$282 Find Cheap Flights from Santa Ana to Panama

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to Panama departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

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Flight Deals

Book Cheap Santa Ana to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to Panama

Thu, Feb 12 - Tue, Feb 17
United Airlines Logo
8:00 am - 7:38 pmSNA-PTY
8h 38m1 stop
United Airlines Logo
11:35 am - 9:45 pmPTY-SNA
13h 10m1 stop
$628United Airlines
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Thu, Feb 12 - Tue, Feb 17
United Airlines Logo
8:00 am - 7:38 pmSNA-PTY
8h 38m1 stop
United Airlines Logo
8:55 am - 8:50 pmPTY-SNA
14h 55m2 stops
$632United Airlines
Find Deal
Fri, Dec 5 - Fri, Dec 12
American Airlines Logo
3:01 pm - 3:42 pmSNA-PTY
21h 41m2 stops
American Airlines Logo
2:50 pm - 9:00 amPTY-SNA
21h 10m2 stops
$672American Airlines
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Fri, Dec 5 - Fri, Dec 12
United Airlines Logo
8:15 am - 7:38 pmSNA-PTY
8h 23m1 stop
United Airlines Logo
8:55 am - 9:49 pmPTY-SNA
15h 54m1 stop
$688United Airlines
Find Deal
Fri, Dec 5 - Fri, Dec 12
United Airlines Logo
7:50 pm - 2:45 pmSNA-PTY
15h 55m2 stops
United Airlines Logo
11:35 am - 9:49 pmPTY-SNA
13h 14m1 stop
$692United Airlines
Find Deal
Sun, Nov 2 - Mon, Nov 10
United Airlines Logo
7:34 pm - 6:49 pmSNA-PTY
20h 15m1 stop
United Airlines Logo
8:55 am - 9:54 pmPTY-SNA
15h 59m1 stop
$708United Airlines
Find Deal
Sun, Nov 2 - Mon, Nov 10
United Airlines Logo
6:41 pm - 7:38 pmSNA-PTY
21h 57m2 stops
United Airlines Logo
8:55 am - 10:19 pmPTY-SNA
16h 24m2 stops
$712United Airlines
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Sat, Nov 1 - Sat, Nov 8
American Airlines Logo
4:00 pm - 1:49 pmSNA-PTY
19h 49m2 stops
American Airlines Logo
2:49 pm - 9:02 amPTY-SNA
21h 13m2 stops
$892American Airlines
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Sat, Nov 1 - Sun, Nov 9
Delta Logo
12:26 pm - 1:56 pmSNA-PTY
23h 30m1 stop
Delta Logo
3:37 pm - 11:35 amPTY-SNA
22h 58m1 stop
$1,488Delta
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Sat, Jan 17 - Sun, Jan 25
Multiple Airlines Logo
2:15 pm - 9:20 amSNA-PTY
16h 05m1 stop
Multiple Airlines Logo
12:56 pm - 9:18 pmPTY-SNA
11h 22m1 stop
$2,116Multiple Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Santa Ana to Panama flights

Get data-powered insights and trends into flights from Santa Ana to Panama to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from John Wayne (Santa Ana) to Panama?

The average price of all round-trip flights from Santa Ana to Panama clicked on KAYAK for each day over the last 12 months.

Your flight ticket price will generally be cheaper if you fly to Panama on a Tuesday and more expensive on a Friday. On your return trip to John Wayne (Santa Ana), you should consider flying back on a Tuesday, and avoid Mondays for better deals.

Good to know

Cheapest flight$282
Flight from John Wayne (Santa Ana) to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Panama?

    The cheapest time of day to fly to Panama is generally in the evening, when round-trip flights cost $584 on average. Morning departures are around 15% more expensive than evening flights, on average. The most expensive time of day to fly to Panama is generally at night, which is peak travel time and where the average cost of a ticket is $689.

Reviews of the top airline flying from Santa Ana to Panama

 
Need help choosing which airline to fly with from Santa Ana to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 8988 reviews
7.7Boarding
6.6Food
8.1Crew
7.1Entertainment
7.3Comfort
Airline reviews

Same as last comment. Food sucks. Quality. Not surprising most people have no clue about nourishment Clearly

4.0 OkayAnonymous, Oct 2025SFO - PTY
Read more United Airlines reviews

Same as last comment. Food sucks. Quality. Not surprising most people have no clue about nourishment Clearly

The flight attendants were great, I joked with one I can’t remember her name, a blond, really sweet. I thought it was run well very professional. This was great i survived Spirit, I know for which I speak.

We were in business class. the angled seats in that class do not have a real window view & the placement of the controls are bad. But we knew that. But the food options were mediocre. The taste was fine, but the size was for a child. It’s just really feels like United is skimping on everything. Even when we were in the Polaris lounge they did not have diet sodas. They said they were out no Coke zero no Diet Coke, etc. I do not think the portion of nuts they serve on the plane could get any smaller. Really a minimal service and offer for what you’re paying for in business.

I was in first class. The outlets at my seat did not work. The plane was shabby and run down. I had prepurchsed a day subscription for internet that was not redeemable. I had to repurchase the internet for my flight and then it didn’t work anyway. Quite disappointed in what was supposed to be the launch of a great vacation.

We had to deboard 2 times due to maintenance issues. They changed the plane, and then we got deviated to LAX due to maibtenance issues on the other plane, had to sleep at LAX and los a full day.

From the first moment you interact with United Airlines, you can expect nothing less but extreme frustration. The baggage handler at the bag drop seems completely unbothered by the presence of customers waiting in line. No help was extended to load the baggage whatsoever. And if any of your bags is overweight by 0.01 pound they will make you re-distribute everything in your suitcase just to play power trip. When it was time to board no help was extended to customers to locate their seats. Moreover. It was a chaotic mess at the gate when it was unclear who should board first and everyone just bunched up, trying to get on the plane. I am sure the crew was doing their best to perform their jobs while being paid their wages however it shouldn’t be that hard to smile once or twice when you’re in the business if serving customers. It is a shame for the United States of America to have a flagship carrier of such low caliber. Our flight was also delayed by about an hour and a half due to further delays prior to our inbound flight. Being someone who has travelled for both business and leisure in Asia, Europe, and South America I have never experienced such poor quality of service.

I understand stuff happens, but plane failures are likely due to lack of maintenance. Additionally, air conditioning wasn't working, no snack/drink service, no WiFi. Fortunately, the crew was communicative and light-hearted. United grabbed another plane and we were able to get to our destination.

The pilots were late and it made us 1 hour late. The meat was tough and bok choy was also tough.

Stuck on tarmac for two hours plus a 5.5 hour flight. Rude flight attendant. And no meals, not even for purchase!

I learned that seating towards the end of plane that a line forms for the restroom and people use your chair as a hand railing, bumping your seat consistently. I was seated in the aisle. I think that next time if I am towards the back row I would want to sit in the middle or window seat.

Everything you need to know for your flight from Santa Ana to Panama

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