$275 Find Cheap Flights from Louisville to Panama

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Louisville to Panama departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Book Cheap Louisville to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Louisville to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Louisville to Panama

Sat, Jul 25 - Wed, Jul 29
United Airlines Logo
6:15 am - 4:12 pm
SDF
-
PTY
10h 57m
1 stop
United Airlines Logo
7:55 am - 10:15 pm
PTY
-
SDF
13h 20m
1 stop
$569United Airlines
Fri, May 29 - Fri, Jun 5
United Airlines Logo
11:45 am - 7:31 pm
SDF
-
PTY
8h 46m
1 stop
United Airlines Logo
10:00 am - 10:15 pm
PTY
-
SDF
11h 15m
1 stop
$571United Airlines
Thu, May 28 - Thu, Jun 4
United Airlines Logo
11:13 am - 7:31 pm
SDF
-
PTY
9h 18m
1 stop
United Airlines Logo
10:00 am - 8:01 pm
PTY
-
SDF
9h 01m
1 stop
$572United Airlines
Sat, Jul 25 - Sat, Aug 1
United Airlines Logo
9:30 am - 6:37 pm
SDF
-
PTY
10h 07m
1 stop
United Airlines Logo
3:30 pm - 9:02 am
PTY
-
SDF
16h 32m
2 stops
$573United Airlines
Mon, May 4 - Thu, May 7
Delta Logo
7:05 am - 1:02 pm
SDF
-
PTY
6h 57m
1 stop
Delta Logo
2:15 pm - 10:36 pm
PTY
-
SDF
7h 21m
1 stop
$575Delta
Thu, May 28 - Thu, Jun 4
United Airlines Logo
11:13 am - 7:31 pm
SDF
-
PTY
9h 18m
1 stop
United Airlines Logo
10:00 am - 9:02 am
PTY
-
SDF
22h 02m
2 stops
$576United Airlines
Mon, Sep 28 - Fri, Oct 2
Delta Logo
7:30 pm - 12:56 pm
SDF
-
PTY
18h 26m
1 stop
Delta Logo
2:21 pm - 10:36 pm
PTY
-
SDF
7h 15m
1 stop
$577Delta
Sun, Sep 6 - Sun, Sep 20
American Airlines Logo
5:53 pm - 12:24 pm
SDF
-
PTY
19h 31m
2 stops
American Airlines Logo
3:40 pm - 10:36 am
PTY
-
SDF
17h 56m
2 stops
$578American Airlines
Tue, Aug 18 - Thu, Aug 20
United Airlines Logo
11:13 am - 7:31 pm
SDF
-
PTY
9h 18m
1 stop
United Airlines Logo
3:30 pm - 12:55 pm
PTY
-
SDF
20h 25m
1 stop
$579United Airlines
Sat, Jul 18 - Fri, Jul 24
United Airlines Logo
9:30 am - 2:14 pm
SDF
-
PTY
29h 44m
1 stop
United Airlines Logo
3:30 pm - 9:05 am
PTY
-
SDF
16h 35m
2 stops
$584United Airlines
Booking Insights

KAYAK's insights & trends for Louisville to Panama flights

Get data-powered insights and trends into flights from Louisville to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Louisville to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Louisville to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Louisville to Panama is February, when tickets cost $437 (return) on average. On the other hand, the most expensive months are December and November, when the average cost of round-trip tickets is $601 and $595 respectively.

Good to know

Low seasonSeptember
Cheapest flight$275
Best time to beat the crowds but there is an average 4% increase in price.
Most popular time to fly with an average 3% increase in price.
Flight from Louisville to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Louisville to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Louisville to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Louisville to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Louisville to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Louisville to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Louisville to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Louisville to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Louisville to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Louisville to Panama

 
Need help choosing which airline to fly with from Louisville to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8409 reviews
8.1Boarding
7.2Food
7.9Comfort
8.5Crew
7.8Entertainment
Airline reviews

Boarding was good. The flight was on time ( arrival was 20 minutes early). Inflight service was average ( US airlines have not mastered the skills of customer service yet). The food was mediocre. “ breakfast “ was downright awful and insulting. It was a piece of dough with mon descript filling that was supposed to be cheese omelette).

6.0 GoodAnonymous, Apr 2026
DTW - AMS
Read more Delta reviews

Boarding was good. The flight was on time ( arrival was 20 minutes early). Inflight service was average ( US airlines have not mastered the skills of customer service yet). The food was mediocre. “ breakfast “ was downright awful and insulting. It was a piece of dough with mon descript filling that was supposed to be cheese omelette).

The tray table was broken and the food was terrible.

The gentleman at the gate I think his name is RIE was exceptional

While they turned off most cabin lights to allow people to sleep, I was bothered by how bright the side lights still were. It was still quite bright for me in a window seat, when I wish I could have slept!

One of the flight attendants was a little cranky. I appreciated the free wifi and plug to charge my laptop

No entertainment. Plane was so small had to pink tag a carry on ive used for 20 years easily on board. The fact the flight got in at midnight, had to wait for crew in fort wayne to allow the plane to approach the gate, THEN had to wait for bag on jet bridge made experience irritating at best.

Crew was great. Near on time departure and early arrival. Snacks are always meh. Not a fan of the "pay for everything including miles " proposal unless base flight rate going to be 100 bucks.

Would have been better if there was a nonstop flight from Tampa to Norfolk or Tampa to New Port News.

Overall Good! The weather delayed our takeoff from Atlanta and our arrival in Miami! If Mother Nature can mess up a flight she will do it every time!

The flight was smooth, the crew was great but the plane was quite old

Due to cancellation of connecting flight (Lufthansa) I didn’t fly with United

The seat was comfortable. There was a lot of turbulence. If it weren't for that,it would have been okay.

It was a red-eye, but the flight felt surprisingly quick. The seats were very comfortable, and that made resting much easier. I also want to thank the gentleman seated next to me, who graciously moved so my mom could sit beside me. We slept almost the entire way. The cabin crew was respectful in not disturbing us, while also being courteous and professional throughout. Thank you, United.

Packed in plane small uncomfortable seats elbow to elbow nobody wants to be in that situation for the money they paid

Vegetarian selection could be better. Bread was too hard to chew.

Crew was friendly and competent. Food, wine, and entertainment were excellent except the raw tuna on the flight to Split. Recommend against serving that - at least as the only option. Many medical conditions do not allow people to eat raw fish.

Overall flight was ok. Flight attendant was receptive to assisting passengers with tight connections.

Checking in united could not figure out my star alliance gold. Baggage did not get marked priority and didn't receive boarding passes. When got to SFO lounge personal fixed everything Immediately

Very comfortable flight, snacks and drinks were good, good communication from crew. Could have used a little more information on timing of boarding for group 5

It's a long flight and I would have liked better snacks between lunch and the arrival meal. It's fine to have fruit and nuts but I really don't like ramen because it's salty junk soup. I'd suggest sandwiches. They're not expensive nor are they hard to store for a long flight. The FA's had a couple of big services and they were super busy preparing, executing and then cleaning up. Then they disappeared.

American Airlines is a miserable experience. It is predictably miserable, in the sense that every time I fly American, I brace myself for the certainty that it will be unpleasant and uncomfortable. But it is unpredictable in the sense that I never know if the flight will be on time or delayed nine hours (both happened to me this week). I never know if I will be able to sit in the seat that I selected when I purchased the ticket or if I will be told by Customer Service (!!!) that I must relocate from first class to a seat in the back of the aircraft with no explanation (both happened to me this week). Will the food be frozen and half defrosted, or scalding hot? Will the drinks be warm? Will the flight attendants be surly and mean? Will the toilets be cramped and foul? Will the seats be narrow and uncomfortable? Will there be a real electric outlet at the seat, or just an unreliable USB-2 port? Will there be enough seats in the boarding lounge or just a few? Will the boarding process be smooth and efficient, or will the gate agents mess it up and delay it needlessly for 30 or 40 minutes? Will the catering and cleaning crew be prompt or will they take an extra 30 minutes? Will the brakes on the aircraft work properly, or will the pilot delay takeoff for four hours while the ground crew attends to what can only be described as routine maintenance that should have been done the night before? I've eexperienced every one of these unpleasant things this year, 2026. The only thing I can reliably count on is that American will find a new way to make the experience of flying as miserable as they possibly can.

Flight was fine, but not having WiFi was a major negative

Friendly crew is the only nice thing. Seats uncomfortable. Food and snacks horrible. Movies were the same as the first 10 hour flight two weeks before

When I booked my flight a month ago - I selected a seat. That seat was NOT the one I ended up with when I checked into my flight the day before. This is the second time this has occurred. So, I checked my next flight on Wednesday and Thursday and no seat was assigned. Poor, very poor customer service.

The staff and service on American Airlines were truly outstanding. I had requested wheelchair assistance for my mother due to her knee issues, and the team went above and beyond every step of the way—from boarding in Boston to our arrival in Chicago. Their care, professionalism, and attentiveness made the entire experience smooth and stress-free. I’m very grateful for the support they provided.

Incredibly delayed. First delay was due to plane coming in being late. Resulted in 30 minute delay. Boarded and then had multiple mechanical issues. Was on plane for an hour until they told people they could get off if they wanted but couldn't come back. Then gate agent rushed in and said they had lost control of who went off and we would all have to deplane and then get back on. They said flight had not been cancelled. Then while sitting waiting to board again they announced it would take two hours to get new plane and to wait at new gate. New plane arrived, reboarded only to find out that pilots had timed out. Waited for new pilots. In that time one of the flight attendants timed out. Never received food or water while waiting. Was confusing mess as to what was happening. Even flight attendants and gate agents were getting frustrated. Almost 6 hours delayed. Called American to received flight credit but can't get anywhere as Kayak reservation and don't have a ticket number. Reached out to Kayak but never heard back.

American flight was diverted and delayed but app didn’t show that information so I wasn’t able to change my connection until the last min.

Wifi was spotty. Tray table was very dirty when I sat down.

Very disappointing. Flight was delayed by 1.5 hours and food options are very underwhelming even for first class seats (same food given to economy seats)

Was not able to do a online check-in because the American Airlines system doesn't store our visa or other passport information, allowing us to have a trouble-free check-in. We were forced to have to check-in at the counter which Changes are upgrade status given that we were not able to check in much earlier.

Everything you need to know for your flight from Louisville to Panama

Information on your arrival and departure airports