TYS - PTY

$251 Find Cheap Flights from Knoxville to Panama City

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 8/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Panama City

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Panama City, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Panama City, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$527
Typical prices: $602-$507
United Airlines
Sun 8/23Wed 8/26
TYS - PTY • 2 stops
Cheapest one-way
$407
GOL
Sat 8/1
TYS - PTY • 2 stops
Top airlines
Cheapest • from $527 (round-trip)
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Knoxville and Panama City. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $639 (round-trip)
Shortest trip • 7h 56m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 22% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Panama City!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Panama City (TYS-PTY)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Panama City

Sun, Aug 23 - Wed, Aug 26
United Airlines Logo
5:57 pm - 2:14 pm
TYS
-
PTY
21h 17m
2 stops
United Airlines Logo
10:00 am - 9:30 pm
PTY
-
TYS
10h 30m
1 stop
$527United Airlines
Sun, Aug 23 - Wed, Aug 26
United Airlines Logo
5:57 pm - 2:14 pm
TYS
-
PTY
21h 17m
2 stops
United Airlines Logo
9:45 am - 10:36 am
PTY
-
TYS
23h 51m
2 stops
$531United Airlines
Sun, Aug 23 - Wed, Aug 26
United Airlines Logo
5:57 pm - 2:14 pm
TYS
-
PTY
21h 17m
2 stops
United Airlines Logo
3:30 pm - 6:05 pm
PTY
-
TYS
25h 35m
1 stop
$536United Airlines
Sun, Aug 23 - Wed, Aug 26
United Airlines Logo
3:25 pm - 6:37 pm
TYS
-
PTY
28h 12m
1 stop
United Airlines Logo
3:30 pm - 6:05 pm
PTY
-
TYS
25h 35m
1 stop
$546United Airlines
Tue, May 12 - Tue, May 19
United Airlines Logo
11:40 am - 6:37 pm
TYS
-
PTY
7h 57m
1 stop
United Airlines Logo
7:55 am - 6:11 pm
PTY
-
TYS
9h 16m
1 stop
$547United Airlines
Thu, May 14 - Thu, May 21
American Airlines Logo
5:11 pm - 12:46 pm
TYS
-
PTY
20h 35m
2 stops
American Airlines Logo
1:14 pm - 11:59 pm
PTY
-
TYS
9h 45m
1 stop
$551American Airlines
Sun, Aug 23 - Wed, Aug 26
United Airlines Logo
7:15 am - 6:37 pm
TYS
-
PTY
12h 22m
1 stop
United Airlines Logo
10:00 am - 9:30 pm
PTY
-
TYS
10h 30m
1 stop
$557United Airlines
Thu, May 28 - Sun, May 31
American Airlines Logo
7:59 pm - 12:14 pm
TYS
-
PTY
17h 15m
2 stops
American Airlines Logo
1:14 pm - 1:10 pm
PTY
-
TYS
22h 56m
2 stops
$566American Airlines
Thu, May 28 - Sun, May 31
American Airlines Logo
7:34 pm - 12:14 pm
TYS
-
PTY
17h 40m
1 stop
American Airlines Logo
1:14 pm - 11:59 pm
PTY
-
TYS
9h 45m
1 stop
$573American Airlines
Fri, Jun 5 - Fri, Jun 12
United Airlines Logo
5:45 am - 7:31 pm
TYS
-
PTY
14h 46m
2 stops
United Airlines Logo
10:55 pm - 8:56 pm
PTY
-
TYS
21h 01m
2 stops
$591United Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Panama City flights

Get data-powered insights and trends into flights from Knoxville to Panama City to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Knoxville to Panama City?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Knoxville to Panama City departing in August.

What is the cheapest month to fly from Knoxville to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Panama City is September, where tickets cost $471 (return) on average. On the other hand, the most expensive months are December and February, where the average cost of round-trip tickets is $754 and $685 respectively.

Good to know

Low seasonMay
Cheapest flight$407
Best time to beat the crowds with an average 17% drop in price.
Most popular time to fly and prices are also 14% lower on average.
Flight from Knoxville to Panama City

When to book flights from Knoxville to Panama City

Are your dates flexible? Find out the best times to travel from Knoxville to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Panama City

  • What is the cheapest flight from Knoxville to Panama City?

    In the last 3 days, the lowest price for a flight from Knoxville to Panama City was $407 for a one-way ticket and $527 for a round-trip.

  • Do I need a passport to fly between Knoxville and Panama City?

    Yes, you’ll need a passport to travel to Panama City from Knoxville.

  • Which aircraft models fly most regularly from Knoxville to Panama City?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Panama City?

    Star Alliance, and oneworld are the airline alliances operating flights between Knoxville and Panama City, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from Knoxville to Panama City, United Airlines or American Airlines?

    The two airlines most popular with KAYAK users for flights from Knoxville to Panama City are United Airlines and American Airlines. With an average price for the route of $507 and an overall rating of 7.4, United Airlines is the most popular choice. American Airlines is also a great choice for the route, with an average price of $617 and an overall rating of 7.1.

  • How does KAYAK find such low prices on flights from Knoxville to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and PTY can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Knoxville to Panama City

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9514 reviews
7.3Comfort
7.1Entertainment
7.7Boarding
6.6Food
8.1Crew
Airline reviews

No meal service to the back of the plane as it started late or was too slow to get it out before it was time to land.

8.0 ExcellentAnonymous, Mar 2026
ORD - EWR
Read more United Airlines reviews

No meal service to the back of the plane as it started late or was too slow to get it out before it was time to land.

Terrible, if possible won't be flying again anytime soon!

Efficient boarding and early departure. Very smooth flight. Early arrival in ATL. Great flight.

We purchase first class seats for the first time for multiples of standard economy ticket. There was no access to the club lounge and no priority boarding. The meal and the service once on the plane were superior and the seat was nicer, but not worth the price difference. I will be happy to seat in economy and spend the difference on more travel.

The business class seat is exceptional. I wish the food is more palatable.

Wonderful in-seat entertainment with seatback screens and huge selection of quality movies. The ability to bluetooth connect headphones was amazing.

the entire flight felt off. The crew seemed uninterested and disengaged. The food service was really bad - overcooked, bland, weird food service. They actually woke us up to serve chicken wraps in the middle of the night, after dinner and before breakfast. Made no sense. Ultimately, I was glad they did though, because the breakfast had been held for so long it was inedible. Eggs, potatoes, sausage - all disgusting. We were asked to "honor" the lavatories for premium customers and stay in our own cabin: this was also strange. So people in economy didn't pay enough to use the closest toilet to them??? It's a toilet. All in all, not the experience I have come to expect from United Airlines. The return flight from Paris to SFO was better, btw.

Smooth and easy boarding, comfortable for the entire 5 hour flight, and the seat back entertainment was great! I appreciated all the features, from location info and maps, movies, the ability to connect with Bluetooth headphones, and good selection of movies. Food was good, normal airline snacks (I didn’t purchase anything)

Overall, the flight was good. Lounge access should be with all business class tickets.

They promise free wi-fi prior to boarding and then once on board you are informed you have to purchase wifi even after being a mileagePlus member.

Better snacks but flight and crew were amazing on this flight

Found that the plane used for this short flight is smaller and therefore the seats are really squeezed tight.

It was the most un-special flight experience in my life.

Plane was super cold. No entertainment unless you were with mileage program Getting off the plane was super slow

Flight was on-time, boarding was flawless and the crew was friendly.

The staff are very, very professional. It's what flying should feel like.

Flight boarded from Gate 159B, the farthest gate in the LAX Bradley Terminal. While the flight operated on time, the first class cabin attendant made no recognition of my being an Advantage Executive Platinum member.

For an international flight the seats were smaller than most flight I have been on in economy. I don’t know the size of the seats or perhaps it was the size of the seat dividers that made the seats feel smaller and little amount of space to even turn your body if you needed to

The flight itself was excellent but the gate attendant made me check my carryon since she said it was an inch too big. I’ve had no problems with this carryon on recent flights on Qantas, Delta, Austrian, Southwest Airlines even though the overhead bins are the same size. there were other carryons in the bins that also looked larger than mine and there was room left in the bins for more. When I picked up my carryon from baggage claim one of the wheels had broken off.

The flight changed gates multiple times and flight had to be delayed multiple times

Everything you need to know for your flight from Knoxville to Panama City

Information on your arrival and departure airports