$79 Find Cheap Flights from Myrtle Beach to Florida Keys

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to Florida Keys departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Florida Keys

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Florida Keys, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to Florida Keys, as well as popular online travel agencies
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Cheap Flights from Myrtle Beach to Florida Keys

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Miami
Miami1 stop$158
Key West
Key West1 stop$229
Miami
Miami1 stop$158
Key West
Key West1 stop$229

Book Cheap Myrtle Beach to Florida Keys Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to Florida Keys that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to Florida Keys

Wed, Jan 7 - Wed, Jan 14
Spirit Airlines Logo
6:00 am - 5:54 pm
MYR
-
MIA
11h 54m1 stop
Spirit Airlines Logo
12:56 pm - 9:04 pm
MIA
-
MYR
8h 08m1 stop
$158Spirit Airlines
Sat, Jan 10 - Fri, Jan 16
Spirit Airlines Logo
10:00 am - 8:13 pm
MYR
-
MIA
10h 13m1 stop
Spirit Airlines Logo
11:38 am - 2:42 pm
MIA
-
MYR
27h 04m1 stop
$162Spirit Airlines
Sat, Jan 17 - Tue, Jan 20
Multiple Airlines Logo
10:00 am - 8:13 pm
MYR
-
MIA
10h 13m1 stop
Multiple Airlines Logo
4:52 pm - 2:42 pm
MIA
-
MYR
21h 50m1 stop
$168Multiple Airlines
Thu, Feb 26 - Mon, Mar 2
Multiple Airlines Logo
10:02 am - 1:14 am
MYR
-
MIA
15h 12m1 stop
Multiple Airlines Logo
4:01 pm - 2:44 pm
MIA
-
MYR
22h 43m1 stop
$170Multiple Airlines
Sun, Jan 18 - Tue, Jan 20
Spirit Airlines Logo
9:59 pm - 2:21 pm
MYR
-
MIA
16h 22m1 stop
Spirit Airlines Logo
12:56 pm - 9:04 pm
MIA
-
MYR
8h 08m1 stop
$171Spirit Airlines
Fri, Jan 16 - Tue, Jan 27
Spirit Airlines Logo
3:39 pm - 9:05 pm
MYR
-
MIA
29h 26m1 stop
Spirit Airlines Logo
12:56 pm - 9:04 pm
MIA
-
MYR
8h 08m1 stop
$174Spirit Airlines
Fri, Jan 23 - Tue, Jan 27
Delta Logo
2:19 pm - 7:40 pm
MYR
-
EYW
5h 21m1 stop
Delta Logo
6:06 pm - 11:41 pm
EYW
-
MYR
5h 35m1 stop
$229Delta
Fri, Jan 23 - Tue, Jan 27
American Airlines Logo
5:29 pm - 9:47 pm
MYR
-
EYW
4h 18m1 stop
American Airlines Logo
12:00 pm - 8:54 pm
EYW
-
MYR
8h 54m2 stops
$234American Airlines
Fri, Jan 23 - Tue, Jan 27
American Airlines Logo
1:53 pm - 11:56 pm
MYR
-
EYW
10h 03m2 stops
American Airlines Logo
6:06 am - 1:23 pm
EYW
-
MYR
7h 17m2 stops
$239American Airlines
Fri, Jan 23 - Tue, Jan 27
Delta Logo
2:19 pm - 7:40 pm
MYR
-
EYW
5h 21m1 stop
Delta Logo
6:06 pm - 11:41 pm
EYW
-
MYR
5h 35m1 stop
$249Delta
Booking Insights

KAYAK's insights & trends for Myrtle Beach to Florida Keys flights

Get data-powered insights and trends into flights from Myrtle Beach to Florida Keys to help you find the cheapest flights, the best time to fly and much more.

Can I save money by flying with a layover from Myrtle Beach to Florida Keys?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $287, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Myrtle Beach to Florida Keys?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Myrtle Beach to Florida Keys, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Myrtle Beach to Florida Keys is October, when tickets cost $291 (return) on average. On the other hand, the most expensive months are April and June, when the average cost of round-trip tickets is $422 and $406 respectively.

What’s the cheapest day of the week to fly from Myrtle Beach to Florida Keys?

The average price of all round-trip flights from Myrtle Beach to Florida Keys clicked on KAYAK for each day over the last 12 months.

When flying from Myrtle Beach to Florida Keys, you should consider leaving on a Monday and avoid Fridays if you are looking for the best rates. For your return to Myrtle Beach, you’ll find the best rates on Mondays and the most expensive ones on Tuesdays.

How far in advance should I book a flight from Myrtle Beach to Florida Keys?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Myrtle Beach to Florida Keys, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Myrtle Beach to Florida Keys, you should book around 1 week before departure. For the absolute cheapest price, our data suggests you should book 16 weeks before departure.

Good to know

Low seasonOctober
Cheapest flight$79
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly with an average 12% increase in price.
Flight from Myrtle Beach to Miami

FAQs - booking Florida Keys flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to Florida Keys?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to Florida Keys.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to Florida Keys?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to Florida Keys is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to Florida Keys?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to Florida Keys with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to Florida Keys?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to Florida Keys up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Florida Keys?

    The cheapest time of day to fly to Florida Keys is generally in the afternoon, when round-trip flights cost $194 on average. Morning departures are around 26% cheaper than evening flights, on average. The most expensive time of day to fly to Florida Keys is generally in the evening, which is peak travel time and where the average cost of a ticket is $357.

Reviews of the top 3 airlines serving from Myrtle Beach to Florida Keys

 
See real verified KAYAK customer reviews for airlines flying from Myrtle Beach to Florida Keys. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Myrtle Beach to Florida Keys? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8007 reviews
7.9Entertainment
8.1Boarding
7.3Food
7.9Comfort
8.5Crew
Airline reviews

Lady Pilot was perfect in every way wheels up to wheels down communication, professionalism, excellent on time departure and on time arrival, excellent communication! Fantastic job with Superb attitude!!

10.0 ExcellentVenkata Krishna, Dec 2025
ATL - SDF
Read more Delta reviews

Lady Pilot was perfect in every way wheels up to wheels down communication, professionalism, excellent on time departure and on time arrival, excellent communication! Fantastic job with Superb attitude!!

First, Delta needs more flights to/from Miami. Second, a 1000pm leaving at 1230pm is unacceptable from their biggest airport world hub. Another aircraft could have been used such as the aircraft scheduled to be used in the morning for that exact same route. Yes, I did get me there but the lack of sleep the next day didn't help me enjoy my entire trip since I was busy with activities during the weekend. This can be and is expected from Spirit (going bankrupt) and Frontier (despite they're nickel and dimers). But from Delta's World Hub? That's totally unacceptable!

Service in business class was not impressive. I ordered coffee with dinner and then watched other people get 2 refills before I got my 1 cup of coffee, and only after I pressed the attendant button overhead. Furthermore, the seats in the forward cabin need maintenance on this 737-800: the upholstery is detaching from the seat frame, at least on the backs of seats 1C, 1D.

I truly love flying with Delta. They have always treated me with the upmost respect

Our flight attendant in FIRST CLASS was one of the worst I’ve ever had. She was not at all pleasant, nor particularly good at her service.

They ended up paying for the bag twice, but the counter wouldn't take my baggage receipt. Left it to me to resolve. Not sure how to resolve the issue.

The flight was an hour and a half late departing which was inconvenient

The flight was great. The gate location was way to far away!!!

The flight attendant in first class was beyond rude and didn't care at all about her job. AND the gate agent was even worse than the flight attendant for rudeness. She was awful.

Movie selection was meh. Food was great. Crew as always great. I paid for premium because that’s the only way not to feel like a sardine. That’s how economy should be imo. Sadly passengers have to pay an extra $1000 to get what they should at base price but that’s all airlines. The airline industry in general treats passengers as cargo.

I got sick nothing contagious but distressing and the care I received by Kayla? Keighly the flight attendant will be memorable for ever. Thank You

Waaay too small plane. They also need to up the size of the overhead bins. I would love to keep me 3k with of camera equipment in my hard case baggahe instead of it being thrown into the belly of the plane

Attendants were pleasant and the flight was smooth and relaxed.

It was fine. No drinks nor snacks offered though. I thought that was unusual.

Delays to take off and to leave the plane after landing added a lot of time to this flight.

It was a red eye flight, so no meals were provided, but it was fine with snacks. The seats felt cramped and almost too narrow.

We didn't take off until an hour after we boarded.

Wish they had the seat-back video screens for watching movies or playing games.

Very good but wish they had the seat-back video screens for movies & games

Flight was delayed not sure why no explanation given and no apologies either. Otherwise the flight was fine

I love a flight without turbulence and you guys deliver It’d be nice to have comfier seats and maybe some inflight entertainment and snacks but that’s for Delta

Terrible Airline I will never fly that airline again. Shame on you for recommending them.

I hope you continue to be one of the great company

I stopped flying spirit as much because they are crooks and thieves. It's not like other airlines where you can at least get credits they just take your money.

The pilot would speak it was painfully load a d the crew had to know this! Maybe the were hesitant to tell him. It was just a mediocre experience and I was in Spirit first class!

My flight was cancelled last minute and I had to pay $1600 for flights, when my original flights were $300. It was a terrible experience.

Excessive fees for flight delays. What a Scam. I was not able to attend the wedding I needed to go.

It was terrible, we had to board and unboard the flight with a hour delay that caused me to miss an appointment and a surprise for my wife

Great! I intend to use Spirit for future flights. No complaints .

They cancelled the flight 3 hours prior departure. Had to spend $400 for a ne way flight with Delta Airlines! Spirit Airlines are not serios!

Everything you need to know for your flight to Florida Keys

Information on your arrival and departure airports