$321 Find Cheap Flights from Lexington to South America - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Lexington to South America departing on 8/20. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

Save 20% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Lexington to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$795
Bogotá
Bogotá1 stop$715
Rio de Janeiro
Rio de Janeiro1 stop$973
Santiago
Santiago2 stops$1,000
Cartagena
Cartagena2 stops$707
Quito
Quito2 stops$740
Guayaquil
Guayaquil2 stops$787
Cusco
Cusco2 stops$1,123
Lima
Lima2 stops$795
Bogotá
Bogotá1 stop$715
Rio de Janeiro
Rio de Janeiro1 stop$973
Santiago
Santiago2 stops$1,000
Cartagena
Cartagena2 stops$707
Quito
Quito2 stops$740
Guayaquil
Guayaquil2 stops$787
Cusco
Cusco2 stops$1,123

Book Cheap Lexington to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Lexington to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Lexington to South America

Sun, Oct 25 - Sat, Oct 31
American Airlines Logo
8:03 pm - 12:48 pm
LEX
-
MDE
17h 45m
2 stops
American Airlines Logo
1:30 am - 3:33 pm
MDE
-
LEX
14h 03m
2 stops
$636American Airlines
Sun, Oct 25 - Sat, Oct 31
American Airlines Logo
5:57 pm - 12:48 pm
LEX
-
MDE
19h 51m
2 stops
American Airlines Logo
1:30 am - 11:16 am
MDE
-
LEX
9h 46m
1 stop
$636American Airlines
Mon, Oct 5 - Tue, Oct 20
American Airlines Logo
5:57 pm - 12:48 pm
LEX
-
MDE
19h 51m
2 stops
American Airlines Logo
6:00 am - 8:52 pm
MDE
-
LEX
13h 52m
2 stops
$661American Airlines
Fri, Oct 23 - Sun, Oct 25
American Airlines Logo
12:30 pm - 10:30 pm
LEX
-
BOG
11h 00m
1 stop
American Airlines Logo
12:25 am - 12:00 pm
BOG
-
LEX
10h 35m
1 stop
$715American Airlines
Sat, Sep 26 - Sun, Oct 4
Delta Logo
1:02 pm - 7:15 pm
LEX
-
BOG
7h 13m
1 stop
Delta Logo
5:15 pm - 5:10 pm
BOG
-
LEX
22h 55m
2 stops
$718Delta
Mon, Sep 28 - Sun, Oct 4
Delta Logo
7:00 am - 5:50 pm
LEX
-
BOG
11h 50m
2 stops
Delta Logo
5:15 pm - 7:42 pm
BOG
-
LEX
25h 27m
2 stops
$725Delta
Sun, Oct 18 - Thu, Oct 22
LATAM Airlines Logo
7:59 pm - 8:05 pm
LEX
-
MDE
25h 06m
2 stops
LATAM Airlines Logo
5:10 am - 11:59 pm
MDE
-
LEX
17h 49m
2 stops
$738LATAM Airlines
Sun, Oct 18 - Thu, Oct 22
LATAM Airlines Logo
7:59 pm - 9:30 pm
LEX
-
MDE
26h 31m
2 stops
LATAM Airlines Logo
7:50 am - 11:59 pm
MDE
-
LEX
15h 09m
2 stops
$739LATAM Airlines
Sun, Oct 18 - Thu, Oct 22
LATAM Airlines Logo
7:59 pm - 9:30 pm
LEX
-
MDE
26h 31m
2 stops
LATAM Airlines Logo
8:55 am - 11:59 pm
MDE
-
LEX
14h 04m
2 stops
$739LATAM Airlines
Sun, Sep 27 - Sun, Oct 4
Delta Logo
6:00 pm - 5:50 pm
LEX
-
BOG
24h 50m
2 stops
Delta Logo
5:15 pm - 5:10 pm
BOG
-
LEX
22h 55m
2 stops
$741Delta
Booking Insights

KAYAK's insights & trends for Lexington to South America flights

Get data-powered insights and trends into flights from Lexington to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Lexington to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Lexington to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Lexington to South America is January, when tickets cost $0 (return) on average. On the other hand, the most expensive months are December and May, when the average cost of round-trip tickets is $1,562 and $1,485 respectively.

Good to know

Low season

October

Cheapest flight

$321
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly with an average 5% increase in price.
Flight from Lexington to Lima

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Lexington to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Lexington to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Lexington to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Lexington to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Lexington to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Lexington to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Lexington to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Lexington to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Lexington to South America

 
Need help choosing which airline to fly with from Lexington to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8497 reviews
8.1Boarding
8.5Crew
7.8Comfort
7.8Entertainment
7.2Food
Airline reviews

Comfortable seats. Nice service online. Short flight, so not a lot of time to enjoy.

8.0 ExcellentMichael, Jul 2026
SEA - SMF
Read more Delta reviews

Comfortable seats. Nice service online. Short flight, so not a lot of time to enjoy.

Awful. There was an unexpected delay of nearly three hours because there were not enough flight attendants. I understand this is likely due to FAA regulations; but in that case, Delta should coordinate with smaller airports such as RDU to have extra flight attendants on the ground and "on call". In addition, this was the second 2-hour+ delay to Boston on this route in one week.

It was strange that the flight attendant was so adamant about having phones turned to airplane mode that he was calling out names from networks shown and waiting until they were all gone. I've never experienced that before, and after already working through an hour+ delay, it felt tone deaf. I take dozens of flights per year and have never experienced anything similar.

The flight was done by SkyWest only WIFI no entertainment center are available on the CRJ

Your survey needs a N/A option. I didn’t use the entertainment or eat food.

The flight was over 2 hours late.. once we finally got boarded things were fine

The boarding agent guy in Lexington on 7/23 that boarded the flights to Atlanta is very rude for working in customer service. I know there were delays but he was dismissive rude and arrogant. Most native Kentucky residents are nice and very cordial he needs to eat a big ole piece of humble pie. I watched him be rude to several people and as much as he could of filled up a delayed flight to save you money and he was so rude to people it was ridiculous. Next no water or snacks on short flights is awful 1st you delay a flight then do not even offer water on the flight.. No thanks I like delta better but I travel ever week and to be treated like this might as well fly American at least they offer water and have better rewards.

The staff was fine. The plane was extremely tight, and I paid for the wifi and it did not work at all. I was actually going to ask for a refund.

Left on time and arrived early this extending our 31 minute transfer. Bags made it also!

The crew was very polite as I have a few handicaps and everything was made pleasant. Check-in was easy as I was brought on board by the wheelchair assistant. One flight attendant did make sure my personal item was carefully stored under the seat in front of me. I was made to feel welcome as a customer as I made my first trip with a few disabilities. Entertainment and wifi worked quite well. The only food service were snacks and drinks. Those were okay. Overall it was a very smooth flight and encouraged me to use Delta again.

Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Everything you need to know for your flight to South America

Information on your arrival and departure airports