SAF - TYS

$324 Find Cheap Flights from Santa Fe to Knoxville - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Fe to Knoxville departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$424
American Airlines
Fri 10/2Mon 10/5
SAF - TYS • 1 stop
Cheapest one-way
$324
United Airlines
Tue 9/29
SAF - TYS • 1 stop
Top airlines
United Airlines
Cheapest • from $424 (round-trip)
American Airlines
Best reviews • 7.1 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Santa Fe and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Denver (DEN)
Cheapest • Avg $315 (round-trip)
Denver (DEN)
Shortest trip • 6h 00m (one-way)
Insights
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Booking Insights
Flight Deals

Cheap Flights from Santa Fe to Knoxville (SAF-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Fe to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Fe to Knoxville

Fri, Oct 2 - Mon, Oct 5
American Airlines Logo
2:01 pm - 11:22 pm
SAF
-
TYS
7h 21m
1 stop
American Airlines Logo
6:00 am - 9:42 am
TYS
-
SAF
5h 42m
1 stop
$424American Airlines
Tue, Aug 25 - Sat, Aug 29
United Airlines Logo
1:22 pm - 10:29 pm
SAF
-
TYS
7h 07m
1 stop
United Airlines Logo
9:00 am - 2:46 pm
TYS
-
SAF
7h 46m
1 stop
$424United Airlines
Sat, Aug 22 - Tue, Aug 25
United Airlines Logo
3:22 pm - 10:29 pm
SAF
-
TYS
5h 07m
1 stop
United Airlines Logo
4:50 pm - 8:36 pm
TYS
-
SAF
5h 46m
1 stop
$424United Airlines
Tue, Aug 25 - Sat, Aug 29
United Airlines Logo
1:22 pm - 11:59 pm
SAF
-
TYS
8h 37m
2 stops
United Airlines Logo
4:50 pm - 8:36 pm
TYS
-
SAF
5h 46m
1 stop
$434United Airlines
Sat, Aug 22 - Tue, Aug 25
United Airlines Logo
3:22 pm - 10:29 pm
SAF
-
TYS
5h 07m
1 stop
United Airlines Logo
7:00 am - 2:46 pm
TYS
-
SAF
9h 46m
2 stops
$434United Airlines
Tue, Aug 25 - Sat, Aug 29
United Airlines Logo
10:30 am - 11:59 pm
SAF
-
TYS
11h 29m
2 stops
United Airlines Logo
7:00 am - 2:46 pm
TYS
-
SAF
9h 46m
2 stops
$439United Airlines
Sat, Aug 22 - Tue, Aug 25
United Airlines Logo
3:22 pm - 10:29 pm
SAF
-
TYS
5h 07m
1 stop
United Airlines Logo
4:50 pm - 8:36 pm
TYS
-
SAF
5h 46m
1 stop
$444United Airlines
Tue, Sep 8 - Tue, Sep 15
American Airlines Logo
2:08 pm - 11:18 pm
SAF
-
TYS
7h 10m
1 stop
American Airlines Logo
5:35 pm - 9:37 pm
TYS
-
SAF
6h 02m
1 stop
$477American Airlines
Fri, Sep 4 - Mon, Sep 7
American Airlines Logo
2:08 pm - 11:18 pm
SAF
-
TYS
7h 10m
1 stop
American Airlines Logo
6:03 am - 9:41 am
TYS
-
SAF
5h 38m
1 stop
$555American Airlines
Thu, Oct 1 - Mon, Oct 5
American Airlines Logo
6:47 am - 4:11 pm
SAF
-
TYS
7h 24m
1 stop
American Airlines Logo
6:00 am - 9:42 am
TYS
-
SAF
5h 42m
1 stop
$561American Airlines
Booking Insights

KAYAK's insights & trends for Santa Fe to Knoxville flights

Get data-powered insights and trends into flights from Santa Fe to Knoxville to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Santa Fe to Knoxville?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 5 days.

In the past 5 days, the cheapest round-trip tickets from Santa Fe to Knoxville were found on United Airlines ($424) and American Airlines ($477).

Find deals

Good to know

Cheapest flight

$324
Flight from Santa Fe to Knoxville

When to book flights from Santa Fe to Knoxville

Are your dates flexible? Find out the best times to travel from Santa Fe to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Santa Fe to Knoxville

  • What is the cheapest flight from Santa Fe to Knoxville?

    In the last 5 days, the lowest price for a flight from Santa Fe to Knoxville was $324 for a one-way ticket and $424 for a round-trip.

  • Do I need a passport to fly between Santa Fe and Knoxville?

    No

  • Which airports will I be using when flying from Santa Fe to Knoxville?

    On your way to Knoxville, you’ll fly out from Santa Fe. You’ll be landing at Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Santa Fe to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Santa Fe to Knoxville?

    oneworld is the only airline alliance operating flights between Santa Fe and Knoxville.

  • How does KAYAK find such low prices on flights from Santa Fe to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Santa Fe to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Santa Fe to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Santa Fe is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Santa Fe to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Santa Fe with another airline. Booking your flights between Santa Fe and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Santa Fe to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Santa Fe up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Santa Fe to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Santa Fe to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Fe to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11842 reviews
6.4Food
7.9Crew
7.5Boarding
7.2Comfort
6.8Entertainment
Airline reviews

The flight was delayed almost three hours. I understand delays happen from time to time, but this flight was delayed no less than 10 times. I wish the amount of time of the delay was more accurate, versus delaying in 10 or 20 minute increments many, many times.

6.0 GoodLisa, Jul 2026
DFW - TYS
Read more American Airlines reviews

The flight was delayed almost three hours. I understand delays happen from time to time, but this flight was delayed no less than 10 times. I wish the amount of time of the delay was more accurate, versus delaying in 10 or 20 minute increments many, many times.

Delayed by 5 hours and I had to wit in the airport for more than 6+ hours.

technology worked well and everything ran smoothly. The seats are quite cramped so please don't try to re-engineer the cabin to squeeze more bodies on board.

Flying in the United States with the major airlines has become so underwhelming. A 2-3hr flight in most other parts of the world with the major carriers of the area comes with newer, CLEANER aircraft and significantly better in flight service in terms of both staff attitude and a actual meal service.

Delays experienced in boarding/take off due to incoming plane delayed. However, the boarding time/depart time in the app was significantly delayed in providing these updates. Usually not updated until an hour after we should have already boarded. Poorly managed.

Arrived early picked up my bag in a few minutes- great trip - thank you

Plane was delayed for 6 hours, at first by weather, which is understandable, but was further delayed with NO given reason for 2 1/2 hours more. We had no clue when we were going to depart actually until they opened the ramp. VERY POOR to ZERO COMMUNICATION!!!

At least it was a short flight. Greyhound with wings.

Our flight got changed and/or delayed 8 times before we boarded.

My first flight from Santa Fe was 1.5 hours delayed, I missed the connecting flight. I got tickets to the next flight to San Francisco. The flight is over two hours delayed and we had to change the plane. I will never fly American Airlines again. Absolutely horrible experience!

Everything you need to know for your flight from Santa Fe to Knoxville

Information on your arrival and departure airports

Santa Fe (SAF)
Knoxville (TYS)