$311 Find Cheap Flights from Knoxville to Panama - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Panama departing on 9/20. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Book Cheap Knoxville to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Panama

Thu, Sep 24 - Fri, Oct 2
American Airlines Logo
6:15 am - 12:16 pm
TYS
-
PTY
7h 01m
1 stop
American Airlines Logo
1:16 pm - 11:19 am
PTY
-
TYS
21h 03m
2 stops
$579American Airlines
Tue, Sep 1 - Tue, Sep 8
Delta Logo
6:00 am - 12:55 pm
TYS
-
PTY
7h 55m
1 stop
Delta Logo
2:23 pm - 10:27 pm
PTY
-
TYS
7h 04m
1 stop
$587Delta
Wed, Aug 26 - Thu, Aug 27
United Airlines Logo
7:15 am - 2:14 pm
TYS
-
PTY
7h 59m
1 stop
United Airlines Logo
3:30 pm - 2:37 pm
PTY
-
TYS
22h 07m
2 stops
$591United Airlines
Wed, Aug 26 - Thu, Aug 27
United Airlines Logo
7:15 am - 2:14 pm
TYS
-
PTY
7h 59m
1 stop
United Airlines Logo
3:30 pm - 6:17 pm
PTY
-
TYS
25h 47m
1 stop
$597United Airlines
Mon, Aug 17 - Wed, Aug 19
United Airlines Logo
7:00 am - 4:04 am
TYS
-
PTY
22h 04m
2 stops
United Airlines Logo
3:30 pm - 9:45 pm
PTY
-
TYS
29h 15m
1 stop
$602United Airlines
Wed, Aug 26 - Thu, Aug 27
United Airlines Logo
7:00 am - 6:37 pm
TYS
-
PTY
12h 37m
2 stops
United Airlines Logo
10:55 pm - 11:59 pm
PTY
-
TYS
24h 04m
2 stops
$606United Airlines
Mon, Aug 17 - Wed, Aug 19
United Airlines Logo
2:21 pm - 2:14 pm
TYS
-
PTY
24h 53m
1 stop
United Airlines Logo
3:30 pm - 9:45 pm
PTY
-
TYS
29h 15m
1 stop
$608United Airlines
Thu, Sep 24 - Fri, Oct 2
Delta Logo
5:35 am - 12:58 pm
TYS
-
PTY
8h 23m
1 stop
Delta Logo
2:23 pm - 11:55 pm
PTY
-
TYS
8h 32m
1 stop
$617Delta
Fri, Sep 4 - Mon, Sep 7
United Airlines Logo
6:02 pm - 2:14 pm
TYS
-
PTY
21h 12m
2 stops
United Airlines Logo
3:30 pm - 11:59 pm
PTY
-
TYS
31h 29m
2 stops
$621United Airlines
Tue, Jul 28 - Mon, Aug 3
United Airlines Logo
7:15 am - 4:12 pm
TYS
-
PTY
9h 57m
1 stop
United Airlines Logo
7:55 am - 11:12 pm
PTY
-
TYS
14h 17m
1 stop
$627United Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Panama flights

Get data-powered insights and trends into flights from Knoxville to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Panama is December, when tickets cost $261 (return) on average. On the other hand, the most expensive months are June and July, when the average cost of round-trip tickets is $740 and $677 respectively.

Good to know

Low seasonJuly
Cheapest flight$311
Best time to beat the crowds with an average 1% drop in price.
Most popular time to fly and prices are also 15% lower on average.
Flight from Knoxville to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Knoxville to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Knoxville to Panama

 
Need help choosing which airline to fly with from Knoxville to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9896 reviews
8.1Crew
7.1Entertainment
6.6Food
7.3Comfort
7.7Boarding
Airline reviews

Our flight to Rome, Italy was cancelled the day of and we were never informed. We only found out because I was trying to get into my husbands account and called to get his account number. Had to pay more for worse seating on another airline.

2.0 MediocreAnonymous, May 2026
TYS - IAD
Read more United Airlines reviews

Our flight to Rome, Italy was cancelled the day of and we were never informed. We only found out because I was trying to get into my husbands account and called to get his account number. Had to pay more for worse seating on another airline.

I wish there were outlets to charge my iPhone. The crew was great; we had a female pilot who was great with explaining what was happening and delays,

The staff was hospitable and professional. The seat had a bit of wear. The winner shade was stuck 1/4 open. I received the best of both worlds. The morning sun was able to come in and blind the screen i was trying to use while at the same time it was too low to look out and enjoy the view. Rather embarrassing for a 1st class ticket.

Even though we were delayed, we were able to make our connection

Another delayed flight. When the delays exceed the duration of the flight, it’s a problem.

Trip was great. A wild landing in Ottawa with the wind and rain, but the pilot did a great job. Always love flying United.👍

The internet service I paid for didn’t work at all and the flight crew was not very friendly.

The planes are so dirty! Food crumbs and finger print smudges, Dust over the vents and carpet stains. It’s disgusting.

Overall it was good. The flight was bumpy at times, but the pilot made us aware every time. As a result, no snacks/drinks were made available. Seats were tight but that’s okay as I had a window seat.

Both of the first class flight attendants were rude, to everyone, not just us. The one in coach was more helpful to us than the ones in first class!

Air condition was not working for long both after boarding and also after landing ; unbearably hot and suffocating

It was canceled at the last minute. While I was literally at the airport. Messed my entire trip up.

Flight was on-time, boarding was flawless and the crew was friendly.

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

I didn’t like anything, being platinum pro get you absolutely nowhere and does not increase the customer service treatment whatsoever anymore. My flight was canceled and they put me on a flight eight hours later that would’ve got me back in the middle of the night. They could’ve easily move me up to an hour Prior on an earlier flight. My second flight was unreasonable to take, the third flight was also canceled due to mechanical issues like the first flight. I don’t know what’s going on with American, but they are falling apart, after seven flight changes I finally got home, Unreasonable.

This was a horrible American Airlines experience, and it discourages me from flying with them again. It may have stemmed from a mechanical delay, but it appeared that the team was unprepared to respond to the delay. After boarding, we waited an hour before finally taking off. After landing at our destination, we waited an additional hour on the tarmac waiting for a gate (at 8:00pm) to be assigned and cleared. The flight crew did their best, but they were clearly tired and also ready to be done for the day. Because of the delay, I missed a connecting flight. It was a very poor experience.

Fantastic! If it had not been for a check-in agent in Knoxville I may have not gotten my passes on British Airways. I couldn’t check-in online because British Airways had messed us the info on my tickets to London & Inverness. AA’s was great! British Airways was a continuous series of delays and frustrations.

Wheelchair was waiting for me,changed to a better seat which was great as it's hard for me to walk

Everything you need to know for your flight from Knoxville to Panama

Information on your arrival and departure airports