$342 Find Cheap Flights from John Wayne (Santa Ana) to Italy - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to Italy departing on 8/12. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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1 adult, Economy, 0 bags

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Cheap Flights from Santa Ana to Italy

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Florence
Florence2 stops$720
Naples
Naples2 stops$714
Palermo
Palermo1 stop$766
Catania
Catania2 stops$1,023
Bologna
Bologna2 stops$717
Pisa
Pisa2 stops$959
Turin
Turin2 stops$903
Genoa
Genoa2 stops$1,087
Verona
Verona2 stops$776
Florence
Florence2 stops$720
Naples
Naples2 stops$714
Palermo
Palermo1 stop$766
Catania
Catania2 stops$1,023
Bologna
Bologna2 stops$717
Pisa
Pisa2 stops$959
Turin
Turin2 stops$903
Genoa
Genoa2 stops$1,087
Verona
Verona2 stops$776

Book Cheap Santa Ana to Italy Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to Italy that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to Italy

Mon, Oct 12 - Fri, Oct 23
Delta Logo
7:10 pm - 6:45 am
SNA
-
MXP
26h 35m
2 stops
Delta Logo
2:15 pm - 1:07 pm
MXP
-
SNA
31h 52m
2 stops
$696Delta
Mon, Oct 12 - Thu, Oct 22
Delta Logo
8:45 pm - 6:45 am
SNA
-
MXP
25h 00m
1 stop
Delta Logo
2:15 pm - 11:12 am
MXP
-
SNA
29h 57m
1 stop
$697Delta
Mon, Oct 19 - Thu, Nov 5
Iberia Logo
2:35 pm - 6:15 pm
SNA
-
MXP
18h 40m
2 stops
Iberia Logo
6:20 am - 8:03 pm
MXP
-
SNA
22h 43m
2 stops
$701Iberia
Wed, Nov 18 - Fri, Nov 27
Multiple Airlines Logo
6:26 pm - 8:45 pm
SNA
-
MXP
17h 19m
2 stops
Multiple Airlines Logo
12:55 pm - 1:30 pm
MXP
-
SNA
33h 35m
2 stops
$712Multiple Airlines
Mon, Nov 9 - Tue, Nov 17
Lufthansa Logo
6:26 pm - 8:45 pm
SNA
-
MXP
17h 19m
2 stops
Lufthansa Logo
6:55 am - 8:45 pm
MXP
-
SNA
22h 50m
2 stops
$713Lufthansa
Sun, Aug 16 - Tue, Aug 25
United Airlines Logo
4:14 pm - 7:55 am
SNA
-
VCE
30h 41m
2 stops
United Airlines Logo
12:20 pm - 1:53 pm
VCE
-
SNA
34h 33m
2 stops
$716United Airlines
Tue, Nov 10 - Thu, Nov 12
United Airlines Logo
7:20 am - 12:40 pm
SNA
-
BLQ
20h 20m
2 stops
United Airlines Logo
10:20 am - 10:00 pm
BLQ
-
SNA
20h 40m
2 stops
$717United Airlines
Tue, Nov 24 - Thu, Dec 3
British Airways Logo
8:45 am - 11:30 am
SNA
-
LIN
17h 45m
2 stops
British Airways Logo
11:25 am - 10:10 pm
LIN
-
SNA
19h 45m
2 stops
$749British Airways
Mon, Aug 24 - Mon, Aug 31
Lufthansa Logo
11:10 am - 4:45 pm
SNA
-
NAP
20h 35m
2 stops
Lufthansa Logo
6:00 am - 9:45 pm
NAP
-
SNA
24h 45m
2 stops
$763Lufthansa
Mon, Nov 23 - Wed, Dec 2
British Airways Logo
2:41 pm - 5:45 pm
SNA
-
LIN
18h 04m
2 stops
British Airways Logo
11:25 am - 10:10 pm
LIN
-
SNA
19h 45m
2 stops
$786British Airways
Booking Insights

KAYAK's insights & trends for Santa Ana to Italy flights

Get data-powered insights and trends into flights from Santa Ana to Italy to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from John Wayne (Santa Ana) to Italy?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to Italy, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from John Wayne (Santa Ana) to Italy is November, when tickets cost $509 (return) on average. On the other hand, the most expensive months are June and December, when the average cost of round-trip tickets is $1,289 and $1,067 respectively.

Good to know

Low season

November

Cheapest flight

$342
Best time to beat the crowds with an average 34% drop in price.
Most popular time to fly and prices are also 53% lower on average.
Flight from John Wayne (Santa Ana) to Florence

FAQs - booking Italy flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to Italy?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to Italy.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to Italy?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to Italy is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to Italy?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to Italy with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to Italy?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to Italy up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Santa Ana to Italy

 
Need help choosing which airline to fly with from Santa Ana to Italy? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8480 reviews
8.1Boarding
7.2Food
7.8Comfort
7.8Entertainment
8.5Crew
Airline reviews

Crew was absolutely fantastic and we’re so welcoming and friendly ❤️

10.0 ExcellentRachel, Jul 2026
SFO - SLC
Read more Delta reviews

Crew was absolutely fantastic and we’re so welcoming and friendly ❤️

It was as good as it could be. Flying is not a pleasant experience these days.

Very good flight. Crew was great. No issues and we even arrived early.

Be on time? When not on time a circling for over an hour offer more than 1 bag of chips to the passengers? It was a 7 hour flight by the time we got done.

Flight delayed four separate times. I’m now one hour hours late to landing.

Checkin was good, fllight ws good. Onlly complaint is lack of foot on 6 hour flight from Seattle to Boston. Snacks were flimsy - chips and cookies. could have offered something more substantial for such a long flight. I know you can buy food in airport but for the price you pay for a ticket, they should step up for the passengers.

Long story short, it was one of the better flight experiences I've had in some time when compared with other airlines.

Flight late, the waited for a long time for “personal” to arrive at gate to dock the plane in Rochester. So annoying. This flight was expected, why aren’t personel available for the jet bridge?

Flight delayed for two and half hours and then canceled altogether due to mechanical issues. No mechanic onsite to fix so had to send one from LAX.

Flight and seats were great. Food service was average at best. The real main problem we had is that we got cheeseburgers for the kids but the plates was extremely hot. Like ridiculously hot and the stewardess never said anything. Luckily or unluckily my wife touched the plate and was able to deal with it before the kids got burned.

It was a short, comfortable flight. It did leave an hour late due to the pilot having to be replaced (family emergency) but that didn’t inconvenience myself & my friend. The situation was explained, eventually.

The seats were very uncomfortable. I paid for the front economy. i swear they added a row of seats in there. It was so tight, that I could measure the distance between my seat and the one in front from my elbow to the tips of my fingers plus six inches. The seat cushion was completely worn out. The dinner was very good. Thank you for having a vegetarian option as a standard. But breakfast was nothing but sugar. that's not food. The crew was crabby and rude, especially in regards to coming to the back gallery. And the entertainment choice: why would you put violent movies on the choice? the Godfather? Some movies with black women being beaten over the head with clubs? What the heck? You know that when there is a movie on a plane, everyone gets to watch it. Why choose the most violent titles possible? The total number of movies were very limited, and the television, even more so. No games were available on the set. The wellness section was nice, thank you. I appreciated a galley in the middle where I could stand. The seats were unbearable.

UA594 was delayed multiple times. I ended up getting picked up so I can make it in time for work 6AM on Monday, 7/6/2026

Boarded from a very small gate at LAX. Staff at gate had us line up, then waited 25 minutes to board without a word of explanation. Plane arrived on time then waited 20 minutes for a plane to vacate our gate. Majority of bags arrived after 15 minutes but it took an hour for a small number of remaining bags to be off-loaded despite my “priority” bag tag.

Booked through Kayak Business, had a seat in middle and towards back due to booking rate, not comfortable.

Flight itself excellent, but delayed so missed connection & got to destination 2 hrs later

Not a great experience. We paid for the upgrade for premium economy seats and seated ourselves in very comfortable seats. Someone came along with the same seat on their boarding pass. The aircraft had been changed and as a result we were booted out and sent further back to small uncomfortable seats. After complaining we were moved to emergency row seats, which gave us more leg room but the seats don’t recline. For people in our 70’s we found having to sit upright from California to NJ very uncomfortable. Not sure why they chose to move senior citizens instead of the two people that were allowed to take the more comfortable seats. Not happy.

Very poor the plane itself was really old, slight smell that couldn’t be named. I didn’t even get a boarding pass UNTIL AFTER clearing security! Even then, they said when I get to my connected flight I’ll get my 2nd boarding pass there! A bit ridiculous!

Due to one crew member not showing up to work, our flight was significantly delayed causing us to miss our connecting flight in Houston to Mississippi causing us to be delayed by more than 6 hours and missing our event all together. Very disappointing. All because ONE crew member called in sick. United did grant us a $15 meal voucher, which was a small but appreciated concession that I wasn’t able to use because I ordered my lunch and paid for it before applying the concession, and the staff said it was too late to use it. Ugh! We also had a TWO delay coming back from Mississippi, but that was on American Airlines and it was due to weather, so not their fault. Anyway, not at all impressed with United’s handling of our flight and the HUGE disappointment of missing our important family event for our 90 year old mother. All that money and all that stress and emotions for nothing. Having to wait the hour to bring an employee from LAX seemed like something that should not have happened. Why don’t you have a local back-up? Santa Ana is not a little airport in a rural area.

the head jack on my seat didn't work and the power outlet didn't work for my seat

Flight attendants were fine, seats a bit hard but I use a cushion for extra support. The only issue was it was a bit too cool and I needed to ask for and received and extra blanket. I survived!!!

Very few things and/or people are excellent. It was very good.

Food choices limited & not enticing Seats quite uncomfortable & difficult to control

Definitely get premium economy on a flight this long if you can. Your legs and while body will thank you.

Boarding was disorganized. The door to one to the toilets wouldn’t lock. The plane was shockingly cramped, and clearly used for domestic flights due to the menus for items to sell domestic travelers. United should be ashamed of its small seats, tiny unclean toilets, and money grubbing stance toward services, compared to Lufthansa, Emirates, and most international carriers United is awful.

Terrible. Lost our luggage for 4 days. Did not advise passengers there was a strike in Barcelona Airport and had zero personnel on hand at airport to advise passengers on where to go to file claims. We had to fend for ourselves. No assistance at all other than an online claims submission process that we had to find out about on our own.

Lufthansa cancelled our flight from Los Angeles to Naples Italy on March 10 for scheduled flight on March 12 Very stressful experience trying to arrange alternatives. Will never fly again with Lufthansa

Service and food were excellent. Incredibly friendly and competent staff. Flight was delayed over and hour and I had to run between terminals to get my connecting flight.

Late flight Delays Poor service Poor staff Worst airline ever

Lufthansa still has a good level of quality compared to US airlines, especially with respect to (1) food quality - actually tasty, (2) good French red wine - free, (3) good movie selection. Also my ticket price includes 1 free check-in luggage, while some other budget airlines sneak in an extra $150 for a checkin.

I was booked in Premium Economy and never given a chance to choose to purchase my own seat. Ended up with a middle seat, which was very difficult for me. The airline then left my bag in London so when I arrived in Instanbul it was not there. They delivered it to me the next day but many valuable items had been stolen. I've been flying with BA for years and this was the first time I had such a bizarre and bad experience with them.

Canceled flight late London to Florence. Help at airport very poor. Treated poorly. Had to sleep in the airport. Lost bags- still do not have them. Horrible. I should be reimbursed!

Boarding was orderly, pilot and flight attendants were nice, entertainment options were good, and low sodium meals were quite tasty.

Flight delayed, connection was not at gate listed and so missed, staff were rude at Heathrow, phone tree stupid and difficult, took me 21 actual hours to reach my destination. Almost lost my hotel reservation after walking in a strange city alone after midnight because they would not put me up in a hotel at sfo or heathrow. I will never fly BA again and will tell all people and Instagram followers never to fly BA.

Check-in in SAN was long. ORD was good. Flight delayed On board crew was ok. No warmth or personality. LHrR barely made connection

Wish the food and overall service was better. They treat Business class passengers same as economy

They had us seating down for one hour just waiting on the plane

Flying with BA is always a good experience—even in economy class. It is better if in business and first class. Timely, breeze through security and timely connections

The issue was not with BA it was with the link yoiu sent fopr booking the flight

Loved the boarding option from Business class lounge, experience on flight was excellent, plenty of good food choices

Everything you need to know for your flight from Santa Ana to Italy

Information on your arrival and departure airports