$183 Find Cheap Flights from Knoxville to Panama

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Panama departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

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Cheap Flights from Knoxville to Panama

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Panama City
Panama City1 stop$466
Panama City
Panama City1 stop$466

Book Cheap Knoxville to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Panama

Thu, Oct 30 - Thu, Nov 6
Multiple Airlines Logo
9:58 am - 8:19 pmTYS-PTY
11h 21m1 stop
Multiple Airlines Logo
12:03 pm - 10:33 pmPTY-TYS
10h 30m1 stop
$466Multiple Airlines
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Thu, Oct 30 - Thu, Nov 6
American Airlines Logo
5:37 pm - 2:03 pmTYS-PTY
21h 26m2 stops
American Airlines Logo
2:49 pm - 9:50 amPTY-TYS
19h 01m2 stops
$492American Airlines
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Mon, Nov 24 - Fri, Nov 28
American Airlines Logo
4:18 pm - 1:43 pmTYS-PTY
21h 25m2 stops
American Airlines Logo
2:43 pm - 10:52 amPTY-TYS
20h 09m2 stops
$522American Airlines
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Sun, Jan 4 - Sun, Jan 18
Delta Logo
8:25 am - 8:00 pmTYS-PTY
11h 35m1 stop
Delta Logo
8:05 am - 3:06 pmPTY-TYS
7h 01m1 stop
$527Delta
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Mon, Nov 24 - Fri, Nov 28
American Airlines Logo
5:07 pm - 1:43 pmTYS-PTY
20h 36m1 stop
American Airlines Logo
2:43 pm - 10:52 amPTY-TYS
20h 09m2 stops
$533American Airlines
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Thu, Oct 30 - Wed, Nov 5
Multiple Airlines Logo
9:58 am - 1:00 amTYS-PTY
16h 02m2 stops
Multiple Airlines Logo
2:55 am - 10:33 pmPTY-TYS
19h 38m3 stops
$582Multiple Airlines
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Sat, Sep 27 - Wed, Oct 1
Delta Logo
6:59 am - 12:55 pmTYS-PTY
6h 56m1 stop
Delta Logo
2:10 pm - 11:44 pmPTY-TYS
8h 34m1 stop
$597Delta
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Sun, Oct 12 - Sun, Oct 19
United Airlines Logo
7:15 am - 6:37 pmTYS-PTY
12h 22m1 stop
United Airlines Logo
10:00 am - 11:43 pmPTY-TYS
12h 43m1 stop
$791United Airlines
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Sat, Sep 27 - Tue, Sep 30
Avianca Logo
7:26 pm - 10:25 amTYS-PTY
15h 59m2 stops
Avianca Logo
3:20 am - 9:11 pmPTY-TYS
16h 51m2 stops
$1,014Avianca
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Sat, Sep 27 - Tue, Sep 30
Avianca Logo
7:26 pm - 12:35 pmTYS-PTY
18h 09m3 stops
Avianca Logo
3:20 am - 10:50 pmPTY-TYS
18h 30m2 stops
$1,072Avianca
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Booking Insights

KAYAK's insights & trends for Knoxville to Panama flights

Get data-powered insights and trends into flights from Knoxville to Panama to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Knoxville to Panama?

The average price of all round-trip flights from Knoxville to Panama clicked on KAYAK for each day over the last 12 months.

Your flight ticket price will generally be cheaper if you fly to Panama on a Friday and more expensive on a Monday. On your return trip to Knoxville, you should consider flying back on a Tuesday, and avoid Wednesdays for better deals.

Good to know

Low seasonSeptember
Cheapest flight$183
Best time to beat the crowds with an average 25% drop in price.
Most popular time to fly with an average 71% increase in price.
Flight from Knoxville to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Knoxville to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Panama?

    The cheapest time of day to fly to Panama is generally in the morning, when round-trip flights cost $595 on average. The most expensive time of day to fly to Panama is generally in the morning, which is peak travel time and where the average cost of a ticket is $595.

Reviews of the top airlines flying from Knoxville to Panama

 
Need help choosing which airline to fly with from Knoxville to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 8924 reviews
7.7Boarding
6.6Food
7.3Comfort
8.1Crew
7.1Entertainment
Airline reviews

Terrible. They wouldn't allow me on my flight on the 14th..

2.0 MediocreJulian, Sep 2025DEN - DRO
Read more United Airlines reviews

Terrible. They wouldn't allow me on my flight on the 14th..

We had to deboard 2 times due to maintenance issues. They changed the plane, and then we got deviated to LAX due to maibtenance issues on the other plane, had to sleep at LAX and los a full day.

Everything was good, except the seats in economy were so close together, you could barely get out when the seat in front of your was reclined. If the airlines keep jamming in more and more seats, it will become intolerable. I will look for another airline that considers customer comfort and does not keep adding more rows of seats for more profit.

The newer screen was super cool and had the option to watch many different shows or movies. Crew was polite and helpful. However again, many children screaming bloody murder and kicking my seat, and parents doing nothing about it as usual.

Flight was good and crew was super polite. However, there were around 5 kids screaming the WHOLE 2 hours. I understand kids have to come but parents need to do something to control their children. They make the experience terrible, especially after finishing 16 hour shifts at the hospital I needed some sleep, which I did not get.

IAD with the archaic people movers is just a place to be avoided.

Great service on board. Boarding a bit slow due to process. Food was pretty average.

Tastless food and too obvious lack of enthusiasm for service in the economy vesus business class

All of the United employees I interacted with were professional and courteous. The aircraft was clean, the food on the flight was good. No complaints here.

I had no checked baggage but was required to hand over carry on baggage at the door of the plane. There was a lot of overboard space in the plane and I was one of the last ones. I ran to get my carry on but it was gone. I was given back at the plane door in Toronto, so the wait was not as long as it would have been at the carousel.

Given it’s a red-eye into Charolotte, we didn’t get any food. The survey does not include “N/A” so the rating will be skewed.

Great. Quick and quiet and east. The breakfast choices were a welcome surprise!

American airlines suck they delay the flights all the time made me sleep in an airport because my flight was delayed and I miss my connecting flight

There's nothing I liked about it. For first off I scheduled this trip two weeks in advance then they delayed my flight which messed up my whole trip. So I scheduled it for the following weekend thinking there won't be a delay and guess what as soon as I got to the airport we said in the airplane on the tarmac for an hour and a half. Not only was it delayed I missed my connecting flight meaning I had to stay the night at Dallas-Fort Worth airport sleeping on the floor. I will tell you this I will never fly American airlines ever again I have had nothing but horrible experience with them and I just throw money at them

The stewardess hit me with the food kart twice on the head and didn't say I'm sorry once. The same stewardess gave me a warm Apple Juice with No ice. The Flight was delayed for Departure 6 times, starting from 2:36pm, finally taking off 7:50pm. I was late picking up my child from the sitter by 3 hours.

Don’t know they cancelled the flight day before I was to leave. They sent a email at 9:00 pm at night saying they cancelled. That is the smooth way to say we don’t want your business! I think they didn’t have enough people booking so they cancelled the flight! It’s all about the money anymore there is no honesty in business.

Having to reschedule flights a day later, they loaded by luggage on the wrong plane from Little rock now I have to HOPE they deliver it to where im staying like they said would. International flight crew was very disgruntled and not very friendly.

We will be writing a long, detailed letter to corporate about our awful experience with American airlines.

It took way too long to diagnose and solve the problem of a broken crew member cabin seat. Though compensation for the volunteer who left the flight was very kind.

The entertainment package was vast and the selections were very current. Keep updating it was great.

Everything you need to know for your flight from Knoxville to Panama

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