$198 Find Cheap Flights from Panama City to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South Carolina departing on 6/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 24% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$337
Myrtle Beach
Myrtle Beach1 stop$341
Charlotte
Charlotte1 stop$277
Charleston
Charleston1 stop$337
Myrtle Beach
Myrtle Beach1 stop$341
Charlotte
Charlotte1 stop$277

Book Cheap Panama City to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South Carolina

Wed, Jul 29 - Wed, Aug 5
Delta Logo
7:50 am - 12:00 pm
ECP
-
CHS
3h 10m
1 stop
Delta Logo
6:45 pm - 9:40 pm
CHS
-
ECP
3h 55m
1 stop
$337Delta
Wed, Jul 1 - Thu, Jul 2
American Airlines Logo
4:16 pm - 9:46 pm
ECP
-
MYR
4h 30m
1 stop
American Airlines Logo
8:44 pm - 11:37 pm
MYR
-
ECP
3h 53m
1 stop
$341American Airlines
Wed, Jul 29 - Wed, Aug 5
American Airlines Logo
7:05 am - 6:51 pm
ECP
-
CHS
10h 46m
2 stops
American Airlines Logo
2:06 pm - 5:16 pm
CHS
-
ECP
4h 10m
1 stop
$342American Airlines
Mon, Jul 13 - Mon, Jul 13
Delta Logo
7:50 am - 1:00 pm
ECP
-
MYR
4h 10m
1 stop
Delta Logo
7:59 pm - 11:37 pm
MYR
-
ECP
4h 38m
1 stop
$347Delta
Fri, Aug 7 - Fri, Aug 14
Southwest Logo
7:05 am - 2:45 pm
ECP
-
MYR
6h 40m
1 stop
Southwest Logo
6:40 am - 4:35 pm
MYR
-
ECP
10h 55m
2 stops
$352Southwest
Fri, Aug 7 - Fri, Aug 14
Southwest Logo
6:00 am - 2:45 pm
ECP
-
MYR
7h 45m
2 stops
Southwest Logo
6:40 am - 4:35 pm
MYR
-
ECP
10h 55m
2 stops
$357Southwest
Tue, Jun 30 - Sun, Jul 5
Delta Logo
6:00 am - 10:14 am
ECP
-
CHS
3h 14m
1 stop
Delta Logo
6:24 pm - 8:47 pm
CHS
-
ECP
3h 23m
1 stop
$366Delta
Sat, Jul 11 - Sat, Jul 11
Southwest Logo
9:30 am - 3:50 pm
ECP
-
MYR
5h 20m
1 stop
Southwest Logo
7:15 pm - 10:00 pm
MYR
-
ECP
3h 45m
1 stop
$367Southwest
Tue, Oct 27 - Wed, Oct 28
United Airlines Logo
10:25 am - 11:19 pm
ECP
-
GSP
11h 54m
2 stops
United Airlines Logo
7:00 am - 2:17 pm
GSP
-
ECP
8h 17m
1 stop
$376United Airlines
Tue, Oct 27 - Wed, Oct 28
United Airlines Logo
3:10 pm - 9:46 pm
ECP
-
GSP
5h 36m
1 stop
United Airlines Logo
7:00 am - 2:17 pm
GSP
-
ECP
8h 17m
1 stop
$400United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to South Carolina flights

Get data-powered insights and trends into flights from Panama City to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to South Carolina is June, when tickets cost $0 (return) on average. On the other hand, the most expensive months are May and December, when the average cost of round-trip tickets is $636 and $533 respectively.

Find deals

Good to know

Low seasonJanuary
Cheapest flight$198
Best time to beat the crowds but there is an average 11% increase in price.
Most popular time to fly and prices are also 21% lower on average.
Flight from Panama City to Charleston

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Panama City to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Panama City to the following destinations at these prices or less: Charlotte $224 one-way - $391 round-trip

Reviews of the top airline flying from Panama City to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Panama City to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8419 reviews
8.5Crew
7.8Entertainment
8.1Boarding
7.2Food
7.8Comfort
Airline reviews

Clean planes and not take my comfort class seat away.

6.0 GoodAnonymous, May 2026
MCO - ATL
Read more Delta reviews

Clean planes and not take my comfort class seat away.

Weather caused a long delay, but the efficiency and updates from the pilot were helpful. We were able to make our connection fortunately.

Planes were clean, no water or snacks on either flight.

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

Aside from a completely packed plane, I really have no complaints.

Much better than Latam, the worse airline company ever. I hope I don't have the need to fly Latam ever in my life again.

Flight was delayed it was hot while sitting on the plane, one engine was working on the plane until they had to do some jimmy rigging down the runway in order for the other engine to charge up. It was ridiculous

The flight was very good and the staff was very friendly and helpful!

Landed without a gate ready. Plane is extremely old and dirty.

All the amenities was wonderful, if they could keep their prices that low. I'd fly with them all the time.

Everything you need to know for your flight from Panama City to South Carolina

Information on your arrival and departure airports

Panama City (ECP)