Which airports can I use when flying from Knoxville to St. Louis?

Flights from Knoxville to St. Louis usually depart from Knoxville McGhee Tyson (TYS) and arrive at Lambert-St Louis (STL).

What cabin classes can I book on flights from Knoxville to St. Louis?

Only Economy Class is available on flights from Knoxville to St. Louis.

Which airports do connecting flights from Knoxville to St. Louis pass through?

One-stop flights from Knoxville to St. Louis most commonly connect through: • Atlanta Hartsfield-Jackson (ATL) - 48% of one-stop connections • Charlotte Douglas (CLT) - 17% of one-stop connections • Chicago O'Hare Intl (ORD) - 17% of one-stop connections • Nashville Intl (BNA) - 7% of one-stop connections Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.

Can I save money by using flexible dates for flights from Knoxville to St. Louis?

Yes. Being flexible with your travel dates can save you up to 38% on the Knoxville to St. Louis route. Friday is the cheapest departure day at $278 round-trip on average, while Monday is the most expensive at $442, a difference of $164. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

What popular places can I visit in St. Louis?

Some of the most popular sights in St. Louis are Busch Stadium, Enterprise Center and America's Center Convention Complex. These are among the most viewed places in St. Louis on KAYAK.

How long is a flight from Knoxville to St. Louis?

A nonstop flight from Knoxville to St. Louis takes 0h 00m, covering 405 miles.

Do I need a passport to fly from Knoxville to St. Louis?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

Have flight prices from Knoxville to St. Louis changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $205 to $799. That means the highest observed fare was about 4x higher than the lowest one.

How are flight prices from Knoxville to St. Louis looking right now?

One-way fares from Knoxville to St. Louis are currently lower than usual. Average one-way flight prices are about $183, which is 22% below the typical average for this route.

How much time can I save by choosing a different layover airport from Knoxville to St. Louis?

Flying via Nashville Intl (BNA) gives the shortest average 1-stop total travel time at 3h 57m, compared with 4h 07m via Atlanta Hartsfield-Jackson (ATL) and 4h 33m via Charlotte Douglas (CLT).

What is the time difference between Knoxville and St. Louis?

St. Louis is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

What car rental options are available at Lambert-St Louis Airport (STL)?

Lambert-St Louis Airport (STL) hosts 5 major car rental companies, with daily rates starting from around $31 for economy cars. Top options include: • Hertz • Budget • Alamo • Enterprise Rent-A-Car • Payless

How much should I expect to pay for a Knoxville to St. Louis flight?

Round-trip flights from Knoxville to St. Louis range from $270 to $455, with an average of $325 over the past 12 months. Anything below $270 counts as a good deal.

What is the cheapest airline to fly from Knoxville to St. Louis?

American Airlines ($205) and Southwest ($223) are the cheapest airlines to fly round-trip from Knoxville to St. Louis according to KAYAK data over the last 5 days.

What is the most popular layover airport when flying from Knoxville to St. Louis?

Atlanta Hartsfield-Jackson (ATL) is the most popular layover for the Knoxville to St. Louis route. 48% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via ATL.

What is the cheapest layover airport when flying from Knoxville to St. Louis?

Flights via Orlando (MCO) offer the most affordable fares, with an average round-trip price of $125. Based on KAYAK data over the past 3 months.

When flying from Knoxville to St. Louis which airport offers the shortest layover?

Atlanta Hartsfield-Jackson (ATL) had the shortest average connection time for Knoxville to St. Louis layovers at 164 minutes over the past 3 months.

$129 CHEAP FLIGHTS from Knoxville to St. Louis (TYS - STL)

Save 21% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$205

Typical prices: $270-$455

American Airlines

Sun 10/14Wed 10/17

TYS - STL • 1 stop

Cheapest one-way

$129

Typical prices: $167-$303

American Airlines

Tue 10/9

TYS - STL • 1 stop

Nonstop flights

Not available

There are currently no direct flights between Knoxville and St. Louis. You'll need to take a connecting flight to reach the destination.

Insights

When to travel

May

Cheapest • 15% price drop

October

Most popular

Good to know

Top layover airports

Orlando (MCO)

Cheapest • Avg $125 (round-trip)

Nashville Intl (BNA)

Shortest trip • 3h 57m (one-way)

Insights

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KAYAK searches 100s of sites at once to find you the best travel deals.

We hope you love your trip to St. Louis!

Flight Deals

Cheap Flights from Knoxville to St. Louis (TYS-STL)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Recent round-trip flight deals from Knoxville to St. Louis

Wed, Oct 14 - Sat, Oct 17

7:17 am - 12:35 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 18m1 stop Washington, D.C. Reagan-National

11:31 am - 6:20 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 49m1 stop Chicago O'Hare Intl

$205American Airlines

Thu, Nov 12 - Wed, Nov 18

8:04 pm - 11:58 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

4h 54m1 stop Charlotte Douglas

6:00 am - 11:01 amSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 01m1 stop Chicago O'Hare Intl

$218American Airlines

Thu, Nov 12 - Wed, Nov 18

12:50 pm - 6:40 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 50m1 stop Orlando

8:30 am - 7:50 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

10h 20m2 stops Houston Hobby Nashville Intl

$223Southwest

Sat, Jan 9 - Fri, Jan 15

2:15 pm - 7:10 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 55m1 stop Nashville Intl

5:35 am - 2:00 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

7h 25m1 stop Dallas Love Field

$239Southwest

Fri, Oct 16 - Mon, Oct 19

5:40 am - 10:51 amTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 11m1 stop Atlanta Hartsfield-Jackson

6:00 am - 10:54 amSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 54m1 stop Atlanta Hartsfield-Jackson

$244Delta

Sat, Jan 9 - Fri, Jan 15

6:55 am - 3:30 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

9h 35m2 stops Nashville Intl Tampa

5:35 am - 2:00 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

7h 25m1 stop Dallas Love Field

$245Southwest

Fri, Dec 25 - Fri, Jan 1

10:56 am - 4:04 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 08m1 stop Atlanta Hartsfield-Jackson

6:00 am - 1:38 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 38m1 stop Atlanta Hartsfield-Jackson

$257Delta

Tue, Nov 17 - Sun, Nov 22

6:01 am - 9:44 amTYS Knoxville McGhee Tyson-STL Lambert-St Louis

4h 43m1 stop Charlotte Douglas

5:02 am - 11:11 amSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 09m1 stop Chicago O'Hare Intl

$257American Airlines

Thu, Oct 22 - Mon, Oct 26

6:00 am - 12:13 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

7h 13m1 stop Chicago O'Hare Intl

2:55 pm - 9:57 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 02m1 stop Houston George Bush Intcntl

$328United Airlines

Thu, Oct 22 - Mon, Oct 26

7:15 am - 2:10 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

7h 55m1 stop Houston George Bush Intcntl

1:08 pm - 8:54 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 46m1 stop Chicago O'Hare Intl

$359United Airlines

Recent last minute flight deals from Knoxville to St. Louis

Fri, Sep 18 - Sat, Sep 19

2:08 pm - 5:45 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

4h 37m1 stop Atlanta Hartsfield-Jackson

5:46 pm - 10:27 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 41m1 stop Atlanta Hartsfield-Jackson

$605Delta

Sun, Sep 20 - Wed, Sep 23

8:20 am - 7:17 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

35h 57m2 stops Las Vegas Harry Reid Intl Denver Intl

12:17 pm - 5:18 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

28h 01m1 stop Las Vegas Harry Reid Intl

$616Multiple Airlines

Fri, Sep 18 - Sun, Sep 20

8:00 am - 7:17 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

12h 17m2 stops Austin Bergstrom Denver Intl

5:19 pm - 8:39 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

26h 20m1 stop Orlando

$628Multiple Airlines

Sat, Sep 19 - Mon, Sep 21

6:00 am - 11:57 amTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 57m1 stop Chicago O'Hare Intl

6:00 am - 1:18 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 18m1 stop Chicago O'Hare Intl

$629United Airlines

Sun, Sep 20 - Wed, Sep 23

8:13 pm - 11:41 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

4h 28m1 stop Charlotte Douglas

1:54 pm - 6:52 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 58m1 stop Charlotte Douglas

$637American Airlines

Sat, Sep 19 - Mon, Sep 21

6:50 am - 3:15 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

9h 25m2 stops Nashville Intl Orlando

6:25 am - 3:55 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

8h 30m1 stop Denver Intl

$644Southwest

Thu, Sep 17 - Sat, Sep 19

5:45 pm - 10:10 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 25m1 stop Nashville Intl

8:25 am - 5:45 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

8h 20m2 stops Austin Bergstrom Nashville Intl

$644Southwest

Fri, Sep 18 - Sat, Sep 19

4:50 pm - 10:00 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 10m1 stop Denver Intl

8:00 am - 5:45 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

8h 45m2 stops Orlando Nashville Intl

$644Southwest

Fri, Sep 18 - Sun, Sep 20

7:30 am - 2:44 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

8h 14m1 stop Dallas/Fort Worth

12:50 pm - 7:47 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 57m1 stop Charlotte Douglas

$669American Airlines

Thu, Sep 17 - Sun, Sep 20

7:50 am - 1:23 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 33m1 stop Atlanta Hartsfield-Jackson

4:59 pm - 11:55 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 56m1 stop Atlanta Hartsfield-Jackson

$669Delta

Booking Insights

Price, demand and travel trends for Knoxville to St. Louis flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Knoxville to St. Louis with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from Knoxville to St. Louis?

Round-trip flights from Knoxville to St. Louis start at $205. Prices are below average for this route right now, with typical round-trip fares ranging from $270 to $455. The lowest price found in the past 5 days was $205 on American Airlines.

What's the cheapest day of the week to fly from Knoxville to St. Louis?

Friday is the cheapest day of the week to fly from Knoxville to St. Louis, it is 15% cheaper than the average day. Monday is the most expensive day with flight prices 36% higher than average. Based on deals found by KAYAK users in the last 12 months.

Find deals

Low season	July
High season	October
Cheapest flight	$129

Best time to beat the crowds but there is an average 8% increase in price.

Most popular time to fly with an average 15% increase in price.

Flight from Knoxville to St. Louis

When to book flights from Knoxville to St. Louis

Are your dates flexible? Find out the best times to travel from Knoxville to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

Which airports can I use when flying from Knoxville to St. Louis?
Flights from Knoxville to St. Louis usually depart from Knoxville McGhee Tyson (TYS) and arrive at Lambert-St Louis (STL).
What cabin classes can I book on flights from Knoxville to St. Louis?
Only Economy Class is available on flights from Knoxville to St. Louis.
Which airports do connecting flights from Knoxville to St. Louis pass through?
One-stop flights from Knoxville to St. Louis most commonly connect through:

• Atlanta Hartsfield-Jackson (ATL) - 48% of one-stop connections
• Charlotte Douglas (CLT) - 17% of one-stop connections
• Chicago O'Hare Intl (ORD) - 17% of one-stop connections
• Nashville Intl (BNA) - 7% of one-stop connections

Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.
Can I save money by using flexible dates for flights from Knoxville to St. Louis?
Yes. Being flexible with your travel dates can save you up to 38% on the Knoxville to St. Louis route. Friday is the cheapest departure day at $278 round-trip on average, while Monday is the most expensive at $442, a difference of $164. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.
What popular places can I visit in St. Louis?
Some of the most popular sights in St. Louis are Busch Stadium, Enterprise Center and America's Center Convention Complex. These are among the most viewed places in St. Louis on KAYAK.
How long is a flight from Knoxville to St. Louis?
A nonstop flight from Knoxville to St. Louis takes 0h 00m, covering 405 miles.
Do I need a passport to fly from Knoxville to St. Louis?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.
Have flight prices from Knoxville to St. Louis changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $205 to $799. That means the highest observed fare was about 4x higher than the lowest one.
How are flight prices from Knoxville to St. Louis looking right now?
One-way fares from Knoxville to St. Louis are currently lower than usual. Average one-way flight prices are about $183, which is 22% below the typical average for this route.
How much time can I save by choosing a different layover airport from Knoxville to St. Louis?
Flying via Nashville Intl (BNA) gives the shortest average 1-stop total travel time at 3h 57m, compared with 4h 07m via Atlanta Hartsfield-Jackson (ATL) and 4h 33m via Charlotte Douglas (CLT).
What is the time difference between Knoxville and St. Louis?
St. Louis is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.
What car rental options are available at Lambert-St Louis Airport (STL)?
Lambert-St Louis Airport (STL) hosts 5 major car rental companies, with daily rates starting from around $31 for economy cars. Top options include:
• Hertz
• Budget
• Alamo
• Enterprise Rent-A-Car
• Payless
How much should I expect to pay for a Knoxville to St. Louis flight?
Round-trip flights from Knoxville to St. Louis range from $270 to $455, with an average of $325 over the past 12 months. Anything below $270 counts as a good deal.

If your dates can be flexible, aim for a Friday departure instead of Monday. On this route, Friday flights average $278 - about $164 less than Monday (37% savings) based on the last 12 months.
If you can choose when to travel, plan your Knoxville to St. Louis trip for May. Fares historically average $276 round-trip in that month - typically $272 less than the most expensive month, which is November (based on the last 12 months).
If you're arriving late at night and need somewhere to stay, check out these hotels close to Lambert-St Louis Airport.
- Drury Inn & Suites St. Louis Airport
- Renaissance St. Louis Airport Hotel
- DoubleTree by Hilton St. Louis Airport

More options for your flight from Knoxville to St. Louis

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TYS - STL

$129 Find Cheap Flights from Knoxville to St. Louis - Compare and Save

Everything you should know

Cheap Flights from Knoxville to St. Louis (TYS-STL)

Recent round-trip flight deals from Knoxville to St. Louis

Recent one-way flight deals from Knoxville to St. Louis

Recent last minute flight deals from Knoxville to St. Louis

Price, demand and travel trends for Knoxville to St. Louis flights

How much is a round-trip flight from Knoxville to St. Louis?

What's the cheapest day of the week to fly from Knoxville to St. Louis?

What is the cheapest airline to fly from Knoxville to St. Louis?

What is the most popular layover airport when flying from Knoxville to St. Louis?

What is the cheapest layover airport when flying from Knoxville to St. Louis?

When flying from Knoxville to St. Louis which airport offers the shortest layover?

Key details for Knoxville to St. Louis flights

Low season

High season

Cheapest flight

When to book flights from Knoxville to St. Louis

Your Knoxville to St. Louis flight questions, answered

Your guide to booking Knoxville to St. Louis flights

More options for your flight from Knoxville to St. Louis

Complete your trip to St. Louis with a hotel stay or car rental

Information on your arrival and departure airports

Cabin class types available on flights from Knoxville to St. Louis

Find direct flights to and from Knoxville and St. Louis

Flights from domestic origins to St. Louis

Flights to other popular destinations

Find deals for your return flight