TYS - SCL

$997 Find Cheap Flights from Knoxville to Santiago

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Santiago departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Santiago, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$997
LATAM Airlines
mié. 9/30vie. 10/9
TYS - SCL • 1 stop
Top airlines
Cheapest • from $997 (round-trip)
Best reviews • 7.1 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Knoxville and Santiago. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $950 (round-trip)
Shortest trip • 13h 00m (one-way)
Insights
Insights
Insights
Insights
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We hope you love your trip to Santiago!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Santiago (TYS-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Santiago

mié., sep. 30 - vie., oct. 9
LATAM Airlines Logo
4:00 pm - 8:15 am
TYS
-
SCL
15h 15m
1 stop
LATAM Airlines Logo
8:40 pm - 11:06 am
SCL
-
TYS
15h 26m
1 stop
$997LATAM Airlines
mié., sep. 30 - vie., oct. 9
Delta Logo
2:30 pm - 8:15 am
TYS
-
SCL
16h 45m
1 stop
Delta Logo
8:40 pm - 9:12 am
SCL
-
TYS
13h 32m
1 stop
$1,005Delta
mié., sep. 30 - vie., oct. 9
LATAM Airlines Logo
4:00 pm - 8:15 am
TYS
-
SCL
15h 15m
1 stop
LATAM Airlines Logo
12:05 am - 11:46 pm
SCL
-
TYS
24h 41m
2 stops
$1,031LATAM Airlines
mié., sep. 30 - vie., oct. 9
LATAM Airlines Logo
5:57 pm - 5:25 pm
TYS
-
SCL
22h 28m
2 stops
LATAM Airlines Logo
12:05 am - 11:46 pm
SCL
-
TYS
24h 41m
2 stops
$1,036LATAM Airlines
mié., sep. 30 - vie., oct. 9
LATAM Airlines Logo
5:57 pm - 9:55 pm
TYS
-
SCL
26h 58m
2 stops
LATAM Airlines Logo
9:30 am - 6:13 pm
SCL
-
TYS
33h 43m
3 stops
$1,041LATAM Airlines
mar., may. 19 - mié., may. 27
Multiple Airlines Logo
3:48 pm - 6:25 am
TYS
-
SCL
38h 37m
2 stops
Multiple Airlines Logo
10:55 pm - 12:05 pm
SCL
-
TYS
37h 10m
1 stop
$1,044Multiple Airlines
jue., may. 28 - jue., jun. 4
American Airlines Logo
3:40 pm - 7:05 am
TYS
-
SCL
15h 25m
2 stops
American Airlines Logo
9:00 pm - 5:37 pm
SCL
-
TYS
20h 37m
2 stops
$1,130American Airlines
jue., may. 28 - jue., jun. 4
American Airlines Logo
7:34 pm - 7:05 am
TYS
-
SCL
11h 31m
1 stop
American Airlines Logo
9:00 pm - 11:59 pm
SCL
-
TYS
26h 59m
1 stop
$1,136American Airlines
mar., may. 19 - mié., may. 27
American Airlines Logo
11:31 am - 7:05 am
TYS
-
SCL
19h 34m
2 stops
American Airlines Logo
9:00 pm - 12:35 pm
SCL
-
TYS
15h 35m
2 stops
$1,180American Airlines
mar., may. 19 - mié., may. 27
American Airlines Logo
6:30 am - 7:05 am
TYS
-
SCL
24h 35m
1 stop
American Airlines Logo
9:00 pm - 7:04 pm
SCL
-
TYS
22h 04m
1 stop
$1,186American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Santiago flights

Get data-powered insights and trends into flights from Knoxville to Santiago to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Knoxville to Santiago?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Knoxville to Santiago were found on LATAM Airlines ($997) and Delta ($1,005).

Good to know

Cheapest flight$997
Flight from Knoxville to Santiago

When to book flights from Knoxville to Santiago

Are your dates flexible? Find out the best times to travel from Knoxville to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Santiago

  • What is the cheapest flight from Knoxville to Santiago?

    In the last 3 days, the lowest price for a flight from Knoxville to Santiago was $997 for a round-trip ticket.

  • Do I need a passport to fly between Knoxville and Santiago?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Knoxville and on arrival in Santiago.

  • Which aircraft models fly most regularly from Knoxville to Santiago?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Santiago?

    oneworld is the only airline alliance operating flights between Knoxville and Santiago.

  • How does KAYAK find such low prices on flights from Knoxville to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11583 reviews
7.5Boarding
6.4Food
6.9Entertainment
7.9Crew
7.2Comfort
Airline reviews

I almost missed my flight and they helped me out enormously

10.0 ExcellentAnonymous, Apr 2026
ORD - BUF
Read more American Airlines reviews

I almost missed my flight and they helped me out enormously

Business class was very good, one of my best flights

The "on the ground" A/C was not working. It was so hot while waiting to get in the air, a passenger from the rear of the plan declared "I just can't!" and waited in the gangway until time to close the doors. It was miserable. But the crew were champs and had an amazing attitude. I know they were as miserable as we were but didn't let that affect their performance.

The captain announced to the cabin there would be a delay because they observed a "cut" on a tire during precheck that needed to be cleared by maintenance. We were delayed during this inspection and allowed to proceed after maintenance "measured the cut and decided it was acceptable". My complaint is not about the delay or due diligence. I wish the captain had been more generic when making his announcement. I was a nervous wreck all the way to Charlotte worried that we would have a blowout when landing!

The SFO Lounge crew were amazing. The bartender Faris was great. Thanks!

The flight was on time and the landing was very smooth. The crew and flight attendants were all very friendly and professional.

Very good I can’t complain one bit. Thank you American Airlines for making my flight enjoyable and safe!

American Airlines is a miserable experience. It is predictably miserable, in the sense that every time I fly American, I brace myself for the certainty that it will be unpleasant and uncomfortable. But it is unpredictable in the sense that I never know if the flight will be on time or delayed nine hours (both happened to me this week). I never know if I will be able to sit in the seat that I selected when I purchased the ticket or if I will be told by Customer Service (!!!) that I must relocate from first class to a seat in the back of the aircraft with no explanation (both happened to me this week). Will the food be frozen and half defrosted, or scalding hot? Will the drinks be warm? Will the flight attendants be surly and mean? Will the toilets be cramped and foul? Will the seats be narrow and uncomfortable? Will there be a real electric outlet at the seat, or just an unreliable USB-2 port? Will there be enough seats in the boarding lounge or just a few? Will the boarding process be smooth and efficient, or will the gate agents mess it up and delay it needlessly for 30 or 40 minutes? Will the catering and cleaning crew be prompt or will they take an extra 30 minutes? Will the brakes on the aircraft work properly, or will the pilot delay takeoff for four hours while the ground crew attends to what can only be described as routine maintenance that should have been done the night before? I've eexperienced every one of these unpleasant things this year, 2026. The only thing I can reliably count on is that American will find a new way to make the experience of flying as miserable as they possibly can.

Flight was fine, but not having WiFi was a major negative

Friendly crew is the only nice thing. Seats uncomfortable. Food and snacks horrible. Movies were the same as the first 10 hour flight two weeks before

Everything you need to know for your flight from Knoxville to Santiago

Information on your arrival and departure airports