$207 Find Cheap Flights from Santiago to Guayaquil

If you are looking for a flight deal from Santiago to Guayaquil, look for departures on Mondays and avoid leaving on a Sunday, as it's usually the priciest day. When flying back from Guayaquil, Thursday is the cheapest day to fly and Saturday is the most expensive.

The cheapest month for flights from Santiago to Guayaquil is November, where tickets cost $340 (return) on average. On the other hand, the most expensive months are January and February, where the average cost of round-trip tickets is $471 and $456 respectively.

No, with an average price for the route of $340, prices are generally cheapest when you fly direct.

To get a below average price on the flight from Santiago to Guayaquil, you should book around 4 weeks before departure. For the absolute cheapest price, our data suggests you should book 16 weeks before departure.

There are 2 cabin class options for the route. These are Economy and Prem Economy. Perform a search on KAYAK to find the latest prices and availability for all cabin fares, which differ across airlines.

There is a maximum of 1 nonstop flight a day that takes off from Santiago and lands in Guayaquil, with an average flight time of 5h 23m. The most common departure time is 11:00 pm and most flights take off at night. Each week, there are 7 flights.

Early birds can take the earliest flight from Santiago at 11:50 pm and will be landing in Guayaquil at 4:13 am.

If you prefer to fly at night, the latest flight from Santiago to Guayaquil jets off at 11:50 pm and lands at 4:13 am.