TYS - SAF

$364 Find Cheap Flights from Knoxville to Santa Fe - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$364
Typical prices: $459-$704
American Airlines
Mon 11/26Mon 12/3
TYS - SAF • 1 stop
When to travel
July
Cheapest • 47% price drop
July
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Dallas/Fort Worth (DFW)
Cheapest • Avg $595 (round-trip)
Denver Intl (DEN)
Shortest trip • 6h 03m (one-way)
Insights
Insights
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Flight Deals

Cheap Flights from Knoxville to Santa Fe (TYS-SAF)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Santa Fe

Thu, Nov 26 - Thu, Dec 3
American Airlines Logo
5:30 am - 9:41 amTYS  Knoxville McGhee Tyson-SAF Santa Fe
6h 11m1 stop Dallas/Fort Worth
American Airlines Logo
12:07 pm - 11:59 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
9h 52m2 stops Phoenix Sky Harbor Intl Charlotte Douglas
$364American Airlines
Thu, Nov 26 - Thu, Dec 3
United Airlines Logo
5:45 am - 12:51 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
9h 06m2 stops Washington, D.C. Dulles Intl Denver Intl
United Airlines Logo
1:25 pm - 11:59 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
8h 34m2 stops Denver Intl Washington, D.C. Dulles Intl
$443United Airlines
Thu, Nov 26 - Thu, Dec 3
American Airlines Logo
5:30 am - 9:41 amTYS  Knoxville McGhee Tyson-SAF Santa Fe
6h 11m1 stop Dallas/Fort Worth
American Airlines Logo
8:00 am - 4:39 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
6h 39m1 stop Dallas/Fort Worth
$453American Airlines
Tue, Feb 2 - Sat, Feb 6
United Airlines Logo
4:28 pm - 8:33 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
6h 05m1 stop Denver Intl
United Airlines Logo
12:20 pm - 9:05 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
6h 45m1 stop Chicago O'Hare Intl
$467United Airlines
Tue, Feb 2 - Sat, Feb 6
United Airlines Logo
10:45 am - 8:33 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
11h 48m2 stops Chicago O'Hare Intl Denver Intl
United Airlines Logo
12:20 pm - 9:05 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
6h 45m1 stop Chicago O'Hare Intl
$473United Airlines
Booking Insights

Price, demand and travel trends for Knoxville to Santa Fe flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Knoxville to Santa Fe?

Round-trip flights from Knoxville to Santa Fe typically range from $459 to $704. The lowest price found in the past 5 days was $364, on American Airlines.

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Key details for Knoxville to Santa Fe flights

Low season

November

Cheapest flight

$364
Beat the crowds with an average 73% drop in travelers.
The most popular month to fly with an average 23% increase in travelers.
Round-trip flight from Knoxville to Santa Fe

When to book flights from Knoxville to Santa Fe

Are your dates flexible? Find out the best times to travel from Knoxville to Santa Fe based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Knoxville to Santa Fe flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Knoxville to Santa Fe?

    Only Economy Class is available on flights from Knoxville to Santa Fe.

  • Do I need a passport to fly from Knoxville to Santa Fe?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Knoxville to Santa Fe flight?

    Round-trip flights from Knoxville to Santa Fe range from $459 to $704, with an average of $590 over the past 12 months. Anything below $459 counts as a good deal.

  • Have flight prices from Knoxville to Santa Fe changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $364 to $959. That means the highest observed fare was about 3x higher than the lowest one.

  • What car rental options are available at Santa Fe Airport (SAF)?

    Santa Fe Airport (SAF) hosts 5 major car rental companies, with daily rates averaging $77 for economy cars. Top options include:

    • Hertz
    • Enterprise Rent-A-Car
    • Avis
    • Budget
    • National

  • Which airports can I use when flying from Knoxville to Santa Fe?

    Flights from Knoxville to Santa Fe usually depart from Knoxville McGhee Tyson (TYS) and arrive at Santa Fe (SAF).

  • Which airports do connecting flights from Knoxville to Santa Fe pass through?

    Connecting flights from Knoxville to Santa Fe most commonly pass through:

    • Dallas/Fort Worth (DFW) - 92% of one-stop connections
    • Denver Intl (DEN) - 8% of one-stop connections

  • Can I save money by using flexible dates for flights from Knoxville to Santa Fe?

    Yes. Flexible dates can save you up to 53% on flights from Knoxville to Santa Fe. Tuesday is the cheapest departure day at $459 round-trip on average, while Monday is the most expensive at $970, a difference of $511.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Knoxville to Santa Fe?

    Flying via Dallas/Fort Worth (DFW) gives the shortest average 1-stop total travel time at 6h 03m, compared with 6h 03m via Denver Intl (DEN).

  • What is the time difference between Knoxville and Santa Fe?

    Santa Fe is 2 hours behind Knoxville (Mountain Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

Your guide to booking Knoxville to Santa Fe flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Tuesday departure and avoid flying on Monday. On this route, Tuesday flights average $459, about $511 less than Monday fares (53% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Knoxville to Santa Fe trip for July. Fares historically average $315 round-trip in that month - typically $480 less than the most expensive month, which is March (based on the last 12 months).

More options for your flight from Knoxville to Santa Fe

Complete your trip to Santa Fe with a hotel stay or car rental

Car rentals in Santa Fe
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