TYS - SCL

$714 Find Cheap Flights from Knoxville to Santiago

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Santiago departing on 3/19. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Santiago, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$714
Delta
Thu 3/19Mon 3/23
TYS - SCL • 1 stop
Cheapest one-way
Multiple Airlines
Wed 11/26
TYS - SCL • multi-stop
Top airlines
Delta
Cheapest • from $714 (round-trip)
LATAM Airlines
Best reviews • 7.5 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
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Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Santiago (TYS-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Santiago

Thu, Mar 19 - Mon, Mar 23
Delta Logo
7:07 pm - 7:40 amTYS-SCL
11h 33m1 stop
Delta Logo
10:10 pm - 4:06 pmSCL-TYS
18h 56m1 stop
$714Delta
Find Deal
Mon, Feb 2 - Tue, Feb 17
Multiple Airlines Logo
7:15 am - 10:39 amTYS-SCL
25h 24m3 stops
Multiple Airlines Logo
11:24 am - 10:08 amSCL-TYS
24h 44m2 stops
$804Multiple Airlines
Find Deal
Mon, Feb 2 - Tue, Feb 17
Multiple Airlines Logo
7:15 am - 10:39 amTYS-SCL
25h 24m3 stops
Multiple Airlines Logo
3:45 pm - 10:08 amSCL-TYS
20h 23m3 stops
$859Multiple Airlines
Find Deal
Mon, Feb 2 - Mon, Feb 16
Multiple Airlines Logo
8:30 am - 10:39 amTYS-SCL
24h 09m2 stops
Multiple Airlines Logo
4:35 am - 10:08 amSCL-TYS
31h 33m3 stops
$948Multiple Airlines
Find Deal
Mon, Feb 2 - Mon, Feb 16
Multiple Airlines Logo
7:15 am - 10:39 amTYS-SCL
25h 24m3 stops
Multiple Airlines Logo
4:35 am - 10:08 amSCL-TYS
31h 33m3 stops
$956Multiple Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Knoxville to Santiago flights

Get data-powered insights and trends into flights from Knoxville to Santiago to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Knoxville to Santiago?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Knoxville to Santiago were found on Delta ($714) and LATAM Airlines ($714).

Which airlines fly non-stop between Knoxville and Santiago?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Knoxville to Santiago.

There are 2 airlines that fly nonstop from Knoxville to Santiago. They are American Airlines and LATAM Airlines. The cheapest airline for this route is American Airlines, with the best round-trip deal found costing $678. On average, the best prices for this route can be found at American Airlines.

Good to know

Cheapest flight$714
Flight from Knoxville to Santiago

When to book flights from Knoxville to Santiago

Are your dates flexible? Find out the best times to travel from Knoxville to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Santiago

  • What is the cheapest flight from Knoxville to Santiago?

    In the last 3 days, the lowest price for a flight from Knoxville to Santiago was $714 for a round-trip ticket.

  • Do I need a passport to fly between Knoxville and Santiago?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Knoxville and on arrival in Santiago.

  • Which aircraft models fly most regularly from Knoxville to Santiago?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Santiago?

    oneworld is the only airline alliance operating flights between Knoxville and Santiago.

  • Which is the best airline for flights from Knoxville to Santiago, LATAM Airlines or American Airlines?

    The two airlines most popular with KAYAK users for flights from Knoxville to Santiago are LATAM Airlines and American Airlines. With an average price for the route of $1,313 and an overall rating of 7.5, LATAM Airlines is the most popular choice. American Airlines is also a great choice for the route, with an average price of $931 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Knoxville to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Knoxville to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1886 reviews
6.7Food
7.3Comfort
8.0Crew
7.0Entertainment
7.6Boarding
Airline reviews

Good flight, boarding ok and crew very nice. Flight was not full so I was able to be very comfortable. Blanket and pillow provided with was good as it was very cold during the flight . Food was very good(small snack sandwich and an excellent piece of orange cake). Overall good flight, no complaints.

10.0 ExcellentMaría Victoria, Nov 2025GRU - COR
Read more LATAM Airlines reviews

Good flight, boarding ok and crew very nice. Flight was not full so I was able to be very comfortable. Blanket and pillow provided with was good as it was very cold during the flight . Food was very good(small snack sandwich and an excellent piece of orange cake). Overall good flight, no complaints.

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

I’m entitled to a refund per LATAM due to the mid flight itinerary change and being stuck in São Paulo for 24 hours and needing to get a hotel. The airline was dismissive and of no help.

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

The flight was delayed multiple times, again no fault of American but again the extra cost, for everything makes it feel like a cheap airline! Especially when flights are outrageously expensive already

Horrible. Both legs of my flight were delayed more than 6 hours. No compensation, no screens on the plane, and the plane was not clean.

I had a positive experience on American. I'm blind and traveling with a guide dog and the flight attendants were so kind, friendly, and helpful towards us. They checked in on us during the flight and they made us feel comfortable and welcomed. There was an hour delay before depature, but overall the flight was a smooth ride. I appreciate that there were no issues on this long flight back home.

We were told the flight was delayed 5 times, then it was moved to the next day.

More choices on snacks. Built-in video screen to enjoy entertainment choices.

we landed at cmh ten minutes early but had to sit on tarmac for twenty minutes because a plane was at our gate despite the fact that 3 other gates were open.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

I have a gluten allergy so did have any food

I have a gluten allergy so didn't have any food

Loved the crew . Absolutely no complaints. Except for luggage lost

Everything you need to know for your flight from Knoxville to Santiago

Information on your arrival and departure airports