TYS - MYR

$124 Find Cheap Flights from Knoxville to Myrtle Beach - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Myrtle Beach departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$211
Typical prices: $321-$736
American Airlines
Sat 9/5Fri 9/11
TYS - MYR • 1 stop
Cheapest one-way
$124
Typical prices: $227-$700
American Airlines
Sat 9/26
TYS - MYR • 1 stop
Top airlines
Cheapest • from $211 (round-trip)
Best reviews • 7.8 score
Airline reviews
Airline reviews
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Nonstop flights
Not available
There are currently no direct flights between Knoxville and Myrtle Beach. You'll need at least 1 connection.
Insights
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Top layover airports
Cheapest • Avg $393 (round-trip)
Shortest trip • 3h 45m (one-way)
Insights
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Insights
When to travel
Cheapest • 100% price drop
Most popular
Good to know
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We hope you love your trip to Myrtle Beach!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Myrtle Beach (TYS-MYR)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Myrtle Beach that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Myrtle Beach

Sat, Sep 5 - Fri, Sep 11
American Airlines Logo
6:05 pm - 9:26 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
3h 21m1 stop Charlotte Douglas
American Airlines Logo
5:45 pm - 10:50 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
5h 05m1 stop Charlotte Douglas
$211American Airlines
Fri, Aug 28 - Mon, Aug 31
American Airlines Logo
5:15 am - 9:40 amTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
4h 25m1 stop Charlotte Douglas
American Airlines Logo
7:33 pm - 10:58 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 25m1 stop Charlotte Douglas
$221American Airlines
Sat, Aug 29 - Tue, Sep 1
American Airlines Logo
4:22 pm - 10:38 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
6h 16m1 stop Charlotte Douglas
American Airlines Logo
6:15 am - 9:43 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 28m1 stop Charlotte Douglas
$247American Airlines
Sat, Aug 29 - Tue, Sep 1
Southwest Logo
6:50 am - 3:40 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
8h 50m2 stops Nashville Intl Baltimore/Washington
Southwest Logo
2:25 pm - 7:50 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
5h 25m1 stop Baltimore/Washington
$252Southwest
Sat, Aug 29 - Tue, Sep 1
Southwest Logo
6:50 am - 3:40 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
8h 50m2 stops Nashville Intl Baltimore/Washington
Southwest Logo
7:50 am - 6:55 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
11h 05m2 stops Chicago Midway Nashville Intl
$257Southwest
Thu, Oct 22 - Mon, Oct 26
Multiple Airlines Logo
5:28 pm - 7:58 amTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
14h 30m1 stop Fort Lauderdale
Multiple Airlines Logo
1:48 pm - 5:14 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
27h 26m1 stop Fort Lauderdale
$258Multiple Airlines
Sat, Sep 5 - Sun, Sep 6
American Airlines Logo
6:05 pm - 9:26 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
3h 21m1 stop Charlotte Douglas
American Airlines Logo
6:32 pm - 9:50 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 18m1 stop Charlotte Douglas
$265American Airlines
Thu, Sep 10 - Sun, Sep 13
Delta Logo
4:00 pm - 9:41 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
5h 41m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:58 pm - 11:55 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
4h 57m1 stop Atlanta Hartsfield-Jackson
$284Delta
Tue, Sep 8 - Sun, Sep 13
Delta Logo
5:40 am - 10:07 amTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
4h 27m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:58 pm - 11:55 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
4h 57m1 stop Atlanta Hartsfield-Jackson
$297Delta
Sun, Oct 11 - Thu, Oct 15
Delta Logo
5:40 am - 10:07 amTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
4h 27m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:01 pm - 11:59 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
4h 58m1 stop Atlanta Hartsfield-Jackson
$297Delta
Booking Insights

KAYAK's insights & trends for Knoxville to Myrtle Beach flights

Get data-powered insights and trends into flights from Knoxville to Myrtle Beach to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to Myrtle Beach?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Myrtle Beach, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Myrtle Beach is January, where tickets cost $0 (return) on average. On the other hand, the most expensive months are March and December, where the average cost of round-trip tickets is $585 and $544 respectively.

Good to know

Low season

August

Cheapest flight

$124
Best time to beat the crowds with an average 36% drop in price.
Most popular time to fly and prices are also 15% lower on average.
Flight from Knoxville to Myrtle Beach

When to book flights from Knoxville to Myrtle Beach

Are your dates flexible? Find out the best times to travel from Knoxville to Myrtle Beach based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Myrtle Beach

  • Does Knoxville McGhee Tyson Airport allow passengers to travel with animals?

    Yes. TYS allows approved service animals to accompany passengers. Service animals must be on a leash while in the airport. You will find animal relief areas for your furry friend on the West side of the Terminal, near the west surface or economy lot crosswalk.

  • Does Knoxville McGhee Tyson Airport have any amenities for nursing mothers?

    Yes. Traveling nursing mothers departing from TYS can enjoy the privacy of the private Mamava pod located past the security checkpoint opposite the food concession area. The pod is lockable, self-contained, and has a comfortable sitting space, a fold-down table, and an electrical outlet for plugging in a breast pump.

  • What ground transportation options do I have upon arrival at MYR?

    You can choose any of the following six ground transportation options upon arrival; public transportation, taxi cab service, rideshare service, hotel shuttle, limousine service, or car rental service. Taxicab service, available on a first-come, first-serve basis, is located outside Door 6 at Baggage Claim. Public Transport is the most affordable and the nearest bus stop is Jet port road.

  • Does Myrtle Beach International Airport have lounges?

    Yes. You can get access to MYR business lounge. The luxury airport lounge is open to passengers from all classes, and it features a comfortable sitting area, access to snacks and drinks, conference facilities and newspapers and magazines to keep you entertained.

  • What is the cheapest flight from Knoxville to Myrtle Beach?

    In the last 5 days, the lowest price for a flight from Knoxville to Myrtle Beach was $124 for a one-way ticket and $211 for a round-trip.

  • Do I need a passport to fly between Knoxville and Myrtle Beach?

    No

  • Which aircraft models fly most regularly from Knoxville to Myrtle Beach?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Myrtle Beach?

    SkyTeam, and oneworld are the airline alliances operating flights between Knoxville and Myrtle Beach, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Knoxville to Myrtle Beach, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Knoxville to Myrtle Beach are Delta and American Airlines. With an average price for the route of $336 and an overall rating of 7.8, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $336 and an overall rating of 7.1.

  • How does KAYAK find such low prices on flights from Knoxville to Myrtle Beach?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Myrtle Beach.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Myrtle Beach?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Myrtle Beach from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Myrtle Beach?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Myrtle Beach with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and MYR can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Myrtle Beach?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Myrtle Beach from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Knoxville to Myrtle Beach

  • Knoxville McGhee Tyson Airport (TYS) is located approximately 12 miles from downtown Knoxville. The most convenient transport option for you to use to get to the airport would be the Knoxville Airport shuttle transfers. You can reserve a ride at an affordable fee and have the shuttle pick you up from your home, office, hotel, or a famous landmark.
  • Suppose you prefer to drive to TYS, you can leave your car at the airport for extended stay parking. The long-term parking lot is located offsite, about a 10-minute walk to the main Terminal, but you can also take the free shuttle to the main Terminal. The parking lot features both covered and garage parking spaces and charges affordable rates daily. It applies a free cancellation policy if you have a last-minute change of plans.
  • If you are not rushing through TYS to catch your flight; you can enrich your airport experience by enjoying art exhibitions at the airport. The art exhibitions feature around 40 to 45 exquisite art pieces of all styles and genres by regional artists. You will find the display of artwork in the secured area behind McGhee Tyson Airport's security gate checkpoint.
  • Myrtle Beach International Airport (MYR) features an airport concierge service to make your post-arrival procedures less stressful. At an affordable fee, you can book Airssist before your arrival. A professional will meet you at your aircraft, assist you with your carry-on luggage, help you trace your baggage, fast track clearance at security checkpoints and immigration, and connect you to your ground transportation.
  • MYR also has facilities to cater to the needs of differently-abled passengers. The airport has a Flight Information Display System (FIDS) to page passengers with hearing and visual impairments. Telecommunication Devices for the Deaf (TDD) are available throughout the terminals. Wheelchairs are also available, and you may book in advance or request one upon arrival. The airport also has a quiet room in the baggage claim area for passengers with special needs to destress.

Reviews of the top airlines flying from Knoxville to Myrtle Beach

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Myrtle Beach. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Myrtle Beach? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8499 reviews
8.5Crew
8.1Boarding
7.8Entertainment
7.2Food
7.8Comfort
Airline reviews

My flight home from Knoxville, TN, included a layover in Atlanta. I boarded the aircraft in Zone 5 and although there was limited overhead space, I was able to put my 'backpack' style roller-bag above my seat. Unfortunately, due to continued bad weather, we had to deplane. There were many people who would have missed their connection, so they rebooked. When we were re-boarding, the gate agent welcomed zone 5 and then made an announcement: All roller-bags for zone 5 passengers and higher will need to be gate checked. I promptly pushed the telescoping handle in and held my bag like a backpack. I was able to bring it on board, which was a relief. Upon entering the aircraft it became apparent that there was easily 40% open overhead space. There were audible signs of angry passengers who felt duped into checking their bags when in fact there were noticeably LESS passengers on the aircraft and TONS of overhead space. I'm not sure what kinds of parameters are used to determine when to cut off roller-bags from being brought on board, but it seemed deceptive and underhanded to have so many people get stuck checking their bags when clearly there was ample room for at least one more zone.

4.0 OkayErnest, Jul 2026
Read more Delta reviews

My flight home from Knoxville, TN, included a layover in Atlanta. I boarded the aircraft in Zone 5 and although there was limited overhead space, I was able to put my 'backpack' style roller-bag above my seat. Unfortunately, due to continued bad weather, we had to deplane. There were many people who would have missed their connection, so they rebooked. When we were re-boarding, the gate agent welcomed zone 5 and then made an announcement: All roller-bags for zone 5 passengers and higher will need to be gate checked. I promptly pushed the telescoping handle in and held my bag like a backpack. I was able to bring it on board, which was a relief. Upon entering the aircraft it became apparent that there was easily 40% open overhead space. There were audible signs of angry passengers who felt duped into checking their bags when in fact there were noticeably LESS passengers on the aircraft and TONS of overhead space. I'm not sure what kinds of parameters are used to determine when to cut off roller-bags from being brought on board, but it seemed deceptive and underhanded to have so many people get stuck checking their bags when clearly there was ample room for at least one more zone.

The CRJ-900 was clean but the overhead air vents were broken in our First Class row, making the cabin very hot until about 30 mins into the flight. The flight attendants were both extremely apologetic and accommodating though so that is why I rated the flight as very good. They checked on us many times and truly showed they cared. The snacks for an hour and a half flight could be better. Would be nice if there was a small plated meal over convenient store snacks. WiFi also was not working. And it would be nice if Delta had adjustable headrests on these planes.

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

I am still at the Airport! Delayed Delayed and Delyaed

The landing was the worst I’ve experienced with a flight.

It was last minute due to weather - considering - it was amazing! Good smiles, friendly staff and they were making sure we knew what was going on when and where.

All good on Delta's part. Passengers could be a little more courteous to each other.

From Atlanta to Cabo I would have hoped on a plane that size I would have been able to breathe and wiggle my feet a little! The leg room in that plane is non existent and I am only 5”4’. And the air vent either wasn’t working very well or just could not blow air from the ceiling to the seat area as I was suffocating through the entire flight! And please don’t say I would have been more comfortable in first class because I cannot afford those rates and have always travelled Main Cabin without issues !

The pilots were good. Disappointing when planes don't have electrical ports

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

Poor seat in rear of aircraft Food at Admiral’s Club Terminal D at DFW inedible

I didn’t like anything, being platinum pro get you absolutely nowhere and does not increase the customer service treatment whatsoever anymore. My flight was canceled and they put me on a flight eight hours later that would’ve got me back in the middle of the night. They could’ve easily move me up to an hour Prior on an earlier flight. My second flight was unreasonable to take, the third flight was also canceled due to mechanical issues like the first flight. I don’t know what’s going on with American, but they are falling apart, after seven flight changes I finally got home, Unreasonable.

This was a horrible American Airlines experience, and it discourages me from flying with them again. It may have stemmed from a mechanical delay, but it appeared that the team was unprepared to respond to the delay. After boarding, we waited an hour before finally taking off. After landing at our destination, we waited an additional hour on the tarmac waiting for a gate (at 8:00pm) to be assigned and cleared. The flight crew did their best, but they were clearly tired and also ready to be done for the day. Because of the delay, I missed a connecting flight. It was a very poor experience.

Fantastic! If it had not been for a check-in agent in Knoxville I may have not gotten my passes on British Airways. I couldn’t check-in online because British Airways had messed us the info on my tickets to London & Inverness. AA’s was great! British Airways was a continuous series of delays and frustrations.

Multiple gate changes and significant delay leaving DFW. Made for a late arrival

Wheelchair was waiting for me,changed to a better seat which was great as it's hard for me to walk

Everything you need to know for your flight from Knoxville to Myrtle Beach

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