$440 Find Cheap Flights from Myrtle Beach to Panama

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to Panama departing on 3/19. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Book Cheap Myrtle Beach to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to Panama

Thu, Mar 19 - Thu, Mar 26
American Airlines Logo
6:40 pm - 12:10 pmMYR-PTY
18h 30m2 stops
American Airlines Logo
1:50 pm - 9:52 amPTY-MYR
19h 02m2 stops
$440American Airlines
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Tue, Jan 13 - Sat, Jan 17
American Airlines Logo
5:44 pm - 1:27 pmMYR-PTY
19h 43m2 stops
American Airlines Logo
2:27 pm - 9:48 amPTY-MYR
19h 21m2 stops
$500American Airlines
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Tue, Nov 18 - Wed, Feb 25
American Airlines Logo
5:46 pm - 1:49 pmMYR-PTY
20h 03m2 stops
American Airlines Logo
2:52 pm - 11:44 amPTY-MYR
20h 52m2 stops
$520American Airlines
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Tue, Nov 18 - Wed, Feb 25
Delta Logo
6:00 am - 2:12 pmMYR-PTY
8h 12m1 stop
Delta Logo
3:27 pm - 11:58 pmPTY-MYR
8h 31m1 stop
$618Delta
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Tue, Nov 18 - Wed, Feb 25
Multiple Airlines Logo
9:22 am - 8:50 amMYR-PTY
23h 28m3 stops
Multiple Airlines Logo
3:50 pm - 2:34 pmPTY-MYR
22h 44m2 stops
$667Multiple Airlines
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Tue, Nov 18 - Wed, Feb 25
Multiple Airlines Logo
9:22 am - 8:50 amMYR-PTY
23h 28m3 stops
Multiple Airlines Logo
9:45 am - 2:34 pmPTY-MYR
28h 49m3 stops
$679Multiple Airlines
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Tue, Nov 18 - Tue, Feb 24
Multiple Airlines Logo
9:22 am - 12:40 amMYR-PTY
39h 18m3 stops
Multiple Airlines Logo
2:55 am - 8:51 pmPTY-MYR
17h 56m3 stops
$779Multiple Airlines
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Thu, Mar 19 - Thu, Mar 26
Delta Logo
6:00 am - 12:55 pmMYR-PTY
7h 55m1 stop
Delta Logo
2:20 pm - 11:35 pmPTY-MYR
8h 15m1 stop
$791Delta
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Fri, Dec 19 - Fri, Dec 26
Delta Logo
10:32 am - 7:59 pmMYR-PTY
9h 27m1 stop
Delta Logo
8:00 am - 6:14 pmPTY-MYR
10h 14m1 stop
$962Delta
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Fri, Dec 19 - Fri, Dec 26
American Airlines Logo
5:11 am - 1:53 pmMYR-PTY
8h 42m2 stops
American Airlines Logo
2:53 pm - 9:20 amPTY-MYR
18h 27m2 stops
$976American Airlines
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Booking Insights

KAYAK's insights & trends for Myrtle Beach to Panama flights

Get data-powered insights and trends into flights from Myrtle Beach to Panama to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Myrtle Beach to Panama?

The average price of all round-trip flights from Myrtle Beach to Panama clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Panama on a Wednesday, as we generally find the cheapest rates on that day for this route. On the other hand, Thursday is the most expensive day to fly from Myrtle Beach to Panama. For your return ticket, we recommend flying on a Monday and avoiding Wednesdays for the best deals.

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Good to know

Cheapest flight$440
Flight from Myrtle Beach to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Panama?

    The cheapest time of day to fly to Panama is generally in the morning, when round-trip flights cost $572 on average. The most expensive time of day to fly to Panama is generally in the morning, which is peak travel time and where the average cost of a ticket is $572.

Reviews of the top airline flying from Myrtle Beach to Panama

 
Need help choosing which airline to fly with from Myrtle Beach to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11042 reviews
7.2Comfort
6.9Entertainment
7.5Boarding
8.0Crew
6.4Food
Airline reviews

We loved the steward on the plane. He made the night enjoyable

10.0 Excellentchloe, Nov 2025ORD - ATW
Read more American Airlines reviews

We loved the steward on the plane. He made the night enjoyable

I enjoyed the extra leg room compared to other airlines. The first stewards made my daughter’s birthday special by giving her an extra snack. Then the last one coming home from Chicago to Appleton made our night really enjoyable Thanks for making our trip enjoyable

The flight was smooth, the pilot kept us informed about delays and we arrived more of less on time

Flight delay was communicated before leaving for airport which caused it to be a non-event. Great flight and crew!

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish some foods provided rather than just biscuit/cookie for flight more than 2 hours

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

The flight attendant, a black woman with curly hair who sat near Row 21, was wonderful and kind.

It was good..clean, comfy seat. Friendly warm welcoming crew. Was able to check my cabin luggage at the gate which I was able to pickup in a decent time from baggage claim. The app gave all updates from delays to baggage claim info. Overall smooth flight.

Flight was delayed leaving Dallas. Arrived about 2 hours later than scheduled.

Everything you need to know for your flight from Myrtle Beach to Panama

Information on your arrival and departure airports

Myrtle Beach (MYR)