$164 Find Cheap Flights from Panama City to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South Carolina departing on 12/21. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Panama City to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$312
Myrtle Beach
Myrtle Beach1 stop$317
Charlotte
Charlottenonstop$230
Charleston
Charleston1 stop$312
Myrtle Beach
Myrtle Beach1 stop$317
Charlotte
Charlottenonstop$230

Book Cheap Panama City to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South Carolina

Fri, Oct 31 - Sat, Nov 8
Delta Logo
5:00 pm - 11:59 pmECP-CHS
5h 59m1 stop
Delta Logo
12:59 pm - 3:39 pmCHS-ECP
3h 40m1 stop
$312Delta
Find Deal
Tue, Mar 31 - Wed, Apr 1
Delta Logo
6:00 am - 1:29 pmECP-MYR
6h 29m1 stop
Delta Logo
6:00 am - 8:20 amMYR-ECP
3h 20m1 stop
$317Delta
Find Deal
Mon, Apr 6 - Fri, Apr 10
Delta Logo
7:05 pm - 11:39 pmECP-CHS
3h 34m1 stop
Delta Logo
5:30 am - 8:20 amCHS-ECP
3h 50m1 stop
$327Delta
Find Deal
Fri, Oct 31 - Sat, Nov 8
Southwest Logo
3:05 pm - 7:35 pmECP-CHS
3h 30m1 stop
Southwest Logo
8:00 am - 5:00 pmCHS-ECP
10h 00m2 stops
$334Southwest
Find Deal
Thu, Oct 30 - Tue, Nov 4
American Airlines Logo
3:41 pm - 8:47 pmECP-MYR
4h 06m1 stop
American Airlines Logo
7:41 pm - 11:15 pmMYR-ECP
4h 34m1 stop
$338American Airlines
Find Deal
Fri, Oct 31 - Sat, Nov 8
Southwest Logo
8:00 am - 5:00 pmECP-CHS
8h 00m2 stops
Southwest Logo
8:00 am - 5:00 pmCHS-ECP
10h 00m2 stops
$339Southwest
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Mon, Oct 27 - Fri, Oct 31
Delta Logo
6:00 am - 11:46 amECP-CHS
4h 46m1 stop
Delta Logo
5:35 am - 8:44 amCHS-ECP
4h 09m1 stop
$345Delta
Find Deal
Mon, Oct 27 - Fri, Oct 31
American Airlines Logo
2:40 pm - 11:59 pmECP-CHS
8h 19m2 stops
American Airlines Logo
10:21 am - 3:06 pmCHS-ECP
5h 45m1 stop
$350American Airlines
Find Deal
Mon, Oct 27 - Fri, Oct 31
United Airlines Logo
5:00 pm - 2:20 pmECP-GSP
20h 20m2 stops
United Airlines Logo
4:17 pm - 4:24 pmGSP-ECP
25h 07m2 stops
$818United Airlines
Find Deal
Mon, Apr 6 - Fri, Apr 10
United Airlines Logo
4:55 pm - 3:24 pmECP-CHS
21h 29m3 stops
United Airlines Logo
7:40 pm - 12:37 pmCHS-ECP
17h 57m2 stops
$1,002United Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Panama City to South Carolina flights

Get data-powered insights and trends into flights from Panama City to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to South Carolina is August, when tickets cost $266 (return) on average. On the other hand, the most expensive months are April and June, when the average cost of round-trip tickets is $587 and $457 respectively.

Good to know

Low seasonAugust
Cheapest flight$164
Best time to beat the crowds with an average 21% drop in price.
Most popular time to fly and prices are also 1% lower on average.
Flight from Panama City to Myrtle Beach

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Panama City to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Panama City to the following destinations at these prices or less: Charlotte $179 one-way - $315 round-trip

Reviews of the top airline flying from Panama City to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Panama City to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7971 reviews
8.5Crew
7.9Comfort
8.2Boarding
7.3Food
7.9Entertainment
Airline reviews

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

8.0 ExcellentOlaf, Sep 2025FLL - ATL
Read more Delta reviews

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

For a 69 year old with health problems I had the worse experience, no wheelchair when I entered a lady told me to sit and wait while a gentleman told me I had to walk to the Delta station, which I did. I had a carry on and a bag, and I was traveling with my service dog, which was on his carrier and the lady charged me for my carry on luggage, beside all the waiting cause of the delay, I had to walk to get my luggage cause no wheelchair showed up, I am so disappointed. I will get in touch with the company. I got home at 3:00 am, not good for my health situation.

Flight was an hour late, who knows why. It was OK, nothing outstanding.

Excellent check-in. Crew was good. Excellent communication from flight deck.

Amazing flight! I have never noticed the uniforms of the attendants before in twenty years of flying except today when one female had the most amazing dress on. It was beautifully designed and showed she was in charge. I never dreamed I would google who designed Delta uniforms . The ultimate compliment is when another woman admires your outfit. . I hope your designer puts it on the market

This had nothing to do with Delta… The flights were on time and flawless. The service was excellent. We purchased seats in (aisle/middle) comfort plus since this was a cross country flight. Unfortunately, the woman seated at the window was 300+ pounds and, as might be expected, covered up about a third of the middle seat also. there was absolutely nothing that Delta could have done about that… I just don’t know what the answer should be. If you purchase a seat, you should should be able to use the entire seat and not just the portion that someone else is not sitting/oozing in. Disappointing…there should be something that could be done….I'm just not sure what solution could be.

The worst part was I was NOT allowed in the lounge even though I was holding a first class ticket and have a premium American Express card. I have flown Business or First Class with many airlines. Delta is the ONLY one who does not extend this courtesy to anyone except people who hold the very expensive American Express card. As a result, I won’t fly Delta if I have any other choice.

The Dekta Rep that checked us in was great. She's very personable, pleasant, and can tell she enjoys her job.

The young man who was our flight attendant in first class was lazy and did not do his job well at all. Never offered drinks upon boarding - actually I take that back... said "are you okay with water" as if I do not want to get you anything else, only passed the snacks around once, got my drink order wrong and then never offered a second round of drinks. He was the worst I have ever seen on Delta and we fly a lot.

Flight left early and arrived early. the whole trip was excellent.

Everything you need to know for your flight from Panama City to South Carolina

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