TYS - FSD

$305 Find Cheap Flights from Knoxville to Sioux Falls - Compare and Save

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Sioux Falls departing on 9/16. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$305
Typical prices: $248-$572
Delta
Wed 9/16Sat 9/19
TYS - FSD • 1 stop
Top airlines
Cheapest • from $305 (round-trip)
Best reviews • 7.8 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Knoxville and Sioux Falls. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $399 (round-trip)
Shortest trip • 4h 39m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 42% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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We hope you love your trip to Sioux Falls!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Sioux Falls (TYS-FSD)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Sioux Falls that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Sioux Falls

Wed, Sep 16 - Sat, Sep 19
Delta Logo
2:08 pm - 7:49 pm
TYS
-
FSD
6h 41m
1 stop
Delta Logo
5:30 am - 10:44 am
FSD
-
TYS
4h 14m
1 stop
$305Delta
Fri, Aug 28 - Sun, Aug 30
Delta Logo
4:38 pm - 7:59 pm
TYS
-
FSD
4h 21m
1 stop
Delta Logo
5:30 am - 1:34 pm
FSD
-
TYS
7h 04m
1 stop
$309Delta
Fri, Aug 7 - Sun, Aug 9
Delta Logo
2:14 pm - 7:59 pm
TYS
-
FSD
6h 45m
1 stop
Delta Logo
5:30 am - 11:11 am
FSD
-
TYS
4h 41m
1 stop
$324Delta
Thu, Jul 30 - Mon, Aug 3
American Airlines Logo
6:32 pm - 12:18 am
TYS
-
FSD
6h 46m
1 stop
American Airlines Logo
5:34 pm - 11:51 pm
FSD
-
TYS
5h 17m
1 stop
$339American Airlines
Wed, Sep 16 - Sat, Sep 19
American Airlines Logo
2:43 pm - 7:42 pm
TYS
-
FSD
5h 59m
1 stop
American Airlines Logo
12:06 pm - 10:50 pm
FSD
-
TYS
9h 44m
2 stops
$350American Airlines
Fri, Aug 28 - Sun, Aug 30
Delta Logo
4:38 pm - 7:59 pm
TYS
-
FSD
4h 21m
1 stop
Delta Logo
5:30 am - 1:34 pm
FSD
-
TYS
7h 04m
1 stop
$354Delta
Thu, Aug 6 - Wed, Aug 12
American Airlines Logo
6:52 pm - 12:30 am
TYS
-
FSD
6h 38m
1 stop
American Airlines Logo
12:57 pm - 11:51 pm
FSD
-
TYS
9h 54m
2 stops
$374American Airlines
Fri, Aug 28 - Sun, Aug 30
American Airlines Logo
5:15 am - 11:36 am
TYS
-
FSD
7h 21m
2 stops
American Airlines Logo
6:24 am - 12:51 pm
FSD
-
TYS
5h 27m
1 stop
$389American Airlines
Wed, Sep 16 - Sat, Sep 19
American Airlines Logo
8:18 am - 6:11 pm
TYS
-
FSD
10h 53m
2 stops
American Airlines Logo
12:06 pm - 10:50 pm
FSD
-
TYS
9h 44m
2 stops
$395American Airlines
Fri, Aug 28 - Sun, Aug 30
United Airlines Logo
2:21 pm - 11:22 pm
TYS
-
FSD
10h 01m
2 stops
United Airlines Logo
6:00 am - 4:58 pm
FSD
-
TYS
9h 58m
2 stops
$399United Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Sioux Falls flights

Get data-powered insights and trends into flights from Knoxville to Sioux Falls to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to Sioux Falls?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Sioux Falls, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Sioux Falls is February, where tickets cost $269 (return) on average. On the other hand, the most expensive months are June and September, where the average cost of round-trip tickets is $850 and $570 respectively.

Good to know

Low season

February

Cheapest flight

$305
Best time to beat the crowds with an average 42% drop in price.
Most popular time to fly and prices are also 7% lower on average.
Flight from Knoxville to Sioux Falls

When to book flights from Knoxville to Sioux Falls

Are your dates flexible? Find out the best times to travel from Knoxville to Sioux Falls based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Sioux Falls

  • What is the cheapest flight from Knoxville to Sioux Falls?

    In the last 5 days, the lowest price for a flight from Knoxville to Sioux Falls was $305 for a round-trip ticket.

  • Do I need a passport to fly between Knoxville and Sioux Falls?

    No

  • Which airports will I be using when flying from Knoxville to Sioux Falls?

    Knoxville and Sioux Falls are both served by 1 main airport. You will leave Knoxville from Knoxville McGhee Tyson and will be arriving at Sioux Falls Joe Foss Field.

  • Which aircraft models fly most regularly from Knoxville to Sioux Falls?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Sioux Falls?

    SkyTeam, Star Alliance, and oneworld are the airline alliances operating flights between Knoxville and Sioux Falls, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Knoxville to Sioux Falls, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from Knoxville to Sioux Falls are Delta and United Airlines. With an average price for the route of $448 and an overall rating of 7.8, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $408 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from Knoxville to Sioux Falls?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Sioux Falls.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Sioux Falls?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Sioux Falls from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Sioux Falls?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Sioux Falls with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and FSD can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Sioux Falls?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Sioux Falls from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Knoxville to Sioux Falls

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Sioux Falls. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Sioux Falls? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8477 reviews
7.8Entertainment
8.1Boarding
8.5Crew
7.2Food
7.8Comfort
Airline reviews

My flight home from Knoxville, TN, included a layover in Atlanta. I boarded the aircraft in Zone 5 and although there was limited overhead space, I was able to put my 'backpack' style roller-bag above my seat. Unfortunately, due to continued bad weather, we had to deplane. There were many people who would have missed their connection, so they rebooked. When we were re-boarding, the gate agent welcomed zone 5 and then made an announcement: All roller-bags for zone 5 passengers and higher will need to be gate checked. I promptly pushed the telescoping handle in and held my bag like a backpack. I was able to bring it on board, which was a relief. Upon entering the aircraft it became apparent that there was easily 40% open overhead space. There were audible signs of angry passengers who felt duped into checking their bags when in fact there were noticeably LESS passengers on the aircraft and TONS of overhead space. I'm not sure what kinds of parameters are used to determine when to cut off roller-bags from being brought on board, but it seemed deceptive and underhanded to have so many people get stuck checking their bags when clearly there was ample room for at least one more zone.

4.0 OkayErnest, Jul 2026
TYS - ATL
Read more Delta reviews

My flight home from Knoxville, TN, included a layover in Atlanta. I boarded the aircraft in Zone 5 and although there was limited overhead space, I was able to put my 'backpack' style roller-bag above my seat. Unfortunately, due to continued bad weather, we had to deplane. There were many people who would have missed their connection, so they rebooked. When we were re-boarding, the gate agent welcomed zone 5 and then made an announcement: All roller-bags for zone 5 passengers and higher will need to be gate checked. I promptly pushed the telescoping handle in and held my bag like a backpack. I was able to bring it on board, which was a relief. Upon entering the aircraft it became apparent that there was easily 40% open overhead space. There were audible signs of angry passengers who felt duped into checking their bags when in fact there were noticeably LESS passengers on the aircraft and TONS of overhead space. I'm not sure what kinds of parameters are used to determine when to cut off roller-bags from being brought on board, but it seemed deceptive and underhanded to have so many people get stuck checking their bags when clearly there was ample room for at least one more zone.

The CRJ-900 was clean but the overhead air vents were broken in our First Class row, making the cabin very hot until about 30 mins into the flight. The flight attendants were both extremely apologetic and accommodating though so that is why I rated the flight as very good. They checked on us many times and truly showed they cared. The snacks for an hour and a half flight could be better. Would be nice if there was a small plated meal over convenient store snacks. WiFi also was not working. And it would be nice if Delta had adjustable headrests on these planes.

I was in Comfort and we didn’t get any drinks, chips or anything! First Class got full service on the flight and Comfort got nothing. Seat was horrible and uncomfortable

Short trip, no food and therefore no expectation for much interaction with staff who were pleasant and professional. My critique is on comfort of the seats. Exit rows and comfort seats do not provide enough personal space for 3 side-by-side seats, especially when in the middle row. Some passengers are not considerate of the middle seat and there should be signs that state something to the effect of: "please consider giving middle seats use of the armrests."

The tray table was broken and the food was terrible.

THEY FAILED ME AND I NEVER GOT ON THE FLIGHT BECAUSE IT WAS SO DELAYED! I ENDED UP HAVING TO PAY OUT OF POCKET FOR A HOTEL AND STAY IN NASHVILLE TO CATCH A FLIGHT FOR THE FOLLOWING DAY. DELTA IS POOR CUSTOMER SERVICE>

The staff on board and gate was nice - a welcome change from the usual. We also arrived early, which was a great benefit, given that it takes 30 minutes plus to get bags at SRQ.

No in flight service, no explanation - FC got service, C+ did not, unsure about Economy. No turbulence to speak of, so I guess another way to cut cost, or promote health and well being of Delta employees? Also, boarding in MEM combined zones, and with overhead space already full on both flights after Zone 2/ Diamond, presents a huge challenge to find a space for a bag. Delta, other than point A to B, is no longer reasonable to fly - very poor experiences, not even taking into account the chastising at the gate and rude crews, across the board.

It would’ve been nice for all that money to have a more substantial snack for free. I remember once upon a time getting a very nice turkey sandwich with Swiss cheese on whole wheat bread for no charge along with a drink. I guess those days are gone. it’s a little insulting being given a cookie or a bag of baked chips Going forward I’ll just bring my own.

From Atlanta to Cabo I would have hoped on a plane that size I would have been able to breathe and wiggle my feet a little! The leg room in that plane is non existent and I am only 5”4’. And the air vent either wasn’t working very well or just could not blow air from the ceiling to the seat area as I was suffocating through the entire flight! And please don’t say I would have been more comfortable in first class because I cannot afford those rates and have always travelled Main Cabin without issues !

The head rest is too big and cannot be placed differently/removed. Causes one head to tilt forward and increase back pain

Our flight to Rome, Italy was cancelled the day of and we were never informed. We only found out because I was trying to get into my husbands account and called to get his account number. Had to pay more for worse seating on another airline.

I wish there were outlets to charge my iPhone. The crew was great; we had a female pilot who was great with explaining what was happening and delays,

The staff was hospitable and professional. The seat had a bit of wear. The winner shade was stuck 1/4 open. I received the best of both worlds. The morning sun was able to come in and blind the screen i was trying to use while at the same time it was too low to look out and enjoy the view. Rather embarrassing for a 1st class ticket.

Even though we were delayed, we were able to make our connection

Another delayed flight. When the delays exceed the duration of the flight, it’s a problem.

Trip was great. A wild landing in Ottawa with the wind and rain, but the pilot did a great job. Always love flying United.👍

The internet service I paid for didn’t work at all and the flight crew was not very friendly.

The planes are so dirty! Food crumbs and finger print smudges, Dust over the vents and carpet stains. It’s disgusting.

Overall it was good. The flight was bumpy at times, but the pilot made us aware every time. As a result, no snacks/drinks were made available. Seats were tight but that’s okay as I had a window seat.

The flight attendants were very friendly, efficient, and helpful. The plane was ahead of schedule, and it all went very smoothly. Thank you.

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

I have a gluten allergy so did have any food

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

Wonderful crew and early arrival to our destination. It was so nice to have free wifi access and movies too. Thank you!

I didn’t like anything, being platinum pro get you absolutely nowhere and does not increase the customer service treatment whatsoever anymore. My flight was canceled and they put me on a flight eight hours later that would’ve got me back in the middle of the night. They could’ve easily move me up to an hour Prior on an earlier flight. My second flight was unreasonable to take, the third flight was also canceled due to mechanical issues like the first flight. I don’t know what’s going on with American, but they are falling apart, after seven flight changes I finally got home, Unreasonable.

This was a horrible American Airlines experience, and it discourages me from flying with them again. It may have stemmed from a mechanical delay, but it appeared that the team was unprepared to respond to the delay. After boarding, we waited an hour before finally taking off. After landing at our destination, we waited an additional hour on the tarmac waiting for a gate (at 8:00pm) to be assigned and cleared. The flight crew did their best, but they were clearly tired and also ready to be done for the day. Because of the delay, I missed a connecting flight. It was a very poor experience.

Fantastic! If it had not been for a check-in agent in Knoxville I may have not gotten my passes on British Airways. I couldn’t check-in online because British Airways had messed us the info on my tickets to London & Inverness. AA’s was great! British Airways was a continuous series of delays and frustrations.

Wheelchair was waiting for me,changed to a better seat which was great as it's hard for me to walk

Everything you need to know for your flight from Knoxville to Sioux Falls

Information on your arrival and departure airports