$480 Find Cheap Flights from Myrtle Beach to Panama

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to Panama departing on 4/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Book Cheap Myrtle Beach to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to Panama

Thu, Mar 19 - Thu, Mar 26
American Airlines Logo
6:35 pm - 2:22 pm
MYR
-
PTY
20h 47m2 stops
American Airlines Logo
3:13 pm - 11:39 am
PTY
-
MYR
19h 26m2 stops
$480American Airlines
Mon, Jan 19 - Mon, Jan 26
Multiple Airlines Logo
10:00 am - 2:00 pm
MYR
-
PTY
28h 00m3 stops
Multiple Airlines Logo
7:50 pm - 2:42 pm
PTY
-
MYR
18h 52m2 stops
$677Multiple Airlines
Mon, Jan 19 - Mon, Jan 26
Multiple Airlines Logo
10:00 am - 2:00 pm
MYR
-
PTY
28h 00m3 stops
Multiple Airlines Logo
9:45 am - 2:42 pm
PTY
-
MYR
28h 57m3 stops
$688Multiple Airlines
Mon, Jan 19 - Sun, Jan 25
Multiple Airlines Logo
8:15 pm - 8:19 pm
MYR
-
PTY
24h 04m1 stop
Multiple Airlines Logo
2:55 am - 7:20 pm
PTY
-
MYR
16h 25m2 stops
$692Multiple Airlines
Mon, Jan 19 - Mon, Jan 26
Delta Logo
6:00 am - 1:55 pm
MYR
-
PTY
7h 55m1 stop
Delta Logo
3:20 pm - 11:41 pm
PTY
-
MYR
8h 21m1 stop
$794Delta
Thu, Mar 19 - Thu, Mar 26
Delta Logo
6:00 am - 12:55 pm
MYR
-
PTY
7h 55m1 stop
Delta Logo
2:20 pm - 11:59 pm
PTY
-
MYR
8h 39m1 stop
$868Delta
Booking Insights

KAYAK's insights & trends for Myrtle Beach to Panama flights

Get data-powered insights and trends into flights from Myrtle Beach to Panama to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Myrtle Beach to Panama?

The average price of all round-trip flights from Myrtle Beach to Panama clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Panama on a Wednesday, as we generally find the cheapest rates on that day for this route. On the other hand, Thursday is the most expensive day to fly from Myrtle Beach to Panama. For your return ticket, we recommend flying on a Monday and avoiding Wednesdays for the best deals.

Good to know

Cheapest flight$225
Flight from Myrtle Beach to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Myrtle Beach to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Myrtle Beach to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Myrtle Beach to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Myrtle Beach to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Panama?

    The cheapest time of day to fly to Panama is generally in the morning, when round-trip flights cost $572 on average. The most expensive time of day to fly to Panama is generally in the morning, which is peak travel time and where the average cost of a ticket is $572.

Reviews of the top airline flying from Myrtle Beach to Panama

 
Need help choosing which airline to fly with from Myrtle Beach to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11046 reviews
6.5Food
8.0Crew
7.2Comfort
6.9Entertainment
7.5Boarding
Airline reviews

Waaay too small plane. They also need to up the size of the overhead bins. I would love to keep me 3k with of camera equipment in my hard case baggahe instead of it being thrown into the belly of the plane

2.0 MediocreJeremy, Dec 2025
CLT - GNV
Read more American Airlines reviews

Waaay too small plane. They also need to up the size of the overhead bins. I would love to keep me 3k with of camera equipment in my hard case baggahe instead of it being thrown into the belly of the plane

Attendants were pleasant and the flight was smooth and relaxed.

A little late at the start but all worked out well.

It was fine. No drinks nor snacks offered though. I thought that was unusual.

I liked the humor of the captain and crew on the flight from Flagstaff to Dallas. They were humorous.

AA delayed the flight for 3 hours and 50 minutes, but delayed the last 2 hours, 30 minutes at a time, so if we knew before, could have stayed at home and worked instead of being at the airport wasting time... The plane's crew was excellent, not their fault.

After arriving in Dallas, the aircraft taxied for an unusually long time and was unable to park at the gate, which caused a significant delay and made me miss my connecting flight. I then had to wait in a very long line to be rebooked, and I was told that no hotel or meal accommodations would be provided. What is even more unacceptable is that my luggage was mishandled and has still not been located. My suitcase contains important medications that I urgently need, and I have been unable to access them due to the airline’s mishandling. This situation has caused me considerable stress and inconvenience, and I need this issue to be resolved immediately.

RIC Staff was not enough. Elderly passengers had to wait 30 minutes to deplane, so we could board and still had to walk as no chairs were provided. And, passenger in front of my seat assignment rammed seat against my legs entire flight time. Was mildly bruised and left thigh still sore.

Liked that it was on time. Staff professional and friendly.

Things were delayed a little. But that didn’t affect my plans. It was fine. I was surprised it was so full thanksgiving day. The crew were friendly and professional.

Everything you need to know for your flight from Myrtle Beach to Panama

Information on your arrival and departure airports