$228 Find Cheap Flights from Medford to San Luis Obispo - Compare and Save

Two cabin classes are available on flights from Medford to San Luis Obispo:

• Economy Class
• First Class

A nonstop flight from Medford to San Luis Obispo takes 00m, covering 507 miles.

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

Round-trip flights from Medford to San Luis Obispo range from $277 to $554, with an average of $438 over the past 12 months. Anything below $277 counts as a good deal.

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $455 to $2,595. That means the highest observed fare was about 6x higher than the lowest one.

One-way fares from Medford to San Luis Obispo are currently higher than usual. Average one-way flight prices are about $345, which is 19% above the typical average for this route.

San Luis Obispo County Airport (SBP) hosts 5 major car rental companies, with daily rates starting from around $31 for economy cars. Top options include:

• Avis
• Enterprise Rent-A-Car
• Budget
• Hertz
• National

Flights from Medford to San Luis Obispo usually depart from Medford (MFR) and arrive at San Luis Obispo County (SBP).

One-stop flights from Medford to San Luis Obispo most commonly connect through:

• San Francisco (SFO) - 69% of one-stop connections
• Seattle/Tacoma Intl (SEA) - 15% of one-stop connections
• Portland (PDX) - 12% of one-stop connections
• Phoenix Sky Harbor Intl (PHX) - 4% of one-stop connections

Yes. Flexible dates can save you up to 50% on flights from Medford to San Luis Obispo. Tuesday is the cheapest departure day at $277 round-trip on average, while Monday is the most expensive at $554, a difference of $277.

KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

Flying via San Francisco (SFO) gives the shortest average 1-stop total travel time at 4h 04m, compared with 4h 37m via Portland (PDX) and 4h 38m via Seattle/Tacoma Intl (SEA).