$170 Find Cheap Flights from Panama City to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South Carolina departing on 5/14. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Panama City to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$355
Myrtle Beach
Myrtle Beach1 stop$280
Charlotte
Charlotte1 stop$229
Charleston
Charleston1 stop$355
Myrtle Beach
Myrtle Beach1 stop$280
Charlotte
Charlotte1 stop$229

Book Cheap Panama City to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South Carolina

Mon, Mar 23 - Tue, Mar 31
Delta Logo
6:43 pm - 12:04 am
ECP
-
MYR
4h 21m
1 stop
Delta Logo
6:00 am - 8:40 am
MYR
-
ECP
3h 40m
1 stop
$280Delta
Thu, Jun 4 - Mon, Jun 8
Delta Logo
6:47 pm - 11:57 pm
ECP
-
MYR
4h 10m
1 stop
Delta Logo
7:50 pm - 10:46 pm
MYR
-
ECP
3h 56m
1 stop
$341Delta
Fri, Aug 21 - Sun, Aug 23
American Airlines Logo
7:06 pm - 11:57 pm
ECP
-
GSP
3h 51m
1 stop
American Airlines Logo
6:00 am - 9:38 am
GSP
-
ECP
4h 38m
1 stop
$347American Airlines
Thu, Jun 4 - Mon, Jun 8
Southwest Logo
7:50 am - 7:30 pm
ECP
-
MYR
10h 40m
2 stops
Southwest Logo
10:35 am - 2:15 pm
MYR
-
ECP
4h 40m
1 stop
$352Southwest
Thu, Mar 12 - Tue, Mar 24
Southwest Logo
7:20 am - 11:45 am
ECP
-
GSP
3h 25m
1 stop
Southwest Logo
6:20 am - 9:35 am
GSP
-
ECP
4h 15m
1 stop
$355Southwest
Fri, May 1 - Sun, May 3
Delta Logo
5:49 am - 9:55 am
ECP
-
CHS
3h 06m
1 stop
Delta Logo
6:25 am - 8:35 am
CHS
-
ECP
3h 10m
1 stop
$355Delta
Thu, Jun 4 - Mon, Jun 8
Southwest Logo
7:50 am - 7:30 pm
ECP
-
MYR
10h 40m
2 stops
Southwest Logo
7:25 am - 5:40 pm
MYR
-
ECP
11h 15m
2 stops
$357Southwest
Thu, Mar 12 - Tue, Mar 24
Southwest Logo
7:20 am - 11:45 am
ECP
-
GSP
3h 25m
1 stop
Southwest Logo
12:35 pm - 8:00 pm
GSP
-
ECP
8h 25m
2 stops
$360Southwest
Thu, Mar 12 - Tue, Mar 24
American Airlines Logo
1:20 pm - 11:42 pm
ECP
-
GSP
9h 22m
1 stop
American Airlines Logo
5:20 am - 9:36 am
GSP
-
ECP
5h 16m
1 stop
$369American Airlines
Fri, Aug 21 - Sun, Aug 23
United Airlines Logo
6:40 am - 3:18 pm
ECP
-
GSP
7h 38m
1 stop
United Airlines Logo
6:00 am - 1:09 pm
GSP
-
ECP
8h 09m
2 stops
$392United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to South Carolina flights

Get data-powered insights and trends into flights from Panama City to South Carolina to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Panama City to South Carolina?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Panama City to South Carolina were found on Delta ($341) and Southwest ($352).

Find deals

Good to know

Low seasonJanuary
Cheapest flight$170
Best time to beat the crowds but there is an average 26% increase in price.
Most popular time to fly and prices are also 31% lower on average.
Flight from Panama City to Myrtle Beach

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Panama City to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Panama City to the following destinations at these prices or less: Charlotte $209 one-way - $387 round-trip

Reviews of the top airline flying from Panama City to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Panama City to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8240 reviews
7.9Comfort
8.5Crew
7.8Entertainment
8.1Boarding
7.2Food
Airline reviews

The landing was the worst I’ve experienced with a flight.

2.0 MediocreTara, Feb 2026
ATL - CAE
Read more Delta reviews

The landing was the worst I’ve experienced with a flight.

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Totally worth the miles to upgrade to Delta Comfort. Plenty of legroom.

This was my first time flying Delta ever and I had a great experience!

The flight was great as well as the airline staff

Comfort seating was on the tight side. Maybe it was a smaller plane(?)

It was last minute due to weather - considering - it was amazing! Good smiles, friendly staff and they were making sure we knew what was going on when and where.

Excellent flight and got us around tough weather. Only issue was seat TV did not work and crew tried to reboot.

Connection through Atlanta was difficult. Mechanical issue on plane caused a two hour delay. New gate was a mile away.

No WiFi. Comfort plus should have alcohol provided, crew only offered water or tea. Who the heck wants tea?

Everything you need to know for your flight from Panama City to South Carolina

Information on your arrival and departure airports

Panama City (ECP)