TYS - SAF

$329 Find Cheap Flights from Knoxville to Santa Fe - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Santa Fe departing on 10/11. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$392
American Airlines
Sat 10/10Wed 10/14
TYS - SAF • 1 stop
Cheapest one-way
$329
American Airlines
Sun 10/11
TYS - SAF • 1 stop
Top airlines
Cheapest • from $392 (round-trip)
Best reviews • 7.1 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Knoxville and Santa Fe. You'll need at least 1 connection.
Insights
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Top layover airports
Cheapest • Avg $675 (round-trip)
Shortest trip • 5h 59m (one-way)
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Booking Insights
Flight Deals

Cheap Flights from Knoxville to Santa Fe (TYS-SAF)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Santa Fe that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Santa Fe

Sat, Oct 10 - Wed, Oct 14
American Airlines Logo
5:29 pm - 9:53 pm
TYS
-
SAF
6h 24m
1 stop
American Airlines Logo
6:05 am - 2:07 pm
SAF
-
TYS
6h 02m
1 stop
$392American Airlines
Tue, Aug 11 - Sat, Aug 15
American Airlines Logo
1:46 pm - 6:59 pm
TYS
-
SAF
7h 13m
1 stop
American Airlines Logo
7:10 am - 3:29 pm
SAF
-
TYS
6h 19m
1 stop
$404American Airlines
Sat, Aug 15 - Wed, Aug 19
United Airlines Logo
4:50 pm - 8:36 pm
TYS
-
SAF
5h 46m
1 stop
United Airlines Logo
10:30 am - 11:59 pm
SAF
-
TYS
11h 29m
2 stops
$414United Airlines
Tue, Aug 11 - Sat, Aug 15
American Airlines Logo
1:56 pm - 9:58 pm
TYS
-
SAF
10h 02m
2 stops
American Airlines Logo
7:10 am - 3:29 pm
SAF
-
TYS
6h 19m
1 stop
$414American Airlines
Tue, Aug 11 - Sat, Aug 15
American Airlines Logo
1:56 pm - 9:58 pm
TYS
-
SAF
10h 02m
2 stops
American Airlines Logo
7:10 am - 7:00 pm
SAF
-
TYS
9h 50m
2 stops
$419American Airlines
Sat, Jan 9 - Tue, Jan 12
United Airlines Logo
4:25 pm - 10:01 pm
TYS
-
SAF
7h 36m
1 stop
United Airlines Logo
7:00 am - 2:36 pm
SAF
-
TYS
5h 36m
1 stop
$424United Airlines
Sat, Aug 15 - Wed, Aug 19
American Airlines Logo
7:19 am - 1:38 pm
TYS
-
SAF
8h 19m
1 stop
American Airlines Logo
2:08 pm - 9:53 pm
SAF
-
TYS
5h 45m
1 stop
$424American Airlines
Sat, Aug 29 - Tue, Sep 1
United Airlines Logo
4:50 pm - 8:36 pm
TYS
-
SAF
5h 46m
1 stop
United Airlines Logo
7:10 am - 3:54 pm
SAF
-
TYS
6h 44m
1 stop
$424United Airlines
Sat, Oct 10 - Wed, Oct 14
American Airlines Logo
5:29 pm - 9:53 pm
TYS
-
SAF
6h 24m
1 stop
American Airlines Logo
6:05 am - 2:07 pm
SAF
-
TYS
6h 02m
1 stop
$426American Airlines
Tue, Sep 8 - Mon, Sep 14
American Airlines Logo
6:03 am - 9:41 am
TYS
-
SAF
5h 38m
1 stop
American Airlines Logo
6:05 am - 1:53 pm
SAF
-
TYS
5h 48m
1 stop
$429American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Santa Fe flights

Get data-powered insights and trends into flights from Knoxville to Santa Fe to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Knoxville to Santa Fe?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 5 days.

In the past 5 days, the cheapest round-trip tickets from Knoxville to Santa Fe were found on American Airlines ($392) and United Airlines ($424).

Good to know

Cheapest flight

$329
Flight from Knoxville to Santa Fe

When to book flights from Knoxville to Santa Fe

Are your dates flexible? Find out the best times to travel from Knoxville to Santa Fe based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Santa Fe

  • What is the cheapest flight from Knoxville to Santa Fe?

    In the last 5 days, the lowest price for a flight from Knoxville to Santa Fe was $329 for a one-way ticket and $392 for a round-trip.

  • Do I need a passport to fly between Knoxville and Santa Fe?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which aircraft models fly most regularly from Knoxville to Santa Fe?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Santa Fe?

    oneworld is the only airline alliance operating flights between Knoxville and Santa Fe.

  • How does KAYAK find such low prices on flights from Knoxville to Santa Fe?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Santa Fe.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Santa Fe?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santa Fe from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Santa Fe?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santa Fe with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and SAF can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Santa Fe?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santa Fe from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to Santa Fe

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Santa Fe. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Santa Fe? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11845 reviews
6.8Entertainment
7.2Comfort
6.4Food
7.5Boarding
7.9Crew
Airline reviews

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

2.0 MediocreChristopher, Mar 2026
TYS - DCA
Read more American Airlines reviews

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

Flight was delayed for 2 hours, then last minute the change to on time. The satélite location is far and a nightmare to get to.

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

I didn’t like anything, being platinum pro get you absolutely nowhere and does not increase the customer service treatment whatsoever anymore. My flight was canceled and they put me on a flight eight hours later that would’ve got me back in the middle of the night. They could’ve easily move me up to an hour Prior on an earlier flight. My second flight was unreasonable to take, the third flight was also canceled due to mechanical issues like the first flight. I don’t know what’s going on with American, but they are falling apart, after seven flight changes I finally got home, Unreasonable.

This was a horrible American Airlines experience, and it discourages me from flying with them again. It may have stemmed from a mechanical delay, but it appeared that the team was unprepared to respond to the delay. After boarding, we waited an hour before finally taking off. After landing at our destination, we waited an additional hour on the tarmac waiting for a gate (at 8:00pm) to be assigned and cleared. The flight crew did their best, but they were clearly tired and also ready to be done for the day. Because of the delay, I missed a connecting flight. It was a very poor experience.

This time there was nothing to be better, really! Boarding on time, taking off on time and arriving earlier. The only complain is about way too long line at pre-check security point at DFW. But this is the airport’s problem, not American Airline.

Fantastic! If it had not been for a check-in agent in Knoxville I may have not gotten my passes on British Airways. I couldn’t check-in online because British Airways had messed us the info on my tickets to London & Inverness. AA’s was great! British Airways was a continuous series of delays and frustrations.

Re-checking our bags, the workers were not able to help us with boarding passes for the flight, told us to wait, then ignored us while they helped many other passengers. Until I got rude, they would have left us standing there, and even then they were very curt and dismissive in telling us where to get boarding passes printed. We made it to the gate just as they were starting to board passengers. It was just rude customer service.

Wheelchair was waiting for me,changed to a better seat which was great as it's hard for me to walk

Everything you need to know for your flight from Knoxville to Santa Fe

Information on your arrival and departure airports