$270 Find Cheap Flights from La Crosse to South Carolina - Compare and Save

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from La Crosse to South Carolina departing on 9/19. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from La Crosse to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$324
Greenville
Greenville1 stop$306
Charlotte
Charlotte1 stop$270
Charleston
Charleston1 stop$324
Greenville
Greenville1 stop$306
Charlotte
Charlotte1 stop$270

Book Cheap La Crosse to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from La Crosse to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from La Crosse to South Carolina

Sat, Sep 19 - Sat, Oct 3
American Airlines Logo
5:22 pm - 12:04 am
LSE
-
CLT
5h 42m
1 stop
American Airlines Logo
6:15 pm - 12:20 am
CLT
-
LSE
7h 05m
1 stop
$270American Airlines
Wed, Sep 23 - Sat, Sep 26
American Airlines Logo
12:02 pm - 10:07 pm
LSE
-
SAV
9h 05m
2 stops
American Airlines Logo
7:00 am - 4:52 pm
SAV
-
LSE
10h 52m
2 stops
$281American Airlines
Tue, Aug 11 - Tue, Aug 18
American Airlines Logo
5:20 pm - 11:25 pm
LSE
-
GSP
5h 05m
1 stop
American Airlines Logo
6:34 pm - 12:22 am
GSP
-
LSE
6h 48m
1 stop
$306American Airlines
Wed, Aug 12 - Tue, Aug 18
American Airlines Logo
5:20 pm - 11:54 pm
LSE
-
CLT
5h 34m
1 stop
American Airlines Logo
8:31 pm - 12:22 am
CLT
-
LSE
4h 51m
1 stop
$306American Airlines
Tue, Aug 11 - Tue, Aug 18
American Airlines Logo
5:20 pm - 11:25 pm
LSE
-
GSP
5h 05m
1 stop
American Airlines Logo
4:40 pm - 12:22 am
GSP
-
LSE
8h 42m
2 stops
$312American Airlines
Wed, Aug 12 - Tue, Aug 18
American Airlines Logo
5:20 pm - 11:54 pm
LSE
-
CLT
5h 34m
1 stop
American Airlines Logo
6:26 pm - 12:22 am
CLT
-
LSE
6h 56m
2 stops
$312American Airlines
Wed, Sep 23 - Sat, Sep 26
American Airlines Logo
5:54 am - 11:26 am
LSE
-
SAV
4h 32m
1 stop
American Airlines Logo
7:00 am - 4:52 pm
SAV
-
LSE
10h 52m
2 stops
$312American Airlines
Thu, Aug 20 - Sat, Aug 22
Multiple Airlines Logo
10:51 am - 8:45 am
LSE
-
CHS
20h 54m
1 stop
Multiple Airlines Logo
3:44 pm - 10:01 am
CHS
-
LSE
19h 17m
1 stop
$324Multiple Airlines
Sat, Sep 19 - Sat, Oct 3
American Airlines Logo
12:26 pm - 8:55 pm
LSE
-
CLT
7h 29m
2 stops
American Airlines Logo
7:30 am - 11:22 am
CLT
-
LSE
4h 52m
1 stop
$329American Airlines
Thu, Aug 20 - Sat, Aug 22
Multiple Airlines Logo
10:51 am - 1:50 pm
LSE
-
CLT
25h 59m
1 stop
Multiple Airlines Logo
9:52 pm - 10:01 am
CLT
-
LSE
13h 09m
1 stop
$346Multiple Airlines
Booking Insights

KAYAK's insights & trends for La Crosse to South Carolina flights

Get data-powered insights and trends into flights from La Crosse to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How long does a flight from La Crosse to South Carolina take?

The duration of a flight to South Carolina depends on your arrival airport. The shortest routes to South Carolina from La Crosse are to Greenville, which takes 5h 05m, and Charleston, which takes 6h 19m.

Good to know

Cheapest flight

$270
Flight from La Crosse to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from La Crosse to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from La Crosse to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from La Crosse to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from La Crosse to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from La Crosse to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from La Crosse to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from La Crosse to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from La Crosse to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from La Crosse to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from La Crosse to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from La Crosse to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11824 reviews
6.8Entertainment
7.2Comfort
7.9Crew
7.5Boarding
6.4Food
Airline reviews

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

4.0 OkayCaleb, Jun 2026
ORD - GSP
Read more American Airlines reviews

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

Crew was helpful and cheerful especially when they had no refreshments to work with. The plane was never serviced and had nothing but limited water and coffee onboard. For the price point, a concern of services.

I bought wifi and most of the flight could not even use it my apps would just spin. I couldn't even listen to music. super frustrating.

Poor seat in rear of aircraft Food at Admiral’s Club Terminal D at DFW inedible

Seating was horrible. Small seats. Access to flight information and extras very iser unfriendly. Kept losing internet after paying for it. Staff in madison was as unprofessional and unhelpful.

There were several different delays but we ended up being delayed a total of 40 mins or so. It was annoying we had a gate change which made it take longer to leave DFW, and we had to check our carry on. Ugh

Multiple gate changes and significant delay leaving DFW. Made for a late arrival

For the price of the ticket you get nothing. The plane had 1 bathroom in the back and when the flight attendant did service no one could use it. No announcement just was told to go back to my seat. Ridiculous and rude.

In-flight Wi-Fi didn’t work and the flight was 25 minutes late. The Embraer plane I was on was pretty old and the tray table was broken.

American Airlines no longer has Bischoff biscuits. This is intolerable.

Everything you need to know for your flight from La Crosse to South Carolina

Information on your arrival and departure airports