Which airports can I use when flying from Santiago to Knoxville?

Flights from Santiago to Knoxville usually depart from Santiago Arturo Merino Benitez (SCL) and arrive at Knoxville McGhee Tyson (TYS).

What cabin classes can I book on flights from Santiago to Knoxville?

Only Economy Class is available on flights from Santiago to Knoxville.

Which airports do connecting flights from Santiago to Knoxville pass through?

Most connecting flights from Santiago to Knoxville pass through Atlanta Hartsfield-Jackson (ATL), which handles 100% of one-stop traffic on this route.

Can I save money by using flexible dates for flights from Santiago to Knoxville?

Yes. Flexible dates can save you up to 35% on flights from Santiago to Knoxville. Tuesday is the cheapest departure day at $705 round-trip on average, while Monday is the most expensive at $1,070, a difference of $365. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

How long is a flight from Santiago to Knoxville?

A nonstop flight from Santiago to Knoxville takes 00m, covering 4,853 miles.

Do I need a passport to fly from Santiago to Knoxville?

Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

Have flight prices from Santiago to Knoxville changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route varied from about $938 to $1,595. That means the highest observed fare was about 70% higher than the lowest one.

What is the time difference between Santiago and Knoxville?

Knoxville is 1 hour behind Santiago (Eastern Time vs Chile Time). Plan for the time shift when scheduling connections or first-day activities.

What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include: • Budget • Alamo • Enterprise Rent-A-Car • Thrifty • Avis

How much should I expect to pay for a Santiago to Knoxville flight?

Round-trip flights from Santiago to Knoxville range from $895 to $1,016, with an average of $972 over the past 12 months. Anything below $895 counts as a good deal.

Which airline is the cheapest to fly from Santiago to Knoxville?

United Airlines ($1,095) and LATAM Airlines ($1,551) are the cheapest airlines to fly round-trip from Santiago to Knoxville according to KAYAK data over the last 5 days.

What is the cheapest layover airport when flying from Santiago to Knoxville?

Flights via Atlanta Hartsfield-Jackson (ATL) offer the most affordable fares, with an average round-trip price of $927. Based on KAYAK data over the past 3 months.

When flying from Santiago to Knoxville which airport offers the shortest layover?

Atlanta Hartsfield-Jackson (ATL) had the shortest average connection time for Santiago to Knoxville layovers at 7h 18m over the past 3 months.

Cheap Flights from Santiago to Knoxville | KAYAK

Save 19% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$938

Typical prices: $895-$1,016

Multiple Airlines

Fri 2/16Tue 2/27

SCL - TYS • 3 stops

Nonstop flights

Not available

There are currently no direct flights between Santiago and Knoxville. You'll need to take a connecting flight to reach the destination.

Insights

Start a new search

KAYAK searches 100s of sites at once to find you the best travel deals.

We hope you love your trip to Knoxville!

Cheap Flights from Santiago to Knoxville (SCL-TYS)

Cheap flights from Santiago to Knoxville with top airlines, updated regularly. Compare round-trip, one-way, direct and last-minute deals.

Round-trip

One-way

Tue, Feb 16 - Sat, Feb 27

7:45 am - 5:20 pmSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

59h 35m3 stops Sao Paulo Guarulhos Intl Lima J Chavez Intl Miami

8:26 pm - 11:55 pmTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

49h 29m3 stops Fort Lauderdale Lima J Chavez Intl Rio de Janeiro–Galeão Intl

$938Multiple Airlines

Mon, Feb 15 - Sat, Feb 27

3:29 am - 11:13 amSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

33h 44m2 stops Panama City Tocumen Intl Fort Lauderdale

8:26 pm - 11:55 pmTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

49h 29m3 stops Fort Lauderdale Lima J Chavez Intl Rio de Janeiro–Galeão Intl

$982Multiple Airlines

Mon, Feb 15 - Sat, Feb 27

3:29 am - 11:13 amSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

33h 44m2 stops Panama City Tocumen Intl Fort Lauderdale

8:26 pm - 5:00 amTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

30h 34m2 stops Fort Lauderdale Punta Cana

$1,081Multiple Airlines

Tue, Feb 16 - Sat, Feb 27

10:45 pm - 11:01 amSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

14h 16m1 stop Houston George Bush Intcntl

7:35 pm - 8:50 amTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

35h 15m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl

$1,095United Airlines

Tue, Feb 16 - Sat, Feb 27

10:45 pm - 11:01 amSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

14h 16m1 stop Houston George Bush Intcntl

5:20 pm - 8:50 amTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

13h 30m1 stop Houston George Bush Intcntl

$1,327United Airlines

Tue, Oct 27 - Fri, Oct 30

9:45 pm - 11:12 amSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

14h 27m1 stop Houston George Bush Intcntl

3:45 pm - 7:50 amTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

15h 05m1 stop Houston George Bush Intcntl

$1,541United Airlines

Tue, Oct 27 - Fri, Oct 30

9:45 pm - 5:54 pmSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

21h 09m1 stop Houston George Bush Intcntl

10:43 am - 7:50 amTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

20h 07m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

$1,545United Airlines

Tue, Oct 27 - Fri, Oct 30

11:10 pm - 10:54 amSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

12h 44m1 stop Atlanta Hartsfield-Jackson

6:23 pm - 6:00 pmTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

22h 37m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

$1,551LATAM Airlines

Tue, Oct 27 - Fri, Oct 30

11:10 pm - 10:54 amSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

12h 44m1 stop Atlanta Hartsfield-Jackson

6:23 pm - 6:00 pmTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

22h 37m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

$1,569LATAM Airlines

Tue, Oct 27 - Fri, Oct 30

9:45 pm - 11:12 amSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

14h 27m1 stop Houston George Bush Intcntl

3:45 pm - 7:50 amTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

15h 05m1 stop Houston George Bush Intcntl

$1,591United Airlines

Price, demand and travel trends for Santiago to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Airlines

Layovers

Which airline is the cheapest to fly from Santiago to Knoxville?: United Airlines ($1,095) and LATAM Airlines ($1,551) are the cheapest airlines to fly round-trip from Santiago to Knoxville according to KAYAK data over the last 5 days.

Find deals

Cheapest flight	$938

Round-trip flight from Santiago to Knoxville

When to book flights from Santiago to Knoxville

Are your dates flexible? Find out the best times to travel from Santiago to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

What cabin classes can I book on flights from Santiago to Knoxville?
Only Economy Class is available on flights from Santiago to Knoxville.
How long is a flight from Santiago to Knoxville?
A nonstop flight from Santiago to Knoxville takes 00m, covering 4,853 miles.
Do I need a passport to fly from Santiago to Knoxville?
Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.
How much should I expect to pay for a Santiago to Knoxville flight?
Round-trip flights from Santiago to Knoxville range from $895 to $1,016, with an average of $972 over the past 12 months. Anything below $895 counts as a good deal.
Have flight prices from Santiago to Knoxville changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route varied from about $938 to $1,595. That means the highest observed fare was about 70% higher than the lowest one.
What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?
Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:

• Budget
• Alamo
• Enterprise Rent-A-Car
• Thrifty
• Avis
Which airports can I use when flying from Santiago to Knoxville?
Flights from Santiago to Knoxville usually depart from Santiago Arturo Merino Benitez (SCL) and arrive at Knoxville McGhee Tyson (TYS).
Which airports do connecting flights from Santiago to Knoxville pass through?
Most connecting flights from Santiago to Knoxville pass through Atlanta Hartsfield-Jackson (ATL), which handles 100% of one-stop traffic on this route.
Can I save money by using flexible dates for flights from Santiago to Knoxville?
Yes. Flexible dates can save you up to 35% on flights from Santiago to Knoxville. Tuesday is the cheapest departure day at $705 round-trip on average, while Monday is the most expensive at $1,070, a difference of $365.

KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.
What is the time difference between Santiago and Knoxville?
Knoxville is 1 hour behind Santiago (Eastern Time vs Chile Time). Plan for the time shift when scheduling connections or first-day activities.

If your dates are flexible, aim for a Tuesday departure and avoid flying on Monday. On this route, Tuesday flights average $705, about $365 less than Monday fares (34% savings) based on the last 12 months.

More options for your flight from Santiago to Knoxville

Add a hotel or car rental

Airports

Cabin class

Direct Flights

Origins

Other destinations

Return flight

Complete your trip to Knoxville with a hotel stay or car rental

Car rentals in Knoxville

Hotels in Knoxville

Vacations in Knoxville

SCL - TYS

$938 Find Cheap Flights from Santiago to Knoxville - Compare and Save

Everything you should know

Cheap Flights from Santiago to Knoxville (SCL-TYS)

Cheap flights from Santiago to Knoxville with top airlines, updated regularly. Compare round-trip, one-way, direct and last-minute deals.

Price, demand and travel trends for Santiago to Knoxville flights

Which airline is the cheapest to fly from Santiago to Knoxville?

What is the cheapest layover airport when flying from Santiago to Knoxville?

When flying from Santiago to Knoxville which airport offers the shortest layover?

Key details for Santiago to Knoxville flights

Cheapest flight

When to book flights from Santiago to Knoxville

Your Santiago to Knoxville flight questions, answered

Your guide to booking Santiago to Knoxville flights

More options for your flight from Santiago to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

Information on your arrival and departure airports

Cabin class types available on flights from Santiago to Knoxville

Find direct flights to and from Santiago and Knoxville

Flights from domestic origins to Knoxville

Flights to other popular destinations

Find deals for your return flight