$100 Find Cheap Flights from Knoxville to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to South Carolina departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to South Carolina, as well as popular online travel agencies
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Cheap Flights from Knoxville to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston2 stops$267
Myrtle Beach
Myrtle Beach1 stop$198
Columbia
Columbia1 stop$279
Charlotte
Charlotte1 stop$222
Charleston
Charleston2 stops$267
Myrtle Beach
Myrtle Beach1 stop$198
Columbia
Columbia1 stop$279
Charlotte
Charlotte1 stop$222

Book Cheap Knoxville to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to South Carolina

Mon, Aug 18 - Fri, Aug 22
 Logo
6:00 am - 7:45 pmTYS-MYR
13h 45m1 stop
 Logo
6:45 am - 5:38 pmMYR-TYS
10h 53m1 stop
Sat, Aug 30 - Sun, Aug 31
American Airlines Logo
6:13 am - 10:30 amTYS-CLT
28h 17m1 stop
American Airlines Logo
2:21 pm - 3:35 pmCLT-TYS
1h 14mnonstop
$222American Airlines
Find Deal
Tue, Sep 16 - Mon, Sep 22
American Airlines Logo
8:23 am - 11:43 amTYS-MYR
3h 20m1 stop
American Airlines Logo
8:06 am - 11:50 amMYR-TYS
3h 44m1 stop
$229American Airlines
Find Deal
Sat, Aug 30 - Sun, Aug 31
 Logo
4:41 pm - 10:58 pmTYS-CLT
6h 17m1 stop
 Logo
6:00 am - 7:54 pmCLT-TYS
13h 54m1 stop
Fri, Sep 12 - Mon, Sep 15
 Logo
1:22 pm - 6:21 pmTYS-CLT
4h 59m1 stop
 Logo
5:45 am - 4:37 pmCLT-TYS
10h 52m1 stop
Thu, Aug 14 - Thu, Aug 28
American Airlines Logo
6:07 pm - 11:45 pmTYS-MYR
5h 38m1 stop
American Airlines Logo
4:22 pm - 7:45 pmMYR-TYS
3h 23m1 stop
$249American Airlines
Find Deal
Sat, Aug 30 - Sat, Sep 6
United Airlines Logo
9:55 am - 2:06 pmTYS-MYR
4h 11m1 stop
United Airlines Logo
2:47 pm - 8:56 pmMYR-TYS
6h 09m1 stop
$278United Airlines
Find Deal
Sat, Sep 6 - Tue, Sep 9
Delta Logo
8:35 am - 2:26 pmTYS-CAE
5h 51m1 stop
Delta Logo
3:08 pm - 7:03 pmCAE-TYS
3h 55m1 stop
$297Delta
Find Deal
Sat, Nov 15 - Tue, Nov 18
Delta Logo
4:00 pm - 6:44 pmTYS-SAV
2h 44m1 stop
Delta Logo
5:30 am - 9:11 amSAV-TYS
3h 41m1 stop
$297Delta
Find Deal
Tue, Sep 9 - Fri, Sep 12
United Airlines Logo
7:00 am - 2:42 pmTYS-MYR
7h 42m1 stop
United Airlines Logo
2:47 pm - 10:28 amMYR-TYS
19h 41m1 stop
$388United Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Knoxville to South Carolina flights

Get data-powered insights and trends into flights from Knoxville to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Knoxville to South Carolina?

What is the cheapest month to fly from Knoxville to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to South Carolina is May, when tickets cost $366 (return) on average. On the other hand, the most expensive months are December and July, when the average cost of round-trip tickets is $623 and $529 respectively.

What’s the cheapest day of the week to fly from Knoxville to South Carolina?

The average price of all round-trip flights from Knoxville to South Carolina clicked on KAYAK for each day over the last 12 months.

If you are looking for a flight deal from Knoxville to South Carolina, look for departures on Saturdays and avoid leaving on a Monday, as it's usually the priciest day. When flying back from South Carolina, Tuesday is the cheapest day to fly and Saturday is the most expensive.


Good to know

Low seasonJanuary
Cheapest flight$100
Best time to beat the crowds with an average 1% drop in price.
Most popular time to fly with an average 16% increase in price.
Flight from Knoxville to Myrtle Beach

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Knoxville to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South Carolina?

    The cheapest time of day to fly to South Carolina is generally in the morning, when round-trip flights cost $478 on average. Morning departures are around 19% cheaper than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the evening, which is peak travel time and where the average cost of a ticket is $588.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Knoxville to the following destinations at these prices or less: Charlotte $238 one-way - $297 round-trip

Reviews of the top airlines flying from Knoxville to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 7986 reviews
8.2Boarding
7.9Entertainment
7.9Comfort
8.5Crew
7.3Food
Airline reviews

Was charged for my luggage despite having been on one ticket from an international flight. Too tired to argue after 15 hours on flight. Was charged for rechecking it at JFK airport. Not sure why those off Kenya Airways were required to do that.

4.0 OkayAnonymous, Aug 2025JFK - PHX
Read more Delta reviews

Was charged for my luggage despite having been on one ticket from an international flight. Too tired to argue after 15 hours on flight. Was charged for rechecking it at JFK airport. Not sure why those off Kenya Airways were required to do that.

De planning was an absolute mess. We were never told that we weren’t at the gate and that we had to go down unstable stairs and then hop on a bus. People were falling, we couldn’t tell who was in charge. Overall terrible communication that ended up leaving a bad impression at the very end of the experience.

My experience on any Delta flight is always overshadowed by the time Delta removed me from a flight for no apparent reason.

Delayed and took off even later than the scheduled delay time

For a 69 year old with health problems I had the worse experience, no wheelchair when I entered a lady told me to sit and wait while a gentleman told me I had to walk to the Delta station, which I did. I had a carry on and a bag, and I was traveling with my service dog, which was on his carrier and the lady charged me for my carry on luggage, beside all the waiting cause of the delay, I had to walk to get my luggage cause no wheelchair showed up, I am so disappointed. I will get in touch with the company. I got home at 3:00 am, not good for my health situation.

Great experience on Delta. Staff from baggage check to flight attendants were very courteous and professional. My only issue was a personal preference for pretzels instead of the chips and cookies that were offered.

There was no problems, just a little uncomfortable with seats that do not lay back a little

Always good but we must do something about people in rows ahead of you that don't put their seats back up when they are suppose to. And It's rough to not be able to even lean over to get something out of my purse.

Flight was delayed, 30+ bags had to be gate checked. Crew were very friendly!

Everything was good until we were boarding our connection flight in Atlanta, we were told to gate check our carry-on, but when we got inside the plane, there was plenty of room in the overhead.

Dreadful experience. Our flight was delayed more than 8 hours due to a maintenance issue and the assistance from rebooking was poor. I was travelling with a bad knee and needed assistance waited in one place more than 3 hours before someone came with a wheelchair. The woman next to me was a 91 year old great grandmother who had waited more than 4 hours. There were moments of support from the staff but it appeared as they were going against the direction of management. It was apathy, lack of ownership and dismissive responses with small moments of kindness and understanding typically from grey haired, female, veteran staff..

We had to turn around and head back to Manchester. Problem with a plane engine.

Flight was delayed. Staff at the gate effectively and proactively communicated about the delay.

Very poor delay in dfw was really bad n long

Our flight was 1.5 hours delayed. There was no weather for the inbound flight, so I don't understand why. This meant a VERY late arrival and only a quick nap before my morning flight.

Because of rescheduling, they had to put me on a flight that didn't go through Dallas

It was very difficult to stretch my knee out and I am very short. I also had a torn tendon in my knee which made it extra uncomfortable anyways. My husband is 6'2" and I can't imagine him flying in that plane.

3 hour weather delay followed by 1 hour (and counting) maintenance delay. UGH!

Couldn’t get the door on the plane to close leading to a nearly 2 hour delay. But, hey at least they didn’t cancel the flight.

Flight was cancelled 3 hrs AFTER etd. Thetefore Missed connection from JFK to New Zealand . No accommodation provided… This cost ne aporox 1000 USD in extra expenses and turned whst should have been a 24 hr trip ftom Boston - New Zealand into a VERY expensive , late 70+ hr nightmare … Complete nonsense!!!

Everything you need to know for your flight from Knoxville to South Carolina

Information on your arrival and departure airports

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