ECP - STL

$96 Find Cheap Flights from Panama City to St. Louis

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 24% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Everything you should know

Cheapest round-trip
$289
Overall average: $504
Delta
Fri 1/23Mon 1/26
ECP - STL • 1 stop
Cheapest one-way
$96
Typical prices: $279-$305
American Airlines
Wed 2/18
ECP - STL • 1 stop
Top airlines
Delta
Cheapest • from $289 (round-trip)
Southwest
Best reviews • 8.0 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
October
Cheapest • 52% price drop
November
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Nonstop flights
1 day a week
There are direct flights from Panama City to St. Louis 1 day a week: Sat.
Direct flights
Direct flights
Direct flights
Direct flights
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to St. Louis (ECP-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Fri, Jan 23 - Mon, Jan 26
Delta Logo
9:24 am - 2:49 pmECP-STL
5h 25m1 stop
Delta Logo
6:00 am - 11:08 amSTL-ECP
5h 08m1 stop
$289Delta
Find Deal
Tue, Dec 16 - Tue, Dec 23
Southwest Logo
3:15 pm - 9:35 pmECP-STL
6h 20m1 stop
Southwest Logo
6:05 pm - 9:20 pmSTL-ECP
3h 15m1 stop
$293Southwest
Find Deal
Fri, Jan 23 - Sun, Jan 25
United Airlines Logo
4:54 pm - 10:00 pmECP-STL
5h 06m1 stop
United Airlines Logo
9:57 am - 9:59 pmSTL-ECP
12h 02m2 stops
$294United Airlines
Find Deal
Tue, Dec 16 - Tue, Dec 23
Southwest Logo
10:00 am - 5:25 pmECP-STL
7h 25m2 stops
Southwest Logo
6:05 pm - 9:20 pmSTL-ECP
3h 15m1 stop
$298Southwest
Find Deal
Fri, Jan 23 - Mon, Jan 26
American Airlines Logo
12:03 pm - 9:15 pmECP-STL
9h 12m2 stops
American Airlines Logo
6:00 am - 5:33 pmSTL-ECP
11h 33m2 stops
$299American Airlines
Find Deal
Fri, Dec 5 - Sun, Dec 7
Delta Logo
4:26 pm - 9:02 pmECP-STL
4h 36m1 stop
Delta Logo
7:02 pm - 11:06 pmSTL-ECP
4h 04m1 stop
$317Delta
Find Deal
Fri, Dec 5 - Sun, Dec 7
American Airlines Logo
8:30 am - 1:14 pmECP-STL
4h 44m1 stop
American Airlines Logo
5:15 am - 2:13 pmSTL-ECP
8h 58m2 stops
$322American Airlines
Find Deal
Fri, Jan 23 - Sun, Jan 25
United Airlines Logo
6:30 am - 5:43 pmECP-STL
11h 13m2 stops
United Airlines Logo
9:57 am - 9:59 pmSTL-ECP
12h 02m2 stops
$323United Airlines
Find Deal
Fri, Dec 5 - Sun, Dec 7
American Airlines Logo
12:08 pm - 8:38 pmECP-STL
8h 30m2 stops
American Airlines Logo
5:15 am - 2:13 pmSTL-ECP
8h 58m2 stops
$327American Airlines
Find Deal
Tue, Dec 2 - Sat, Dec 6
Delta Logo
5:00 pm - 9:57 pmECP-STL
4h 57m1 stop
Delta Logo
11:19 am - 3:52 pmSTL-ECP
4h 33m1 stop
$338Delta
Find Deal
Booking Insights

KAYAK's insights & trends for Panama City to St. Louis flights

Get data-powered insights and trends into flights from Panama City to St. Louis to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to St. Louis is October, where tickets cost $197 (return) on average. On the other hand, the most expensive months are February and January, where the average cost of round-trip tickets is $808 and $504 respectively.

Can I save money by flying with a layover from Panama City to St. Louis?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $274 on average.

Good to know

Low seasonJanuary
Cheapest flight$96
Best time to beat the crowds but there is an average 22% increase in price.
Most popular time to fly and prices are also 12% lower on average.
Flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to St. Louis

  • What is the cheapest flight from Panama City to St. Louis?

    In the last 3 days, the lowest price for a flight from Panama City to St. Louis was $96 for a one-way ticket and $289 for a round-trip.

  • Do I need a passport to fly between Panama City and St. Louis?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which airports will I be using when flying from Panama City to St. Louis?

    When flying out of Panama City you will be using Panama City NW Florida Beaches. You will be landing at St. Louis, also known as Lambert-St Louis.

  • Which airlines offer Wi-Fi service onboard planes from Panama City to St. Louis?

    American Airlines, and Delta offer inflight Wi-Fi service on the Panama City to St. Louis flight route.

  • Which aircraft models fly most regularly from Panama City to St. Louis?

    The Boeing 737-700 Passenger/BBJ1 (winglets) is the aircraft model that flies most regularly on the Panama City to St. Louis flight route.

  • Which airline alliances offer flights from Panama City to St. Louis?

    SkyTeam is the only airline alliance operating flights between Panama City and St. Louis.

  • On which days can I fly direct from Panama City to St. Louis?

    You can catch a nonstop flight from Panama City to St. Louis on on Saturday.

  • Which is the best airline for flights from Panama City to St. Louis, Southwest or Delta?

    The two airlines most popular with KAYAK users for flights from Panama City to St. Louis are Southwest and Delta. With an average price for the route of $405 and an overall rating of 8.0, Southwest is the most popular choice. Delta is also a great choice for the route, with an average price of $369 and an overall rating of 7.9.

  • How does KAYAK find such low prices on flights from Panama City to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Panama City with another airline. Booking your flights between Panama City and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Panama City to St. Louis

  • Looking for a cheap flight? 25% of our users found flights on this route for $214 or less one-way and $503 or less round-trip.

Prefer to fly direct from Panama City to St. Louis?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Panama City NW Florida Beaches to Lambert-St Louis.
Find which airlines fly direct from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport, which days they fly and book direct flights.

Direct departures

Panama City NW Florida Beaches to Lambert-St Louis

Saturday

Southwest

Southwest

See more direct flights

Direct returns

Lambert-St Louis to Panama City NW Florida Beaches

Saturday

Southwest

Southwest

See more direct flights

Reviews of the top airlines flying from Panama City to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Panama City to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4248 reviews
8.6Crew
7.0Food
8.1Boarding
8.0Comfort
7.5Entertainment
Airline reviews

Boarded on time but once we were ready for take off, the crew determined that, although every seat was taken, somehow someone was on the wrong flight. Delay, delay delay, announcements and ended up with one person checking EVERY ID against their passenger Manifest only to figure out it was a "clerical error." We departed 54 minutes late causing me to run in the St. Louis Airport to make my connection and lose the priority boarding spot I had paid for. Unnecessary delay.

2.0 MediocreThomas, Oct 2025SAT - STL
Read more Southwest reviews

Boarded on time but once we were ready for take off, the crew determined that, although every seat was taken, somehow someone was on the wrong flight. Delay, delay delay, announcements and ended up with one person checking EVERY ID against their passenger Manifest only to figure out it was a "clerical error." We departed 54 minutes late causing me to run in the St. Louis Airport to make my connection and lose the priority boarding spot I had paid for. Unnecessary delay.

Flight was delayed due to plane not passing inspection And one of the crew had to time out and we had to wait for another one A 3 hour delay

Near 4 hour flight with only 1 service. Had to use call button to request water. Internet and power not working until into flight. Internet would stop working during flight.

Southwest's seats are the least comfortable I have ever sat in.

My flight was delayed 50 minutes and we were rushed to board to then sit for 15 minutes until the pilot arrived. Unacceptable since we could have waited to board. Also the delayed flight was updated AFTER we boarded to more than the 10 minutes as originally stated.

If we are going to have to pay for luggage, make it easier to do. Put something on the app during check-in so I don't need to do it at the kiosk. I've done it twice recently and I ended up having to pay at the desk because something went wrong at the kiosk in Tampa.

It was one and half hour late... Not sure if any other experience matters.

For my birthday trip this was my second time ever flying, this trip was the best.

Everything was on time. I was disappointed by the front section female, African American flight attendant. I did not see her name tag or would have identified by name not race. As passengers moved to the bathroom early in flight, she would say with a disdainful tone “I have to say the seat belt light is on” then go back to her book. Better trained flight attendants say something like be careful the seat belt light is on.

Flight crew and cabin crew were great. I had to rearrange flights because my original flight was 3hrs delayed for weather, the rub is the flight I moved to boarded on time then we sat at the gate for 2 hours because scheduling stole our first officer for another flight, TWICE. Then our actual FO was an hour delayed. To make it worse my original flight went from a 3 hour delay to departing 15min EARLY. Just poor scheduling operations all around.

The ticket agents in West Palm Beach on Friday afternoon Nov. 7th were incredible in getting us on an earlier plane to Atlanta during the government shutdown. Had the taken our original flight we would have missed our connection. She did this on her own, We didn't even have to ask, and she did it all with a smile and showing genuine concern that we would be taken care of. We are very grateful and thankful. We fly often, and now we will be sure to fly Delta.

Non stop on long haul is the way to go. Great experience

The boarding process needs to be refined. Sometimes the gate crew calls out the zones and then flip to showing the.zones boarding on the gate monitor display. So, unless you are huddled around the gate lanes watching the monitor, you could miss your boarding zone. Suggest the zones be announced each time a new zone is allowed to board.

The boarding process needs to be refined. Sometimes the gate crew call out the boarding zone, and then flip to the monitor to show which zones are boarding. So unless everyone is gathered around to see the monitor there is usually confusion as wi which zones are boarding.

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

This route with Delta always has delays or is cancelled. Aircrafts seem smaller and older. I fly Delta quite a bit - haven’t had issues with the international flights. But this route has always been the troublesome one

For a 69 year old with health problems I had the worse experience, no wheelchair when I entered a lady told me to sit and wait while a gentleman told me I had to walk to the Delta station, which I did. I had a carry on and a bag, and I was traveling with my service dog, which was on his carrier and the lady charged me for my carry on luggage, beside all the waiting cause of the delay, I had to walk to get my luggage cause no wheelchair showed up, I am so disappointed. I will get in touch with the company. I got home at 3:00 am, not good for my health situation.

Flight was an hour late, who knows why. It was OK, nothing outstanding.

Excellent check-in. Crew was good. Excellent communication from flight deck.

Amazing flight! I have never noticed the uniforms of the attendants before in twenty years of flying except today when one female had the most amazing dress on. It was beautifully designed and showed she was in charge. I never dreamed I would google who designed Delta uniforms . The ultimate compliment is when another woman admires your outfit. . I hope your designer puts it on the market

Everything you need to know for your flight from Panama City to St. Louis

Information on your arrival and departure airports