TYS - SAF

$278 Find Cheap Flights from Knoxville to Santa Fe

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Santa Fe departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santa Fe

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Santa Fe, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Santa Fe, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$278
United Airlines
Tue 2/24Tue 3/3
TYS - SAF • 2 stops
Cheapest one-way
Multiple Airlines
Wed 1/28
TYS - SAF • multi-stop
Top airlines
United Airlines
Cheapest • from $278 (round-trip)
American Airlines
Best reviews • 7.2 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
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We hope you love your trip to Santa Fe!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Santa Fe (TYS-SAF)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Santa Fe that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Santa Fe

Tue, Feb 24 - Tue, Mar 3
United Airlines Logo
6:45 am - 5:08 pm
TYS
-
SAF
12h 23m
2 stops
United Airlines Logo
3:20 pm - 10:30 pm
SAF
-
TYS
5h 10m
1 stop
$278United Airlines
Tue, Feb 10 - Sat, Feb 14
American Airlines Logo
6:00 am - 9:58 am
TYS
-
SAF
5h 58m
1 stop
American Airlines Logo
3:55 pm - 12:28 am
SAF
-
TYS
6h 33m
1 stop
$335American Airlines
Tue, Feb 10 - Sat, Feb 14
American Airlines Logo
6:20 am - 4:35 pm
TYS
-
SAF
12h 15m
2 stops
American Airlines Logo
10:09 am - 5:31 pm
SAF
-
TYS
5h 22m
1 stop
$344American Airlines
Tue, Feb 24 - Tue, Mar 3
American Airlines Logo
5:05 am - 9:39 am
TYS
-
SAF
6h 34m
1 stop
American Airlines Logo
6:15 am - 3:37 pm
SAF
-
TYS
7h 22m
1 stop
$384American Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
5:40 am - 9:39 am
TYS
-
SAF
5h 59m
1 stop
American Airlines Logo
6:42 pm - 9:53 am
SAF
-
TYS
13h 11m
2 stops
$393American Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
5:40 am - 9:39 am
TYS
-
SAF
5h 59m
1 stop
American Airlines Logo
4:15 pm - 12:28 am
SAF
-
TYS
6h 13m
1 stop
$409American Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
5:40 am - 9:39 am
TYS
-
SAF
5h 59m
1 stop
American Airlines Logo
4:15 pm - 12:28 am
SAF
-
TYS
6h 13m
1 stop
$410American Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
5:40 am - 9:39 am
TYS
-
SAF
5h 59m
1 stop
American Airlines Logo
6:42 pm - 9:53 am
SAF
-
TYS
13h 11m
2 stops
$419American Airlines
Tue, Feb 24 - Tue, Mar 3
United Airlines Logo
6:45 am - 5:08 pm
TYS
-
SAF
12h 23m
2 stops
United Airlines Logo
7:00 am - 8:37 pm
SAF
-
TYS
11h 37m
2 stops
$453United Airlines
Tue, Feb 10 - Sat, Feb 14
United Airlines Logo
11:10 am - 8:47 pm
TYS
-
SAF
11h 37m
2 stops
United Airlines Logo
10:45 am - 8:37 pm
SAF
-
TYS
7h 52m
2 stops
$526United Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Santa Fe flights

Get data-powered insights and trends into flights from Knoxville to Santa Fe to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Knoxville to Santa Fe?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Knoxville to Santa Fe were found on United Airlines ($278) and American Airlines ($335).

Find deals

Good to know

Low seasonMay
Cheapest flight$278
Best time to beat the crowds with an average 52% drop in price.
Most popular time to fly with an average 80% increase in price.
Flight from Knoxville to Santa Fe

When to book flights from Knoxville to Santa Fe

Are your dates flexible? Find out the best times to travel from Knoxville to Santa Fe based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Santa Fe

  • What is the cheapest flight from Knoxville to Santa Fe?

    In the last 3 days, the lowest price for a flight from Knoxville to Santa Fe was $278 for a round-trip ticket.

  • Do I need a passport to fly between Knoxville and Santa Fe?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which aircraft models fly most regularly from Knoxville to Santa Fe?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Santa Fe?

    oneworld is the only airline alliance operating flights between Knoxville and Santa Fe.

  • How does KAYAK find such low prices on flights from Knoxville to Santa Fe?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Santa Fe.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Santa Fe?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santa Fe from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Santa Fe?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santa Fe with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and SAF can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Santa Fe?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santa Fe from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to Santa Fe

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Santa Fe. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Santa Fe? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11201 reviews
6.4Food
7.5Boarding
8.0Crew
7.2Comfort
6.9Entertainment
Airline reviews

On time on a day with lots of weather cancellations on other flights. Thank you for getting me home during a winter storm!

10.0 ExcellentCindy, Jan 2026
MIA - BHM
Read more American Airlines reviews

On time on a day with lots of weather cancellations on other flights. Thank you for getting me home during a winter storm!

Don't change gate multiple times make people run across the airport. Announce delays in a timely manner. Have maintenance crew ready. Don't delay and keep passengers on the plane for 3 hrs. on tarmac.

The plane was experiencing problems with the HVAC system, it was very cold in the front of the plane and very hot in the back.

The attendants were kind and helpful. A sugar-free drink would have been very welcome.

Pilot navigated severe weather/snow storm with skill. Described his intentions clearly

one crew said "he" didn't serve double alcohol drinks for travelers in exit rows. crew on prior flight did. Is this a AA rule, and the prior crew was being nice? Also, I think we deserve more than a 25% refund for losing first class seats when rescheduling a flight due to weather

It was a little concerning to hear the ground crew arguing with the flight crew over baggage space. Instead of taking them and checking them, they started checking for space in the first class cabin moving items around like the flight crew didn't know what they were doing. I was embarrassed for them.

2 hour delay due to equipment failure. No updates via the app and airport screens (which continued to show a departure time in the past). AA eventually switched planes and the new plane was not catered or cleaned correctly.

I booked an aisle seat and was given a middle. At 6'4" 230lbs, it is not ideal to fly in the middle row for myself and passengers.

Trip delayed for 2 hours because of rain. We boarded and have to get down the flight and reboard again.

Everything you need to know for your flight from Knoxville to Santa Fe

Information on your arrival and departure airports

Knoxville (TYS)
Santa Fe (SAF)