$407 Find Cheap Flights from Knoxville to Panama

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Panama departing on 8/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Book Cheap Knoxville to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Panama

Sun, Aug 23 - Wed, Aug 26
United Airlines Logo
5:57 pm - 2:14 pm
TYS
-
PTY
21h 17m
2 stops
United Airlines Logo
10:00 am - 9:30 pm
PTY
-
TYS
10h 30m
1 stop
$527United Airlines
Mon, Aug 17 - Thu, Aug 20
United Airlines Logo
7:15 am - 2:14 pm
TYS
-
PTY
7h 59m
1 stop
United Airlines Logo
10:55 pm - 4:59 pm
PTY
-
TYS
17h 04m
2 stops
$531United Airlines
Sun, Aug 23 - Wed, Aug 26
United Airlines Logo
5:57 pm - 2:14 pm
TYS
-
PTY
21h 17m
2 stops
United Airlines Logo
3:30 pm - 6:05 pm
PTY
-
TYS
25h 35m
1 stop
$536United Airlines
Sun, Aug 23 - Wed, Aug 26
United Airlines Logo
3:25 pm - 6:37 pm
TYS
-
PTY
28h 12m
1 stop
United Airlines Logo
3:30 pm - 6:05 pm
PTY
-
TYS
25h 35m
1 stop
$546United Airlines
Tue, May 12 - Tue, May 19
United Airlines Logo
7:00 am - 7:31 pm
TYS
-
PTY
13h 31m
2 stops
United Airlines Logo
7:55 am - 6:11 pm
PTY
-
TYS
9h 16m
1 stop
$547United Airlines
Tue, May 12 - Tue, May 19
United Airlines Logo
7:18 pm - 2:14 pm
TYS
-
PTY
19h 56m
2 stops
United Airlines Logo
9:45 am - 10:49 am
PTY
-
TYS
24h 04m
2 stops
$551United Airlines
Sun, Aug 23 - Wed, Aug 26
United Airlines Logo
7:15 am - 2:14 pm
TYS
-
PTY
7h 59m
1 stop
United Airlines Logo
10:00 am - 9:30 pm
PTY
-
TYS
10h 30m
1 stop
$557United Airlines
Sat, Aug 8 - Fri, Aug 14
American Airlines Logo
5:13 pm - 2:20 pm
TYS
-
PTY
22h 07m
2 stops
American Airlines Logo
3:20 pm - 10:30 am
PTY
-
TYS
18h 10m
2 stops
$561American Airlines
Thu, May 28 - Sun, May 31
American Airlines Logo
7:59 pm - 12:14 pm
TYS
-
PTY
17h 15m
2 stops
American Airlines Logo
1:14 pm - 1:10 pm
PTY
-
TYS
22h 56m
2 stops
$566American Airlines
Thu, May 28 - Sun, May 31
American Airlines Logo
7:34 pm - 12:14 pm
TYS
-
PTY
17h 40m
1 stop
American Airlines Logo
1:14 pm - 11:59 pm
PTY
-
TYS
9h 45m
1 stop
$573American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Panama flights

Get data-powered insights and trends into flights from Knoxville to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Panama is September, when tickets cost $471 (return) on average. On the other hand, the most expensive months are December and February, when the average cost of round-trip tickets is $754 and $685 respectively.

Good to know

Low seasonMay
Cheapest flight$430
Best time to beat the crowds with an average 17% drop in price.
Most popular time to fly and prices are also 14% lower on average.
Flight from Knoxville to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Knoxville to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Knoxville to Panama

 
Need help choosing which airline to fly with from Knoxville to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9514 reviews
6.6Food
7.1Entertainment
8.1Crew
7.3Comfort
7.7Boarding
Airline reviews

The business class seat is exceptional. I wish the food is more palatable.

8.0 ExcellentAnonymous, Mar 2026
LAX - HND
Read more United Airlines reviews

The business class seat is exceptional. I wish the food is more palatable.

Wonderful in-seat entertainment with seatback screens and huge selection of quality movies. The ability to bluetooth connect headphones was amazing.

the entire flight felt off. The crew seemed uninterested and disengaged. The food service was really bad - overcooked, bland, weird food service. They actually woke us up to serve chicken wraps in the middle of the night, after dinner and before breakfast. Made no sense. Ultimately, I was glad they did though, because the breakfast had been held for so long it was inedible. Eggs, potatoes, sausage - all disgusting. We were asked to "honor" the lavatories for premium customers and stay in our own cabin: this was also strange. So people in economy didn't pay enough to use the closest toilet to them??? It's a toilet. All in all, not the experience I have come to expect from United Airlines. The return flight from Paris to SFO was better, btw.

Smooth and easy boarding, comfortable for the entire 5 hour flight, and the seat back entertainment was great! I appreciated all the features, from location info and maps, movies, the ability to connect with Bluetooth headphones, and good selection of movies. Food was good, normal airline snacks (I didn’t purchase anything)

Overall, the flight was good. Lounge access should be with all business class tickets.

They promise free wi-fi prior to boarding and then once on board you are informed you have to purchase wifi even after being a mileagePlus member.

I've been flying American mostly, and it's been very frustrating. This united flight makes me realize maybe the issue isn't flying, but the airline. United was a significantly better experience. The plane was more comfortable, with a normal amount of leg room (vs the ridiculous reductions AA has made), more comfortable seats, screens to watch movies. It was a much better experience!

Awful. No counter attendants. No dinner offered due to delays.

Horrible service no Wi-Fi connection on both leg of the flight and they are refusing to fix bad service

3 hour delay…. Nearly 2 hours sitting on tarmac. Do better, United. Or at least have the sense to not say “we hope you enjoyed your flight with us” upon disembarking.

Flight was on-time, boarding was flawless and the crew was friendly.

The staff are very, very professional. It's what flying should feel like.

Flight boarded from Gate 159B, the farthest gate in the LAX Bradley Terminal. While the flight operated on time, the first class cabin attendant made no recognition of my being an Advantage Executive Platinum member.

For an international flight the seats were smaller than most flight I have been on in economy. I don’t know the size of the seats or perhaps it was the size of the seat dividers that made the seats feel smaller and little amount of space to even turn your body if you needed to

The flight itself was excellent but the gate attendant made me check my carryon since she said it was an inch too big. I’ve had no problems with this carryon on recent flights on Qantas, Delta, Austrian, Southwest Airlines even though the overhead bins are the same size. there were other carryons in the bins that also looked larger than mine and there was room left in the bins for more. When I picked up my carryon from baggage claim one of the wheels had broken off.

The flight changed gates multiple times and flight had to be delayed multiple times

We called Kayak for a change due to the TSA situation in Atlanta. What we got was a canceled return flight (in error) and we had to find the mistake. Not happy with Kayak who blamed it on AA.

Tv screens and movie selection v good. Friendly staff. They were really worried about max capacity and room for carryons. That is never fun but i had no problem finding space when I boarded.

I was in last row so that is never great bc the person in front of me leaned his seat all the way back into me.

Delayed for mechanical and no updates on what was happening and how long the delay might be.

Everything you need to know for your flight from Knoxville to Panama

Information on your arrival and departure airports