SAF - TYS

$440 Find Cheap Flights from Santa Fe to Knoxville

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Fe to Knoxville departing on 1/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Fe to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Fe to Knoxville, as well as popular online travel agencies
Travelers love KAYAK
41.299.237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Everything you should know

Cheapest round-trip
$440
American Airlines
Sun 1/25Thu 3/19
SAF - TYS • 1 stop
Cheapest one-way
$565
United Airlines
Tue 11/25
SAF - TYS • 1 stop
Top airlines
American Airlines
Cheapest • from $440 (round-trip)
American Airlines
Best reviews • 7.2 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Santa Fe to Knoxville (SAF-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Fe to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Fe to Knoxville

Sun, Jan 25 - Thu, Mar 19
American Airlines Logo
6:25 am - 3:46 pmSAF-TYS
7h 21m1 stop
American Airlines Logo
12:17 pm - 3:46 pmTYS-SAF
5h 29m1 stop
$440American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
10:11 am - 5:30 pmSAF-TYS
5h 19m1 stop
American Airlines Logo
5:46 am - 12:22 pmTYS-SAF
8h 36m1 stop
$476American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
6:15 am - 3:35 pmSAF-TYS
7h 20m1 stop
American Airlines Logo
5:46 am - 12:22 pmTYS-SAF
8h 36m1 stop
$480American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
10:11 am - 5:30 pmSAF-TYS
5h 19m1 stop
American Airlines Logo
7:00 am - 6:03 pmTYS-SAF
13h 03m2 stops
$486American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
6:15 am - 3:35 pmSAF-TYS
7h 20m1 stop
American Airlines Logo
7:00 am - 6:03 pmTYS-SAF
13h 03m2 stops
$490American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
6:15 am - 8:27 pmSAF-TYS
12h 12m2 stops
American Airlines Logo
10:46 am - 6:03 pmTYS-SAF
9h 17m2 stops
$491American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
6:15 am - 8:27 pmSAF-TYS
12h 12m2 stops
American Airlines Logo
10:46 am - 6:03 pmTYS-SAF
9h 17m2 stops
$495American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
6:15 am - 8:27 pmSAF-TYS
12h 12m2 stops
American Airlines Logo
5:46 am - 9:38 amTYS-SAF
5h 52m1 stop
$496American Airlines
Find Deal
Sun, Jan 25 - Thu, Mar 19
United Airlines Logo
6:05 pm - 10:31 pmSAF-TYS
26h 26m1 stop
United Airlines Logo
7:25 pm - 9:38 amTYS-SAF
16h 13m2 stops
$597United Airlines
Find Deal
Sun, Jan 25 - Thu, Mar 19
United Airlines Logo
6:05 pm - 10:57 amSAF-TYS
14h 52m2 stops
United Airlines Logo
2:30 pm - 9:38 amTYS-SAF
21h 08m2 stops
$603United Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Santa Fe to Knoxville flights

Get data-powered insights and trends into flights from Santa Fe to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Santa Fe to Knoxville?

The average price of all round-trip flights from Santa Fe to Knoxville clicked on KAYAK for each day over the last 12 months.

When flying from Santa Fe to Knoxville, you should consider leaving on a Wednesday and avoid Thursdays if you are looking for the best rates. For your return to Santa Fe, you’ll find the best rates on Saturdays and the most expensive ones on Wednesdays.

Find deals

Good to know

Cheapest flight$440
Flight from Santa Fe to Knoxville

When to book flights from Santa Fe to Knoxville

Are your dates flexible? Find out the best times to travel from Santa Fe to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Santa Fe to Knoxville

  • What is the cheapest flight from Santa Fe to Knoxville?

    In the last 3 days, the lowest price for a flight from Santa Fe to Knoxville was $565 for a one-way ticket and $440 for a round-trip.

  • Do I need a passport to fly between Santa Fe and Knoxville?

    No

  • Which airports will I be using when flying from Santa Fe to Knoxville?

    On your way to Knoxville, you’ll fly out from Santa Fe. You’ll be landing at Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Santa Fe to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Santa Fe to Knoxville?

    oneworld is the only airline alliance operating flights between Santa Fe and Knoxville.

  • How does KAYAK find such low prices on flights from Santa Fe to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Santa Fe to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Santa Fe to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Santa Fe is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Santa Fe to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Santa Fe with another airline. Booking your flights between Santa Fe and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Santa Fe to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Santa Fe up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Santa Fe to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Santa Fe to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Fe to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11034 reviews
7.5Boarding
7.2Comfort
8.0Crew
6.4Food
6.9Entertainment
Airline reviews

Wish some foods provided rather than just biscuit/cookie for flight more than 2 hours

8.0 ExcellentKohMeng, Oct 2025DFW - LAX
Read more American Airlines reviews

Wish some foods provided rather than just biscuit/cookie for flight more than 2 hours

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

The flight attendant, a black woman with curly hair who sat near Row 21, was wonderful and kind.

It was good..clean, comfy seat. Friendly warm welcoming crew. Was able to check my cabin luggage at the gate which I was able to pickup in a decent time from baggage claim. The app gave all updates from delays to baggage claim info. Overall smooth flight.

Flight was delayed leaving Dallas. Arrived about 2 hours later than scheduled.

Flight delayed and missed connection. Rescheduled flight cancelled after 6 hrs wait. Rerouted thru ORD, flight cancelled, overnight stay in ORD. Still in the air on new flight!

We are too tired and frustrated to comment politely at this point

Terrible. Our luggage was delayed and couldn’t be delivered for several days. We got bad information from the airline agents at baggage claim. We had to pick up our car so we wouldn’t be charged for an extra day. We got lost in the maze of airport parking. The baggage claim agents didn’t offer us any compensation for our extra time and expense. We are tired, hungry and very frustrated.

The flight was flawless and we even arrived between 20 and 25 minutes early!

The only thing to like was that we eventually got to our destination

Everything you need to know for your flight from Santa Fe to Knoxville

Information on your arrival and departure airports

Santa Fe (SAF)
Knoxville (TYS)

Not what you’re looking for? Find thousands of other hotels, flights, car rentals and package deals with KAYAK.