TYS - SCL

$714 Find Cheap Flights from Knoxville to Santiago

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Santiago departing on 1/22. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Santiago, as well as popular online travel agencies
Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Everything you should know

Cheapest round-trip
$714
Delta
Thu 1/22Tue 2/3
TYS - SCL • 1 stop
Cheapest one-way
Multiple Airlines
Tue 10/14
TYS - SCL • multi-stop
Top airlines
Delta
Cheapest • from $714 (round-trip)
LATAM Airlines
Best reviews • 7.5 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Santiago!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Santiago (TYS-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Santiago

Thu, Jan 22 - Tue, Feb 3
Delta Logo
12:00 pm - 7:00 amTYS-SCL
17h 00m1 stop
Delta Logo
11:15 pm - 9:13 amSCL-TYS
11h 58m1 stop
$714Delta
Find Deal
Thu, Jan 22 - Tue, Feb 3
American Airlines Logo
2:57 pm - 9:05 amTYS-SCL
16h 08m2 stops
American Airlines Logo
11:15 pm - 3:46 pmSCL-TYS
18h 31m1 stop
$719American Airlines
Find Deal
Tue, Dec 9 - Mon, Jan 5
American Airlines Logo
12:10 pm - 7:45 amTYS-SCL
17h 35m1 stop
American Airlines Logo
11:55 pm - 11:59 pmSCL-TYS
26h 04m1 stop
$1,142American Airlines
Find Deal
Tue, Dec 9 - Mon, Jan 5
American Airlines Logo
10:20 am - 8:55 amTYS-SCL
20h 35m2 stops
American Airlines Logo
11:55 pm - 11:59 pmSCL-TYS
26h 04m1 stop
$1,147American Airlines
Find Deal
Tue, Dec 9 - Mon, Jan 5
American Airlines Logo
5:24 am - 7:45 amTYS-SCL
24h 21m1 stop
American Airlines Logo
11:55 pm - 5:06 pmSCL-TYS
19h 11m1 stop
$1,232American Airlines
Find Deal
Tue, Dec 9 - Mon, Jan 5
American Airlines Logo
10:20 am - 8:55 amTYS-SCL
20h 35m2 stops
American Airlines Logo
11:55 pm - 5:06 pmSCL-TYS
19h 11m1 stop
$1,236American Airlines
Find Deal
Thu, Nov 27 - Thu, Dec 4
Multiple Airlines Logo
9:00 am - 3:20 pmTYS-SCL
28h 20m3 stops
Multiple Airlines Logo
4:25 pm - 9:49 pmSCL-TYS
31h 24m3 stops
$1,312Multiple Airlines
Find Deal
Tue, Dec 9 - Mon, Jan 5
LATAM Airlines Logo
7:10 am - 2:30 pmTYS-SCL
29h 20m3 stops
LATAM Airlines Logo
11:25 pm - 11:44 pmSCL-TYS
26h 19m2 stops
$1,347LATAM Airlines
Find Deal
Tue, Dec 9 - Mon, Jan 5
LATAM Airlines Logo
11:25 am - 7:00 amTYS-SCL
17h 35m2 stops
LATAM Airlines Logo
11:25 pm - 11:44 pmSCL-TYS
26h 19m2 stops
$1,402LATAM Airlines
Find Deal
Tue, Dec 9 - Sun, Jan 4
LATAM Airlines Logo
6:00 pm - 2:05 pmTYS-SCL
18h 05m2 stops
LATAM Airlines Logo
12:20 am - 9:43 pmSCL-TYS
23h 23m2 stops
$2,214LATAM Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Knoxville to Santiago flights

Get data-powered insights and trends into flights from Knoxville to Santiago to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Knoxville to Santiago?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Knoxville to Santiago were found on Delta ($714) and American Airlines ($719).

Which airlines fly non-stop between Knoxville and Santiago?

Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from Knoxville to Santiago.

There are 2 airlines that fly nonstop from Knoxville to Santiago. They are American Airlines and LATAM Airlines. The cheapest airline for this route is American Airlines, with the best round-trip deal found costing $678. On average, the best prices for this route can be found at American Airlines.

Good to know

Cheapest flight$714
Flight from Knoxville to Santiago

When to book flights from Knoxville to Santiago

Are your dates flexible? Find out the best times to travel from Knoxville to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Santiago

  • What is the cheapest flight from Knoxville to Santiago?

    In the last 3 days, the lowest price for a flight from Knoxville to Santiago was $714 for a round-trip ticket.

  • Do I need a passport to fly between Knoxville and Santiago?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Knoxville and on arrival in Santiago.

  • Which aircraft models fly most regularly from Knoxville to Santiago?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Santiago?

    oneworld is the only airline alliance operating flights between Knoxville and Santiago.

  • Which is the best airline for flights from Knoxville to Santiago, LATAM Airlines or American Airlines?

    The two airlines most popular with KAYAK users for flights from Knoxville to Santiago are LATAM Airlines and American Airlines. With an average price for the route of $1,520 and an overall rating of 7.5, LATAM Airlines is the most popular choice. American Airlines is also a great choice for the route, with an average price of $931 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Knoxville to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Knoxville to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1865 reviews
7.0Entertainment
7.6Boarding
6.7Food
8.0Crew
7.3Comfort
Airline reviews

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

8.0 ExcellentLUIS JOSE, Sep 2025AEP - SCL
Read more LATAM Airlines reviews

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

I’m entitled to a refund per LATAM due to the mid flight itinerary change and being stuck in São Paulo for 24 hours and needing to get a hotel. The airline was dismissive and of no help.

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

Boarding was done by woman who insisted on strict standing in line policy; food was ok; entertainment minimal

The boarding and new bag drop-off process was confusing and causing massive delays.

Wider seats, better seat cushions, (I felt like there was a board I was sitting on). I had the chicken to eat but It neither tasted nor looked like chicken. The fruit was good.

Mostly good. Flight was crowded but Airline personnel were very friendly & accommodating. It would be good to have savory snacks rather than just sweet Biscoff cookies.

It was a typical flight. We had a delay which seems to be the normality now. And we had no in flight service due to conditions.

Flight attendants on this flight were very attentive and friendly

After we landed we sat on the tarmac for 1.5 hours waiting to get to our gate. Ridiculous.

Food should be better quality. Video screens have poor resolution and the library of movies is poor. The other airlines are much better.

the trip to madrid was uncomfortable with my legs touching the seat in front of me

The plane was late, when we did board the plane was as cold as a freezer. I was freezing the entire flight, no blankets. Lost miserable flight I’ve ever had.

My flight was delayed for 17hs because the pilot forgot his passport!!! What a joke. AA used to be a great airline, now I have to think twice before flying with them again.

Terrible. Flight delayed for more than 8 hours with only a $12 meal voucher provided for the inconvenience. The airplane did not have breaks on arrival yet they still made us go through the motions and board on time knowing we could not take off then sit for 40+ minutes before having to get of the time. A complete waste of my time. I cannot believe they can stay business with these shenanigans. I’ll avoid this company like the plague moving forward as the lack of accountability is disgraceful.

This was the best 2 flights I have had with American out of SGF. Great crew both flights.

Everything you need to know for your flight from Knoxville to Santiago

Information on your arrival and departure airports

Not what you’re looking for? Find thousands of other hotels, flights, car rentals and package deals with KAYAK.