$119 Find Cheap Flights from Knoxville to South Carolina - Compare and Save

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Cheap Flights from Knoxville to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 5 days
Charleston
Charleston1 stop$239
Myrtle Beach
Myrtle Beach1 stop$273
Columbia
Columbia1 stop$367
Charlotte
Charlotte1 stop$239
Charleston
Charleston1 stop$239
Myrtle Beach
Myrtle Beach1 stop$273
Columbia
Columbia1 stop$367
Charlotte
Charlotte1 stop$239
Booking Insights

KAYAK's insights & trends for Knoxville to South Carolina flights

Get data-powered insights and trends into flights from Knoxville to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Knoxville to South Carolina?

Flight prices are below average for this route right now.

Flights to South Carolina from Knoxville usually cost between $309 and $469 in September.
The lowest price found in the past 5 days was $239 on Multiple Airlines (Sep 14-Sep 18).

What is the cheapest month to fly from Knoxville to South Carolina?

The cheapest month for flights from Knoxville to South Carolina is August, when tickets cost $336 (return) on average. On the other hand, the most expensive months are January and December, when the average cost of round-trip tickets is $601 and $544 respectively.

Good to know

Low season

February

Cheapest flight

$119
Best time to beat the crowds with an average 25% drop in price.
Most popular time to fly and prices are also 2% lower on average.
Flight from Knoxville to Charleston

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Knoxville to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Knoxville to the following destinations at these prices or less: Charlotte $222 one-way - $404 round-trip

Reviews of the top airlines flying from Knoxville to South Carolina

 
Need help choosing which airline to fly with from Knoxville to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8533 reviews
8.1Boarding
7.8Entertainment
7.8Comfort
8.5Crew
7.2Food
Airline reviews

My flight home from Knoxville, TN, included a layover in Atlanta. I boarded the aircraft in Zone 5 and although there was limited overhead space, I was able to put my 'backpack' style roller-bag above my seat. Unfortunately, due to continued bad weather, we had to deplane. There were many people who would have missed their connection, so they rebooked. When we were re-boarding, the gate agent welcomed zone 5 and then made an announcement: All roller-bags for zone 5 passengers and higher will need to be gate checked. I promptly pushed the telescoping handle in and held my bag like a backpack. I was able to bring it on board, which was a relief. Upon entering the aircraft it became apparent that there was easily 40% open overhead space. There were audible signs of angry passengers who felt duped into checking their bags when in fact there were noticeably LESS passengers on the aircraft and TONS of overhead space. I'm not sure what kinds of parameters are used to determine when to cut off roller-bags from being brought on board, but it seemed deceptive and underhanded to have so many people get stuck checking their bags when clearly there was ample room for at least one more zone.

4.0 OkayErnest, Jul 2026
Read more Delta reviews

My flight home from Knoxville, TN, included a layover in Atlanta. I boarded the aircraft in Zone 5 and although there was limited overhead space, I was able to put my 'backpack' style roller-bag above my seat. Unfortunately, due to continued bad weather, we had to deplane. There were many people who would have missed their connection, so they rebooked. When we were re-boarding, the gate agent welcomed zone 5 and then made an announcement: All roller-bags for zone 5 passengers and higher will need to be gate checked. I promptly pushed the telescoping handle in and held my bag like a backpack. I was able to bring it on board, which was a relief. Upon entering the aircraft it became apparent that there was easily 40% open overhead space. There were audible signs of angry passengers who felt duped into checking their bags when in fact there were noticeably LESS passengers on the aircraft and TONS of overhead space. I'm not sure what kinds of parameters are used to determine when to cut off roller-bags from being brought on board, but it seemed deceptive and underhanded to have so many people get stuck checking their bags when clearly there was ample room for at least one more zone.

The CRJ-900 was clean but the overhead air vents were broken in our First Class row, making the cabin very hot until about 30 mins into the flight. The flight attendants were both extremely apologetic and accommodating though so that is why I rated the flight as very good. They checked on us many times and truly showed they cared. The snacks for an hour and a half flight could be better. Would be nice if there was a small plated meal over convenient store snacks. WiFi also was not working. And it would be nice if Delta had adjustable headrests on these planes.

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

I am still at the Airport! Delayed Delayed and Delyaed

The landing was the worst I’ve experienced with a flight.

It was last minute due to weather - considering - it was amazing! Good smiles, friendly staff and they were making sure we knew what was going on when and where.

All good on Delta's part. Passengers could be a little more courteous to each other.

From Atlanta to Cabo I would have hoped on a plane that size I would have been able to breathe and wiggle my feet a little! The leg room in that plane is non existent and I am only 5”4’. And the air vent either wasn’t working very well or just could not blow air from the ceiling to the seat area as I was suffocating through the entire flight! And please don’t say I would have been more comfortable in first class because I cannot afford those rates and have always travelled Main Cabin without issues !

The pilots were good. Disappointing when planes don't have electrical ports

My wife has a scooter and they where supposed to send from departure to destination and had it go to connecting flight,not good.Nobody has knowledge of the scooters or the battery's.

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

Poor seat in rear of aircraft Food at Admiral’s Club Terminal D at DFW inedible

I didn’t like anything, being platinum pro get you absolutely nowhere and does not increase the customer service treatment whatsoever anymore. My flight was canceled and they put me on a flight eight hours later that would’ve got me back in the middle of the night. They could’ve easily move me up to an hour Prior on an earlier flight. My second flight was unreasonable to take, the third flight was also canceled due to mechanical issues like the first flight. I don’t know what’s going on with American, but they are falling apart, after seven flight changes I finally got home, Unreasonable.

This was a horrible American Airlines experience, and it discourages me from flying with them again. It may have stemmed from a mechanical delay, but it appeared that the team was unprepared to respond to the delay. After boarding, we waited an hour before finally taking off. After landing at our destination, we waited an additional hour on the tarmac waiting for a gate (at 8:00pm) to be assigned and cleared. The flight crew did their best, but they were clearly tired and also ready to be done for the day. Because of the delay, I missed a connecting flight. It was a very poor experience.

Fantastic! If it had not been for a check-in agent in Knoxville I may have not gotten my passes on British Airways. I couldn’t check-in online because British Airways had messed us the info on my tickets to London & Inverness. AA’s was great! British Airways was a continuous series of delays and frustrations.

Wheelchair was waiting for me,changed to a better seat which was great as it's hard for me to walk

Everything you need to know for your flight from Knoxville to South Carolina

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