Which airports can I use when flying from Knoxville to Panama City?

Flights from Knoxville to Panama City usually depart from Knoxville McGhee Tyson (TYS) and arrive at Panama City Tocumen Intl (PTY).

What cabin classes can I book on flights from Knoxville to Panama City?

Only Economy Class is available on flights from Knoxville to Panama City.

Which airports do connecting flights from Knoxville to Panama City pass through?

One-stop flights from Knoxville to Panama City most commonly connect through: • Miami (MIA) - 39% of one-stop connections • Houston George Bush Intcntl (IAH) - 32% of one-stop connections • Atlanta Hartsfield-Jackson (ATL) - 29% of one-stop connections Miami (MIA) handles the largest share of one-stop connections on this route.

Can I save money by using flexible dates for flights from Knoxville to Panama City?

On the Knoxville to Panama City route, being flexible with your departure day can save you up to 43%. Saturday is the cheapest day at $529 round-trip on average, while Sunday is the most expensive at $916: a $387 difference. Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

What popular places can I visit in Panama City?

Some of the most popular sights in Panama City are Avenida Balboa, Multiplaza Pacific and ATLAPA Conventions Center. These are among the most viewed places in Panama City on KAYAK.

How long is a flight from Knoxville to Panama City?

A nonstop flight from Knoxville to Panama City takes 0h 00m, covering 1,869 miles.

Do I need a passport to fly from Knoxville to Panama City?

Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

Have flight prices from Knoxville to Panama City changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $653 to $2,715. That means the highest observed fare was about 4x higher than the lowest one.

How much time can I save by choosing a different layover airport from Knoxville to Panama City?

Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 7h 52m, compared with 7h 58m via Miami (MIA) and 9h 52m via Houston George Bush Intcntl (IAH).

What is the time difference between Knoxville and Panama City?

Panama City is 1 hour behind Knoxville (Eastern Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

What car rental options are available at Panama City Tocumen Intl Airport (PTY)?

Panama City Tocumen Intl Airport (PTY) hosts 5 major car rental companies, with daily rates starting from around $1 for economy cars. Top options include: · Avis · Europcar · Ace · Budget · Hertz

How much should I expect to pay for a Knoxville to Panama City flight?

Round-trip flights from Knoxville to Panama City range from $556 to $781, with an average of $655 over the past 12 months. Anything below $556 counts as a good deal.

What is the cheapest airline to fly from Knoxville to Panama City?

United Airlines ($653) and American Airlines ($692) are the cheapest airlines to fly round-trip from Knoxville to Panama City according to KAYAK data over the last 5 days.

What is the most popular layover airport when flying from Knoxville to Panama City?

Miami (MIA) is the most popular layover for the Knoxville to Panama City route. 39% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via MIA.

What is the cheapest layover airport when flying from Knoxville to Panama City?

Flights via Houston George Bush Intcntl (IAH) offer the most affordable fares, with an average round-trip price of $595. Based on KAYAK data over the past 3 months.

When flying from Knoxville to Panama City which airport offers the shortest layover?

Atlanta Hartsfield-Jackson (ATL) had the shortest average connection time for Knoxville to Panama City layovers at 310 minutes over the past 3 months.

$402 CHEAP FLIGHTS from Knoxville to Panama City (TYS - PTY)

Save 21% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$653

Typical prices: $556-$781

United Airlines

Wed 11/14Sun 12/2

TYS - PTY • 1 stop

Nonstop flights

Not available

There are currently no direct flights between Knoxville and Panama City. You'll need to take a connecting flight to reach the destination.

Insights

When to travel

April

Cheapest • 24% price drop

January

Most popular

Good to know

Top layover airports

Houston George Bush Intcntl (IAH)

Cheapest • Avg $595 (round-trip)

Atlanta Hartsfield-Jackson (ATL)

Shortest trip • 7h 52m (one-way)

Insights

Start a new search

KAYAK searches 100s of sites at once to find you the best travel deals.

We hope you love your trip to Panama City!

Flight Deals

Cheap Flights from Knoxville to Panama City (TYS-PTY)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Recent round-trip flight deals from Knoxville to Panama City

Wed, Oct 7 - Wed, Oct 14

7:15 am - 2:14 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

7h 59m1 stop Houston George Bush Intcntl

9:45 am - 8:45 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

10h 00m1 stop Newark

$653United Airlines

Sat, Nov 14 - Wed, Dec 2

11:20 am - 8:02 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

8h 42m1 stop Newark

8:55 am - 6:28 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

9h 33m1 stop Houston George Bush Intcntl

$653United Airlines

Sat, Nov 14 - Wed, Dec 2

1:56 pm - 2:45 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

24h 49m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

4:41 pm - 11:02 amPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

18h 21m1 stop Houston George Bush Intcntl

$657United Airlines

Sat, Nov 14 - Wed, Dec 2

5:40 pm - 8:02 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

26h 22m2 stops Chicago O'Hare Intl Newark

8:55 am - 11:39 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

14h 44m2 stops Houston George Bush Intcntl Washington, D.C. Dulles Intl

$657United Airlines

Thu, Oct 8 - Thu, Oct 15

6:55 pm - 1:02 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

19h 07m2 stops Chicago O'Hare Intl Miami

2:02 pm - 4:18 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

25h 16m2 stops Miami Charlotte Douglas

$692American Airlines

Sun, Sep 20 - Fri, Sep 25

6:05 am - 12:16 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

7h 11m1 stop Miami

1:16 pm - 11:07 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

8h 51m1 stop Miami

$719American Airlines

Sun, Sep 20 - Fri, Sep 25

6:09 pm - 12:16 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

19h 07m2 stops Charlotte Douglas Miami

1:16 pm - 11:26 amPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

21h 10m2 stops Miami Washington, D.C. Reagan-National

$723American Airlines

Sat, Oct 10 - Sat, Oct 17

7:25 pm - 2:55 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

20h 30m3 stops Washington, D.C. Dulles Intl Guatemala City La Aurora San José Juan Santamaria Intl

3:50 pm - 10:37 amPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

17h 47m2 stops San Salvador El Salvador Intl Washington, D.C. Dulles Intl

$852Avianca

Sat, Oct 10 - Sat, Oct 17

7:25 pm - 2:55 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

20h 30m3 stops Washington, D.C. Dulles Intl Guatemala City La Aurora San José Juan Santamaria Intl

11:25 am - 10:37 amPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

22h 12m3 stops San José Juan Santamaria Intl Guatemala City La Aurora Washington, D.C. Dulles Intl

$858Avianca

Sat, Nov 14 - Wed, Dec 2

5:45 am - 3:00 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

33h 15m3 stops Washington, D.C. Dulles Intl Guatemala City La Aurora San José Juan Santamaria Intl

5:30 am - 11:39 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

18h 09m2 stops San Salvador El Salvador Intl Washington, D.C. Dulles Intl

$862Avianca

Booking Insights

Price, demand and travel trends for Knoxville to Panama City flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Knoxville to Panama City with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from Knoxville to Panama City?

Round-trip flights from Knoxville to Panama City start at $653. Prices are typical for this route right now, with typical round-trip fares ranging from $556 to $781. The lowest price found in the past 5 days was $653 on United Airlines.

Find deals

Low season	June
High season	January
Cheapest flight	$653

Best time to beat the crowds but there is an average 35% increase in price.

Most popular time to fly with an average 1% increase in price.

Flight from Knoxville to Panama City

When to book flights from Knoxville to Panama City

Are your dates flexible? Find out the best times to travel from Knoxville to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

Which airports can I use when flying from Knoxville to Panama City?
Flights from Knoxville to Panama City usually depart from Knoxville McGhee Tyson (TYS) and arrive at Panama City Tocumen Intl (PTY).
What cabin classes can I book on flights from Knoxville to Panama City?
Only Economy Class is available on flights from Knoxville to Panama City.
Which airports do connecting flights from Knoxville to Panama City pass through?
One-stop flights from Knoxville to Panama City most commonly connect through:

• Miami (MIA) - 39% of one-stop connections
• Houston George Bush Intcntl (IAH) - 32% of one-stop connections
• Atlanta Hartsfield-Jackson (ATL) - 29% of one-stop connections

Miami (MIA) handles the largest share of one-stop connections on this route.
Can I save money by using flexible dates for flights from Knoxville to Panama City?
On the Knoxville to Panama City route, being flexible with your departure day can save you up to 43%. Saturday is the cheapest day at $529 round-trip on average, while Sunday is the most expensive at $916: a $387 difference. Cheaper weekend fares like these are typical of routes dominated by weekday business travel.
What popular places can I visit in Panama City?
Some of the most popular sights in Panama City are Avenida Balboa, Multiplaza Pacific and ATLAPA Conventions Center. These are among the most viewed places in Panama City on KAYAK.
How long is a flight from Knoxville to Panama City?
A nonstop flight from Knoxville to Panama City takes 0h 00m, covering 1,869 miles.
Do I need a passport to fly from Knoxville to Panama City?
Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.
Have flight prices from Knoxville to Panama City changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $653 to $2,715. That means the highest observed fare was about 4x higher than the lowest one.
How much time can I save by choosing a different layover airport from Knoxville to Panama City?
Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 7h 52m, compared with 7h 58m via Miami (MIA) and 9h 52m via Houston George Bush Intcntl (IAH).
What is the time difference between Knoxville and Panama City?
Panama City is 1 hour behind Knoxville (Eastern Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.
What car rental options are available at Panama City Tocumen Intl Airport (PTY)?
Panama City Tocumen Intl Airport (PTY) hosts 5 major car rental companies, with daily rates starting from around $1 for economy cars. Top options include:
· Avis
· Europcar
· Ace
· Budget
· Hertz
How much should I expect to pay for a Knoxville to Panama City flight?
Round-trip flights from Knoxville to Panama City range from $556 to $781, with an average of $655 over the past 12 months. Anything below $556 counts as a good deal.

If your dates can be flexible, aim for a Saturday departure instead of Sunday. On this route, Saturday flights average $529 - about $387 less than Sunday (42% savings) based on the last 12 months.
If you can choose when to travel, plan your Knoxville to Panama City trip for April. Fares historically average $496 round-trip in that month - typically $501 less than the most expensive month, which is March (based on the last 12 months).
If you're arriving late at night and need somewhere to stay, check out these hotels close to Panama City Tocumen Intl Airport.
- Riande Aeropuerto Hotel & Casino

Everything you need to know for your flight from Knoxville to Panama City

Airports

Cabin class

Complete your trip

Direct Flights

Flights to other cities

Origins

Other airports

Information on your arrival and departure airports

Knoxville (TYS)

Panama City (PTY)

TYS - PTY

$402 Find Cheap Flights from Knoxville to Panama City - Compare and Save

Everything you should know

Cheap Flights from Knoxville to Panama City (TYS-PTY)

Recent round-trip flight deals from Knoxville to Panama City

Recent one-way flight deals from Knoxville to Panama City

Recent last minute flight deals from Knoxville to Panama City

Price, demand and travel trends for Knoxville to Panama City flights

How much is a round-trip flight from Knoxville to Panama City?

What is the cheapest airline to fly from Knoxville to Panama City?

What is the most popular layover airport when flying from Knoxville to Panama City?

What is the cheapest layover airport when flying from Knoxville to Panama City?

When flying from Knoxville to Panama City which airport offers the shortest layover?

Key details for Knoxville to Panama City flights

Low season

High season

Cheapest flight

When to book flights from Knoxville to Panama City

Your Knoxville to Panama City flight questions, answered

Your guide to booking Knoxville to Panama City flights

Everything you need to know for your flight from Knoxville to Panama City

Information on your arrival and departure airports

Cabin class types available on flights from Knoxville to Panama City

Complete your trip to Panama City with a hotel stay or car rental

Find direct flights to and from Knoxville and Panama City

Flights to other popular destinations

Flights from domestic origins to Panama City

Choose which airport to fly into in Panama City