SAF - TYS

$357 Find Cheap Flights from Santa Fe to Knoxville - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$357
Typical prices: $299-$559
American Airlines
Mon 11/26Mon 12/3
SAF - TYS • 1 stop
When to travel
March
Cheapest • 36% price drop
November
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Denver Intl (DEN)
Cheapest • Avg $412 (round-trip)
Dallas/Fort Worth (DFW)
Shortest trip • 6h 25m (one-way)
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Flight Deals

Cheap Flights from Santa Fe to Knoxville (SAF-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Fe to Knoxville

Thu, Nov 26 - Thu, Dec 3
American Airlines Logo
8:00 am - 4:40 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
6h 40m1 stop Dallas/Fort Worth
American Airlines Logo
2:55 pm - 7:45 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
6h 50m1 stop Dallas/Fort Worth
$357American Airlines
Thu, Nov 26 - Thu, Dec 3
United Airlines Logo
7:00 am - 9:57 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
12h 57m2 stops Denver Intl Houston George Bush Intcntl
United Airlines Logo
4:43 pm - 8:59 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
6h 16m1 stop Denver Intl
$437United Airlines
Sat, Jan 23 - Wed, Jan 27
United Airlines Logo
7:00 am - 2:56 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
5h 56m1 stop Denver Intl
United Airlines Logo
9:45 am - 8:33 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
12h 48m2 stops Washington, D.C. Dulles Intl Denver Intl
$473United Airlines
Sat, Jan 23 - Wed, Jan 27
United Airlines Logo
7:00 am - 2:56 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
5h 56m1 stop Denver Intl
United Airlines Logo
6:30 am - 5:11 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
12h 41m2 stops Houston George Bush Intcntl Denver Intl
$473United Airlines
Sat, Jan 23 - Wed, Jan 27
United Airlines Logo
10:45 am - 9:05 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
8h 20m2 stops Denver Intl Chicago O'Hare Intl
United Airlines Logo
9:45 am - 8:33 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
12h 48m2 stops Washington, D.C. Dulles Intl Denver Intl
$478United Airlines
Sat, Jan 23 - Wed, Jan 27
United Airlines Logo
7:00 am - 7:51 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
10h 51m2 stops Denver Intl Newark
United Airlines Logo
11:53 am - 8:33 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
10h 40m2 stops Houston George Bush Intcntl Denver Intl
$478United Airlines
Sat, Jan 23 - Wed, Jan 27
United Airlines Logo
7:00 am - 9:05 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
12h 05m2 stops Denver Intl Chicago O'Hare Intl
United Airlines Logo
6:30 am - 5:11 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
12h 41m2 stops Houston George Bush Intcntl Denver Intl
$478United Airlines
Booking Insights

Price, demand and travel trends for Santa Fe to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Santa Fe to Knoxville?

Round-trip flights from Santa Fe to Knoxville typically range from $299 to $559. The lowest price found in the past 5 days was $357, on American Airlines.

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Key details for Santa Fe to Knoxville flights

Low season

July

Cheapest flight

$357
Beat the crowds with an average 85% drop in travelers.
Round-trip flight from Santa Fe to Knoxville

When to book flights from Santa Fe to Knoxville

Are your dates flexible? Find out the best times to travel from Santa Fe to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Santa Fe to Knoxville flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Santa Fe to Knoxville?

    Only Economy Class is available on flights from Santa Fe to Knoxville.

  • How long is a flight from Santa Fe to Knoxville?

    There are currently no nonstop flights available from Santa Fe to Knoxville. Flights with 1 layover take between 6h 25m and 6h 34m in total, depending on the connection.

  • Do I need a passport to fly from Santa Fe to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Santa Fe to Knoxville flight?

    Round-trip flights from Santa Fe to Knoxville range from $299 to $559, with an average of $424 over the past 12 months. Anything below $299 counts as a good deal.

  • Have flight prices from Santa Fe to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route varied from about $357 to $541. That means the highest observed fare was about 51% higher than the lowest one.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates averaging $80 for economy cars. Top options include:

    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Thrifty
    • Avis

  • Which airports can I use when flying from Santa Fe to Knoxville?

    Flights from Santa Fe to Knoxville usually depart from Santa Fe (SAF) and arrive at Knoxville McGhee Tyson (TYS).

  • Which airports do connecting flights from Santa Fe to Knoxville pass through?

    Connecting flights from Santa Fe to Knoxville most commonly pass through:

    • Dallas/Fort Worth (DFW) - 82% of one-stop connections
    • Denver Intl (DEN) - 18% of one-stop connections

  • Can I save money by using flexible dates for flights from Santa Fe to Knoxville?

    Yes. Flexible dates can save you up to 49% on flights from Santa Fe to Knoxville. Monday is the cheapest departure day at $299 round-trip on average, while Saturday is the most expensive at $578, a difference of $279.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Santa Fe to Knoxville?

    Flying via Dallas/Fort Worth (DFW) gives the shortest average 1-stop total travel time at 6h 25m, compared with 6h 34m via Denver Intl (DEN).

  • What is the time difference between Santa Fe and Knoxville?

    Knoxville is 2 hours ahead of Santa Fe (Eastern Time vs Mountain Time). Plan for the time shift when scheduling connections or first-day activities.

Your guide to booking Santa Fe to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Monday departure and avoid flying on Saturday. On this route, Monday flights average $299, about $279 less than Saturday fares (48% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Santa Fe to Knoxville trip for March. Fares historically average $270 round-trip in that month - typically $319 less than the most expensive month, which is July (based on the last 12 months).

More options for your flight from Santa Fe to Knoxville

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