$329 Find Cheap Flights from John Wayne (Santa Ana) to Italy - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to Italy departing on 11/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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1 adult, Economy, 0 bags

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Cheap Flights from Santa Ana to Italy

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Florence
Florence2 stops$789
Naples
Naples2 stops$704
Palermo
Palermo2 stops$977
Catania
Catania2 stops$989
Bologna
Bologna2 stops$719
Pisa
Pisa2 stops$996
Turin
Turin2 stops$1,176
Genoa
Genoa2 stops$833
Verona
Verona2 stops$837
Florence
Florence2 stops$789
Naples
Naples2 stops$704
Palermo
Palermo2 stops$977
Catania
Catania2 stops$989
Bologna
Bologna2 stops$719
Pisa
Pisa2 stops$996
Turin
Turin2 stops$1,176
Genoa
Genoa2 stops$833
Verona
Verona2 stops$837

Book Cheap Santa Ana to Italy Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to Italy that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to Italy

Tue, Jan 12 - Tue, Jan 26
SWISS Logo
2:38 pm - 10:50 pm
SNA
-
MXP
23h 12m
2 stops
SWISS Logo
10:30 am - 8:19 pm
MXP
-
SNA
18h 49m
2 stops
$689SWISS
Tue, Jan 12 - Tue, Jan 26
United Airlines Logo
7:00 am - 7:30 am
SNA
-
MXP
15h 30m
1 stop
United Airlines Logo
12:55 pm - 4:51 pm
MXP
-
SNA
36h 56m
2 stops
$691United Airlines
Sun, Aug 16 - Tue, Aug 25
American Airlines Logo
7:45 am - 10:00 am
SNA
-
NAP
17h 15m
2 stops
American Airlines Logo
3:00 pm - 2:31 pm
NAP
-
SNA
32h 31m
1 stop
$704American Airlines
Tue, Jan 12 - Tue, Jan 26
British Airways Logo
3:15 pm - 5:45 pm
SNA
-
LIN
17h 30m
2 stops
British Airways Logo
11:25 am - 10:45 pm
LIN
-
SNA
20h 20m
2 stops
$709British Airways
Tue, Jan 12 - Tue, Jan 26
United Airlines Logo
7:00 am - 7:30 am
SNA
-
MXP
15h 30m
1 stop
United Airlines Logo
9:45 am - 8:56 pm
MXP
-
SNA
20h 11m
1 stop
$711United Airlines
Tue, Jan 12 - Tue, Jan 26
Lufthansa Logo
11:30 am - 6:50 pm
SNA
-
LIN
22h 20m
2 stops
Lufthansa Logo
6:25 am - 8:19 pm
LIN
-
SNA
22h 54m
2 stops
$712Lufthansa
Sun, Aug 16 - Tue, Aug 25
British Airways Logo
8:45 am - 10:00 am
SNA
-
NAP
16h 15m
1 stop
British Airways Logo
3:00 pm - 8:39 pm
NAP
-
SNA
38h 39m
1 stop
$718British Airways
Sun, Aug 16 - Tue, Aug 25
Delta Logo
12:20 pm - 4:40 pm
SNA
-
NAP
19h 20m
2 stops
Delta Logo
11:40 am - 10:30 pm
NAP
-
SNA
19h 50m
2 stops
$721Delta
Wed, Dec 9 - Tue, Dec 15
Delta Logo
6:45 am - 12:15 pm
SNA
-
VCE
20h 30m
2 stops
Delta Logo
2:15 pm - 12:50 pm
VCE
-
SNA
31h 35m
2 stops
$728Delta
Tue, Aug 18 - Tue, Aug 25
Lufthansa Logo
11:10 am - 1:00 pm
SNA
-
LIN
16h 50m
2 stops
Lufthansa Logo
6:50 am - 6:59 pm
LIN
-
SNA
21h 09m
2 stops
$768Lufthansa
Booking Insights

KAYAK's insights & trends for Santa Ana to Italy flights

Get data-powered insights and trends into flights from Santa Ana to Italy to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from John Wayne (Santa Ana) to Italy?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to Italy, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from John Wayne (Santa Ana) to Italy is November, when tickets cost $509 (return) on average. On the other hand, the most expensive months are June and December, when the average cost of round-trip tickets is $1,289 and $1,067 respectively.

Good to know

Low season

November

Cheapest flight

$329
Best time to beat the crowds with an average 35% drop in price.
Most popular time to fly and prices are also 52% lower on average.
Flight from John Wayne (Santa Ana) to Rome

FAQs - booking Italy flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to Italy?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to Italy.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to Italy?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to Italy is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to Italy?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to Italy with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to Italy?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to Italy up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Santa Ana to Italy

 
Need help choosing which airline to fly with from Santa Ana to Italy? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8493 reviews
7.8Comfort
8.5Crew
7.8Entertainment
8.1Boarding
7.2Food
Airline reviews

Delta is always late. Ruined our first day of a short vacation. Timing is important. We pay to stay on an itinerary

4.0 OkayAnonymous, Jul 2026
LAX - SFO
Read more Delta reviews

Delta is always late. Ruined our first day of a short vacation. Timing is important. We pay to stay on an itinerary

My son’s suitcase was left behind at SFO and did not make the flight.

Seats were not bad enough and uncomfortable good legroom in the emergency exit row we were in, but we were forbidden to hold my grandson on my lap for a little while, and the stewardess passed us saying it was against regulations which makes little or no sense when you’re 36,000 feet. The food snacks were really bad. Tasteless tasted like wallpaper, but we’re supposed to be protein bars, and the announcements were all completely incoherent because of the noise of the airplane and the lowness and crackly nature of the PA system.. this was disgraceful. No one in our party could understand a word of what the captain or the flight attendant were saying —not a word! The landing was a little hairy in a pretty stiff crosswind -we bounced before the plane stabilized on the runway

Flight team was great and we even arrived ahead of plan!

First The flight got delayed because one of the crew members was late and we couldn’t board until she arrived. Then we all boarded and got held in the tarmac for another 30 min.

Crew was absolutely fantastic and we’re so welcoming and friendly ❤️

It was as good as it could be. Flying is not a pleasant experience these days.

Flight late, the waited for a long time for “personal” to arrive at gate to dock the plane in Rochester. So annoying. This flight was expected, why aren’t personel available for the jet bridge?

Flight delayed for two and half hours and then canceled altogether due to mechanical issues. No mechanic onsite to fix so had to send one from LAX.

Flight and seats were great. Food service was average at best. The real main problem we had is that we got cheeseburgers for the kids but the plates was extremely hot. Like ridiculously hot and the stewardess never said anything. Luckily or unluckily my wife touched the plate and was able to deal with it before the kids got burned.

The pilot was late so we didn’t take off til almost 2 hours late.

Flight was late, the only reason I almost missed my flight was that my connection was also late.

Baggage claim signs were not updated with my flight information, so I had to guess. The app wasn't updated either.

It was a short, comfortable flight. It did leave an hour late due to the pilot having to be replaced (family emergency) but that didn’t inconvenience myself & my friend. The situation was explained, eventually.

Booked through Kayak Business, had a seat in middle and towards back due to booking rate, not comfortable.

Flight itself excellent, but delayed so missed connection & got to destination 2 hrs later

Not a great experience. We paid for the upgrade for premium economy seats and seated ourselves in very comfortable seats. Someone came along with the same seat on their boarding pass. The aircraft had been changed and as a result we were booted out and sent further back to small uncomfortable seats. After complaining we were moved to emergency row seats, which gave us more leg room but the seats don’t recline. For people in our 70’s we found having to sit upright from California to NJ very uncomfortable. Not sure why they chose to move senior citizens instead of the two people that were allowed to take the more comfortable seats. Not happy.

Very poor the plane itself was really old, slight smell that couldn’t be named. I didn’t even get a boarding pass UNTIL AFTER clearing security! Even then, they said when I get to my connected flight I’ll get my 2nd boarding pass there! A bit ridiculous!

Due to one crew member not showing up to work, our flight was significantly delayed causing us to miss our connecting flight in Houston to Mississippi causing us to be delayed by more than 6 hours and missing our event all together. Very disappointing. All because ONE crew member called in sick. United did grant us a $15 meal voucher, which was a small but appreciated concession that I wasn’t able to use because I ordered my lunch and paid for it before applying the concession, and the staff said it was too late to use it. Ugh! We also had a TWO delay coming back from Mississippi, but that was on American Airlines and it was due to weather, so not their fault. Anyway, not at all impressed with United’s handling of our flight and the HUGE disappointment of missing our important family event for our 90 year old mother. All that money and all that stress and emotions for nothing. Having to wait the hour to bring an employee from LAX seemed like something that should not have happened. Why don’t you have a local back-up? Santa Ana is not a little airport in a rural area.

the head jack on my seat didn't work and the power outlet didn't work for my seat

They set someone on our assigned seats and we ended up finding seats for ourselves to ensure the family sits together.

Flight attendants were fine, seats a bit hard but I use a cushion for extra support. The only issue was it was a bit too cool and I needed to ask for and received and extra blanket. I survived!!!

Very few things and/or people are excellent. It was very good.

Food choices limited & not enticing Seats quite uncomfortable & difficult to control

Definitely get premium economy on a flight this long if you can. Your legs and while body will thank you.

Boarding was disorganized. The door to one to the toilets wouldn’t lock. The plane was shockingly cramped, and clearly used for domestic flights due to the menus for items to sell domestic travelers. United should be ashamed of its small seats, tiny unclean toilets, and money grubbing stance toward services, compared to Lufthansa, Emirates, and most international carriers United is awful.

Terrible. Lost our luggage for 4 days. Did not advise passengers there was a strike in Barcelona Airport and had zero personnel on hand at airport to advise passengers on where to go to file claims. We had to fend for ourselves. No assistance at all other than an online claims submission process that we had to find out about on our own.

Lufthansa cancelled our flight from Los Angeles to Naples Italy on March 10 for scheduled flight on March 12 Very stressful experience trying to arrange alternatives. Will never fly again with Lufthansa

Service and food were excellent. Incredibly friendly and competent staff. Flight was delayed over and hour and I had to run between terminals to get my connecting flight.

Late flight Delays Poor service Poor staff Worst airline ever

Spent unnecessary hours on phone calls to resolve small error on one of the passengers name... It was extremely stressful and time consuming... Not great... Also all 4 members of the family: 2 parents/ 2 teenagers were allocated separate seats (even separate floors... Not great...

I was booked in Premium Economy and never given a chance to choose to purchase my own seat. Ended up with a middle seat, which was very difficult for me. The airline then left my bag in London so when I arrived in Instanbul it was not there. They delivered it to me the next day but many valuable items had been stolen. I've been flying with BA for years and this was the first time I had such a bizarre and bad experience with them.

Canceled flight late London to Florence. Help at airport very poor. Treated poorly. Had to sleep in the airport. Lost bags- still do not have them. Horrible. I should be reimbursed!

Boarding was orderly, pilot and flight attendants were nice, entertainment options were good, and low sodium meals were quite tasty.

Flight delayed, connection was not at gate listed and so missed, staff were rude at Heathrow, phone tree stupid and difficult, took me 21 actual hours to reach my destination. Almost lost my hotel reservation after walking in a strange city alone after midnight because they would not put me up in a hotel at sfo or heathrow. I will never fly BA again and will tell all people and Instagram followers never to fly BA.

Check-in in SAN was long. ORD was good. Flight delayed On board crew was ok. No warmth or personality. LHrR barely made connection

Wish the food and overall service was better. They treat Business class passengers same as economy

They had us seating down for one hour just waiting on the plane

Flying with BA is always a good experience—even in economy class. It is better if in business and first class. Timely, breeze through security and timely connections

The issue was not with BA it was with the link yoiu sent fopr booking the flight

Everything you need to know for your flight from Santa Ana to Italy

Information on your arrival and departure airports