$145 Find Cheap Flights from Panama City to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South Carolina departing on 2/28. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Panama City to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$355
Myrtle Beach
Myrtle Beach1 stop$289
Charlotte
Charlottenonstop$229
Charleston
Charleston1 stop$355
Myrtle Beach
Myrtle Beach1 stop$289
Charlotte
Charlottenonstop$229

Book Cheap Panama City to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South Carolina

Wed, Mar 4 - Wed, Mar 11
Delta Logo
12:10 pm - 6:37 pm
ECP
-
GSP
5h 27m
1 stop
Delta Logo
5:40 am - 10:20 am
GSP
-
ECP
5h 40m
1 stop
$289Delta
Thu, Apr 30 - Mon, May 4
Delta Logo
8:15 am - 3:03 pm
ECP
-
MYR
5h 48m
1 stop
Delta Logo
1:32 pm - 6:00 pm
MYR
-
ECP
5h 28m
1 stop
$289Delta
Wed, Feb 4 - Wed, Feb 11
American Airlines Logo
6:03 pm - 11:36 pm
ECP
-
GSP
4h 33m
1 stop
American Airlines Logo
7:03 am - 11:33 am
GSP
-
ECP
5h 30m
1 stop
$290American Airlines
Wed, Mar 4 - Wed, Mar 11
Southwest Logo
8:00 am - 7:50 pm
ECP
-
GSP
10h 50m
2 stops
Southwest Logo
6:20 am - 9:35 am
GSP
-
ECP
4h 15m
1 stop
$300Southwest
Wed, Mar 4 - Wed, Mar 11
Southwest Logo
8:00 am - 7:50 pm
ECP
-
GSP
10h 50m
2 stops
Southwest Logo
6:20 am - 1:10 pm
GSP
-
ECP
7h 50m
2 stops
$305Southwest
Wed, Apr 22 - Wed, Apr 29
Delta Logo
8:15 am - 12:46 pm
ECP
-
MYR
3h 31m
1 stop
Delta Logo
3:48 pm - 7:38 pm
MYR
-
ECP
4h 50m
1 stop
$309Delta
Sat, Feb 14 - Wed, Feb 18
United Airlines Logo
1:01 pm - 9:59 pm
ECP
-
GSP
7h 58m
1 stop
United Airlines Logo
6:50 am - 12:04 pm
GSP
-
ECP
6h 14m
1 stop
$349United Airlines
Wed, Feb 4 - Wed, Feb 11
Southwest Logo
8:00 am - 7:50 pm
ECP
-
GSP
10h 50m
2 stops
Southwest Logo
11:15 am - 6:10 pm
GSP
-
ECP
7h 55m
1 stop
$355Southwest
Sat, Feb 14 - Wed, Feb 18
United Airlines Logo
1:01 pm - 9:59 pm
ECP
-
GSP
7h 58m
1 stop
United Airlines Logo
6:50 am - 12:04 pm
GSP
-
ECP
6h 14m
1 stop
$362United Airlines
Wed, Mar 18 - Sun, Mar 22
American Airlines Logo
7:19 am - 2:27 pm
ECP
-
MYR
6h 08m
1 stop
American Airlines Logo
6:00 am - 10:06 am
MYR
-
ECP
5h 06m
1 stop
$388American Airlines
Booking Insights

KAYAK's insights & trends for Panama City to South Carolina flights

Get data-powered insights and trends into flights from Panama City to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to South Carolina is August, when tickets cost $266 (return) on average. On the other hand, the most expensive months are April and January, when the average cost of round-trip tickets is $587 and $515 respectively.

Good to know

Low seasonAugust
Best time to beat the crowds with an average 23% drop in price.
Most popular time to fly and prices are also 31% lower on average.

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Panama City to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Panama City to the following destinations at these prices or less: Charlotte $171 one-way - $361 round-trip

Reviews of the top airline flying from Panama City to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Panama City to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8032 reviews
7.9Comfort
7.8Entertainment
7.2Food
8.1Boarding
8.5Crew
Airline reviews

Food is basically Sun Chips, cookies or Cheezits. I had an exit row seat so I had plenty of room. The crew was very nice and efficient. Pilot kept us informed. Pretty good flight.

8.0 ExcellentG, Jan 2026
FLL - ATL
Read more Delta reviews

Food is basically Sun Chips, cookies or Cheezits. I had an exit row seat so I had plenty of room. The crew was very nice and efficient. Pilot kept us informed. Pretty good flight.

The only thing nice I can say is the flight crew was really nice and apologetic about the situation. They shared as much information as they had and advised us on what we could do about missing connecting flights. The boarding process was so slow. The gate agent was working by herself and should have had someone working with her. It took almost an hour to board because she was trying to board a full flight of people and provide customer service to everyone who was flying standby and/or had questions. It was really chaotic. This didn't help the fact that we were delayed and folks were missing connections the longer it took.

The food is terrible. The staff is wonderful. Comfort is good.

I fly Delta all the time, have Platinum Medallion status. But this route seems to have major problems with delays and seems to never leave on time! Have only taken it twice in the last two weeks, and each time it had delays of more than 1 hour... very disappointed!!!!

We had a lot of really rough weather but that was not Delta's fault. Pilot was amazing.

This flight was straightforward and without difficulty. Service was OK, but I continue to be underwhelmed by level of attention given to Sky Priority passengers.

The ticket agents in West Palm Beach on Friday afternoon Nov. 7th were incredible in getting us on an earlier plane to Atlanta during the government shutdown. Had the taken our original flight we would have missed our connection. She did this on her own, We didn't even have to ask, and she did it all with a smile and showing genuine concern that we would be taken care of. We are very grateful and thankful. We fly often, and now we will be sure to fly Delta.

Non stop on long haul is the way to go. Great experience

The boarding process needs to be refined. Sometimes the gate crew call out the boarding zone, and then flip to the monitor to show which zones are boarding. So unless everyone is gathered around to see the monitor there is usually confusion as wi which zones are boarding.

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

Everything you need to know for your flight from Panama City to South Carolina

Information on your arrival and departure airports