$480 Find Cheap Flights from Myrtle Beach to Panama

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to Panama departing on 3/19. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Book Cheap Myrtle Beach to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to Panama

Thu, Mar 19 - Thu, Mar 26
American Airlines Logo
6:35 pm - 2:22 pm
MYR
-
PTY
20h 47m2 stops
American Airlines Logo
1:44 pm - 10:01 am
PTY
-
MYR
19h 17m2 stops
$480American Airlines
Sun, Mar 1 - Sun, Mar 8
American Airlines Logo
7:56 pm - 3:15 pm
MYR
-
PTY
19h 19m2 stops
American Airlines Logo
3:13 pm - 2:21 pm
PTY
-
MYR
22h 08m2 stops
$501American Airlines
Sun, Jan 25 - Sun, Feb 1
American Airlines Logo
7:19 pm - 1:27 pm
MYR
-
PTY
18h 08m2 stops
American Airlines Logo
2:27 pm - 11:35 am
PTY
-
MYR
21h 08m2 stops
$505American Airlines
Fri, Feb 20 - Mon, Mar 2
American Airlines Logo
7:56 pm - 1:50 pm
MYR
-
PTY
17h 54m2 stops
American Airlines Logo
4:05 pm - 11:49 am
PTY
-
MYR
19h 44m2 stops
$520American Airlines
Fri, Feb 20 - Sun, Mar 1
American Airlines Logo
7:56 pm - 1:50 pm
MYR
-
PTY
17h 54m2 stops
American Airlines Logo
4:05 pm - 2:28 pm
PTY
-
MYR
22h 23m2 stops
$542American Airlines
Sat, Jun 6 - Thu, Jun 11
American Airlines Logo
6:17 pm - 12:25 pm
MYR
-
PTY
19h 08m2 stops
American Airlines Logo
1:50 pm - 1:56 pm
PTY
-
MYR
23h 06m2 stops
$580American Airlines
Wed, Dec 24 - Tue, Dec 30
American Airlines Logo
2:34 pm - 1:53 pm
MYR
-
PTY
23h 19m2 stops
American Airlines Logo
4:55 pm - 9:20 am
PTY
-
MYR
16h 25m2 stops
$609American Airlines
Sun, Jan 25 - Sat, Jan 31
Multiple Airlines Logo
8:15 pm - 8:19 pm
MYR
-
PTY
24h 04m1 stop
Multiple Airlines Logo
2:55 am - 7:20 pm
PTY
-
MYR
16h 25m2 stops
$693Multiple Airlines
Wed, Dec 24 - Tue, Dec 30
Delta Logo
11:09 am - 8:00 pm
MYR
-
PTY
8h 51m1 stop
Delta Logo
8:00 am - 10:50 pm
PTY
-
MYR
14h 50m1 stop
$720Delta
Sun, Jan 25 - Sun, Feb 1
Multiple Airlines Logo
10:00 am - 2:00 pm
MYR
-
PTY
28h 00m3 stops
Multiple Airlines Logo
2:55 pm - 7:20 pm
PTY
-
MYR
28h 25m2 stops
$721Multiple Airlines
Booking Insights

KAYAK's insights & trends for Myrtle Beach to Panama flights

Get data-powered insights and trends into flights from Myrtle Beach to Panama to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Myrtle Beach to Panama?

The average price of all round-trip flights from Myrtle Beach to Panama clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Panama on a Wednesday, as we generally find the cheapest rates on that day for this route. On the other hand, Thursday is the most expensive day to fly from Myrtle Beach to Panama. For your return ticket, we recommend flying on a Monday and avoiding Wednesdays for the best deals.

Good to know

Cheapest flight$480
Flight from Myrtle Beach to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Panama?

    The cheapest time of day to fly to Panama is generally in the morning, when round-trip flights cost $572 on average. The most expensive time of day to fly to Panama is generally in the morning, which is peak travel time and where the average cost of a ticket is $572.

Reviews of the top airline flying from Myrtle Beach to Panama

 
Need help choosing which airline to fly with from Myrtle Beach to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11052 reviews
7.5Boarding
6.9Entertainment
7.2Comfort
8.0Crew
6.5Food
Airline reviews

The boarding was as always, the crew tried their best but not enough. The food was a disaster I had dietary restrictions that were half met because the company did not loaded the food for the flight. The entertainment screen was fine but content was not and also they removed the free messaging option from the flight and they charged 30 dollars for that crappy bandwidth. This flight is not worth the cost and the company is going down on quality.

6.0 GoodAndres, Dec 2025
PDX - DFW
Read more American Airlines reviews

The boarding was as always, the crew tried their best but not enough. The food was a disaster I had dietary restrictions that were half met because the company did not loaded the food for the flight. The entertainment screen was fine but content was not and also they removed the free messaging option from the flight and they charged 30 dollars for that crappy bandwidth. This flight is not worth the cost and the company is going down on quality.

Not comparable to Qatar Airways services on flights to Doha. Flight attendants provided basic services; I was never recognized by name or as an Executive Platinum member. Restrooms were not kept clean during the flight.

Awful. They won’t help me with anything. I booked on American but they abdicated to Iberia. The ticket was overpriced. Everything negative

it was fine, decent flight... dont get food besides cookies or pretzels so not sure why you ask about food. same for entertainment..

I got sick nothing contagious but distressing and the care I received by Kayla? Keighly the flight attendant will be memorable for ever. Thank You

I got sick nothing contagious but distressing enough and the care I received on the flight was astounding.

Waaay too small plane. They also need to up the size of the overhead bins. I would love to keep me 3k with of camera equipment in my hard case baggahe instead of it being thrown into the belly of the plane

Attendants were pleasant and the flight was smooth and relaxed.

A little late at the start but all worked out well.

It was fine. No drinks nor snacks offered though. I thought that was unusual.

Everything you need to know for your flight from Myrtle Beach to Panama

Information on your arrival and departure airports