SAF - TYS

$153 Find Cheap Flights from Santa Fe to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Fe to Knoxville departing on 9/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Fe to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Fe to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$390
United Airlines
Sat 8/22Wed 8/26
SAF - TYS • 1 stop
Cheapest one-way
$153
American Airlines
Sat 9/5
SAF - TYS • 1 stop
Top airlines
United Airlines
Cheapest • from $390 (round-trip)
American Airlines
Best reviews • 7.1 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Santa Fe and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Denver (DEN)
Cheapest • Avg $315 (round-trip)
Dallas (DFW)
Shortest trip • 5h 29m (one-way)
Insights
Insights
Insights
Insights
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Santa Fe to Knoxville (SAF-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Fe to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Fe to Knoxville

Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
3:21 pm - 10:38 pm
SAF
-
TYS
5h 17m
1 stop
United Airlines Logo
8:48 am - 2:46 pm
TYS
-
SAF
7h 58m
1 stop
$390United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
3:21 pm - 10:38 pm
SAF
-
TYS
5h 17m
1 stop
United Airlines Logo
7:15 am - 2:46 pm
TYS
-
SAF
9h 31m
2 stops
$400United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
3:21 pm - 10:38 pm
SAF
-
TYS
5h 17m
1 stop
United Airlines Logo
4:56 pm - 8:43 pm
TYS
-
SAF
5h 47m
1 stop
$410United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
3:21 pm - 10:38 pm
SAF
-
TYS
5h 17m
1 stop
United Airlines Logo
7:15 am - 2:46 pm
TYS
-
SAF
9h 31m
2 stops
$420United Airlines
Fri, May 22 - Fri, May 29
American Airlines Logo
7:30 am - 4:43 pm
SAF
-
TYS
7h 13m
1 stop
American Airlines Logo
7:01 am - 12:25 pm
TYS
-
SAF
7h 24m
1 stop
$559American Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
3:21 pm - 10:36 am
SAF
-
TYS
17h 15m
2 stops
United Airlines Logo
7:15 am - 2:46 pm
TYS
-
SAF
9h 31m
2 stops
$560United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
6:00 pm - 10:36 am
SAF
-
TYS
14h 36m
2 stops
United Airlines Logo
7:15 am - 2:46 pm
TYS
-
SAF
9h 31m
2 stops
$590United Airlines
Fri, May 22 - Thu, May 28
American Airlines Logo
7:30 am - 4:43 pm
SAF
-
TYS
7h 13m
1 stop
American Airlines Logo
5:36 am - 9:38 am
TYS
-
SAF
6h 02m
1 stop
$663American Airlines
Fri, May 22 - Thu, May 28
American Airlines Logo
7:30 am - 4:43 pm
SAF
-
TYS
7h 13m
1 stop
American Airlines Logo
7:01 am - 6:08 pm
TYS
-
SAF
13h 07m
2 stops
$673American Airlines
Fri, May 22 - Thu, May 28
United Airlines Logo
6:00 pm - 4:51 pm
SAF
-
TYS
20h 51m
2 stops
United Airlines Logo
8:20 am - 5:12 pm
TYS
-
SAF
10h 52m
2 stops
$755United Airlines
Booking Insights

KAYAK's insights & trends for Santa Fe to Knoxville flights

Get data-powered insights and trends into flights from Santa Fe to Knoxville to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Santa Fe to Knoxville?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Santa Fe to Knoxville were found on United Airlines ($390) and American Airlines ($559).

Find deals

Good to know

Low seasonDecember
Cheapest flight$153
Best time to beat the crowds with an average 32% drop in price.
Most popular time to fly and prices are also 22% lower on average.
Flight from Santa Fe to Knoxville

When to book flights from Santa Fe to Knoxville

Are your dates flexible? Find out the best times to travel from Santa Fe to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Santa Fe to Knoxville

  • What is the cheapest flight from Santa Fe to Knoxville?

    In the last 3 days, the lowest price for a flight from Santa Fe to Knoxville was $153 for a one-way ticket and $390 for a round-trip.

  • Do I need a passport to fly between Santa Fe and Knoxville?

    No

  • Which airports will I be using when flying from Santa Fe to Knoxville?

    On your way to Knoxville, you’ll fly out from Santa Fe. You’ll be landing at Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Santa Fe to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Santa Fe to Knoxville?

    oneworld is the only airline alliance operating flights between Santa Fe and Knoxville.

  • How does KAYAK find such low prices on flights from Santa Fe to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Santa Fe to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Santa Fe to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Santa Fe is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Santa Fe to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Santa Fe with another airline. Booking your flights between Santa Fe and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Santa Fe to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Santa Fe up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Santa Fe to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Santa Fe to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Fe to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11468 reviews
7.2Comfort
6.9Entertainment
7.5Boarding
7.9Crew
6.4Food
Airline reviews

As a first class customer, there was no power the entire flight which limited my ability to work. I find this unacceptable. The first 11 rows on the left side of the plan were out. I was only offered the option to charge my phone which was not the issue because my laptop was out of power. I asked if there was anything that can be done for me, and the answer was, "no". I was not offered any type of compensation for this AA problem which caused me unnecessary stress due to inability to address business issues on an already challenging travel day. Flight attendants tried to reset the power once but that was the extent of their support. Very disappointing for the lack of expected services on a flight. Please contact me with customer focused response to this complaint.

2.0 MediocreMarianne, Mar 2026
DFW - ORD
Read more American Airlines reviews

As a first class customer, there was no power the entire flight which limited my ability to work. I find this unacceptable. The first 11 rows on the left side of the plan were out. I was only offered the option to charge my phone which was not the issue because my laptop was out of power. I asked if there was anything that can be done for me, and the answer was, "no". I was not offered any type of compensation for this AA problem which caused me unnecessary stress due to inability to address business issues on an already challenging travel day. Flight attendants tried to reset the power once but that was the extent of their support. Very disappointing for the lack of expected services on a flight. Please contact me with customer focused response to this complaint.

Delay after delay with little communication then AA lost my luggage and at airport would not assist just said scan this QR code to track your luggage and submit a claim. However QR code provided did not work so have to go back to airport

After changing the departure gate 5 times making us mo e from one side of the airport to the other and then back the flight was delayed nearly 2 hours. The male flight attendant had a bad attitude with the guest being condescending, disrespectful with people who were already on edge.

Easy boarding. Rows are smaller but that may be an older and bigger me now :)

It would have been nice if American tried to care.

American Airlines did everything they could with the high Spring Break crowd. I was frustrated to be changed from 1st class to a middle seat at the back of the plane. This has happened before, not sure booking 1st class and paying the extra actually works.

I booked 1st class, my flights were changed and I was sitting in the middle at the back of the plane. A far cry from the 1st class I purchased for my flights. I am grateful I arrived on time.

There was no beverage service and the only time I saw a crew member walk through the cabin is when we were preparing to land.

Our flight was delayed 3 times and this is why I am giving such low reviews. Everything else was okay but being in the airport at 4:30pm for my initial flight at 7pm to not leave until after 9:30pm is insane,

Flights were constantly delayed. CRW took 50 minutes to get bags

Everything you need to know for your flight from Santa Fe to Knoxville

Information on your arrival and departure airports

Santa Fe (SAF)
Knoxville (TYS)