$110 Find Cheap Flights from Knoxville to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to South Carolina departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to South Carolina, as well as popular online travel agencies
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Cheap Flights from Knoxville to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston2 stops$229
Myrtle Beach
Myrtle Beach1 stop$278
Columbia
Columbia1 stop$327
Charlotte
Charlotte1 stop$236
Charleston
Charleston2 stops$229
Myrtle Beach
Myrtle Beach1 stop$278
Columbia
Columbia1 stop$327
Charlotte
Charlotte1 stop$236

Book Cheap Knoxville to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to South Carolina

Fri, Nov 14 - Tue, Nov 18
Multiple Airlines Logo
9:38 pm - 5:06 pmTYS-CHS
19h 28m2 stops
Multiple Airlines Logo
6:11 pm - 12:57 pmCHS-TYS
18h 46m1 stop
$229Multiple Airlines
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Fri, Nov 14 - Tue, Nov 18
Multiple Airlines Logo
9:28 pm - 2:29 pmTYS-CHS
17h 01m1 stop
Multiple Airlines Logo
6:11 pm - 12:57 pmCHS-TYS
18h 46m1 stop
$230Multiple Airlines
Find Deal
Fri, Oct 24 - Mon, Oct 27
Multiple Airlines Logo
7:44 pm - 1:52 pmTYS-CLT
18h 08m1 stop
Multiple Airlines Logo
5:49 pm - 10:33 amCLT-TYS
16h 44m1 stop
$236Multiple Airlines
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Sat, Oct 25 - Sun, Oct 26
American Airlines Logo
6:03 am - 6:26 amTYS-CLT
24h 23m1 stop
American Airlines Logo
8:20 am - 9:32 amCLT-TYS
1h 12mnonstop
$259American Airlines
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Sat, Nov 15 - Sun, Nov 16
American Airlines Logo
11:23 am - 6:35 amTYS-CLT
19h 12m1 stop
American Airlines Logo
9:01 am - 10:19 amCLT-TYS
1h 18mnonstop
$289American Airlines
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Sat, Jan 10 - Fri, Jan 16
Allegiant Air Logo
5:59 pm - 5:05 pmTYS-SAV
23h 06m1 stop
Allegiant Air Logo
7:00 am - 11:09 amSAV-TYS
28h 09m1 stop
$312Allegiant Air
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Tue, Mar 10 - Wed, Mar 11
Delta Logo
5:30 am - 10:08 amTYS-MYR
4h 38m1 stop
Delta Logo
6:00 am - 9:13 amMYR-TYS
3h 13m1 stop
$317Delta
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Sat, Nov 15 - Tue, Nov 18
Delta Logo
1:27 pm - 4:22 pmTYS-SAV
2h 55m1 stop
Delta Logo
5:36 am - 9:37 amSAV-TYS
4h 01m1 stop
$317Delta
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Thu, Apr 2 - Sun, Apr 5
Southwest Logo
7:50 am - 7:20 pmTYS-CHS
11h 30m1 stop
Southwest Logo
12:55 pm - 9:00 pmCHS-TYS
8h 05m1 stop
$383Southwest
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Thu, Apr 2 - Sun, Apr 5
Southwest Logo
6:30 am - 7:20 pmTYS-CHS
12h 50m2 stops
Southwest Logo
6:15 am - 12:55 pmCHS-TYS
6h 40m1 stop
$388Southwest
Find Deal
Booking Insights

KAYAK's insights & trends for Knoxville to South Carolina flights

Get data-powered insights and trends into flights from Knoxville to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to South Carolina is August, when tickets cost $320 (return) on average. On the other hand, the most expensive months are October and December, when the average cost of round-trip tickets is $728 and $568 respectively.

What’s the cheapest day of the week to fly from Knoxville to South Carolina?

The average price of all round-trip flights from Knoxville to South Carolina clicked on KAYAK for each day over the last 12 months.

If you are looking for a flight deal from Knoxville to South Carolina, look for departures on Saturdays and avoid leaving on a Monday, as it's usually the priciest day. When flying back from South Carolina, Tuesday is the cheapest day to fly and Saturday is the most expensive.

Good to know

Low seasonJanuary
Cheapest flight$110
Best time to beat the crowds but there is an average 5% increase in price.
Most popular time to fly with an average 32% increase in price.
Flight from Knoxville to Charleston

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Knoxville to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South Carolina?

    The cheapest time of day to fly to South Carolina is generally in the morning, when round-trip flights cost $478 on average. Morning departures are around 19% cheaper than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the evening, which is peak travel time and where the average cost of a ticket is $588.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Knoxville to the following destinations at these prices or less: Charlotte $208 one-way - $356 round-trip

Reviews of the top airlines flying from Knoxville to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7975 reviews
7.3Food
8.2Boarding
7.9Comfort
7.9Entertainment
8.5Crew
Airline reviews

The boarding process needs to be refined. Sometimes the gate crew calls out the zones and then flip to showing the.zones boarding on the gate monitor display. So, unless you are huddled around the gate lanes watching the monitor, you could miss your boarding zone. Suggest the zones be announced each time a new zone is allowed to board.

8.0 ExcellentAnonymous, Oct 2025ATL - STL
Read more Delta reviews

The boarding process needs to be refined. Sometimes the gate crew calls out the zones and then flip to showing the.zones boarding on the gate monitor display. So, unless you are huddled around the gate lanes watching the monitor, you could miss your boarding zone. Suggest the zones be announced each time a new zone is allowed to board.

The boarding process needs to be refined. Sometimes the gate crew call out the boarding zone, and then flip to the monitor to show which zones are boarding. So unless everyone is gathered around to see the monitor there is usually confusion as wi which zones are boarding.

On time flight. Seat comfort could be better in the Comfort section.

My issue was with TSA agents for delta airlines. My luggage got flagged. The agent was going thru another persons first. He took 20 min to go thru hers. I asked them to bring mine closer so I could sit down . They said you can go sit it will be fine. I said I am supposed to keep my eyes on my bags at all times. The agent was meticulously unwrapping 2 gifts that the lady had and then tried to re warp it. He was trying to be kind i get it but 20 min for me to stand watching him do that was ridiculous. It was 6 am and there were a ton of travelers. Mine was flagged for some air packed tea that I bought in Turkey. My previous delta flight and 2 others before didn’t flag it. Consistency would be nice. Also on the flight the window shades were down for take off and landing - I thought that was very odd I thought they had to remain open for take off and landing.

The flight was an hour and a half late departing which was inconvenient

Delay in SLC jammed us up in Chicago. Got caught up in rush hour traffic

The crew took good care of us. The flight from ATL to SFO is a longer one, and there were multiple beverage offerings. I like the 757's that Delta uses. Good airplane that is comfortable. I do wish Delta would separate Priority boarding from the better seats. I would gladly take a smaller seat in an open row than be jammed into Comfort just to get priority boarding, just to make sure I don't have to check a bag.

The flight was great. The gate location was way to far away!!!

The flight attendant in first class was beyond rude and didn't care at all about her job. AND the gate agent was even worse than the flight attendant for rudeness. She was awful.

Gate agent rushed to fill hot jetway with crowd so it took over 12 minutes to go from gate to plane. Just like a discount airline Pooly prepared cabin and third time that claim of rough air prevented any cabin service. Friends on a Southwest flight at similar time had service.

Mostly good. Flight was crowded but Airline personnel were very friendly & accommodating. It would be good to have savory snacks rather than just sweet Biscoff cookies.

It was a typical flight. We had a delay which seems to be the normality now. And we had no in flight service due to conditions.

Flight attendants on this flight were very attentive and friendly

After we landed we sat on the tarmac for 1.5 hours waiting to get to our gate. Ridiculous.

the trip to madrid was uncomfortable with my legs touching the seat in front of me

The plane was late, when we did board the plane was as cold as a freezer. I was freezing the entire flight, no blankets. Lost miserable flight I’ve ever had.

Terrible. Flight delayed for more than 8 hours with only a $12 meal voucher provided for the inconvenience. The airplane did not have breaks on arrival yet they still made us go through the motions and board on time knowing we could not take off then sit for 40+ minutes before having to get of the time. A complete waste of my time. I cannot believe they can stay business with these shenanigans. I’ll avoid this company like the plague moving forward as the lack of accountability is disgraceful.

This was the best 2 flights I have had with American out of SGF. Great crew both flights.

We were delayed for a “couple of maintenance issues.” They were resolved rather quickly but a computer glitch caused someone in the airport to have to bring a physical copy of the paperwork so we could leave. I don’t know where they had to drive from to get to our plane but it took forever & we were 1 1/2 hrs late in leaving. The flight itself was fine.

You can plug your phone in & use their wifi to watch movies, etc, but the plane’s wifi was disconnected for most of the flight.

Everything you need to know for your flight from Knoxville to South Carolina

Information on your arrival and departure airports

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