ECP - STL

$122 Find Cheap Flights from Panama City to St. Louis - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 9/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$362
Typical prices: $194-$345
Southwest
Wed 8/5Tue 8/11
ECP - STL • 1 stop
Cheapest non-stop
$403
Southwest
Sun 8/2Wed 8/5
ECP - STL • Non-stop
Top airlines
Cheapest • from $362 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
You can fly direct with Southwest. Average duration is 1h 48m
Direct flights
Direct flights
+1
+1
Direct flights
Direct flights
+1
Top layover airports
Cheapest • Avg $326 (round-trip)
Shortest trip • 3h 45m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 25% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
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We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to St. Louis (ECP-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Wed, Aug 5 - Tue, Aug 11
Southwest Logo
9:10 am - 2:25 pm
ECP
-
STL
5h 15m
1 stop
Southwest Logo
1:55 pm - 3:40 pm
STL
-
ECP
1h 45mnonstop
$362Southwest
Wed, Aug 5 - Tue, Aug 11
Southwest Logo
11:30 am - 4:45 pm
ECP
-
STL
5h 15m
1 stop
Southwest Logo
2:45 pm - 6:10 pm
STL
-
ECP
3h 25m
1 stop
$366Southwest
Wed, Aug 5 - Tue, Aug 11
Southwest Logo
11:30 am - 4:45 pm
ECP
-
STL
5h 15m
1 stop
Southwest Logo
12:50 pm - 6:10 pm
STL
-
ECP
5h 20m
2 stops
$371Southwest
Wed, Aug 5 - Tue, Aug 11
Southwest Logo
9:10 am - 4:45 pm
ECP
-
STL
7h 35m
2 stops
Southwest Logo
12:45 pm - 8:30 pm
STL
-
ECP
7h 45m
2 stops
$377Southwest
Thu, Sep 17 - Sun, Sep 20
American Airlines Logo
8:29 am - 1:03 pm
ECP
-
STL
4h 34m
1 stop
American Airlines Logo
7:00 am - 12:47 pm
STL
-
ECP
5h 47m
1 stop
$397American Airlines
Sun, Aug 2 - Wed, Aug 5
Southwest Logo
7:20 am - 9:10 am
ECP
-
STL
1h 50mnonstop
Southwest Logo
1:55 pm - 3:40 pm
STL
-
ECP
1h 45mnonstop
$403Southwest
Sun, Aug 2 - Wed, Aug 5
Southwest Logo
1:05 pm - 11:15 pm
ECP
-
STL
10h 10m
2 stops
Southwest Logo
1:55 pm - 3:40 pm
STL
-
ECP
1h 45mnonstop
$408Southwest
Sun, Aug 2 - Wed, Aug 5
Southwest Logo
1:05 pm - 11:15 pm
ECP
-
STL
10h 10m
2 stops
Southwest Logo
2:45 pm - 6:10 pm
STL
-
ECP
3h 25m
1 stop
$418Southwest
Thu, Sep 17 - Sun, Sep 20
American Airlines Logo
8:29 am - 1:03 pm
ECP
-
STL
4h 34m
1 stop
American Airlines Logo
5:00 am - 1:56 pm
STL
-
ECP
8h 56m
2 stops
$423American Airlines
Wed, Aug 5 - Tue, Aug 11
Southwest Logo
9:10 am - 2:25 pm
ECP
-
STL
5h 15m
1 stop
Southwest Logo
1:55 pm - 3:40 pm
STL
-
ECP
1h 45mnonstop
$445Southwest
Booking Insights

KAYAK's insights & trends for Panama City to St. Louis flights

Get data-powered insights and trends into flights from Panama City to St. Louis to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to St. Louis is August, where tickets cost $249 (return) on average. On the other hand, the most expensive months are June and January, where the average cost of round-trip tickets is $444 and $403 respectively.

Can I save money by flying with a layover from Panama City to St. Louis?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $316 on average.

Good to know

Low seasonDecember
Cheapest flight$122
Best time to beat the crowds with an average 22% drop in price.
Most popular time to fly and prices are also 9% lower on average.
Flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to St. Louis

  • What is the cheapest flight from Panama City to St. Louis?

    In the last 5 days, the lowest price for a flight from Panama City to St. Louis was $122 for a one-way ticket and $362 for a round-trip.

  • Do I need a passport to fly between Panama City and St. Louis?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which airports will I be using when flying from Panama City to St. Louis?

    When flying out of Panama City you will be using Panama City NW Florida Beaches. You will be landing at St. Louis, also known as Lambert-St Louis.

  • Which airlines offer Wi-Fi service onboard planes from Panama City to St. Louis?

    American Airlines, and Delta offer inflight Wi-Fi service on the Panama City to St. Louis flight route.

  • Which aircraft models fly most regularly from Panama City to St. Louis?

    The Boeing 737 MAX 8 is the aircraft model that flies most regularly on the Panama City to St. Louis flight route.

  • Which airline alliances offer flights from Panama City to St. Louis?

    SkyTeam is the only airline alliance operating flights between Panama City and St. Louis.

  • On which days can I fly direct from Panama City to St. Louis?

    There are nonstop flights from Panama City to St. Louis on a daily basis.

  • Which is the best airline for flights from Panama City to St. Louis, Southwest or Delta?

    The two airlines most popular with KAYAK users for flights from Panama City to St. Louis are Southwest and Delta. With an average price for the route of $345 and an overall rating of 7.9, Southwest is the most popular choice. Delta is also a great choice for the route, with an average price of $350 and an overall rating of 7.8.

  • How does KAYAK find such low prices on flights from Panama City to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Panama City with another airline. Booking your flights between Panama City and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Panama City to St. Louis

  • Looking for a cheap flight? 25% of our users found flights on this route for $231 or less one-way and $376 or less round-trip.

Prefer to fly direct from Panama City to St. Louis?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Panama City NW Florida Beaches to Lambert-St Louis.
Find which airlines fly direct from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport, which days they fly and book direct flights.

Direct departures

Panama City NW Florida Beaches to Lambert-St Louis

Monday

Southwest

Southwest

Tuesday

Southwest

Southwest

Wednesday

Southwest

Southwest

Thursday

Southwest

Southwest

Friday

Southwest

Southwest

Saturday

Southwest

Southwest

Sunday

Southwest

Southwest

See more direct flights

Direct returns

Lambert-St Louis to Panama City NW Florida Beaches

Monday

Southwest

Southwest

Tuesday

Southwest

Southwest

Wednesday

Southwest

Southwest

Thursday

Southwest

Southwest

Friday

Southwest

Southwest

Saturday

Southwest

Southwest

Sunday

Southwest

Southwest

See more direct flights

Reviews of the top airlines flying from Panama City to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Panama City to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4249 reviews
8.0Comfort
8.1Boarding
7.5Entertainment
7.0Food
8.6Crew
Airline reviews

I have roller bag with food and medication told me I couldn't bring on my 2nd flight today. 15 years flying with SW never an issue with that bag.

2.0 MediocreStuart, Mar 2026
HOU - STL
Read more Southwest reviews

I have roller bag with food and medication told me I couldn't bring on my 2nd flight today. 15 years flying with SW never an issue with that bag.

I have not flown Southwest in awhile and had a very pleasant experience. From ticketing to boarding to the flight. The flight left on time and landed ahead of schedule. It won't be so long next time!!

Everything went smoothly and we even arrived a little bit early.

Boarded on time but once we were ready for take off, the crew determined that, although every seat was taken, somehow someone was on the wrong flight. Delay, delay delay, announcements and ended up with one person checking EVERY ID against their passenger Manifest only to figure out it was a "clerical error." We departed 54 minutes late causing me to run in the St. Louis Airport to make my connection and lose the priority boarding spot I had paid for. Unnecessary delay.

Southwest's seats are the least comfortable I have ever sat in.

For my birthday trip this was my second time ever flying, this trip was the best.

Crew was great flight was great baggage claim was a failure. It took over 1 hour for bags to arrive. Poor communication poor effort when I spoke to the supervisor about the delay

Everything was great except the food. The pretzels are really crappy.

Southwest is definitely the happiest airline to fly with. They are always kind and friendly with a sense of humor.

Noticed the width between seats seemed less. I wasn’t very comfortable. I’m of regular weight btw. We got graham cracker cookie snack, no choices. The bathrooms toilet roll was broken, and the light wouldn’t come on when I tried to close bathroom door.. I wasn’t sure it was locked?

I had only one problem. The temperature on the flight was too COLD. I froze throughout the flight. I thought it might be only my problem but when I went to the restroom during the flight, I saw several people huddling in their jackets. A couple had their winter coats on and I was jealous since I had only a very light jacket.

Five hour delays every hour, I wish it were all at once

Planes were clean, no water or snacks on either flight.

We departed early and made up time in the air allowing us to arrive 30 minutes early. Capt was incredibly genuine and thanked every passenger for flying with Delta. Completely humble and professional!

The boarding process needs to be refined. Sometimes the gate crew calls out the zones and then flip to showing the.zones boarding on the gate monitor display. So, unless you are huddled around the gate lanes watching the monitor, you could miss your boarding zone. Suggest the zones be announced each time a new zone is allowed to board.

This route with Delta always has delays or is cancelled. Aircrafts seem smaller and older. I fly Delta quite a bit - haven’t had issues with the international flights. But this route has always been the troublesome one

On 2 different flights the wifi was horrible and there was no drink or snack service.

There was no FREE wi-fi nor entertainment screens at all.

Great, on time departure, friendly and accommodating crew, great leg room, Smith flight

As we lined up to board they gave our plane to a flight going to Newark. So then we got delayed until they could find another plane. Flight crew was ok. I’m assuming since it’s a shorter flight they only offered water and coffee.

Everything you need to know for your flight from Panama City to St. Louis

Information on your arrival and departure airports