$103 Find Cheap Flights from Panama City to Missouri

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Missouri departing on 3/6. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Missouri

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Missouri, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Missouri, as well as popular online travel agencies
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Cheap Flights from Panama City to Missouri

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
St. Louis
St. Louis1 stop$205
Kansas City
Kansas City1 stop$267
Springfield
Springfield1 stop$269
St. Louis
St. Louis1 stop$205
Kansas City
Kansas City1 stop$267
Springfield
Springfield1 stop$269

Book Cheap Panama City to Missouri Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Missouri that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Missouri

Sat, Mar 7 - Wed, Mar 11
United Airlines Logo
10:24 am - 5:44 pm
ECP
-
STL
7h 20m
1 stop
United Airlines Logo
5:00 am - 9:43 am
STL
-
ECP
4h 43m
1 stop
$205United Airlines
Thu, May 7 - Mon, May 11
United Airlines Logo
2:14 pm - 9:08 pm
ECP
-
STL
6h 54m
1 stop
United Airlines Logo
7:45 am - 1:12 pm
STL
-
ECP
5h 27m
1 stop
$243United Airlines
Thu, Apr 9 - Sun, Apr 12
United Airlines Logo
4:57 pm - 10:28 pm
ECP
-
STL
5h 31m
1 stop
United Airlines Logo
7:45 am - 1:23 pm
STL
-
ECP
5h 38m
1 stop
$248United Airlines
Tue, Jun 2 - Tue, Jun 9
Southwest Logo
7:55 am - 2:10 pm
ECP
-
MCI
6h 15m
1 stop
Southwest Logo
2:30 pm - 7:40 pm
MCI
-
ECP
5h 10m
1 stop
$267Southwest
Tue, Jul 21 - Mon, Jul 27
Delta Logo
1:30 pm - 6:10 pm
ECP
-
SGF
4h 40m
1 stop
Delta Logo
6:45 pm - 10:46 pm
SGF
-
ECP
4h 01m
1 stop
$269Delta
Tue, Jun 2 - Tue, Jun 9
Southwest Logo
7:15 am - 2:35 pm
ECP
-
MCI
7h 20m
2 stops
Southwest Logo
2:30 pm - 7:40 pm
MCI
-
ECP
5h 10m
1 stop
$272Southwest
Sat, Mar 14 - Sat, Mar 21
United Airlines Logo
10:24 am - 5:22 pm
ECP
-
MCI
6h 58m
1 stop
United Airlines Logo
6:05 am - 12:04 pm
MCI
-
ECP
5h 59m
1 stop
$275United Airlines
Fri, Apr 3 - Sun, Apr 5
Delta Logo
6:43 pm - 11:58 pm
ECP
-
STL
5h 15m
1 stop
Delta Logo
6:59 pm - 11:04 pm
STL
-
ECP
4h 05m
1 stop
$289Delta
Tue, Mar 24 - Wed, Mar 25
American Airlines Logo
3:38 pm - 11:22 pm
ECP
-
STL
7h 44m
1 stop
American Airlines Logo
2:29 pm - 11:49 pm
STL
-
ECP
9h 20m
2 stops
$294American Airlines
Sat, Mar 7 - Wed, Mar 11
American Airlines Logo
3:37 pm - 11:22 pm
ECP
-
STL
7h 45m
1 stop
American Airlines Logo
2:29 pm - 11:49 pm
STL
-
ECP
9h 20m
2 stops
$296American Airlines
Booking Insights

KAYAK's insights & trends for Panama City to Missouri flights

Get data-powered insights and trends into flights from Panama City to Missouri to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest Panama City to Missouri flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to Missouri from Panama City found in the last 72 hours was to St. Louis, at $278 round-trip. The most popular route is from Panama City (ECP) to St. Louis (STL), and the cheapest round-trip airline ticket found on this route in the last 72 hours was $278.

Can I save money by flying with a layover from Panama City to Missouri?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $348 on average.

What is the cheapest month to fly from Panama City to Missouri?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to Missouri, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to Missouri is October, when tickets cost $198 (return) on average. On the other hand, the most expensive months are February and April, when the average cost of round-trip tickets is $763 and $499 respectively.

Good to know

Low seasonDecember
Cheapest flight$103
Best time to beat the crowds with an average 7% drop in price.
Most popular time to fly with an average 5% increase in price.
Flight from Panama City to St. Louis

FAQs - booking Missouri flights

  • How does KAYAK find such low prices on flights from Panama City to Missouri?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Missouri.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Missouri?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to Missouri is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Missouri?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to Missouri with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Missouri?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to Missouri up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to Missouri

  • Looking for a cheap flight? 25% of our users found tickets from Panama City to the following destinations at these prices or less: St. Louis $196 one-way - $363 round-trip

Reviews of the top 3 airlines serving from Panama City to Missouri

 
See real verified KAYAK customer reviews for airlines flying from Panama City to Missouri. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4300 reviews
8.6Crew
8.0Comfort
8.1Boarding
7.0Food
7.5Entertainment
Airline reviews

I have not flown Southwest in awhile and had a very pleasant experience. From ticketing to boarding to the flight. The flight left on time and landed ahead of schedule. It won't be so long next time!!

10.0 ExcellentTy&Steph, Feb 2026
CLT - STL
Read more Southwest reviews

I have not flown Southwest in awhile and had a very pleasant experience. From ticketing to boarding to the flight. The flight left on time and landed ahead of schedule. It won't be so long next time!!

An entire day of delays. Cost lots of money. Meals and a hotel.

I appreciate the staff who allowed me to board though I arrived a little late! Regarding the assigned seating, I had booked my flight before this change and wasn't aware of the change at the time, and so I didn't select a seat at booking as I didn't realize it was relevant. Better communication about the change would have been helpful for preparing.

Everything went smoothly and we even arrived a little bit early.

Departure was delayed more than 1/2 hour while we waited for luggage (only) transfer from another flight/plane. Once approved for takeoff, the flight was excellent.

Flight was on time. Wi-fi was a little spotty/slow. Boarding and exit were efficient.

Boarded on time but once we were ready for take off, the crew determined that, although every seat was taken, somehow someone was on the wrong flight. Delay, delay delay, announcements and ended up with one person checking EVERY ID against their passenger Manifest only to figure out it was a "clerical error." We departed 54 minutes late causing me to run in the St. Louis Airport to make my connection and lose the priority boarding spot I had paid for. Unnecessary delay.

Flight was delayed due to plane not passing inspection And one of the crew had to time out and we had to wait for another one A 3 hour delay

Near 4 hour flight with only 1 service. Had to use call button to request water. Internet and power not working until into flight. Internet would stop working during flight.

Southwest's seats are the least comfortable I have ever sat in.

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Totally worth the miles to upgrade to Delta Comfort. Plenty of legroom.

This was my first time flying Delta ever and I had a great experience!

We departed early and made up time in the air allowing us to arrive 30 minutes early. Capt was incredibly genuine and thanked every passenger for flying with Delta. Completely humble and professional!

The flight was great as well as the airline staff

Comfort seating was on the tight side. Maybe it was a smaller plane(?)

Excellent flight and got us around tough weather. Only issue was seat TV did not work and crew tried to reboot.

Connection through Atlanta was difficult. Mechanical issue on plane caused a two hour delay. New gate was a mile away.

No WiFi. Comfort plus should have alcohol provided, crew only offered water or tea. Who the heck wants tea?

I have diamond medallion status and usually we are in comfort plus . We were in main this time ( which was fine ) and my husband wanted wine . I have at least 10 vouchers for drinks that are good for this year and next! The attendant would not take the picture of the voucher as proof and never came back to check as She asked me to pull it up on delta Wi-Fi. Instead my husband just used his Amex to buy the wine . Disappointing!!!

Everything was good. Flight was very full so crew was busy. After we boarded and plane pulled away from the gate, we were delayed about 40 minutes- sitting on the runway - due to weather en route or at the destination. While weather is not the fault of the airline- it’s terrible to sit on a plane and not moving.

The smell from the bathroom kept wafting through the cabin. It made people sick.

Boarding delayed 20 minutes for no reason, no wifi, in flight entertainment, or snacks / waters?

Waited for oxygen tanks for 30 minutes after boarding was complete.

Awful. Original flight was delayed 5 hours. Had to to take a connecting flight instead of direct. Had a 4 hour layover. I missed all of my morning meetings getting in 5 hours later than I was supposed to and had to change to take a later flight the next day to get them back in which cia time another $150.

On time on a day with lots of weather cancellations on other flights. Thank you for getting me home during a winter storm!

Don't change gate multiple times make people run across the airport. Announce delays in a timely manner. Have maintenance crew ready. Don't delay and keep passengers on the plane for 3 hrs. on tarmac.

The attendants were kind and helpful. A sugar-free drink would have been very welcome.

This flight captain and crew were amazing, started ahead of time of departure and reached 30 mins before arrival time. Amazing!

Little warm on the plane and delayed for an hour

Everything you need to know for your flight from Panama City to Missouri

Information on your arrival and departure airports