$319 Find Cheap Flights from John Wayne (Santa Ana) to Italy

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to Italy departing on 10/18. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Santa Ana to Italy

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Florence
Florence2 stops$833
Naples
Naples2 stops$924
Palermo
Palermo2 stops$1,081
Catania
Catania2 stops$1,022
Bologna
Bologna2 stops$960
Pisa
Pisa2 stops$1,062
Turin
Turin2 stops$980
Genoa
Genoa3 stops$1,049
Verona
Verona2 stops$1,077
Florence
Florence2 stops$833
Naples
Naples2 stops$924
Palermo
Palermo2 stops$1,081
Catania
Catania2 stops$1,022
Bologna
Bologna2 stops$960
Pisa
Pisa2 stops$1,062
Turin
Turin2 stops$980
Genoa
Genoa3 stops$1,049
Verona
Verona2 stops$1,077

Book Cheap Santa Ana to Italy Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to Italy that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to Italy

Sun, Jul 26 - Wed, Aug 19
Air Canada Logo
1:15 pm - 10:20 am
SNA
-
MXP
36h 05m
2 stops
Air Canada Logo
12:20 pm - 12:23 pm
MXP
-
SNA
33h 03m
2 stops
$711Air Canada
Sun, Jul 26 - Wed, Aug 19
Air Canada Logo
1:15 pm - 10:20 am
SNA
-
MXP
36h 05m
2 stops
Air Canada Logo
12:20 pm - 12:23 pm
MXP
-
SNA
57h 03m
3 stops
$716Air Canada
Wed, Aug 12 - Wed, Aug 26
Lufthansa Logo
11:30 am - 3:05 pm
SNA
-
FCO
18h 35m
2 stops
Lufthansa Logo
6:50 am - 9:53 pm
FCO
-
SNA
24h 03m
2 stops
$726Lufthansa
Wed, Aug 12 - Wed, Aug 26
British Airways Logo
7:45 am - 9:10 am
SNA
-
FCO
16h 25m
1 stop
British Airways Logo
10:00 am - 8:15 pm
FCO
-
SNA
19h 15m
1 stop
$743British Airways
Sat, Aug 15 - Fri, Aug 28
British Airways Logo
7:45 am - 9:10 am
SNA
-
FCO
16h 25m
1 stop
British Airways Logo
10:00 am - 8:15 pm
FCO
-
SNA
19h 15m
1 stop
$762British Airways
Sun, Aug 30 - Tue, Sep 8
Delta Logo
8:55 am - 11:00 pm
SNA
-
MXP
29h 05m
2 stops
Delta Logo
11:40 am - 10:14 pm
MXP
-
SNA
19h 34m
1 stop
$781Delta
Mon, Aug 31 - Tue, Sep 8
United Airlines Logo
8:00 am - 4:40 pm
SNA
-
MXP
23h 40m
2 stops
United Airlines Logo
3:20 pm - 9:15 am
MXP
-
SNA
26h 55m
2 stops
$783United Airlines
Sun, Aug 30 - Wed, Sep 9
Delta Logo
8:55 am - 11:00 pm
SNA
-
MXP
29h 05m
2 stops
Delta Logo
9:00 am - 10:14 pm
MXP
-
SNA
22h 14m
2 stops
$786Delta
Mon, Sep 7 - Mon, Sep 28
United Airlines Logo
10:48 am - 4:40 pm
SNA
-
MXP
20h 52m
2 stops
United Airlines Logo
10:40 am - 10:00 pm
MXP
-
SNA
44h 20m
2 stops
$788United Airlines
Sat, Oct 24 - Sat, Nov 7
Lufthansa Logo
11:10 am - 7:50 pm
SNA
-
LIN
23h 40m
2 stops
Lufthansa Logo
10:45 am - 8:40 pm
LIN
-
SNA
18h 55m
2 stops
$868Lufthansa
Booking Insights

KAYAK's insights & trends for Santa Ana to Italy flights

Get data-powered insights and trends into flights from Santa Ana to Italy to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from John Wayne (Santa Ana) to Italy?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to Italy, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from John Wayne (Santa Ana) to Italy is July, when tickets cost $430 (return) on average. On the other hand, the most expensive months are May and March, when the average cost of round-trip tickets is $550 and $538 respectively.

Good to know

Low seasonJanuary
Cheapest flight$319
Best time to beat the crowds with an average 38% drop in price.
Most popular time to fly and prices are also 14% lower on average.
Flight from John Wayne (Santa Ana) to Florence

FAQs - booking Italy flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to Italy?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to Italy.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to Italy?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to Italy is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to Italy?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to Italy with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to Italy?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to Italy up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Santa Ana to Italy

 
Need help choosing which airline to fly with from Santa Ana to Italy? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8456 reviews
7.8Entertainment
7.9Comfort
7.2Food
8.1Boarding
8.5Crew
Airline reviews

While they turned off most cabin lights to allow people to sleep, I was bothered by how bright the side lights still were. It was still quite bright for me in a window seat, when I wish I could have slept!

10.0 ExcellentTeresa, Apr 2026
SMF - LAX
Read more Delta reviews

While they turned off most cabin lights to allow people to sleep, I was bothered by how bright the side lights still were. It was still quite bright for me in a window seat, when I wish I could have slept!

Generally on time departures and arrivals, clean planes, sky miles membership provides great benefits (complimentary upgrades, etc).

N Everything was perfect from boarding to assistance to baggage in Tampa

Loved the crew! Sucks that we went from 1 hour and 8 minute layover to a 3 hour layover. But weather sucks like that.

Fast, lovely scenery, great info on the Delta flight screen about landmarks we were flying over. Great landing!

Long flight but comfortable and not freezing as I have experienced on Hawaiian flights to the islands. They gave us blankets just in case. Nice touch.

I took seat 15A in anticipation of window seat, there is no window.

Flight late, the waited for a long time for “personal” to arrive at gate to dock the plane in Rochester. So annoying. This flight was expected, why aren’t personel available for the jet bridge?

My recent experience was excellent on Delta! I flew with Delta Comfort and I was really comfortable in my seat. I enjoyed the in-flight service. The flight attendants were so friendly and hospitable. I love the snack on the flight as well. This was my first time flying on Delta and I will definitely consider flying with them again.

My flight was canceled on Sunday. Rebooking took three hours. Had to pay for accommodations another night. New flight was delayed for 5 hours, all that was sent was a 12 dollar food voucher, which doesn’t tell you how to use it. Then when we landed we had to sit on the plane for an hour before we could get off.

No screens or meal options. Freezing cold. Dirty seats. Left late.

I liked that my son and I were reseated next to each other (we had different bookings). I liked that it was a directg flight and mostly on time. I liked that you provided pillows and blankets. Flight attendants were generally courteous. The messaging through wifi did not work well. The food was not good. Seats are very narrow and I felt slightly claustraphobic in the window seat.

Some crew were unfriendly or in some cases just straight up rude.

Booked through Kayak Business, had a seat in middle and towards back due to booking rate, not comfortable.

Outstanding service, efficient & friendly crew, flight was safe, comfortable & on time

United Airline crews were very friendly and very attentive. 12 hours flight was gone like in a shorter one.

Food was surprisingly delicious. Space in the seat is horrible when the seating front is reclined. Movie offerings were terrible. Crew was friendly and helpful.

Flight itself excellent, but delayed so missed connection & got to destination 2 hrs later

Due to cancellation of connecting flight (Lufthansa) I didn’t fly with United

It was a red-eye, but the flight felt surprisingly quick. The seats were very comfortable, and that made resting much easier. I also want to thank the gentleman seated next to me, who graciously moved so my mom could sit beside me. We slept almost the entire way. The cabin crew was respectful in not disturbing us, while also being courteous and professional throughout. Thank you, United.

Definitely get premium economy on a flight this long if you can. Your legs and while body will thank you.

Boarding was disorganized. The door to one to the toilets wouldn’t lock. The plane was shockingly cramped, and clearly used for domestic flights due to the menus for items to sell domestic travelers. United should be ashamed of its small seats, tiny unclean toilets, and money grubbing stance toward services, compared to Lufthansa, Emirates, and most international carriers United is awful.

Terrible. Lost our luggage for 4 days. Did not advise passengers there was a strike in Barcelona Airport and had zero personnel on hand at airport to advise passengers on where to go to file claims. We had to fend for ourselves. No assistance at all other than an online claims submission process that we had to find out about on our own.

Lufthansa cancelled our flight from Los Angeles to Naples Italy on March 10 for scheduled flight on March 12 Very stressful experience trying to arrange alternatives. Will never fly again with Lufthansa

Service and food were excellent. Incredibly friendly and competent staff. Flight was delayed over and hour and I had to run between terminals to get my connecting flight.

Late flight Delays Poor service Poor staff Worst airline ever

Lufthansa still has a good level of quality compared to US airlines, especially with respect to (1) food quality - actually tasty, (2) good French red wine - free, (3) good movie selection. Also my ticket price includes 1 free check-in luggage, while some other budget airlines sneak in an extra $150 for a checkin.

The food could be better, more snacks. And have some plugs to chargue the phone.

Everything was really great just The aircraft was too old and sounded it will break during takeoff

Extremely pleased with the crew. Best flight attendants ever! Very friendly, genuinely caring and attentive.

Boarding was orderly, pilot and flight attendants were nice, entertainment options were good, and low sodium meals were quite tasty.

Flight delayed, connection was not at gate listed and so missed, staff were rude at Heathrow, phone tree stupid and difficult, took me 21 actual hours to reach my destination. Almost lost my hotel reservation after walking in a strange city alone after midnight because they would not put me up in a hotel at sfo or heathrow. I will never fly BA again and will tell all people and Instagram followers never to fly BA.

Check-in in SAN was long. ORD was good. Flight delayed On board crew was ok. No warmth or personality. LHrR barely made connection

Wish the food and overall service was better. They treat Business class passengers same as economy

They had us seating down for one hour just waiting on the plane

Flying with BA is always a good experience—even in economy class. It is better if in business and first class. Timely, breeze through security and timely connections

The issue was not with BA it was with the link yoiu sent fopr booking the flight

Loved the boarding option from Business class lounge, experience on flight was excellent, plenty of good food choices

Awful it always is unfortunately is the only way to fly direct to london

Check in was was and the agent was very friendly and helpful The lounge was nice...boarding was straight from the lounge Everything worked at our seats, and video entertainment was good ..food was mediocre

Everything you need to know for your flight from Santa Ana to Italy

Information on your arrival and departure airports