ECP - STL

$99 Find Cheap Flights from Panama City to St. Louis

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 4/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

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Everything you should know

Cheapest round-trip
$205
Overall average: $353
American Airlines
Thu 3/5Mon 3/9
ECP - STL • 1 stop
Cheapest non-stop
$279
Southwest
Tue 3/31Tue 4/7
ECP - STL • Non-stop
Top airlines
American Airlines
Cheapest • from $205 (round-trip)
Southwest
Best reviews • 8.0 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Every day
You can fly direct with Southwest. Average duration is 1h 55m
Direct flights
Direct flights
+1
+1
Direct flights
Direct flights
+1
Top layover airports
Atlanta (ATL)
Cheapest • Avg $373 (round-trip)
Atlanta (ATL)
Shortest trip • 4h 14m (one-way)
Insights
Insights
Insights
Insights
When to travel
October
Cheapest • 47% price drop
November
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to St. Louis (ECP-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Thu, Mar 5 - Mon, Mar 9
American Airlines Logo
7:19 am - 12:43 pm
ECP
-
STL
5h 24m
1 stop
American Airlines Logo
8:00 am - 12:44 pm
STL
-
ECP
4h 44m
1 stop
$205American Airlines
Thu, Mar 5 - Mon, Mar 9
United Airlines Logo
2:10 pm - 9:07 pm
ECP
-
STL
6h 57m
1 stop
United Airlines Logo
10:00 am - 9:57 pm
STL
-
ECP
11h 57m
2 stops
$210United Airlines
Tue, Mar 3 - Tue, Mar 10
United Airlines Logo
5:00 pm - 10:14 pm
ECP
-
STL
5h 14m
1 stop
United Airlines Logo
7:40 am - 1:14 pm
STL
-
ECP
5h 34m
1 stop
$241United Airlines
Thu, May 7 - Mon, May 11
United Airlines Logo
2:14 pm - 9:08 pm
ECP
-
STL
6h 54m
1 stop
United Airlines Logo
7:45 am - 1:12 pm
STL
-
ECP
5h 27m
1 stop
$243United Airlines
Tue, Mar 3 - Tue, Mar 10
United Airlines Logo
5:00 pm - 10:14 pm
ECP
-
STL
5h 14m
1 stop
United Airlines Logo
10:00 am - 9:57 pm
STL
-
ECP
11h 57m
2 stops
$246United Airlines
Thu, Apr 23 - Wed, May 6
United Airlines Logo
4:57 pm - 10:28 pm
ECP
-
STL
5h 31m
1 stop
United Airlines Logo
7:45 am - 1:18 pm
STL
-
ECP
5h 33m
1 stop
$247United Airlines
Thu, Apr 9 - Sun, Apr 12
United Airlines Logo
4:57 pm - 10:28 pm
ECP
-
STL
5h 31m
1 stop
United Airlines Logo
7:45 am - 1:23 pm
STL
-
ECP
5h 38m
1 stop
$248United Airlines
Tue, Mar 3 - Tue, Mar 10
American Airlines Logo
2:00 pm - 11:04 pm
ECP
-
STL
9h 04m
2 stops
American Airlines Logo
11:41 am - 10:17 pm
STL
-
ECP
10h 36m
2 stops
$252American Airlines
Wed, Mar 25 - Wed, Apr 1
American Airlines Logo
7:19 am - 12:43 pm
ECP
-
STL
5h 24m
1 stop
American Airlines Logo
6:57 pm - 11:49 pm
STL
-
ECP
4h 52m
1 stop
$264American Airlines
Wed, Mar 25 - Wed, Apr 1
American Airlines Logo
7:19 am - 3:35 pm
ECP
-
STL
8h 16m
2 stops
American Airlines Logo
6:57 pm - 11:49 pm
STL
-
ECP
4h 52m
1 stop
$269American Airlines
Booking Insights

KAYAK's insights & trends for Panama City to St. Louis flights

Get data-powered insights and trends into flights from Panama City to St. Louis to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to St. Louis is October, where tickets cost $198 (return) on average. On the other hand, the most expensive months are February and April, where the average cost of round-trip tickets is $763 and $499 respectively.

Can I save money by flying with a layover from Panama City to St. Louis?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $287, prices are generally cheapest when you fly direct.

Good to know

Low seasonDecember
Cheapest flight$99
Best time to beat the crowds with an average 30% drop in price.
Most popular time to fly and prices are also 22% lower on average.
Flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to St. Louis

  • How many flights are there between Panama City and St. Louis per day?

    Each day, there are between 1 and 4 nonstop flights that take off from Panama City and land in St. Louis, with an average flight time of 1h 55m. The most common departure time is 9:00 am and most flights take off in the morning. Each week, there are 10 flights. The most frequent day of departure is Saturday, when 40% of all weekly flights depart. The fewest flights depart on a Thursday.

  • What is the cheapest flight from Panama City to St. Louis?

    In the last 3 days, the lowest price for a flight from Panama City to St. Louis was $99 for a one-way ticket and $205 for a round-trip.

  • Do I need a passport to fly between Panama City and St. Louis?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which airports will I be using when flying from Panama City to St. Louis?

    When flying out of Panama City you will be using Panama City NW Florida Beaches. You will be landing at St. Louis, also known as Lambert-St Louis.

  • Which airlines offer Wi-Fi service onboard planes from Panama City to St. Louis?

    American Airlines, and Delta offer inflight Wi-Fi service on the Panama City to St. Louis flight route.

  • Which aircraft models fly most regularly from Panama City to St. Louis?

    The Embraer 175 (Enhanced Winglets) is the aircraft model that flies most regularly on the Panama City to St. Louis flight route.

  • Which airline alliances offer flights from Panama City to St. Louis?

    SkyTeam is the only airline alliance operating flights between Panama City and St. Louis.

  • On which days can I fly direct from Panama City to St. Louis?

    There are nonstop flights from Panama City to St. Louis on a daily basis.

  • Which is the best airline for flights from Panama City to St. Louis, Southwest or Delta?

    The two airlines most popular with KAYAK users for flights from Panama City to St. Louis are Southwest and Delta. With an average price for the route of $378 and an overall rating of 8.0, Southwest is the most popular choice. Delta is also a great choice for the route, with an average price of $345 and an overall rating of 7.9.

  • How does KAYAK find such low prices on flights from Panama City to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Panama City with another airline. Booking your flights between Panama City and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Panama City to St. Louis

  • Looking for a cheap flight? 25% of our users found flights on this route for $205 or less one-way and $363 or less round-trip.

Prefer to fly direct from Panama City to St. Louis?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Panama City NW Florida Beaches to Lambert-St Louis.
Find which airlines fly direct from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport, which days they fly and book direct flights.

Direct departures

Panama City NW Florida Beaches to Lambert-St Louis

Monday

Southwest

Southwest

Tuesday

Southwest

Southwest

Wednesday

Southwest

Southwest

Thursday

Southwest

Southwest

Friday

Southwest

Southwest

Saturday

Southwest

Southwest

Sunday

Southwest

Southwest

See more direct flights

Direct returns

Lambert-St Louis to Panama City NW Florida Beaches

Monday

Southwest

Southwest

Tuesday

Southwest

Southwest

Wednesday

Southwest

Southwest

Thursday

Southwest

Southwest

Friday

Southwest

Southwest

Saturday

Southwest

Southwest

Sunday

Southwest

Southwest

See more direct flights

Reviews of the top airlines flying from Panama City to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Panama City to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4295 reviews
8.1Boarding
7.0Food
8.6Crew
7.5Entertainment
8.0Comfort
Airline reviews

Great plane, great attendants,great flight crew,on time. Wonderful flight home..

10.0 ExcellentAnonymous, Feb 2026
CUN - STL
Read more Southwest reviews

Great plane, great attendants,great flight crew,on time. Wonderful flight home..

I appreciate the staff who allowed me to board though I arrived a little late! Regarding the assigned seating, I had booked my flight before this change and wasn't aware of the change at the time, and so I didn't select a seat at booking as I didn't realize it was relevant. Better communication about the change would have been helpful for preparing.

Everything went smoothly and we even arrived a little bit early.

Departure was delayed more than 1/2 hour while we waited for luggage (only) transfer from another flight/plane. Once approved for takeoff, the flight was excellent.

Flight was on time. Wi-fi was a little spotty/slow. Boarding and exit were efficient.

Boarded on time but once we were ready for take off, the crew determined that, although every seat was taken, somehow someone was on the wrong flight. Delay, delay delay, announcements and ended up with one person checking EVERY ID against their passenger Manifest only to figure out it was a "clerical error." We departed 54 minutes late causing me to run in the St. Louis Airport to make my connection and lose the priority boarding spot I had paid for. Unnecessary delay.

Flight was delayed due to plane not passing inspection And one of the crew had to time out and we had to wait for another one A 3 hour delay

Near 4 hour flight with only 1 service. Had to use call button to request water. Internet and power not working until into flight. Internet would stop working during flight.

Southwest's seats are the least comfortable I have ever sat in.

My flight was delayed 50 minutes and we were rushed to board to then sit for 15 minutes until the pilot arrived. Unacceptable since we could have waited to board. Also the delayed flight was updated AFTER we boarded to more than the 10 minutes as originally stated.

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Totally worth the miles to upgrade to Delta Comfort. Plenty of legroom.

This was my first time flying Delta ever and I had a great experience!

We departed early and made up time in the air allowing us to arrive 30 minutes early. Capt was incredibly genuine and thanked every passenger for flying with Delta. Completely humble and professional!

The flight was great as well as the airline staff

Comfort seating was on the tight side. Maybe it was a smaller plane(?)

Excellent flight and got us around tough weather. Only issue was seat TV did not work and crew tried to reboot.

Connection through Atlanta was difficult. Mechanical issue on plane caused a two hour delay. New gate was a mile away.

No WiFi. Comfort plus should have alcohol provided, crew only offered water or tea. Who the heck wants tea?

I have diamond medallion status and usually we are in comfort plus . We were in main this time ( which was fine ) and my husband wanted wine . I have at least 10 vouchers for drinks that are good for this year and next! The attendant would not take the picture of the voucher as proof and never came back to check as She asked me to pull it up on delta Wi-Fi. Instead my husband just used his Amex to buy the wine . Disappointing!!!

Everything you need to know for your flight from Panama City to St. Louis

Information on your arrival and departure airports