$205 Find Cheap Flights from Myrtle Beach to Panama

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to Panama departing on 2/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Book Cheap Myrtle Beach to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to Panama

Thu, Feb 5 - Thu, Mar 5
American Airlines Logo
5:44 pm - 3:38 pm
MYR
-
PTY
21h 54m2 stops
American Airlines Logo
4:05 pm - 11:49 am
PTY
-
MYR
19h 44m2 stops
$460American Airlines
Fri, Feb 20 - Mon, Mar 2
American Airlines Logo
6:25 pm - 1:50 pm
MYR
-
PTY
19h 25m2 stops
American Airlines Logo
4:05 pm - 10:44 am
PTY
-
MYR
18h 39m2 stops
$480American Airlines
Sun, Feb 1 - Sun, Feb 8
American Airlines Logo
7:19 pm - 1:27 pm
MYR
-
PTY
18h 08m2 stops
American Airlines Logo
4:50 pm - 11:44 am
PTY
-
MYR
18h 54m2 stops
$505American Airlines
Thu, Mar 19 - Thu, Mar 26
American Airlines Logo
5:18 pm - 12:22 pm
MYR
-
PTY
20h 04m2 stops
American Airlines Logo
1:44 pm - 10:01 am
PTY
-
MYR
19h 17m2 stops
$510American Airlines
Fri, Feb 20 - Mon, Mar 2
American Airlines Logo
5:11 am - 3:15 pm
MYR
-
PTY
10h 04m2 stops
American Airlines Logo
4:05 pm - 9:35 am
PTY
-
MYR
17h 30m2 stops
$530American Airlines
Sun, Feb 1 - Sun, Feb 8
Multiple Airlines Logo
8:15 pm - 8:19 pm
MYR
-
PTY
24h 04m1 stop
Multiple Airlines Logo
5:50 pm - 7:20 pm
PTY
-
MYR
25h 30m2 stops
$687Multiple Airlines
Sun, Feb 1 - Sun, Feb 8
Multiple Airlines Logo
3:39 pm - 12:40 am
MYR
-
PTY
33h 01m3 stops
Multiple Airlines Logo
9:45 am - 7:20 pm
PTY
-
MYR
33h 35m2 stops
$733Multiple Airlines
Fri, Feb 20 - Mon, Mar 2
Multiple Airlines Logo
9:58 am - 12:40 am
MYR
-
PTY
14h 42m2 stops
Multiple Airlines Logo
12:03 pm - 8:13 am
PTY
-
MYR
20h 10m1 stop
$775Multiple Airlines
Thu, Feb 5 - Thu, Mar 5
Delta Logo
6:00 am - 1:55 pm
MYR
-
PTY
7h 55m1 stop
Delta Logo
3:20 pm - 11:57 pm
PTY
-
MYR
8h 37m1 stop
$794Delta
Sun, Feb 1 - Sat, Feb 7
Multiple Airlines Logo
3:39 pm - 12:40 am
MYR
-
PTY
33h 01m3 stops
Multiple Airlines Logo
2:55 am - 7:20 pm
PTY
-
MYR
16h 25m3 stops
$799Multiple Airlines
Booking Insights

KAYAK's insights & trends for Myrtle Beach to Panama flights

Get data-powered insights and trends into flights from Myrtle Beach to Panama to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Myrtle Beach to Panama?

The average price of all round-trip flights from Myrtle Beach to Panama clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Panama on a Wednesday, as we generally find the cheapest rates on that day for this route. On the other hand, Thursday is the most expensive day to fly from Myrtle Beach to Panama. For your return ticket, we recommend flying on a Monday and avoiding Wednesdays for the best deals.

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Good to know

Cheapest flight$205
Flight from Myrtle Beach to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Panama?

    The cheapest time of day to fly to Panama is generally in the morning, when round-trip flights cost $572 on average. The most expensive time of day to fly to Panama is generally in the morning, which is peak travel time and where the average cost of a ticket is $572.

Reviews of the top airline flying from Myrtle Beach to Panama

 
Need help choosing which airline to fly with from Myrtle Beach to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11057 reviews
6.9Entertainment
6.5Food
8.0Crew
7.5Boarding
7.2Comfort
Airline reviews

Not great. Booked Extra seats and got nothing extra at all. It’s basically a big budget airline.

4.0 OkayAnonymous, Dec 2025
LAX - AKL
Read more American Airlines reviews

Not great. Booked Extra seats and got nothing extra at all. It’s basically a big budget airline.

The pilot greased the landing and the crew was fantastic.

I bought wifi and most of the flight could not even use it my apps would just spin. I couldn't even listen to music. super frustrating.

delayed due to weather. Could not communicate with family since the wifi was broken

Experience was good, however I had a delay due to weather happening and had to re purchase a seat on a new plane for a higher price (could be my own issue and misunderstanding) but other than that situation. First time flyer (by myself) was terrific!! The last from ORD to ALO didn't have wifi, but it was only 45 minutes so I'm sure that was part of the reason. Overall my experience was great! Next time I will remember to buy tickets with longer layovers. The delays really saved my overall anxiety. :)

Flight was delayed 17 hours due to aircraft issues. American did provide hotel, transportation and meals, 3 hours past boarding time, but it took us another hour to get the vouchers.

Flight was on time is the only good thing. Person loading the plane called 1-6 to board at the same time, made it chaotic. Plane was too small for even putting backpacks in overhead. Seat for normal sized people were too small. The WIFI didn't work. When we landed had to wait because not enough ground crew.

Did not understand a single word the attendant said on the pa system. I was glad it was not an emergency.

Flight was late and boarding was confusing because gate changed and I didn’t get a notification

Gate was overcrowded. Gate agents performed very well. Flight crew was top notch! Efficient & professional & courteous. Both meals not thermalized well. Dinner main dish was actually cold in the center. Almost inedible. Breakfast sandwich was lukewarm.

Everything you need to know for your flight from Myrtle Beach to Panama

Information on your arrival and departure airports

Myrtle Beach (MYR)