SCL - TYS

$1,336 Find Cheap Flights from Santiago to Knoxville - Compare and Save

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Everything you should know

Cheapest round-trip
$1,336
Typical prices: $895-$1,016
LATAM Airlines
Wed 11/28Wed 12/5
SCL - TYS • 2 stops
Nonstop flights
Not available
There are currently no direct flights between Santiago and Knoxville. You'll need to take a connecting flight to reach the destination.
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Cheap Flights from Santiago to Knoxville (SCL-TYS)

 

Cheap flights from Santiago to Knoxville with top airlines, updated regularly. Compare round-trip, one-way, direct and last-minute deals.

Sat, Nov 28 - Sat, Dec 5
LATAM Airlines Logo
6:30 pm - 5:22 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
48h 52m2 stops Sao Paulo Guarulhos Intl Atlanta Hartsfield-Jackson
LATAM Airlines Logo
6:17 pm - 7:40 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
11h 23m1 stop Atlanta Hartsfield-Jackson
$1,336LATAM Airlines
Sat, Nov 28 - Sat, Dec 5
LATAM Airlines Logo
6:30 pm - 5:22 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
48h 52m2 stops Sao Paulo Guarulhos Intl Atlanta Hartsfield-Jackson
LATAM Airlines Logo
6:17 pm - 3:00 pmTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
18h 43m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl
$1,341LATAM Airlines
Sat, Nov 28 - Sat, Dec 5
LATAM Airlines Logo
8:35 pm - 11:28 amSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
40h 53m2 stops Sao Paulo Guarulhos Intl Atlanta Hartsfield-Jackson
LATAM Airlines Logo
4:01 pm - 3:00 pmTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
20h 59m3 stops Atlanta Hartsfield-Jackson Miami Buenos Aires Ministro Pistarini
$1,345LATAM Airlines
Tue, Oct 27 - Fri, Oct 30
United Airlines Logo
9:45 pm - 11:12 amSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
14h 27m1 stop Houston George Bush Intcntl
United Airlines Logo
3:45 pm - 7:50 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
15h 05m1 stop Houston George Bush Intcntl
$1,591United Airlines
Tue, Oct 27 - Fri, Oct 30
United Airlines Logo
9:45 pm - 4:59 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
20h 14m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
United Airlines Logo
6:45 am - 7:50 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
24h 05m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
$1,595United Airlines

Price, demand and travel trends for Santiago to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Santiago to Knoxville?

Round-trip flights from Santiago to Knoxville typically range from $895 to $1,016. The lowest price found in the past 5 days was $1,336, on LATAM Airlines.

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Key details for Santiago to Knoxville flights

Cheapest flight

$1,336
Round-trip flight from Santiago to Knoxville

When to book flights from Santiago to Knoxville

Are your dates flexible? Find out the best times to travel from Santiago to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Santiago to Knoxville flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • How long is a flight from Santiago to Knoxville?

    A nonstop flight from Santiago to Knoxville takes 00m, covering 4,853 miles.

  • Do I need a passport to fly from Santiago to Knoxville?

    Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

  • How much should I expect to pay for a Santiago to Knoxville flight?

    Round-trip flights from Santiago to Knoxville range from $895 to $1,016, with an average of $972 over the past 12 months. Anything below $895 counts as a good deal.

  • Have flight prices from Santiago to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route varied from about $1,336 to $1,595. That means the highest observed fare was about 19% higher than the lowest one.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:

    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Thrifty
    • Avis

  • Which airports can I use when flying from Santiago to Knoxville?

    Flights from Santiago to Knoxville usually depart from Santiago Arturo Merino Benitez (SCL) and arrive at Knoxville McGhee Tyson (TYS).

  • Which airports do connecting flights from Santiago to Knoxville pass through?

    Most connecting flights from Santiago to Knoxville pass through Atlanta Hartsfield-Jackson (ATL), which handles 100% of one-stop traffic on this route.

  • Can I save money by using flexible dates for flights from Santiago to Knoxville?

    Yes. Flexible dates can save you up to 35% on flights from Santiago to Knoxville. Tuesday is the cheapest departure day at $705 round-trip on average, while Monday is the most expensive at $1,070, a difference of $365.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • What is the time difference between Santiago and Knoxville?

    Knoxville is 1 hour behind Santiago (Eastern Time vs Chile Time). Plan for the time shift when scheduling connections or first-day activities.

Your guide to booking Santiago to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Tuesday departure and avoid flying on Monday. On this route, Tuesday flights average $705, about $365 less than Monday fares (34% savings) based on the last 12 months.

More options for your flight from Santiago to Knoxville

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