$70 Find Cheap Flights from Myrtle Beach to Florida Keys

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to Florida Keys departing on 2/17. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Florida Keys

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Florida Keys, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Florida Keys, as well as popular online travel agencies
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Cheap Flights from Myrtle Beach to Florida Keys

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Miami
Miami1 stop$139
Key West
Key West1 stop$241
Miami
Miami1 stop$139
Key West
Key West1 stop$241

Book Cheap Myrtle Beach to Florida Keys Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to Florida Keys that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to Florida Keys

Wed, Feb 25 - Wed, Mar 4
Spirit Airlines Logo
10:09 am - 8:13 pm
MYR
-
MIA
10h 04m
1 stop
Spirit Airlines Logo
6:02 am - 8:39 pm
MIA
-
MYR
14h 37m
1 stop
$139Spirit Airlines
Tue, Feb 24 - Tue, Mar 3
Multiple Airlines Logo
10:09 am - 8:13 pm
MYR
-
MIA
10h 04m
1 stop
Multiple Airlines Logo
5:55 pm - 8:58 am
MIA
-
MYR
15h 03m
1 stop
$140Multiple Airlines
Tue, Feb 24 - Tue, Mar 3
Spirit Airlines Logo
10:09 am - 8:13 pm
MYR
-
MIA
10h 04m
1 stop
Spirit Airlines Logo
8:37 pm - 12:25 pm
MIA
-
MYR
15h 48m
1 stop
$142Spirit Airlines
Sat, Feb 7 - Sat, Feb 14
Spirit Airlines Logo
10:00 am - 8:13 pm
MYR
-
MIA
10h 13m
1 stop
Spirit Airlines Logo
1:24 pm - 11:57 pm
MIA
-
MYR
10h 33m
1 stop
$162Spirit Airlines
Sat, Feb 7 - Sat, Feb 14
Spirit Airlines Logo
10:00 am - 8:13 pm
MYR
-
MIA
10h 13m
1 stop
Spirit Airlines Logo
1:24 pm - 11:57 pm
MIA
-
MYR
10h 33m
1 stop
$163Spirit Airlines
Sat, Feb 7 - Sun, Feb 15
Spirit Airlines Logo
10:00 am - 8:13 pm
MYR
-
MIA
10h 13m
1 stop
Spirit Airlines Logo
1:24 pm - 11:57 pm
MIA
-
MYR
10h 33m
1 stop
$164Spirit Airlines
Sat, Feb 28 - Mon, Mar 2
Multiple Airlines Logo
11:54 am - 9:06 am
MYR
-
EYW
21h 12m
1 stop
Multiple Airlines Logo
2:25 pm - 8:13 am
EYW
-
MYR
17h 48m
1 stop
$245Multiple Airlines
Tue, Feb 24 - Tue, Mar 3
American Airlines Logo
6:54 am - 12:03 pm
MYR
-
EYW
5h 09m
1 stop
American Airlines Logo
1:55 pm - 10:56 pm
EYW
-
MYR
9h 01m
2 stops
$265American Airlines
Tue, Feb 24 - Tue, Mar 3
American Airlines Logo
6:01 am - 1:15 pm
MYR
-
EYW
7h 14m
2 stops
American Airlines Logo
1:55 pm - 10:56 pm
EYW
-
MYR
9h 01m
2 stops
$270American Airlines
Tue, Feb 24 - Tue, Mar 3
American Airlines Logo
5:40 pm - 10:22 pm
MYR
-
EYW
4h 42m
1 stop
American Airlines Logo
6:34 pm - 10:56 pm
EYW
-
MYR
4h 22m
1 stop
$285American Airlines
Booking Insights

KAYAK's insights & trends for Myrtle Beach to Florida Keys flights

Get data-powered insights and trends into flights from Myrtle Beach to Florida Keys to help you find the cheapest flights, the best time to fly and much more.

Can I save money by flying with a layover from Myrtle Beach to Florida Keys?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $273, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Myrtle Beach to Florida Keys?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Myrtle Beach to Florida Keys, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Myrtle Beach to Florida Keys is October, when tickets cost $291 (return) on average. On the other hand, the most expensive months are June and April, when the average cost of round-trip tickets is $406 and $396 respectively.

How far in advance should I book a flight from Myrtle Beach to Florida Keys?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Myrtle Beach to Florida Keys, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Myrtle Beach to Florida Keys, you should book around 1 week before departure. For the absolute cheapest price, our data suggests you should book 7 weeks before departure.

Good to know

Low seasonMay
Cheapest flight$70
Best time to beat the crowds with an average 14% drop in price.
Most popular time to fly with an average 12% increase in price.
Flight from Myrtle Beach to Miami

FAQs - booking Florida Keys flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to Florida Keys?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to Florida Keys.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to Florida Keys?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to Florida Keys is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to Florida Keys?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to Florida Keys with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to Florida Keys?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to Florida Keys up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Myrtle Beach to Florida Keys

 
See real verified KAYAK customer reviews for airlines flying from Myrtle Beach to Florida Keys. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Myrtle Beach to Florida Keys? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8122 reviews
7.2Food
8.1Boarding
7.8Entertainment
8.5Crew
7.9Comfort
Airline reviews

I've flown several other airlines, and Delta is really on top on things.

10.0 ExcellentBob, Jan 2026
SCL - MIA
Read more Delta reviews

I've flown several other airlines, and Delta is really on top on things.

The flight was delayed and oversold. I volunteered to give up my seat for compensation. Thinking I could get a good night's sleep instead of arriving home at 2 am. It took over an hour to get the new reservation confirmed, three different gate attendants, and two red coats. It took even longer to confirm the overnight hotel, and when I arrived, the line was 45 minutes long, with two people checking in, and at least 15 people slowly, very slowly—no food except frozen convenience food, no coupon for food from airlines. Slept, headed back to the airport, and that flight had an equipment change and a gate change just as they were about to board. It took an additional hour to board as they cleaned the plane from storage.

Comfort Plus seat 11E seemed smaller than prior flights. The movie selection is good. Watched most of the most recent Tron movie. I'll watch the remaining part later as my movie is saved in the Delta Seatback Experience.

Delta is a good airline. I've never had an issue with Delta. I'll continue to fly with them until they show me that I shouldn't.

Flight was operated by Virgin Atlantic and it was up to their usual high standard. Minor grips about some issues, but they are really first world issues and as a whole, was an excellent flight.

Original flight was cancelled and when i was rebooked by the airline, they couldn't seat me in the same type of seat as I had originally booked (went from window/aisle to middle/middle and one was a bulkhead seat, and other wasn't in the same class)

First, Delta needs more flights to/from Miami. Second, a 1000pm leaving at 1230pm is unacceptable from their biggest airport world hub. Another aircraft could have been used such as the aircraft scheduled to be used in the morning for that exact same route. Yes, I did get me there but the lack of sleep the next day didn't help me enjoy my entire trip since I was busy with activities during the weekend. This can be and is expected from Spirit (going bankrupt) and Frontier (despite they're nickel and dimers). But from Delta's World Hub? That's totally unacceptable!

Service in business class was not impressive. I ordered coffee with dinner and then watched other people get 2 refills before I got my 1 cup of coffee, and only after I pressed the attendant button overhead. Furthermore, the seats in the forward cabin need maintenance on this 737-800: the upholstery is detaching from the seat frame, at least on the backs of seats 1C, 1D.

I truly love flying with Delta. They have always treated me with the upmost respect

Our flight attendant in FIRST CLASS was one of the worst I’ve ever had. She was not at all pleasant, nor particularly good at her service.

It was a little concerning to hear the ground crew arguing with the flight crew over baggage space. Instead of taking them and checking them, they started checking for space in the first class cabin moving items around like the flight crew didn't know what they were doing. I was embarrassed for them.

On the plus side, crew was attentive, drinks were cold, and in-flight entertainment selection was better than some other airlines. On the negative aide, Plane was delayed almost an hour, either no announcements from the gate crew. Biscoff cookies are gross, appreciate airlines that give a choice. Also, crew had no personality or enthusiasm at all.

UGH I HAD TO MISS MY FIRST FLIGHT TO TAMPA CAUSE OF THE 10 MINUTE DELAY OF THE ORLANDO TO MIAMI ONE SO THEY HAD ME GET ANOTHER TICKET. I AM NOT HAPPY AT ALL BECAUSE IT MADE ME MISS MY CONNECTING FLIGHT FROM TAMPA TO LONDON AND FORCED ME TO MISS A DAY AT MY ROOM IN THE UK.

Wish they didnt delay off-boarding for 10 minutes so i could connect to my flight from miami to tampa

We experienced gate changes and a long delay. My seat was dirty when I boarded and I had to use wipes to clean it myself. There was an unpleasant and overpowering cleaning product scent on the plane as well that lingered through the flight.

I got sick nothing contagious but distressing and the care I received by Kayla? Keighly the flight attendant will be memorable for ever. Thank You

Waaay too small plane. They also need to up the size of the overhead bins. I would love to keep me 3k with of camera equipment in my hard case baggahe instead of it being thrown into the belly of the plane

Attendants were pleasant and the flight was smooth and relaxed.

It was fine. No drinks nor snacks offered though. I thought that was unusual.

Delays to take off and to leave the plane after landing added a lot of time to this flight.

Everything was OK, the deicing took a long time, our connections were almost missed.

Flight was cancelled. But kayak thought it was still on time.

Spirit was on time. They maintained updates and information. The crew was friendly and professional. Because this is a budget friendly airline, they have dispensed with a lot of frills and part of that comes with a price, for example, the seats are not quite as comfortable as others. I am ok with a pay for beverage and snack service as I prefer my own anyway so this was not a concern. I thought overall, having a great flight crew and on time service was definitely worth losing some of the frills from other carriers.

You can’t beat Spirit’s prices on tickets, especially with the positive experience that comes with it! I appreciated the timeliness of Spirit airlines. The crew in the airport was very kind and wished you a good flight by name. The crew on the flight was attentive and friendly. Overall, I am very pleased with my experience with Spirit.

This was my best experience with spirit. I flew you guys 4 times and I must say this was the BEST

I didn't have a flight because of a ticking problem that was discovered at the airport at checkin for the initial flight of the round trip.

Flight was delayed would have liked it to have been on time. I didn't experience the food or entertainment but the boarding process was smooth and the flight crew worked well together and did a great job!

Cheap, only one short delay. No issues despite bad weather. Able to take a big backpack for free.

I know Spirit gets a lot of criticism, but I've taken three flights recently and all were very good, and tremendous value. On my most recent one, they randomly assigned me to a very comfortable exit row seat! The flight was on time and the boarding process was smooth, and the crew was friendly. No complaints!

My experience with spirit was horrible I had to spend a extra $100 to check in my bag when I already purchased my ticket even when I got to my gate to get my seat the attendant didnt say anything until I was boarding the plane..also to make matters worst I been flying from Florida to New york and Florida to Atlanta often this was my 4th trip to Atlanta with the same bag and never had this problem till yesterday so im extremely upset and I wasnt even giving a reason for the change the attendant just gave a attitude and wouldn't answer me at all

Everything you need to know for your flight to Florida Keys

Information on your arrival and departure airports