheapest flight

$170
Beat the crowds with an average 16% drop in travelers.
The most popular month to fly with an average 22% increase in travelers.
One-way flight from Knoxville to Kansas City

Your Knoxville to Missouri flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • Is now a good time to book a flight from Knoxville to Missouri?

    Yes. Fares from Knoxville to Missouri are low right now. As a rule of thumb, a round-trip under $308 (cheaper than most fares this year) is a good deal, so if you spot one at or below that, it's a good time to book.

  • How much should I budget for a flight from Knoxville to Missouri?

    Over the past 12 months, round-trip fares from Knoxville to Missouri have typically cost between $308 and $518.

  • What are the main airports serving Missouri?

    There are 11 airports in Missouri. 57% of KAYAK users choose Kansas City (MCI) as their arrival airport, while 26% choose Lambert-St Louis (STL).

  • Which airlines fly nonstop from Knoxville to Missouri?

    Based on the flight schedule for the next 3 months, no airline regularly operates nonstop flights from Knoxville to Missouri. One-stop options include Delta and Southwest.

  • Which destinations in Missouri can I fly nonstop from Knoxville?

    Based on the flight schedule for the next 3 months, there are no nonstop flights from Knoxville to Missouri. The most popular destination you can reach with one stop is Kansas City.

  • Which cabin classes are available from Knoxville to Missouri?

    On flights from Knoxville to Missouri you can book Economy Class or First Class.

  • What are some popular landmarks around Missouri?

    Missouri is home to many popular sights. KAYAK travelers' favorites include:

    • Busch Stadium
    • Arrowhead Stadium
    • Enterprise Center
    • Kansas City Convention Center

Your guide to booking Knoxville to Missouri flights

Get tips on when to book, when to fly and what to know before your trip.
  • Flexible with your dates? Fly in January to save some money. It's typically the cheapest month on this route, while flights in November will cost you the most.
  • Fly out on a Wednesday to get the cheapest fares. Avoid Tuesday flights, which are about 68% more expensive.
  • If you're watching your budget, fly into Lambert-St Louis (STL) which has the lowest average airfare in the region. Just remember to budget for any onward travel by bus, car or domestic flight.
  • Start your trip in St. Louis, the most popular destination in Missouri. From there, it's easy to continue on to other popular spots such as Kansas City, Branson and Springfield.

Reviews of the top 3 airlines serving from Knoxville to Missouri

 
Need help choosing which airline to fly with from Knoxville to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4222 reviews
8.0Comfort
7.0Food
8.6Crew
7.5Entertainment
8.1Boarding
Airline reviews

My first flight from LGA to STL was not good. They didn't do service until over halfway through the flight, the internet didn't really work, and the crew all seemed like they didn't want to be there.

4.0 OkayTatyana, Nov 2026
Read more Southwest reviews

My first flight from LGA to STL was not good. They didn't do service until over halfway through the flight, the internet didn't really work, and the crew all seemed like they didn't want to be there.

When I made my reservation it would have been nice if kayak would have included my luggage. Unaware that I had to pay $45 each way. Should have asked at reservation time if luggage was being checked

Southwest has been a nightmare. Delayed flights, missed connections, systems down. Never again am I flying southwest.

Just crazy with times being pushed and pushed and pushed and gate crew at Philly super rude and unprofessional with many under stress with delays.

Great job! My family doesnt fly often but we felt safe 100%

Communication about the delayed flight was poor. We were told to move gates three times but that was bad information. We went from gate 128 to gate 126 and then to gate 123 and back to gate 126. Communication about the delay was bad. Ended up being 1 1/2 hour late getting home.

I have roller bag with food and medication told me I couldn't bring on my 2nd flight today. 15 years flying with SW never an issue with that bag.

I have not flown Southwest in awhile and had a very pleasant experience. From ticketing to boarding to the flight. The flight left on time and landed ahead of schedule. It won't be so long next time!!

Everything went smoothly and we even arrived a little bit early.

Everything went smoothly and the plane wasn’t full. It was delayed though. .

My flight home from Knoxville, TN, included a layover in Atlanta. I boarded the aircraft in Zone 5 and although there was limited overhead space, I was able to put my 'backpack' style roller-bag above my seat. Unfortunately, due to continued bad weather, we had to deplane. There were many people who would have missed their connection, so they rebooked. When we were re-boarding, the gate agent welcomed zone 5 and then made an announcement: All roller-bags for zone 5 passengers and higher will need to be gate checked. I promptly pushed the telescoping handle in and held my bag like a backpack. I was able to bring it on board, which was a relief. Upon entering the aircraft it became apparent that there was easily 40% open overhead space. There were audible signs of angry passengers who felt duped into checking their bags when in fact there were noticeably LESS passengers on the aircraft and TONS of overhead space. I'm not sure what kinds of parameters are used to determine when to cut off roller-bags from being brought on board, but it seemed deceptive and underhanded to have so many people get stuck checking their bags when clearly there was ample room for at least one more zone.

The CRJ-900 was clean but the overhead air vents were broken in our First Class row, making the cabin very hot until about 30 mins into the flight. The flight attendants were both extremely apologetic and accommodating though so that is why I rated the flight as very good. They checked on us many times and truly showed they cared. The snacks for an hour and a half flight could be better. Would be nice if there was a small plated meal over convenient store snacks. WiFi also was not working. And it would be nice if Delta had adjustable headrests on these planes.

We departed early and made up time in the air allowing us to arrive 30 minutes early. Capt was incredibly genuine and thanked every passenger for flying with Delta. Completely humble and professional!

The boarding process needs to be refined. Sometimes the gate crew calls out the zones and then flip to showing the.zones boarding on the gate monitor display. So, unless you are huddled around the gate lanes watching the monitor, you could miss your boarding zone. Suggest the zones be announced each time a new zone is allowed to board.

This route with Delta always has delays or is cancelled. Aircrafts seem smaller and older. I fly Delta quite a bit - haven’t had issues with the international flights. But this route has always been the troublesome one

From Atlanta to Cabo I would have hoped on a plane that size I would have been able to breathe and wiggle my feet a little! The leg room in that plane is non existent and I am only 5”4’. And the air vent either wasn’t working very well or just could not blow air from the ceiling to the seat area as I was suffocating through the entire flight! And please don’t say I would have been more comfortable in first class because I cannot afford those rates and have always travelled Main Cabin without issues !

On 2 different flights the wifi was horrible and there was no drink or snack service.

There was no FREE wi-fi nor entertainment screens at all.

Great, on time departure, friendly and accommodating crew, great leg room, Smith flight

As we lined up to board they gave our plane to a flight going to Newark. So then we got delayed until they could find another plane. Flight crew was ok. I’m assuming since it’s a shorter flight they only offered water and coffee.

After lack of help in Philadelpha made us late to board our flight to akansas City, our flight to Kansas City was very good. And the flight attendants were also very good. The only thing that sucked was problems with assistance in Philadelphia caused our bags not to arrive.

The flight was overbooked. And the gate agent basically said that the flight will not leave unless two people came forward to give up their seats. Offered money. Raised the $$ too. But we were there for a while and flight was delayed. When passengers approached the gate agent asking what would happen if no one volunteered- the answer was flight would be cancelled! Ridiculous! It’s American’s fault for overbooking. The service level is going from Bad to worse it seems.

My wife has a scooter and they where supposed to send from departure to destination and had it go to connecting flight,not good.Nobody has knowledge of the scooters or the battery's.

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

I didn’t like anything, being platinum pro get you absolutely nowhere and does not increase the customer service treatment whatsoever anymore. My flight was canceled and they put me on a flight eight hours later that would’ve got me back in the middle of the night. They could’ve easily move me up to an hour Prior on an earlier flight. My second flight was unreasonable to take, the third flight was also canceled due to mechanical issues like the first flight. I don’t know what’s going on with American, but they are falling apart, after seven flight changes I finally got home, Unreasonable.

This was a horrible American Airlines experience, and it discourages me from flying with them again. It may have stemmed from a mechanical delay, but it appeared that the team was unprepared to respond to the delay. After boarding, we waited an hour before finally taking off. After landing at our destination, we waited an additional hour on the tarmac waiting for a gate (at 8:00pm) to be assigned and cleared. The flight crew did their best, but they were clearly tired and also ready to be done for the day. Because of the delay, I missed a connecting flight. It was a very poor experience.

Fantastic! If it had not been for a check-in agent in Knoxville I may have not gotten my passes on British Airways. I couldn’t check-in online because British Airways had messed us the info on my tickets to London & Inverness. AA’s was great! British Airways was a continuous series of delays and frustrations.

Wheelchair was waiting for me,changed to a better seat which was great as it's hard for me to walk

More options for your flight from Knoxville to Missouri

Complete your trip to Missouri with a hotel stay or car rental