$145 Find Cheap Flights from Panama City to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South Carolina departing on 6/6. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
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Cheap Flights from Panama City to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$311
Myrtle Beach
Myrtle Beach1 stop$287
Charlotte
Charlotte1 stop$287
Charleston
Charleston1 stop$311
Myrtle Beach
Myrtle Beach1 stop$287
Charlotte
Charlotte1 stop$287

Book Cheap Panama City to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South Carolina

Wed, May 6 - Wed, May 13
Delta Logo
5:10 pm - 12:14 am
ECP
-
MYR
6h 04m
1 stop
Delta Logo
6:00 am - 8:30 am
MYR
-
ECP
3h 30m
1 stop
$287Delta
Sat, May 9 - Sat, May 16
Southwest Logo
7:20 am - 12:10 pm
ECP
-
MYR
3h 50m
1 stop
Southwest Logo
10:35 am - 3:45 pm
MYR
-
ECP
6h 10m
1 stop
$289Southwest
Sat, May 9 - Sat, May 16
Southwest Logo
7:55 am - 1:45 pm
ECP
-
MYR
4h 50m
1 stop
Southwest Logo
10:35 am - 7:00 pm
MYR
-
ECP
9h 25m
2 stops
$294Southwest
Sat, May 9 - Sat, May 16
Southwest Logo
9:55 am - 8:45 pm
ECP
-
MYR
9h 50m
2 stops
Southwest Logo
11:50 am - 7:00 pm
MYR
-
ECP
8h 10m
2 stops
$299Southwest
Wed, May 13 - Wed, May 27
Southwest Logo
7:15 am - 12:10 pm
ECP
-
GSP
3h 55m
1 stop
Southwest Logo
8:20 am - 8:25 pm
GSP
-
ECP
13h 05m
2 stops
$302Southwest
Wed, May 6 - Wed, May 13
Delta Logo
5:10 pm - 12:14 am
ECP
-
MYR
6h 04m
1 stop
Delta Logo
6:00 am - 8:30 am
MYR
-
ECP
3h 30m
1 stop
$307Delta
Wed, May 13 - Wed, May 27
American Airlines Logo
4:40 pm - 11:57 pm
ECP
-
GSP
6h 17m
1 stop
American Airlines Logo
7:32 pm - 11:40 pm
GSP
-
ECP
5h 08m
1 stop
$332American Airlines
Tue, Apr 28 - Thu, Apr 30
American Airlines Logo
11:43 am - 6:49 pm
ECP
-
CHS
6h 06m
1 stop
American Airlines Logo
8:21 pm - 11:46 pm
CHS
-
ECP
4h 25m
1 stop
$348American Airlines
Tue, Jun 9 - Wed, Jun 10
United Airlines Logo
10:25 am - 5:00 pm
ECP
-
GSP
5h 35m
1 stop
United Airlines Logo
6:00 am - 1:21 pm
GSP
-
ECP
8h 21m
1 stop
$399United Airlines
Tue, Jun 9 - Wed, Jun 10
United Airlines Logo
10:25 am - 5:00 pm
ECP
-
GSP
5h 35m
1 stop
United Airlines Logo
6:00 am - 1:21 pm
GSP
-
ECP
8h 21m
1 stop
$402United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to South Carolina flights

Get data-powered insights and trends into flights from Panama City to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Panama City, Florida to South Carolina?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Panama City, Florida to South Carolina departing in April.

Good to know

Low seasonJanuary
Cheapest flight$145
Best time to beat the crowds but there is an average 7% increase in price.
Most popular time to fly and prices are also 23% lower on average.
Flight from Panama City to Myrtle Beach

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Panama City to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Panama City to the following destinations at these prices or less: Charlotte $261 one-way - $366 round-trip

Reviews of the top airlines flying from Panama City to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Panama City to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8399 reviews
7.8Entertainment
7.2Food
8.1Boarding
8.5Crew
7.9Comfort
Airline reviews

On the return flight, flight attendant Britt went out of her way to inform passengers that several of us had tight connections.

10.0 ExcellentAnonymous, Apr 2026
MIA - DTW
Read more Delta reviews

On the return flight, flight attendant Britt went out of her way to inform passengers that several of us had tight connections.

Too many people are taking up space in the overhead bins with their extra piece of luggage. Since they cannot fit their backpacks or extra luggage piece under the seat in front of them, they store it in the overheads and thus taking up room for other passengers. It wasn’t only one or two persons; more like 12 or 13 passengers.

I am still at the Airport! Delayed Delayed and Delyaed

Kayak botched up the booking, i had to call delta and fix. In the process Delta failed to honor my comfort plus seat assignment that i had previously.

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

Loved flying First Class. Very comfortable. The seat was amazing. Enjoyed a movie and was able to relax so much better than in coach.

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

An awesome flight crew. FC seat cushion just doesn’t cut it for a 3+ hour flight.

The landing was the worst I’ve experienced with a flight.

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Bag drop was very disorganized in Miami. All main cabin passengers were shunted to just a few lanes and they had an equal number of lanes for first class passengers but there was nobody on those lines. They did nothing to bring the main cab and passengers over to the open lines and they just had employees standing there and doing nothing

Crew at the gate was very crabby and not at all polite. The plane was very hot the entire flight. And the seat cushion was very worn out.

I have never been assaulted they way I was today in Charlotte - shame on American

The staff are very, very professional. It's what flying should feel like.

The flight attendant in business class was excellent! Professional, friendly and attentive.

A first class seat should fit a fat person, and this doesn't. The trays in the armrest are less functional than an ordinary tray in the back of the seat.

It was great. Smooth flight, comfortable, left on time and landed on time.

Really good. I accidentally left my duffel on the plane and the reps were so friendly in retrieving it.

After changing the departure gate 5 times making us mo e from one side of the airport to the other and then back the flight was delayed nearly 2 hours. The male flight attendant had a bad attitude with the guest being condescending, disrespectful with people who were already on edge.

There was no beverage service and the only time I saw a crew member walk through the cabin is when we were preparing to land.

Everything you need to know for your flight from Panama City to South Carolina

Information on your arrival and departure airports