FSD - TYS

$216 Find Cheap Flights from Sioux Falls to Knoxville - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$339
Typical prices: $338-$484
American Airlines
Tue 12/4Fri 12/7
FSD - TYS • 1 stop
Cheapest one-way
$216
Typical prices: $351-$418
Allegiant Air
Sun 11/25
FSD - TYS • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Sioux Falls and Knoxville. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
April
Cheapest • 34% price drop
September
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Dallas/Fort Worth (DFW)
Cheapest • Avg $385 (round-trip)
Chicago O'Hare Intl (ORD)
Shortest trip • 5h 14m (one-way)
Insights
Insights
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Flight Deals

Cheap Flights from Sioux Falls to Knoxville (FSD-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Sioux Falls to Knoxville

Fri, Dec 4 - Mon, Dec 7
American Airlines Logo
12:14 pm - 7:05 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
5h 51m1 stop Chicago O'Hare Intl
American Airlines Logo
7:44 am - 11:44 amTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
5h 00m1 stop Chicago O'Hare Intl
$339American Airlines
Fri, Dec 4 - Mon, Dec 7
American Airlines Logo
3:19 pm - 11:46 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
7h 27m1 stop Chicago O'Hare Intl
American Airlines Logo
8:46 pm - 12:46 amTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
5h 00m1 stop Chicago O'Hare Intl
$339American Airlines
Fri, Dec 4 - Mon, Dec 7
American Airlines Logo
1:04 pm - 11:59 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
9h 55m2 stops Dallas/Fort Worth Charlotte Douglas
American Airlines Logo
8:46 pm - 12:46 amTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
5h 00m1 stop Chicago O'Hare Intl
$344American Airlines
Thu, Dec 3 - Mon, Dec 7
United Airlines Logo
9:45 am - 5:00 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
6h 15m1 stop Chicago O'Hare Intl
United Airlines Logo
4:43 pm - 11:44 pmTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
8h 01m1 stop Denver Intl
$349United Airlines
Tue, Nov 10 - Sat, Nov 14
United Airlines Logo
6:00 am - 1:13 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
6h 13m1 stop Chicago O'Hare Intl
United Airlines Logo
9:00 am - 4:25 pmTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
8h 25m1 stop Denver Intl
$369United Airlines
Fri, Nov 13 - Tue, Nov 17
United Airlines Logo
1:20 pm - 10:32 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
8h 12m1 stop Denver Intl
United Airlines Logo
5:40 pm - 11:29 pmTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
6h 49m1 stop Chicago O'Hare Intl
$369United Airlines
Mon, Nov 9 - Fri, Nov 13
Allegiant Air Logo
9:28 am - 7:59 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
9h 31m2 stops Nashville Intl Orlando Sanford Intl
Allegiant Air Logo
8:35 am - 6:23 pmTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
10h 48m1 stop Tampa St. Petersburg
$406Allegiant Air
Sun, Dec 20 - Tue, Jan 5
Delta Logo
12:40 pm - 11:50 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
10h 10m2 stops Minneapolis St Paul Atlanta Hartsfield-Jackson
Delta Logo
2:35 pm - 7:47 pmTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
6h 12m1 stop Atlanta Hartsfield-Jackson
$434Delta
Sun, Dec 20 - Tue, Jan 5
Delta Logo
12:40 pm - 11:50 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
10h 10m2 stops Minneapolis St Paul Atlanta Hartsfield-Jackson
Delta Logo
7:18 am - 4:43 pmTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
10h 25m2 stops Detroit Metropolitan Wayne County Minneapolis St Paul
$514Delta
Wed, Nov 25 - Mon, Nov 30
Multiple Airlines Logo
5:54 pm - 12:06 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
17h 12m1 stop Fort Lauderdale
Multiple Airlines Logo
2:50 pm - 2:47 pmTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
48h 57m2 stops Phoenix Sky Harbor Intl Las Vegas Harry Reid Intl
$544Multiple Airlines
Booking Insights

Price, demand and travel trends for Sioux Falls to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Sioux Falls to Knoxville?

Round-trip flights from Sioux Falls to Knoxville typically range from $338 to $484. The lowest price found in the past 5 days was $339, on American Airlines.

What's the cheapest day of the week to fly from Sioux Falls to Knoxville?

Based on deals KAYAK users found in the last 12 months, Wednesday is the cheapest day of the week to fly from Sioux Falls to Knoxville. It’s 31% cheaper than the average day, while Friday is the most expensive, with prices 10% higher.

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Key details for Sioux Falls to Knoxville flights

Low season

February

Cheapest flight

$216
Beat the crowds with an average 69% drop in travelers.
The most popular month to fly with an average 64% increase in travelers.
One-way flight from Sioux Falls to Knoxville

When to book flights from Sioux Falls to Knoxville

Are your dates flexible? Find out the best times to travel from Sioux Falls to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Sioux Falls to Knoxville flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Sioux Falls to Knoxville?

    Only Economy Class is available on flights from Sioux Falls to Knoxville.

  • How long is a flight from Sioux Falls to Knoxville?

    A nonstop flight from Sioux Falls to Knoxville takes 00m, covering 863 miles.

  • Do I need a passport to fly from Sioux Falls to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Sioux Falls to Knoxville flight?

    Round-trip flights from Sioux Falls to Knoxville range from $338 to $484, with an average of $439 over the past 12 months. Anything below $338 counts as a good deal.

  • Have flight prices from Sioux Falls to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $339 to $870. That means the highest observed fare was about 3x higher than the lowest one.

  • How are flight prices from Sioux Falls to Knoxville looking right now?

    One-way fares from Sioux Falls to Knoxville are currently lower than usual. Average one-way flight prices are about $359, which is 9% below the typical average for this route.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates averaging $80 for economy cars. Top options include:

    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Thrifty
    • Avis

  • Which airports can I use when flying from Sioux Falls to Knoxville?

    Flights from Sioux Falls to Knoxville usually depart from Sioux Falls Joe Foss Field (FSD) and arrive at Knoxville McGhee Tyson (TYS).

  • Which airports do connecting flights from Sioux Falls to Knoxville pass through?

    One-stop flights from Sioux Falls to Knoxville most commonly connect through:

    • Chicago O'Hare Intl (ORD) - 46% of one-stop connections
    • Dallas/Fort Worth (DFW) - 24% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 22% of one-stop connections
    • Minneapolis St Paul (MSP) - 5% of one-stop connections

  • Can I save money by using flexible dates for flights from Sioux Falls to Knoxville?

    Yes. Flexible dates can save you up to 38% on flights from Sioux Falls to Knoxville. Wednesday is the cheapest departure day at $304 round-trip on average, while Friday is the most expensive at $487, a difference of $183.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Sioux Falls to Knoxville?

    Flying via Chicago O'Hare Intl (ORD) gives the shortest average 1-stop total travel time at 5h 14m, compared with 5h 20m via Atlanta Hartsfield-Jackson (ATL) and 5h 42m via Minneapolis St Paul (MSP).

  • What is the time difference between Sioux Falls and Knoxville?

    Knoxville is 1 hour ahead of Sioux Falls (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

Your guide to booking Sioux Falls to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Wednesday departure and avoid flying on Friday. On this route, Wednesday flights average $304, about $183 less than Friday fares (38% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Sioux Falls to Knoxville trip for April. Fares historically average $289 round-trip in that month - typically $279 less than the most expensive month, which is July (based on the last 12 months).

More options for your flight from Sioux Falls to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

Car rentals in Knoxville
Hotels in Knoxville
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