$467 Find Cheap Flights from Knoxville to Panama

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Panama departing on 4/9. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Book Cheap Knoxville to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Panama

Thu, Apr 9 - Wed, Apr 15
United Airlines Logo
11:40 am - 6:37 pm
TYS
-
PTY
7h 57m
1 stop
United Airlines Logo
7:55 am - 11:41 pm
PTY
-
TYS
14h 46m
1 stop
$467United Airlines
Thu, Apr 9 - Wed, Apr 15
American Airlines Logo
3:58 pm - 12:46 pm
TYS
-
PTY
21h 48m
2 stops
American Airlines Logo
1:49 pm - 11:59 pm
PTY
-
TYS
9h 10m
1 stop
$471American Airlines
Tue, Apr 7 - Fri, May 1
United Airlines Logo
11:40 am - 6:37 pm
TYS
-
PTY
7h 57m
1 stop
United Airlines Logo
3:30 pm - 6:11 pm
PTY
-
TYS
25h 41m
1 stop
$496United Airlines
Wed, Mar 25 - Tue, Mar 31
American Airlines Logo
5:47 pm - 12:40 pm
TYS
-
PTY
19h 53m
2 stops
American Airlines Logo
1:40 pm - 11:30 am
PTY
-
TYS
20h 50m
2 stops
$511American Airlines
Sun, Apr 5 - Fri, May 1
United Airlines Logo
7:05 am - 4:12 pm
TYS
-
PTY
10h 07m
1 stop
United Airlines Logo
3:30 pm - 6:11 pm
PTY
-
TYS
25h 41m
1 stop
$516United Airlines
Tue, Mar 10 - Thu, Mar 12
American Airlines Logo
5:02 pm - 12:40 pm
TYS
-
PTY
20h 38m
2 stops
American Airlines Logo
3:10 pm - 11:59 pm
PTY
-
TYS
7h 49m
1 stop
$531American Airlines
Mon, Apr 6 - Fri, May 1
United Airlines Logo
7:05 am - 4:12 pm
TYS
-
PTY
10h 07m
1 stop
United Airlines Logo
3:30 pm - 6:11 pm
PTY
-
TYS
25h 41m
1 stop
$536United Airlines
Sun, Mar 1 - Tue, Mar 10
United Airlines Logo
9:10 am - 2:45 pm
TYS
-
PTY
29h 35m
1 stop
United Airlines Logo
7:55 am - 7:55 pm
PTY
-
TYS
11h 00m
1 stop
$537United Airlines
Fri, Mar 27 - Fri, Apr 3
American Airlines Logo
6:00 am - 2:20 pm
TYS
-
PTY
9h 20m
1 stop
American Airlines Logo
3:51 pm - 11:30 am
PTY
-
TYS
18h 39m
2 stops
$541American Airlines
Wed, Mar 25 - Tue, Mar 31
American Airlines Logo
6:00 am - 2:20 pm
TYS
-
PTY
9h 20m
1 stop
American Airlines Logo
3:51 pm - 11:30 am
PTY
-
TYS
18h 39m
2 stops
$546American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Panama flights

Get data-powered insights and trends into flights from Knoxville to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Panama is September, when tickets cost $471 (return) on average. On the other hand, the most expensive months are December and March, when the average cost of round-trip tickets is $754 and $732 respectively.

Good to know

Low seasonMay
Cheapest flight$467
Best time to beat the crowds with an average 19% drop in price.
Most popular time to fly with an average 17% increase in price.
Flight from Knoxville to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Knoxville to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Knoxville to Panama

 
Need help choosing which airline to fly with from Knoxville to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9283 reviews
8.1Crew
7.1Entertainment
6.6Food
7.7Boarding
7.3Comfort
Airline reviews

Both of my flights arrived early and check in process was smooth

10.0 ExcellentDarnell, Feb 2026
COS - DEN
Read more United Airlines reviews

Both of my flights arrived early and check in process was smooth

Terrible. No customer service, no food, no drinks on a 6 hour premier economy booking.

Short flight, but no drink/snack service. The flights both going and coming were delayed.

Much better than Spirit. I was please by the easy fast check in and boarding

Check-in and in-flight staff were better than average. The seat was a fair size but too hard and not enough padding. The cushion/pillow provided is poor (thin and seems to be disposable ,it provides no effective cushioning or support). Food was OK-ish but no choice of inflight snacks and no easy place to get drinks other than water (I could ask for juice by intruding into the staff area at the back of the plane) Entertainment was very good actually. Overall better than I expected from a US-based airline (sorry!) but compared to ANA or Singapore it was so-so. (I live in Japan so they are my comparative airlines)

Everything was on time Will use united again for sure

Plane outlets in my row not working to charge phone. Staff response was, well it should be. Plug into seed for volume not working well. Had to find the sweet spot for plug in or it would shut off and on.

Wifi took a while to kick in and we had a maintenance issue that took over 40 mins at the gate in Washington before pulling back

Fine not above and beyond as I had a connection that was delayed due to maintenance

The power at the seat didn't work and the seat itself was difficult to adjust - this was a business class seat. Flight attendant gave me miles to compensate. The attendant was very professional and on top of his game the entire flight.

The seats are too uncomfortable for anyone over 5ft 8in. I'm 5'10" with a back and hip issue and I was in pai for the full duration of the flight.

The flight was on time/early, attentive crew, and everything overall went smoothly. Disappointed that WIFI was not working for the flight.

One day, I do so hope for a gluten free snack! Seems like with the rest of the world FINALLY figuring out what gluten free is, American Airlines would too. Fingers crossed!!

The flight was significantly delayed for 6.5 hours because of snow. There was no communication once the plane returned to the gate regarding when the flight would resume. Other flights were departing while our flight was being unloaded for reasons unknown. Our flight also seemed out of the queue regarding further deicing, refueling, and waiting to Taxi to the runway.

Flight was on time and the meal and service were good.

The accessible bathroom should be visible to people in Economy class.

Flight was delayed for 2 hours, then last minute the change to on time. The satélite location is far and a nightmare to get to.

This was a horrible experience. I’ve experienced several delays at this point and still not home. I was supposed to be home by 8:30 last night and here I sit at 7 am on a plane STILL unable to go home because of American Airlines.

Lexus in first class was absolutely amazing! Beat flight attendant i’ve ever seen.

Generally good. Flight left on time and the seats are comfortable. Plenty of space in front if you in you choose a comfort plus seat, completely worth spending the extra money given the amount of hours the flight lasts. The food tastes good but I would say it’s a the amount is too little. The crew was friendly and efficient. There was a some turbulence at different points into the flight. American Airlines has good deals to NZ if you book with plenty of time before you plan on going.

Everything you need to know for your flight from Knoxville to Panama

Information on your arrival and departure airports