$231 Find Cheap Flights from Knoxville to Panama

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Panama departing on 1/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Book Cheap Knoxville to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Panama

Wed, Feb 18 - Fri, Feb 27
American Airlines Logo
5:08 pm - 1:40 pmTYS-PTY
20h 32m2 stops
American Airlines Logo
4:04 pm - 11:03 amPTY-TYS
18h 59m2 stops
$440American Airlines
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Tue, Mar 10 - Tue, Mar 17
United Airlines Logo
9:10 am - 4:07 pmTYS-PTY
7h 57m1 stop
United Airlines Logo
3:41 pm - 6:09 pmPTY-TYS
25h 28m1 stop
$444United Airlines
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Wed, Feb 18 - Fri, Feb 27
American Airlines Logo
7:06 pm - 3:14 pmTYS-PTY
20h 08m1 stop
American Airlines Logo
4:04 pm - 11:03 amPTY-TYS
18h 59m2 stops
$450American Airlines
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Tue, Mar 17 - Sun, Mar 22
American Airlines Logo
3:00 pm - 12:10 pmTYS-PTY
22h 10m2 stops
American Airlines Logo
3:50 pm - 10:10 pmPTY-TYS
29h 20m1 stop
$475American Airlines
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Tue, Mar 17 - Sun, Mar 22
American Airlines Logo
7:00 pm - 12:10 pmTYS-PTY
18h 10m1 stop
American Airlines Logo
3:50 pm - 10:10 pmPTY-TYS
29h 20m1 stop
$480American Airlines
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Wed, Feb 18 - Fri, Feb 27
United Airlines Logo
9:10 am - 5:07 pmTYS-PTY
7h 57m1 stop
United Airlines Logo
8:55 am - 11:44 pmPTY-TYS
14h 49m1 stop
$483United Airlines
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Sun, Jan 4 - Sun, Jan 18
American Airlines Logo
6:25 pm - 1:53 pmTYS-PTY
19h 28m2 stops
American Airlines Logo
4:50 pm - 10:49 amPTY-TYS
17h 59m2 stops
$485American Airlines
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Tue, Mar 17 - Sun, Mar 22
American Airlines Logo
3:00 pm - 12:10 pmTYS-PTY
22h 10m2 stops
American Airlines Logo
1:50 pm - 10:02 amPTY-TYS
19h 12m2 stops
$505American Airlines
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Mon, Apr 6 - Tue, Apr 7
Delta Logo
5:30 am - 12:55 pmTYS-PTY
8h 25m1 stop
Delta Logo
2:20 pm - 11:44 pmPTY-TYS
8h 24m1 stop
$541Delta
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Sun, Jan 4 - Sun, Jan 18
United Airlines Logo
9:05 am - 2:45 pmTYS-PTY
29h 40m1 stop
United Airlines Logo
4:41 pm - 7:50 pmPTY-TYS
27h 09m1 stop
$623United Airlines
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Booking Insights

KAYAK's insights & trends for Knoxville to Panama flights

Get data-powered insights and trends into flights from Knoxville to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Panama is September, when tickets cost $471 (return) on average. On the other hand, the most expensive months are December and March, when the average cost of round-trip tickets is $1,078 and $704 respectively.

What’s the cheapest day of the week to fly from Knoxville to Panama?

The average price of all round-trip flights from Knoxville to Panama clicked on KAYAK for each day over the last 12 months.

Your flight ticket price will generally be cheaper if you fly to Panama on a Friday and more expensive on a Monday. On your return trip to Knoxville, you should consider flying back on a Tuesday, and avoid Wednesdays for better deals.

Good to know

Low seasonJuly
Cheapest flight$231
Best time to beat the crowds but there is an average 5% increase in price.
Most popular time to fly with an average 67% increase in price.
Flight from Knoxville to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Knoxville to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Panama?

    The cheapest time of day to fly to Panama is generally in the morning, when round-trip flights cost $595 on average. The most expensive time of day to fly to Panama is generally in the morning, which is peak travel time and where the average cost of a ticket is $595.

Reviews of the top airlines flying from Knoxville to Panama

 
Need help choosing which airline to fly with from Knoxville to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9016 reviews
7.3Comfort
8.1Crew
7.7Boarding
6.6Food
7.1Entertainment
Airline reviews

Older aircraft, no meal, only food was for purchase. Not impressed United.

4.0 OkayThomas, Nov 2025SFO - KOA
Read more United Airlines reviews

Older aircraft, no meal, only food was for purchase. Not impressed United.

United needs to step up their game. Delayed flight leaving Seattle, San Francisco. Older aircraft, not very comfortable.

Always wish for more healthy, gluten free options. We have to bring our own.

Having a long layover, I was very appreciative of the ability to stand by for an earlier flight. Other airlines like Delta have refused this to me in the past, just to be mean (because my ticket class wasn't high enough). United went out of their way to help me get to my destination early, which I really appreciated given that it was the third leg of a 24+ hour journey for me.

Other than a way way too cold cabinets for the entire flight, all was great

One bag is incorrect and not acceptable for an international flight. The food was not just good. I won't fly with them again.

Not pleasant trip cross country when the entertainment and WiFi system not working. No entertainment for entirety of route. Staff was rather nonchalant in that they dismissed the problem due to age of plane. It would have been nice to know this up front so I could have come prepared to read or download movies before boarding Coincidentally or not, there was a similar issue with the entertainment system on my previous flight I took on my fist leg of the trip. There are no seat TVs, so you must rely on the app when it works. United can do better. Also, what use it it to pay for boarding group 2 when half of the passengers are in the same line as you?

Plane boarded early a quickly, was mostly full. We left close to on time. And landed early.

My experience on this United Airlines flight was highly uncomfortable, primarily due to two issues: Cabin Temperature: The temperature on the Boeing 737 MAX 8 was unacceptably high, feeling consistently around 80 degrees throughout the flight. This made sleeping impossible and significantly detracted from the experience. Seating Arrangement: Being stuck in a middle seat for a six-and-a-half-hour overnight flight compounded the discomfort. Moving forward, I will always purchase a seat assignment to avoid this situation.

Premium Plus is a really good idea for longer flights

we landed at cmh ten minutes early but had to sit on tarmac for twenty minutes because a plane was at our gate despite the fact that 3 other gates were open.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

I have a gluten allergy so did have any food

I have a gluten allergy so didn't have any food

Loved the crew . Absolutely no complaints. Except for luggage lost

Everything was good The connects, with no blame to crew. Or pilots. I understand they are short staffed. Everything went well for me. I'll be using you guys again in May if not sooner.

this plane was really old, had exit row seats and tray was in arm of seat so super uncomfortable to use. another seat they could t even use the tray it was broke. seat i. front of me had duct tape on it cause seat was ripped open... this plane should either be updated or retired.

We were very rushed by a staff member at the gate when transferring from American Airlines to Fijian. Then the plane stayed put for ages anyhow! The plane was delayed and my bag sent to San Francisco instead of Fiji

Baggage handling poor. Second time this has happened. My bag went to San Francisco instead of Fiji. No apology. Luckily Nadi airport staff are fantastic. My bag arrived in Fiji the next day.

We loved the steward on the plane. He made the night enjoyable

Everything you need to know for your flight from Knoxville to Panama

Information on your arrival and departure airports