$301 Find Cheap Flights from Santa Ana to Panama

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to Panama departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

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Cheap Flights from Santa Ana to Panama

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Panama City
Panama City1 stop$647
Panama City
Panama City1 stop$647

Book Cheap Santa Ana to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to Panama

Wed, Oct 1 - Wed, Oct 8
United Airlines Logo
8:15 am - 6:37 pmSNA-PTY
8h 22m1 stop
United Airlines Logo
10:00 am - 9:40 pmPTY-SNA
13h 40m1 stop
$647United Airlines
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Wed, Oct 1 - Wed, Oct 8
United Airlines Logo
4:15 pm - 2:14 pmSNA-PTY
19h 59m2 stops
United Airlines Logo
10:00 am - 9:40 pmPTY-SNA
13h 40m1 stop
$652United Airlines
Find Deal
Mon, Sep 1 - Sat, Nov 15
United Airlines Logo
7:30 am - 8:10 pmSNA-PTY
10h 40m1 stop
United Airlines Logo
3:35 pm - 8:54 amPTY-SNA
20h 19m1 stop
$687United Airlines
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Mon, Sep 1 - Sat, Nov 15
United Airlines Logo
7:30 am - 8:10 pmSNA-PTY
10h 40m1 stop
United Airlines Logo
4:41 pm - 9:23 amPTY-SNA
19h 42m2 stops
$692United Airlines
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Sun, Aug 31 - Sat, Nov 15
United Airlines Logo
4:00 pm - 8:10 pmSNA-PTY
26h 10m1 stop
United Airlines Logo
3:35 pm - 8:54 amPTY-SNA
20h 19m1 stop
$695United Airlines
Find Deal
Fri, Aug 29 - Fri, Sep 5
American Airlines Logo
12:28 pm - 2:30 pmSNA-PTY
24h 02m2 stops
American Airlines Logo
3:31 pm - 11:57 amPTY-SNA
22h 26m2 stops
$787American Airlines
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Fri, Aug 29 - Thu, Sep 4
 Logo
12:24 pm - 12:10 amSNA-PTY
33h 46m3 stops
 Logo
3:20 am - 10:05 pmPTY-SNA
20h 45m3 stops
Thu, Sep 11 - Sun, Sep 14
Copa Airlines Logo
5:58 pm - 10:41 amSNA-PTY
14h 43m1 stop
Copa Airlines Logo
12:56 pm - 10:05 pmPTY-SNA
11h 09m1 stop
$1,502Copa Airlines
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Sat, Aug 30 - Mon, Sep 1
Copa Airlines Logo
5:58 pm - 10:41 amSNA-PTY
14h 43m1 stop
Copa Airlines Logo
12:56 pm - 10:05 pmPTY-SNA
11h 09m1 stop
$1,732Copa Airlines
Find Deal
Mon, Sep 1 - Sat, Nov 15
Delta Logo
7:00 pm - 12:50 pmSNA-PTY
15h 50m2 stops
Delta Logo
8:05 am - 9:57 pmPTY-SNA
16h 52m2 stops
$3,755Delta
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Booking Insights

KAYAK's insights & trends for Santa Ana to Panama flights

Get data-powered insights and trends into flights from Santa Ana to Panama to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from John Wayne (Santa Ana) to Panama?

The average price of all round-trip flights from Santa Ana to Panama clicked on KAYAK for each day over the last 12 months.

Your flight ticket price will generally be cheaper if you fly to Panama on a Tuesday and more expensive on a Friday. On your return trip to John Wayne (Santa Ana), you should consider flying back on a Tuesday, and avoid Mondays for better deals.

Good to know

Low seasonSeptember
Cheapest flight$301
Best time to beat the crowds with an average 35% drop in price.
Most popular time to fly and prices are also 8% lower on average.
Flight from John Wayne (Santa Ana) to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Panama?

    The cheapest time of day to fly to Panama is generally in the evening, when round-trip flights cost $584 on average. Morning departures are around 15% more expensive than evening flights, on average. The most expensive time of day to fly to Panama is generally at night, which is peak travel time and where the average cost of a ticket is $689.

Reviews of the top airline flying from Santa Ana to Panama

 
Need help choosing which airline to fly with from Santa Ana to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 8925 reviews
8.1Crew
7.1Entertainment
7.3Comfort
6.6Food
7.7Boarding
Airline reviews

The pilots were late and it made us 1 hour late. The meat was tough and bok choy was also tough.

10.0 ExcellentWendy, Aug 2025SFO - YYC
Read more United Airlines reviews

The pilots were late and it made us 1 hour late. The meat was tough and bok choy was also tough.

Stuck on tarmac for two hours plus a 5.5 hour flight. Rude flight attendant. And no meals, not even for purchase!

I learned that seating towards the end of plane that a line forms for the restroom and people use your chair as a hand railing, bumping your seat consistently. I was seated in the aisle. I think that next time if I am towards the back row I would want to sit in the middle or window seat.

The best airline I have ever travel , really good customer service, attention and service !!

United sent me a mileage plus number last year but that number is invalid so I can’t use it to check into flights or collect mileage. There is human to speak about the problem, only computers who keep asking me if I am using the correct email. It’s so frustrating and I cannot resolve it.

Not a great experience. We paid for the upgrade for premium economy seats and seated ourselves in very comfortable seats. Someone came along with the same seat on their boarding pass. The aircraft had been changed and as a result we were booted out and sent further back to small uncomfortable seats. After complaining we were moved to emergency row seats, which gave us more leg room but the seats don’t recline. For people in our 70’s we found having to sit upright from California to NJ very uncomfortable. Not sure why they chose to move senior citizens instead of the two people that were allowed to take the more comfortable seats. Not happy.

Everything was great. Only thing that could’ve made it better was buy on board options for hot food, but the snacks were decent. The flight attendants were great. I had no complaints. I was able to make it to my destination safely

Boarded plane and then delayed 1.5 hours while on the plane

Horrific. They missed my connecting flight to San Diego. I didn’t get there until Monday at 9am when I had a mandatory court settlement conference scheduled at 6am since we had parties on the east coast. This caused many issues. All because United apparently forgot to hold the doors open until my flight landed that only had a 10 minute delay. This was the last flight to Southern California. So I couldn’t even rent a car to finish the trip. United cannot be trusted when traveling on specific days and times since weather didn’t have anything to do with the delays.

Really good 😊 the woman at the gate entrance was a little rude checking in our carry-on but i dont think she worked for the airline, she worked for the airport at sacramento, other than that amazing.

Everything you need to know for your flight from Santa Ana to Panama

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