TYS - PTY

$386 Find Cheap Flights from Knoxville to Panama City - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 7/2. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Panama City

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Panama City, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Panama City, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$587
Typical prices: $562-$610
American Airlines
Tue 8/18Fri 9/4
TYS - PTY • 1 stop
Cheapest one-way
$386
United Airlines
Thu 7/2
TYS - PTY • 2 stops
Top airlines
Cheapest • from $587 (round-trip)
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Knoxville and Panama City. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $648 (round-trip)
Shortest trip • 7h 58m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 28% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Panama City!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Panama City (TYS-PTY)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Panama City

Tue, Aug 18 - Fri, Sep 4
American Airlines Logo
6:00 am - 12:39 pm
TYS
-
PTY
7h 39m
1 stop
American Airlines Logo
1:39 pm - 11:51 pm
PTY
-
TYS
9h 12m
1 stop
$587American Airlines
Wed, Aug 26 - Thu, Aug 27
United Airlines Logo
7:15 am - 2:14 pm
TYS
-
PTY
7h 59m
1 stop
United Airlines Logo
10:55 pm - 11:59 pm
PTY
-
TYS
24h 04m
2 stops
$591United Airlines
Wed, Aug 26 - Thu, Aug 27
United Airlines Logo
7:15 am - 2:14 pm
TYS
-
PTY
7h 59m
1 stop
United Airlines Logo
3:30 pm - 9:45 pm
PTY
-
TYS
29h 15m
1 stop
$597United Airlines
Wed, Aug 26 - Thu, Aug 27
United Airlines Logo
7:00 am - 6:37 pm
TYS
-
PTY
12h 37m
2 stops
United Airlines Logo
10:55 pm - 11:59 pm
PTY
-
TYS
24h 04m
2 stops
$606United Airlines
Wed, Jul 29 - Mon, Sep 28
United Airlines Logo
7:15 am - 4:12 pm
TYS
-
PTY
9h 57m
1 stop
United Airlines Logo
10:00 am - 9:55 pm
PTY
-
TYS
10h 55m
1 stop
$607United Airlines
Wed, Jul 29 - Mon, Sep 28
United Airlines Logo
5:45 am - 4:04 am
TYS
-
PTY
23h 19m
2 stops
United Airlines Logo
3:30 pm - 9:00 pm
PTY
-
TYS
28h 30m
2 stops
$611United Airlines
Wed, Jul 29 - Tue, Sep 29
United Airlines Logo
7:15 am - 4:12 pm
TYS
-
PTY
9h 57m
1 stop
United Airlines Logo
3:30 pm - 9:55 pm
PTY
-
TYS
29h 25m
1 stop
$617United Airlines
Sun, Nov 8 - Thu, Nov 12
American Airlines Logo
6:27 pm - 1:36 pm
TYS
-
PTY
19h 09m
2 stops
American Airlines Logo
2:43 pm - 10:19 am
PTY
-
TYS
19h 36m
2 stops
$621American Airlines
Sat, Aug 1 - Mon, Sep 28
United Airlines Logo
7:15 am - 6:37 pm
TYS
-
PTY
12h 22m
1 stop
United Airlines Logo
10:00 am - 9:55 pm
PTY
-
TYS
10h 55m
1 stop
$622United Airlines
Sat, Aug 1 - Tue, Sep 29
United Airlines Logo
7:15 am - 6:37 pm
TYS
-
PTY
12h 22m
1 stop
United Airlines Logo
3:30 pm - 1:14 pm
PTY
-
TYS
20h 44m
2 stops
$626United Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Panama City flights

Get data-powered insights and trends into flights from Knoxville to Panama City to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Panama City is April, where tickets cost $496 (return) on average. On the other hand, the most expensive months are March and June, where the average cost of round-trip tickets is $997 and $883 respectively.

Good to know

Low seasonJuly
Cheapest flight$386
Best time to beat the crowds with an average 3% drop in price.
Most popular time to fly and prices are also 16% lower on average.
Flight from Knoxville to Panama City

When to book flights from Knoxville to Panama City

Are your dates flexible? Find out the best times to travel from Knoxville to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Panama City

  • What is the cheapest flight from Knoxville to Panama City?

    In the last 5 days, the lowest price for a flight from Knoxville to Panama City was $587 for a round-trip ticket.

  • Do I need a passport to fly between Knoxville and Panama City?

    Yes, you’ll need a passport to travel to Panama City from Knoxville.

  • Which aircraft models fly most regularly from Knoxville to Panama City?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Panama City?

    Star Alliance, and oneworld are the airline alliances operating flights between Knoxville and Panama City, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from Knoxville to Panama City, United Airlines or American Airlines?

    The two airlines most popular with KAYAK users for flights from Knoxville to Panama City are United Airlines and American Airlines. With an average price for the route of $529 and an overall rating of 7.4, United Airlines is the most popular choice. American Airlines is also a great choice for the route, with an average price of $624 and an overall rating of 7.1.

  • How does KAYAK find such low prices on flights from Knoxville to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and PTY can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Knoxville to Panama City

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9894 reviews
7.1Entertainment
6.6Food
7.3Comfort
8.1Crew
7.7Boarding
Airline reviews

Our flight to Rome, Italy was cancelled the day of and we were never informed. We only found out because I was trying to get into my husbands account and called to get his account number. Had to pay more for worse seating on another airline.

2.0 MediocreAnonymous, May 2026
TYS - IAD
Read more United Airlines reviews

Our flight to Rome, Italy was cancelled the day of and we were never informed. We only found out because I was trying to get into my husbands account and called to get his account number. Had to pay more for worse seating on another airline.

I would have liked to have been served more food when it came to Panama to Newark

Didn't make the flight because the first leg of my flight was canceled and the next leg was already booked.

Even though we were delayed, we were able to make our connection

Same as last comment. Food sucks. Quality. Not surprising most people have no clue about nourishment Clearly

Crew was excellent. This was a relatively long flight though and had very little leg room, and no entertainment.

The food should improve! And The flight should leave on time and not make the traveler wait.

I completely missed my flight because the first leg was longer than planned. I had to sleep overnight in the airport because no accommodation was provided and then sent to Trinidad in the morning with an anticipated 7 hour layover before my flight to Georgetown which was now with Caribbean Airlines. I tried twice with customer service to see if they could put me on an earlier flight which had seats available but was told it wasn’t possible.

horrible website for checking in- no option just to write the passport number; ludicrous

We flew SEA -Houston-Panama-GYE round trip. The connections were torturing because we had to sleep over in Seattle to board the early morning flight and froze for 11 hours in Hoston for the return flight to SEA. Not United's problem, just the inconvenience of numerous transits. Restaurants and fast foods were closed and all we got was a cookie/coffee for each flight. Finally we waited for a long time for our baggage at carousel 9 as informed by the APP and all reliable sources. Suddenly some fellow passengers found out that our bags showed up on carousal 8.

Air condition was not working for long both after boarding and also after landing ; unbearably hot and suffocating

It was canceled at the last minute. While I was literally at the airport. Messed my entire trip up.

Flight was on-time, boarding was flawless and the crew was friendly.

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

I didn’t like anything, being platinum pro get you absolutely nowhere and does not increase the customer service treatment whatsoever anymore. My flight was canceled and they put me on a flight eight hours later that would’ve got me back in the middle of the night. They could’ve easily move me up to an hour Prior on an earlier flight. My second flight was unreasonable to take, the third flight was also canceled due to mechanical issues like the first flight. I don’t know what’s going on with American, but they are falling apart, after seven flight changes I finally got home, Unreasonable.

This was a horrible American Airlines experience, and it discourages me from flying with them again. It may have stemmed from a mechanical delay, but it appeared that the team was unprepared to respond to the delay. After boarding, we waited an hour before finally taking off. After landing at our destination, we waited an additional hour on the tarmac waiting for a gate (at 8:00pm) to be assigned and cleared. The flight crew did their best, but they were clearly tired and also ready to be done for the day. Because of the delay, I missed a connecting flight. It was a very poor experience.

Fantastic! If it had not been for a check-in agent in Knoxville I may have not gotten my passes on British Airways. I couldn’t check-in online because British Airways had messed us the info on my tickets to London & Inverness. AA’s was great! British Airways was a continuous series of delays and frustrations.

Wheelchair was waiting for me,changed to a better seat which was great as it's hard for me to walk

Everything you need to know for your flight from Knoxville to Panama City

Information on your arrival and departure airports