$205 Find Cheap Flights from Knoxville to Panama

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Panama departing on 1/26. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Book Cheap Knoxville to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Panama

Fri, Apr 24 - Fri, May 1
American Airlines Logo
6:28 pm - 12:15 pm
TYS
-
PTY
18h 47m2 stops
American Airlines Logo
1:55 pm - 11:14 pm
PTY
-
TYS
8h 19m1 stop
$460American Airlines
Fri, Feb 27 - Tue, Mar 3
United Airlines Logo
7:05 am - 5:07 pm
TYS
-
PTY
10h 02m1 stop
United Airlines Logo
4:41 pm - 7:55 pm
PTY
-
TYS
27h 14m1 stop
$464United Airlines
Fri, Feb 27 - Tue, Mar 3
United Airlines Logo
11:41 am - 7:38 pm
TYS
-
PTY
7h 57m1 stop
United Airlines Logo
8:55 am - 7:55 pm
PTY
-
TYS
11h 00m1 stop
$476United Airlines
Fri, Feb 27 - Tue, Mar 3
United Airlines Logo
11:41 am - 7:38 pm
TYS
-
PTY
7h 57m1 stop
United Airlines Logo
4:41 pm - 7:55 pm
PTY
-
TYS
27h 14m1 stop
$484United Airlines
Fri, Apr 24 - Fri, May 1
United Airlines Logo
5:15 pm - 4:12 pm
TYS
-
PTY
23h 57m1 stop
United Airlines Logo
7:55 am - 7:55 pm
PTY
-
TYS
11h 00m1 stop
$505United Airlines
Fri, Feb 27 - Tue, Mar 3
WestJet Logo
5:35 am - 9:20 am
TYS
-
PTY
27h 45m2 stops
WestJet Logo
10:20 am - 5:56 pm
PTY
-
TYS
31h 36m2 stops
$5,167WestJet
Fri, Feb 27 - Tue, Mar 3
WestJet Logo
5:35 am - 9:20 am
TYS
-
PTY
27h 45m2 stops
WestJet Logo
10:20 am - 5:56 pm
PTY
-
TYS
31h 36m2 stops
$5,177WestJet
Booking Insights

KAYAK's insights & trends for Knoxville to Panama flights

Get data-powered insights and trends into flights from Knoxville to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Panama is September, when tickets cost $471 (return) on average. On the other hand, the most expensive months are December and March, when the average cost of round-trip tickets is $754 and $707 respectively.

Good to know

Low seasonJuly
Cheapest flight$205
Best time to beat the crowds but there is an average 9% increase in price.
Most popular time to fly with an average 14% increase in price.
Flight from Knoxville to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Knoxville to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Knoxville to Panama

 
Need help choosing which airline to fly with from Knoxville to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9113 reviews
6.6Food
8.1Crew
7.3Comfort
7.7Boarding
7.1Entertainment
Airline reviews

Pushed back only to get deplaned due to a tire damaged by ground crew. They did at least go pretty fast. The bathrooms should be banned under the Geneva convention. No room to even sit straight on the toilet. The under-seat entertainment units block what little leg room there is.

6.0 GoodWalter, Dec 2025
SFO - CLE
Read more United Airlines reviews

Pushed back only to get deplaned due to a tire damaged by ground crew. They did at least go pretty fast. The bathrooms should be banned under the Geneva convention. No room to even sit straight on the toilet. The under-seat entertainment units block what little leg room there is.

Essy to get on. The hostess gave very little pop, the plane was late getting in, and we are still waiting for our bags. This sucks. :/

Sat next to a one year old. She crawled all over the place and made me laugh.

Not United Airlines' fault. It's ORL airport's fault.

Great flight. On time boarding. Smooth flight and on time arrival at EWR. The flight crew was marvelous and there was a great selection of movies on the entertainment system. Our bags were at the carousel before we got there. Another excellent flight from United.

United airlines has the best customer experience from booking to arrival. I always fly United airlines. The mileage program is excellent

They did the one thing that really matters - got to Chicago early.

I liked the snacks and the flight attendants were friendly.

Gate agent at Frankfurt was terrible. She denied PRE boarding even as it was printed on the boarding pass. Refused to look at the boarding pass and literally shouting for no reason. Frankfurt airport has horrible and rude staff who avoids trying to answer any question at all. Overall, horrible experience.

The Crew and the food was the worst I ever had in Business Class. First they told us there were no space for carry on. It was plenty of space over our 2 row seats, we had to ask to let us travel with it which was accepted. They were aware that we had to run for the connection due to the previous flight delay. Have us one hour waiting for more customers and not even offer a glass of water. Then started the service and they started to serve other passengers drinks in business and did not offer any drinks until they serve our pre ordered meal and I ask for something to drink. I had to wait until they finished to serve all passengers until Inget something. The crew was the worts I ever had for Business Class in my life.

We were 4+ hours delayed. AA is absolutely obnoxious. They just kept pushing back the time to the point where we did not get into Vegas until after midnight when we were supposed to arrive like 845pm.

My last flight on 25 Dec, it’s Christmas Day, everyone happy and very good mood. I really enjoy traveling with Americans Airlines from Miami to Minneapolis my home town after long flight from lhe to Doha then Miami. Thank you again to make my travels comfortable and relaxed. Best regards

The boarding process needs to be fixed. The zone don't work, especially when there is hardly anyone in zones 3, 4,and 5, leaving the majority of the passengers backed up in the aisle, especially because passengers seated near the front are blocking passengers who are seated in the rear of the plane. It would also help if the size of carry on bags was more strictly enforced.

I requested a low sodium meal. Reason being, I take medicine for high blood pressure and I wear compression socks on long flights to help with leg swelling. Having less sodium in meals really helps me feel better on long flights. I received my initial low sodium meal after takeoff. Just before landing, the crew came through with the meal cart and offered me what was being served. I said no thank you and then noticed my low sodium meal in the meal cart, with my name and seat assignment on it. I motioned to the crew member, but he grabbed the meal cart and proceeded to move to the rear of the aircraft. He didn’t see me or other passengers who had attempted to get this attention. He was more concerned about completing meal service since we were due to land in under 45 minutes. I pressed the call light five times from my seat to receive help, but no crew member responded to me. So, I didn’t receive a second meal, one that I requested (the low sodium option). This led me to have a migraine from only eating one meal on an 11-hour flight. This is why I’m not a fan of flying US-based airlines overseas. The crew members continue to show the absolute worst customer service experience. I would not recommend flying American for overseas flights.

WiFi didn’t work the entire flight. Very disappointing. Minimal food and options - sadly the state of current affairs. All other aspects of the flight were fine.

Great flight - friendly and attentive team! Seats in coach were comfy, but a little cramped - but that is the case with all airlines ;)

The boarding by groups is pointless. The first two groups worked fine, but almost Noone boarded in goups three thru five leaving the vast majority boarding when group six was called. It defeated the purpose of spreading out the crowd.

I don’t know who decides what food to serve on these flights but I would be so embarrassed if I served this to anyone and call it food…

For whatever reason, the flight was not catered -we were told it would be a 45 minute delay waiting for catering - so no food. There were opened candy and peanuts in the seatback pocket. Flight landed early in DFW but due to the assigned gate not being available, we sat on the ground for 30 minutes waiting for the gate to open - making the flight actually arrive at the gate late.

Not great. Booked Extra seats and got nothing extra at all. It’s basically a big budget airline.

Everything you need to know for your flight from Knoxville to Panama

Information on your arrival and departure airports