Which airports can I use when flying from Knoxville to St. Louis?

Flights from Knoxville to St. Louis usually depart from Knoxville McGhee Tyson (TYS) and arrive at Lambert-St Louis (STL).

What cabin classes can I book on flights from Knoxville to St. Louis?

Two cabin classes are available on flights from Knoxville to St. Louis: • Economy Class • First Class

Which airports do connecting flights from Knoxville to St. Louis pass through?

One-stop flights from Knoxville to St. Louis most commonly connect through: • Atlanta Hartsfield-Jackson (ATL) - 50% of one-stop connections • Charlotte Douglas (CLT) - 15% of one-stop connections • Chicago O'Hare Intl (ORD) - 15% of one-stop connections • Nashville Intl (BNA) - 8% of one-stop connections

Can I save money by using flexible dates for flights from Knoxville to St. Louis?

Yes. Flexible dates can save you up to 55% on flights from Knoxville to St. Louis. Friday is the cheapest departure day at $278 round-trip on average, while Saturday is the most expensive at $609, a difference of $331. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

What popular places can I visit in St. Louis?

Some of the most popular sights in St. Louis are Busch Stadium, Enterprise Center and America's Center Convention Complex. These are among the most viewed places in St. Louis on KAYAK.

How long is a flight from Knoxville to St. Louis?

A nonstop flight from Knoxville to St. Louis takes 00m, covering 405 miles.

Do I need a passport to fly from Knoxville to St. Louis?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

Have flight prices from Knoxville to St. Louis changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $243 to $953. That means the highest observed fare was about 4x higher than the lowest one.

How are flight prices from Knoxville to St. Louis looking right now?

One-way fares from Knoxville to St. Louis are currently lower than usual. Average one-way flight prices are about $128, which is 54% below the typical average for this route.

How much time can I save by choosing a different layover airport from Knoxville to St. Louis?

Flying via Nashville Intl (BNA) gives the shortest average 1-stop total travel time at 3h 57m, compared with 4h 12m via Atlanta Hartsfield-Jackson (ATL) and 4h 26m via Charlotte Douglas (CLT).

What is the time difference between Knoxville and St. Louis?

St. Louis is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

What car rental options are available at Lambert-St Louis Airport (STL)?

Lambert-St Louis Airport (STL) hosts 5 major car rental companies, with daily rates averaging $78 for economy cars. Top options include: • Hertz • Budget • Alamo • Enterprise Rent-A-Car • Payless

How much should I expect to pay for a Knoxville to St. Louis flight?

Round-trip flights from Knoxville to St. Louis range from $278 to $506, with an average of $350 over the past 12 months. Anything below $278 counts as a good deal.

How much is a round-trip flight from Knoxville to St. Louis?

Round-trip flights from Knoxville to St. Louis typically range from $278 to $506. The lowest price found in the past 5 days was $243, on American Airlines.

What's the cheapest day of the week to fly from Knoxville to St. Louis?

Based on deals KAYAK users found in the last 12 months, Friday is the cheapest day of the week to fly from Knoxville to St. Louis. It’s 21% cheaper than the average day, while Saturday is the most expensive, with prices 74% higher.

Which airline is the cheapest to fly from Knoxville to St. Louis?

American Airlines ($243) and Delta ($243) are the cheapest airlines to fly round-trip from Knoxville to St. Louis according to KAYAK data over the last 5 days.

What’s the most popular layover airport when flying from Knoxville to St. Louis?

Atlanta Hartsfield-Jackson (ATL) is the most popular layover for the Knoxville to St. Louis route. 50% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via ATL.

What is the cheapest layover airport when flying from Knoxville to St. Louis?

Flights via Orlando (MCO) offer the most affordable fares, with an average round-trip price of $125. Based on KAYAK data over the past 3 months.

When flying from Knoxville to St. Louis which airport offers the shortest layover?

Charlotte Douglas (CLT) had the shortest average connection time for Knoxville to St. Louis layovers at 2h 47m over the past 3 months.

$109 CHEAP FLIGHTS from Knoxville to St. Louis (TYS - STL)

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Cheapest round-trip

$243

Typical prices: $278-$506

American Airlines

Tue 12/25Mon 1/1

TYS - STL • 1 stop

Cheapest one-way

$109

Typical prices: $208-$303

American Airlines

Mon 11/26

TYS - STL • 1 stop

Nonstop flights

Not available

There are currently no direct flights between Knoxville and St. Louis. You'll need to take a connecting flight to reach the destination.

Insights

When to travel

May

Cheapest • 21% price drop

April

Most popular

Good to know

Top layover airports

Orlando (MCO)

Cheapest • Avg $125 (round-trip)

Nashville Intl (BNA)

Shortest trip • 3h 57m (one-way)

Insights

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KAYAK searches 100s of sites at once to find you the best travel deals.

We hope you love your trip to St. Louis!

Flight Deals

Cheap Flights from Knoxville to St. Louis (TYS-STL)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Recent round-trip flight deals from Knoxville to St. Louis

Fri, Dec 25 - Fri, Jan 1

9:16 am - 4:04 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

7h 48m1 stop Charlotte Douglas

6:00 am - 11:02 amSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 02m1 stop Chicago O'Hare Intl

$243American Airlines

Wed, Dec 2 - Wed, Dec 9

8:09 am - 1:20 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 11m1 stop Charlotte Douglas

11:37 am - 4:37 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 00m1 stop Chicago O'Hare Intl

$243American Airlines

Fri, Dec 18 - Sat, Dec 19

5:40 am - 9:01 amTYS Knoxville McGhee Tyson-STL Lambert-St Louis

4h 21m1 stop Atlanta Hartsfield-Jackson

7:15 pm - 11:50 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 35m1 stop Atlanta Hartsfield-Jackson

$243Delta

Fri, Dec 11 - Mon, Dec 14

5:32 pm - 11:34 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

7h 02m1 stop Dallas/Fort Worth

5:02 am - 11:02 amSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 00m1 stop Chicago O'Hare Intl

$243American Airlines

Wed, Dec 2 - Wed, Dec 9

5:15 pm - 10:00 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 45m1 stop Nashville Intl

10:55 am - 8:50 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

8h 55m2 stops Chicago Midway Baltimore/Washington

$248Southwest

Wed, Dec 2 - Wed, Dec 9

7:05 am - 1:45 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

7h 40m2 stops Nashville Intl Atlanta Hartsfield-Jackson

8:30 am - 7:50 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

10h 20m2 stops Houston Hobby Nashville Intl

$253Southwest

Fri, Dec 18 - Sat, Dec 19

12:32 pm - 4:24 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

4h 52m1 stop Atlanta Hartsfield-Jackson

6:00 am - 1:39 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 39m1 stop Atlanta Hartsfield-Jackson

$259Delta

Fri, Dec 18 - Sun, Dec 20

7:26 pm - 12:34 amTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 08m1 stop Atlanta Hartsfield-Jackson

3:48 pm - 9:24 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 36m1 stop Atlanta Hartsfield-Jackson

$270Delta

Mon, Dec 14 - Wed, Dec 16

5:35 pm - 10:59 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 24m1 stop Chicago O'Hare Intl

10:50 am - 5:00 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 10m1 stop Chicago O'Hare Intl

$333United Airlines

Wed, Nov 25 - Sun, Nov 29

6:30 am - 11:59 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

18h 29m1 stop Orlando

6:05 pm - 10:58 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

27h 53m1 stop Orlando

$435Multiple Airlines

Recent last minute flight deals from Knoxville to St. Louis

Thu, Nov 5 - Sun, Nov 8

7:00 am - 11:16 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

17h 16m1 stop Orlando Sanford Intl

4:26 pm - 7:01 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

25h 35m2 stops Orlando Philadelphia

$571Multiple Airlines

Thu, Nov 5 - Mon, Nov 9

7:00 am - 11:16 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

17h 16m1 stop Orlando Sanford Intl

1:28 pm - 12:35 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

22h 07m2 stops Las Vegas Harry Reid Intl Orlando

$618Multiple Airlines

Thu, Nov 5 - Sun, Nov 8

7:00 am - 11:16 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

17h 16m1 stop Orlando Sanford Intl

4:26 pm - 7:59 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

26h 33m1 stop Orlando

$662Multiple Airlines

Thu, Nov 5 - Sun, Nov 8

5:32 pm - 9:59 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 27m1 stop Dallas/Fort Worth

12:43 pm - 7:34 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 51m1 stop Charlotte Douglas

$677American Airlines

Thu, Nov 5 - Sun, Nov 8

7:05 am - 2:05 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

8h 00m2 stops Nashville Intl Atlanta Hartsfield-Jackson

4:30 pm - 8:35 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 05m1 stop Nashville Intl

$682Southwest

Thu, Nov 5 - Mon, Nov 9

7:05 am - 2:05 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

8h 00m2 stops Nashville Intl Atlanta Hartsfield-Jackson

5:10 am - 3:00 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

8h 50m2 stops Houston Hobby Dallas Love Field

$687Southwest

Thu, Nov 5 - Sun, Nov 8

12:50 pm - 9:20 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

9h 30m2 stops Orlando Nashville Intl

5:10 am - 3:00 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

8h 50m2 stops Houston Hobby Dallas Love Field

$703Southwest

Wed, Nov 4 - Thu, Nov 5

12:20 pm - 5:29 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 09m1 stop Charlotte Douglas

6:47 am - 1:17 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 30m1 stop Charlotte Douglas

$759American Airlines

Wed, Nov 4 - Fri, Nov 6

5:19 pm - 9:57 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 38m1 stop Charlotte Douglas

12:43 pm - 7:34 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 51m1 stop Charlotte Douglas

$896American Airlines

Thu, Nov 5 - Thu, Nov 5

5:40 am - 9:17 amTYS Knoxville McGhee Tyson-STL Lambert-St Louis

4h 37m1 stop Atlanta Hartsfield-Jackson

2:25 pm - 6:42 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 17m1 stop Atlanta Hartsfield-Jackson

$1,284Delta

Booking Insights

Price, demand and travel trends for Knoxville to St. Louis flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from Knoxville to St. Louis? This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Knoxville to St. Louis departing in december.
What's the cheapest day of the week to fly from Knoxville to St. Louis?: Based on deals KAYAK users found in the last 12 months, Friday is the cheapest day of the week to fly from Knoxville to St. Louis. It’s 21% cheaper than the average day, while Saturday is the most expensive, with prices 74% higher.

Find deals

Low season	September
High season	April
Cheapest flight	$109

Beat the crowds with an average 45% drop in travelers.

The most popular month to fly with an average 16% increase in travelers.

One-way flight from Knoxville to St. Louis

When to book flights from Knoxville to St. Louis

Are your dates flexible? Find out the best times to travel from Knoxville to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

What cabin classes can I book on flights from Knoxville to St. Louis?
Two cabin classes are available on flights from Knoxville to St. Louis:

• Economy Class
• First Class
How long is a flight from Knoxville to St. Louis?
A nonstop flight from Knoxville to St. Louis takes 00m, covering 405 miles.
Do I need a passport to fly from Knoxville to St. Louis?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.
How much should I expect to pay for a Knoxville to St. Louis flight?
Round-trip flights from Knoxville to St. Louis range from $278 to $506, with an average of $350 over the past 12 months. Anything below $278 counts as a good deal.
Have flight prices from Knoxville to St. Louis changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $243 to $953. That means the highest observed fare was about 4x higher than the lowest one.
How are flight prices from Knoxville to St. Louis looking right now?
One-way fares from Knoxville to St. Louis are currently lower than usual. Average one-way flight prices are about $128, which is 54% below the typical average for this route.
What car rental options are available at Lambert-St Louis Airport (STL)?
Lambert-St Louis Airport (STL) hosts 5 major car rental companies, with daily rates averaging $78 for economy cars. Top options include:

• Hertz
• Budget
• Alamo
• Enterprise Rent-A-Car
• Payless
Which airports can I use when flying from Knoxville to St. Louis?
Flights from Knoxville to St. Louis usually depart from Knoxville McGhee Tyson (TYS) and arrive at Lambert-St Louis (STL).
Which airports do connecting flights from Knoxville to St. Louis pass through?
One-stop flights from Knoxville to St. Louis most commonly connect through:

• Atlanta Hartsfield-Jackson (ATL) - 50% of one-stop connections
• Charlotte Douglas (CLT) - 15% of one-stop connections
• Chicago O'Hare Intl (ORD) - 15% of one-stop connections
• Nashville Intl (BNA) - 8% of one-stop connections
Can I save money by using flexible dates for flights from Knoxville to St. Louis?
Yes. Flexible dates can save you up to 55% on flights from Knoxville to St. Louis. Friday is the cheapest departure day at $278 round-trip on average, while Saturday is the most expensive at $609, a difference of $331.

KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.
How much time can I save by choosing a different layover airport from Knoxville to St. Louis?
Flying via Nashville Intl (BNA) gives the shortest average 1-stop total travel time at 3h 57m, compared with 4h 12m via Atlanta Hartsfield-Jackson (ATL) and 4h 26m via Charlotte Douglas (CLT).
What is the time difference between Knoxville and St. Louis?
St. Louis is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.
What popular places can I visit in St. Louis?
Some of the most popular sights in St. Louis are Busch Stadium, Enterprise Center and America's Center Convention Complex. These are among the most viewed places in St. Louis on KAYAK.

If your dates are flexible, aim for a Friday departure and avoid flying on Saturday. On this route, Friday flights average $278, about $331 less than Saturday fares (54% savings) based on the last 12 months.
If you can choose when to travel, plan your Knoxville to St. Louis trip for May. Fares historically average $276 round-trip in that month - typically $333 less than the most expensive month, which is September (based on the last 12 months).
If you're arriving late at night and need somewhere to stay, check out these hotels close to Lambert-St Louis Airport.

• Renaissance St. Louis Airport Hotel
• Drury Inn & Suites St. Louis Airport
• DoubleTree by Hilton St. Louis Airport

More options for your flight from Knoxville to St. Louis

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TYS - STL

$109 Find Cheap Flights from Knoxville to St. Louis - Compare and Save

Everything you should know

Cheap Flights from Knoxville to St. Louis (TYS-STL)

Recent round-trip flight deals from Knoxville to St. Louis

Recent one-way flight deals from Knoxville to St. Louis

Recent last minute flight deals from Knoxville to St. Louis

Price, demand and travel trends for Knoxville to St. Louis flights

How much is a round-trip flight from Knoxville to St. Louis?

What's the cheapest day of the week to fly from Knoxville to St. Louis?

Which airline is the cheapest to fly from Knoxville to St. Louis?

What’s the most popular layover airport when flying from Knoxville to St. Louis?

What is the cheapest layover airport when flying from Knoxville to St. Louis?

When flying from Knoxville to St. Louis which airport offers the shortest layover?

Key details for Knoxville to St. Louis flights

Low season

High season

Cheapest flight

When to book flights from Knoxville to St. Louis

Your Knoxville to St. Louis flight questions, answered

Your guide to booking Knoxville to St. Louis flights

More options for your flight from Knoxville to St. Louis

Complete your trip to St. Louis with a hotel stay or car rental

Information on your arrival and departure airports

Cabin class types available on flights from Knoxville to St. Louis

Find direct flights to and from Knoxville and St. Louis

Flights from domestic origins to St. Louis

Flights to other popular destinations

Find deals for your return flight