$325 Find Cheap Flights from John Wayne (Santa Ana) to Italy - Compare and Save

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Cheap Flights from Santa Ana to Italy

Cheapest round-trip prices found by our users on KAYAK in the last 5 days
Florence
Florence2 stops$732
Naples
Naples2 stops$729
Catania
Catania2 stops$1,122
Pisa
Pisa2 stops$979
Verona
Verona2 stops$796
Genoa
Genoa2 stops$1,244
Florence
Florence2 stops$732
Naples
Naples2 stops$729
Catania
Catania2 stops$1,122
Pisa
Pisa2 stops$979
Verona
Verona2 stops$796
Genoa
Genoa2 stops$1,244
Booking Insights

Price, demand and travel trends for Santa Ana to Italy flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

What are the cheapest fares from Santa Ana to Italy right now?

Here are the cheapest round-trip fares from Santa Ana to Italy on KAYAK in the last week:

• Milan Malpensa (MXP) from $695
• Palermo Punta Raisi (PMO) from $719
• Rome Fiumicino (FCO) from $724
• Naples (NAP) from $729
• Bologna Guglielmo Marconi (BLQ) from $729

What’s the cheapest month to fly from Santa Ana to Italy?

January is the cheapest time of year to fly, with average fares of $518. Prices are highest in June, when average flight costs increase to around $1,001.

Which airport in Italy is the cheapest to fly to from Santa Ana?

Based on KAYAK data from the past 12 months, the cheapest airports to fly into Italy are:

• Venice Marco Polo (VCE) (avg. price $726)
• Rome Fiumicino (FCO) (avg. price $828)
• Milan Malpensa (MXP) (avg. price $829)

What’s the cheapest day to fly from Santa Ana to Italy?

Tuesday tends to be the cheapest day to fly from Santa Ana to Italy, while Sunday is the most expensive. Fares run about 30% higher that day, based on the past 12 months of KAYAK data.

What's the cheapest time of day to fly from Santa Ana to Italy?

Data from the past 12 months shows it's cheapest to fly to Italy during the night with average prices of $472. The afternoon is the most expensive time to fly, with average prices of $810.

Key details for Santa Ana to Italy flights

Low season

October

Cheapest flight

$325
Beat the crowds with an average 47% drop in travelers.
The most popular month to fly with an average 37% increase in travelers.
One-way flight from Santa Ana to Milan Malpensa Airport

Your Santa Ana to Italy flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • Is now a good time to book a flight from Santa Ana to Italy?

    Fares from Santa Ana to Italy are around their usual level right now. A round-trip under $558 is considered a good deal, so it's worth keeping an eye out, or setting a Price Alert to catch price changes.

  • How much should I budget for a flight from Santa Ana to Italy?

    Over the past 12 months, round-trip fares from Santa Ana to Italy have ranged from $558 to $953.

  • What are the main airports serving Italy?

    Italy has 43 airports. The three busiest are Rome Fiumicino (FCO) (54% of arrivals), Milan Malpensa (MXP) (20%) and Palermo Punta Raisi (PMO) (9%).

  • What airlines fly nonstop from Santa Ana to Italy?

    Based on the flight schedule for the next 3 months, no airline regularly operates nonstop flights from Santa Ana to Italy. One-stop options include:

    • United Airlines
    • Delta
    • American Airlines

  • Which cabin classes are available on flights from Santa Ana to Italy?

    On flights from Santa Ana to Italy you can book Economy Class, Premium Economy Class, Business Class or First Class.

  • What are some popular landmarks in Italy?

    KAYAK travelers' favorite landmarks in Italy include:

    • Piazza Navona
    • Colosseum
    • Pantheon
    • Fontana di Trevi

Your guide to booking Santa Ana to Italy flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your travel dates are flexible, book your trip for January when flights are typically cheapest and avoid June when prices are at their highest.
  • Flying on Tuesday is usually the cheapest. Flights on Sunday cost about 30% more on average, so being flexible with your travel dates could help you save.
  • If you're looking to save, Venice Marco Polo (VCE) is the cheapest airport to fly into from Santa Ana. If you have onward travel, don't forget to factor in the cost of your journey by train, bus or domestic flight.
  • Start your trip in Rome, which is the most popular destination in Italy. From there, it's easy to continue on to other popular destinations such as Milan, Venice and Florence.

Reviews of the top 4 airlines serving from Santa Ana to Italy

 
Need help choosing which airline to fly with from Santa Ana to Italy? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8698 reviews
7.2Food
8.1Boarding
7.8Comfort
7.8Entertainment
8.5Crew
Airline reviews

Great overall experience and use of the Delta One lounge was amazing!

10.0 ExcellentAvery, Nov 2026
Read more Delta reviews

Great overall experience and use of the Delta One lounge was amazing!

I used by Skymiles to upgrade to First so that I could comfortably work using my laptop. But WiFi was intermittent and unavailable for long periods. I feel like I wasted 70,000 miles :(

Chairs don’t recline and the ones that do recline, barely do recline. It was most uncomfortable flight i ever been on.

Everything was pretty good. I would like to have more drinks (water) during four hours of the flight.

Rude staff from baggage check to gate crew. Poor instructions. Inconsistent application of baggage rules.

Seemingly unnecessary delays were compounded by a lack of communication from the flight crew which turned a four hour delay into an overly stressful experience.

Flight team was great and we even arrived ahead of plan!

Flight late, the waited for a long time for “personal” to arrive at gate to dock the plane in Rochester. So annoying. This flight was expected, why aren’t personel available for the jet bridge?

Flight delayed for two and half hours and then canceled altogether due to mechanical issues. No mechanic onsite to fix so had to send one from LAX.

Flight and seats were great. Food service was average at best. The real main problem we had is that we got cheeseburgers for the kids but the plates was extremely hot. Like ridiculously hot and the stewardess never said anything. Luckily or unluckily my wife touched the plate and was able to deal with it before the kids got burned.

Flight delay in lax which delayed our connecting flight to Copenhagen. Was placed on standby the following day and got delayed again at Scandinavian air. Bad bad counter service at ar Canada in Toronto by the name of Camilla who said that she was doing us a courtesy for even finding a earlier flight for us after we the customer are the ones being inconvenient by the cancellation of our flight. Btw, we are going on a tour. Air Canada is the worse

New Max 10, first class seats have been shrunk. End of a 20 hour journey, it was United not Lufthansa, just glad to get home

Seats are uncomfortable and left me in pain in my tailbone area. I got about one hour of sleep.

Excellent. I had a medical emergency on flight SNA-ORD and the attendants were very helpful.

Booked through Kayak Business, had a seat in middle and towards back due to booking rate, not comfortable.

Flight itself excellent, but delayed so missed connection & got to destination 2 hrs later

Not a great experience. We paid for the upgrade for premium economy seats and seated ourselves in very comfortable seats. Someone came along with the same seat on their boarding pass. The aircraft had been changed and as a result we were booted out and sent further back to small uncomfortable seats. After complaining we were moved to emergency row seats, which gave us more leg room but the seats don’t recline. For people in our 70’s we found having to sit upright from California to NJ very uncomfortable. Not sure why they chose to move senior citizens instead of the two people that were allowed to take the more comfortable seats. Not happy.

Very poor the plane itself was really old, slight smell that couldn’t be named. I didn’t even get a boarding pass UNTIL AFTER clearing security! Even then, they said when I get to my connected flight I’ll get my 2nd boarding pass there! A bit ridiculous!

Due to one crew member not showing up to work, our flight was significantly delayed causing us to miss our connecting flight in Houston to Mississippi causing us to be delayed by more than 6 hours and missing our event all together. Very disappointing. All because ONE crew member called in sick. United did grant us a $15 meal voucher, which was a small but appreciated concession that I wasn’t able to use because I ordered my lunch and paid for it before applying the concession, and the staff said it was too late to use it. Ugh! We also had a TWO delay coming back from Mississippi, but that was on American Airlines and it was due to weather, so not their fault. Anyway, not at all impressed with United’s handling of our flight and the HUGE disappointment of missing our important family event for our 90 year old mother. All that money and all that stress and emotions for nothing. Having to wait the hour to bring an employee from LAX seemed like something that should not have happened. Why don’t you have a local back-up? Santa Ana is not a little airport in a rural area.

the head jack on my seat didn't work and the power outlet didn't work for my seat

If was mostly my own fault. I booked and paid for a window seat. That was a mistake for a long flight. It was hard to get up and use the bathroom. The entertainment system seemed primitive for a modern aircraft.

Our seats were not together - one on upstairs business class, the other nicer downstairs business class. Terrible!! A very nice agent worked hard with other passengers & got us upstairs together. Not ideal experience. Check in agent should have caught that! Asked about upgrade to first class for additional $2500 each. Refused upgrade saying we upgraded once already. We booked on business class to begin with so we’re NOT happy!!

Old planes and rude crew. They need a make over and better staff training. Even business class crew was rude and the hospitality was non existent.

Great. Only issue…the cabin was kept as warm as a sauna.

TV wasn’t working, flight attendants never came when turning on the light, luggage was delayed and when delivered it was broken. No suitcase for the rest of our 2 week trip with no response when claimed filed

Lost our luggage, now two days and four $30 each taxi trips to airport and long lines in taxi queue because Lufthansa didn’t get it right, by not recognizing new delays between flights caused byEU new lengthy crossing requirements for non EU travelers, so luggage lost because traditionally methodical and orderly Germans not paying attention.

They set someone on our assigned seats and we ended up finding seats for ourselves to ensure the family sits together.

Flight attendants were fine, seats a bit hard but I use a cushion for extra support. The only issue was it was a bit too cool and I needed to ask for and received and extra blanket. I survived!!!

Very few things and/or people are excellent. It was very good.

Food choices limited & not enticing Seats quite uncomfortable & difficult to control

I really enjoyed the flight…and food and the hospitality but didn’t get the food I requested for.

I washed attendant for assistance and she never got back to me. I asked her a second time and she said she would check. She never did. The flight was over an hour late taking off No food service was offered despite over 4 hours on the flight

Waited until boarding started before saying there was no overhead luggage space on the plane.

A/C temp. was way too cold during the flight.

Boarding from the SFO lounge is a big improvement. Although the first class dining room inside the lounge is becoming very crowded.

Spent unnecessary hours on phone calls to resolve small error on one of the passengers name... It was extremely stressful and time consuming... Not great... Also all 4 members of the family: 2 parents/ 2 teenagers were allocated separate seats (even separate floors... Not great...

I was booked in Premium Economy and never given a chance to choose to purchase my own seat. Ended up with a middle seat, which was very difficult for me. The airline then left my bag in London so when I arrived in Instanbul it was not there. They delivered it to me the next day but many valuable items had been stolen. I've been flying with BA for years and this was the first time I had such a bizarre and bad experience with them.

Canceled flight late London to Florence. Help at airport very poor. Treated poorly. Had to sleep in the airport. Lost bags- still do not have them. Horrible. I should be reimbursed!

Boarding was orderly, pilot and flight attendants were nice, entertainment options were good, and low sodium meals were quite tasty.

Flight delayed, connection was not at gate listed and so missed, staff were rude at Heathrow, phone tree stupid and difficult, took me 21 actual hours to reach my destination. Almost lost my hotel reservation after walking in a strange city alone after midnight because they would not put me up in a hotel at sfo or heathrow. I will never fly BA again and will tell all people and Instagram followers never to fly BA.

More options for your flight from Santa Ana to Italy

Complete your trip to Italy with a hotel stay or car rental