$214 Find Cheap Flights from Santa Ana to Italy

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to Italy departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Santa Ana to Italy

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Florence
Florence2 stops$494
Naples
Naples2 stops$502
Palermo
Palermo2 stops$649
Catania
Catania2 stops$1,180
Bologna
Bologna2 stops$498
Pisa
Pisa2 stops$546
Turin
Turin2 stops$1,170
Verona
Verona2 stops$552
Florence
Florence2 stops$494
Naples
Naples2 stops$502
Palermo
Palermo2 stops$649
Catania
Catania2 stops$1,180
Bologna
Bologna2 stops$498
Pisa
Pisa2 stops$546
Turin
Turin2 stops$1,170
Verona
Verona2 stops$552

Book Cheap Santa Ana to Italy Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to Italy that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to Italy

Wed, Feb 18 - Wed, Feb 25
British Airways Logo
2:48 pm - 8:00 pm
SNA
-
MXP
20h 12m
2 stops
British Airways Logo
11:20 am - 8:33 am
MXP
-
SNA
30h 13m
2 stops
$442British Airways
Wed, Feb 18 - Tue, Feb 24
British Airways Logo
11:41 am - 4:55 pm
SNA
-
VCE
20h 14m
2 stops
British Airways Logo
11:25 am - 8:33 am
VCE
-
SNA
30h 08m
2 stops
$443British Airways
Wed, Feb 18 - Tue, Feb 24
Multiple Airlines Logo
9:23 am - 4:55 pm
SNA
-
VCE
22h 32m
2 stops
Multiple Airlines Logo
10:15 pm - 8:23 pm
VCE
-
SNA
31h 08m
2 stops
$452Multiple Airlines
Wed, Feb 11 - Wed, Feb 18
Multiple Airlines Logo
6:25 pm - 11:00 pm
SNA
-
FCO
19h 35m
2 stops
Multiple Airlines Logo
11:15 am - 10:30 pm
FCO
-
SNA
44h 15m
2 stops
$488Multiple Airlines
Mon, Feb 2 - Tue, Feb 10
Delta Logo
9:20 pm - 9:45 am
SNA
-
MXP
27h 25m
2 stops
Delta Logo
11:05 am - 8:53 am
MXP
-
SNA
30h 48m
2 stops
$496Delta
Thu, Mar 5 - Thu, Mar 12
United Airlines Logo
10:52 am - 5:00 pm
SNA
-
BLQ
21h 08m
2 stops
United Airlines Logo
10:05 am - 10:21 pm
BLQ
-
SNA
20h 16m
2 stops
$498United Airlines
Wed, Mar 4 - Wed, Mar 11
United Airlines Logo
7:01 am - 9:55 am
SNA
-
MXP
17h 54m
2 stops
United Airlines Logo
12:05 pm - 9:48 am
MXP
-
SNA
29h 43m
2 stops
$498United Airlines
Mon, Feb 2 - Tue, Feb 10
Delta Logo
9:20 pm - 9:05 am
SNA
-
MXP
26h 45m
1 stop
Delta Logo
12:00 pm - 10:19 am
MXP
-
SNA
31h 19m
2 stops
$501Delta
Tue, Mar 24 - Tue, Apr 7
Lufthansa Logo
1:27 pm - 2:15 pm
SNA
-
LIN
16h 48m
2 stops
Lufthansa Logo
9:50 am - 5:33 pm
LIN
-
SNA
16h 43m
2 stops
$522Lufthansa
Thu, Mar 5 - Thu, Mar 12
Lufthansa Logo
10:05 am - 1:40 pm
SNA
-
NAP
18h 35m
2 stops
Lufthansa Logo
1:15 pm - 8:50 pm
NAP
-
SNA
39h 35m
2 stops
$690Lufthansa
Booking Insights

KAYAK's insights & trends for Santa Ana to Italy flights

Get data-powered insights and trends into flights from Santa Ana to Italy to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Santa Ana to Italy?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to Italy, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Santa Ana to Italy is November, when tickets cost $509 (return) on average. On the other hand, the most expensive months are December and July, when the average cost of round-trip tickets is $1,440 and $928 respectively.

Good to know

Low seasonNovember
Cheapest flight$214
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly and prices are also 26% lower on average.
Flight from John Wayne (Santa Ana) to Venice

FAQs - booking Italy flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to Italy?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to Italy.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to Italy?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to Italy is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to Italy?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to Italy with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to Italy?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to Italy up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Santa Ana to Italy

 
Need help choosing which airline to fly with from Santa Ana to Italy? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8077 reviews
7.9Comfort
8.5Crew
8.1Boarding
7.8Entertainment
7.2Food
Airline reviews

Delta’s staff is unmatched. From the gate agents, to the pilots, to the flight attendants… all top of the industry.

10.0 ExcellentEric, Jan 2026
SFO - ATL
Read more Delta reviews

Delta’s staff is unmatched. From the gate agents, to the pilots, to the flight attendants… all top of the industry.

The flight was delayed for about 2 hrs. Other than it, it was good.

I am extremely disappointed that delta internal pilot manuals now refer to the Gulf of Mexico as the “gulf of America”. You can bow down to the Orange turd on your own. I will never fly delta again

No lunch on a x-country flight scheduled for 10:50 am departure, arrived 5+ hrs later. That requires a black box label before you pay for the tickets. Worst, when I checked in online, it's specifically said that lunch was served on his flight for economy Plus passengers.

Our flight from SFO to MSP was right on time on 11/15/2025. No delays. As we approached MSP at about 8 pm, we circled in the air until 8:40 pm so I don't call that efficient for MSP. I think the captain should announce the delay and why. (as if we all don't know that we are just circling around the area, slowing down, speeding up, slowing down.) Thank you. Marilyn Fischer

Staff were friendly and happy. Delta could make sure passengers that don't have the app know of changes. Without Kayak I would not have known about the change of gate or the delay. Kayak was faster to notify me.

The flight used a B767 with a very old interior from before 2014. The entertainment system did not work at all during the flight despite attempts to reset the system. It was like they flew this route just to be competitive.

Delayed flight (1hour) plus a long layover after an overnight flight with no backup plane available.

Flight delayed for two and half hours and then canceled altogether due to mechanical issues. No mechanic onsite to fix so had to send one from LAX.

My husband upgraded our seats and I don't know if it was due to the type of planet was or if they didn't upgrade our seats. We were supposed to be in I believe comfort seats and they were just as tight as any other seat- no leg room and we are very tall people but at least it wasn't extremely cold. My husband did put in a complaint about our seating because he paid extra and if we would have known that the space and the tightness would have been the same, we just would have gotten the emergency row emergency row seats that we normally get. We love Delta but both our flights coming home we're not good. Oh I forgot to mention that on our flight to Hawaii our luggage wheels got broke and we had to purse new luggage on vacation then we never had this problem so we didn't know protocol and reported it after we got home only for them to tell is we only had 24hrs to report the damage. Not sure what was going on with Delta this vacation trip.

The flight crew where really good. Better then the crew from BNE to SFO

Food should be changed in menu Many muslims travels in this airlime they need to add one Halal meal

left on time, reasonable boarding process arrived early luggage came out quickly

Some flight attendants were great others were cranky. Seats were very tight and sitting on an aisle was very hard as the carts and people walking constantly bumped shoulder and arm.

It was great with United overall except for two things. 1) It was a 5-hour flight and we were with kids, so we were asking for extra snacks. They were extremely reticent to dole them out even though there wasn't any meal and the kids were starting to hit their limit towards the end. 2) Baggage didn't arrive until 80 minutes after we landed.

I’m so sorry, I can’t remember her name, I believe it was Dimpti. She was stellar, also a mature Asian flight attendant, lots of flowers in her hair, just as amazing! But literally the crew was AWESOME . Only downside is there weren’t any charging outlets. Maybe I needed to ask a flight attendant , but it would’ve been nice to have one easily accessible.

I boarded flight UA#1318 at Sacramento International Airport going back to Houston TX. The flight was scheduled at 5:10am. I was able to check in virtually using the United Airlines app. When I entered the airport, there was no one outside assisting with checked bags as it was for Delta Airlines. Immediately upon entering, there was a LONG, EXTREMELY LONG line to the kiosks to get boarding passes. I stand in line to get boarding passes then had to move to ANOTHER EXTREMELY LONG line to get my bags checked in. While standing in this line, we noticed an agent taking customers to 3 at a time to her station to check their bags in. Lucky for me, she called me back, checked my bags for me and I was on my way. I then encountered another long line at the TSA check and to avoid I ending up having to sign up for CLEAR to bypass it. So glad, I did.,...Both of my flights were great with no issues, butthe check in progress at Bush Airport was so much smoother. Check-in at SMF airport needs to be anaylzed and corrected. Do better United, I know you can....thanks

Pushed back only to get deplaned due to a tire damaged by ground crew. They did at least go pretty fast. The bathrooms should be banned under the Geneva convention. No room to even sit straight on the toilet. The under-seat entertainment units block what little leg room there is.

United airlines has the best customer experience from booking to arrival. I always fly United airlines. The mileage program is excellent

from SFO-> FRA flight, AVML meal was significantly less compared to regular meal, especially no Desert, no Bread, no sides.

Late flight Delays Poor service Poor staff Worst airline ever

Lufthansa still has a good level of quality compared to US airlines, especially with respect to (1) food quality - actually tasty, (2) good French red wine - free, (3) good movie selection. Also my ticket price includes 1 free check-in luggage, while some other budget airlines sneak in an extra $150 for a checkin.

The food could be better, more snacks. And have some plugs to chargue the phone.

Everything was really great just The aircraft was too old and sounded it will break during takeoff

Extremely pleased with the crew. Best flight attendants ever! Very friendly, genuinely caring and attentive.

Best flight attendants ever! Very customer and service oriented, courteous, professional and helpful.

Cheapest airlines I have ever been on. I got downgraded and never got on united. I got rerouted through Vancouver onto jetwesf

Very small and uncomfortable seats, Hard to hear entertainment system sound. Horrible food. Staff doesn't care much about the passengers. 2nd time they didn't give me my vegetarian meal. They asked me regular food with meat. The airline and staff was from United airlines.

Checkin took along timen only.few angents available at.checkin desk. Customer support over phone no existence

At baggage claim, I was given the wrong printed ticket. The ticket belonged to another passenger for a different flight — to Zurich instead of Frankfurt (layover). I was even allowed to pass security, and when I asked the Lufthansa employee if I was on the correct flight, and why it was changed. The employee said everything was correct and I should board. When I got on the plane, there was someone in my seat, and the crew on the plane finally realized that I was on the wrong plane. When I got off the plane, nobody was willing to help, and the security refused to provide my original printed ticket. That was until I showed them that I took a photo of the ticket; once they realized I had photographic evidence, they were suddenly ready to help me. The Lufthansa employee began communicating with other airlines and found a flight that would take me to my destination via Polish Airlines. I was required to once again go through security, re-check my bag, and once again pay for my checked bag and weight overage fees. This experience was incredibly stressful and very frustrating, as you can imagine. A Lufthansa employee told me I would be eligible for a refund. Please tell me what steps I need to take in order to make that happen. Thank you!

My seat was broken and ducted taped and my monitor did not work the entire time over 8 hrs sitting. And I had no books or anything with me

my flight from Rome to Boston was on a very old plane. My video and audio did not work.

Good with timing of flights. The crew was exceptionally unfriendly. I heard more than one person say this. And even with the aisle, it seemed more uncomfortable than usual. The movie selection was old and poor, but the dinner was great - the lasagna and tiramisu.

The check in process is chaotic. It says partially checked-in. Never heard of such a thing. Then lost our reserved seats when we finally checked in at the airport. The seats don’t recline. Then we had to get mew boarding passes at the connection. Last, my companion lost her baggage and up to now there’s no update. We’re already half-way through our vacation and still no news what happened to the luggage.

Wonderful! Everyone very helpful and kind. Returning flight was cancelled but rebooking was easy.

Pretty normal flight was delayed due to traffic could have missed connecting flight to Venice but crew kept us well informed so we made it

Flight was on time and pretty standard. No Hiccups. I have no complaints, which is a lot to say about a 12 hour flight.

-The seats could be roomier -The entertainment in English could be more current! The moves were very old!!! -They served too many carbs! What happened to fruit and yogurt!!!!

We upgraded to premium economy and it made a difference in a 12 hr flight. I didn’t like that we had to deplane in the tarmac with our carryon luggage. Other than that, it was ok.

Everything was much better than I had expected, since I hadn’t heard of your airline before. I hope to take advantage of your excellent service again.

Everything you need to know for your flight from Santa Ana to Italy

Information on your arrival and departure airports