TYS - SCL

$462 Find Cheap Flights from Knoxville to Santiago - Compare and Save

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1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$1,008
Typical prices: $904-$1,520
United Airlines
Sun 1/21Sat 2/3
TYS - SCL • 2 stops
Cheapest one-way
$462
Typical prices: $438-$598
Multiple Airlines
Tue 10/9
TYS - SCL • 2 stops
Nonstop flights
Not available
There are currently no direct flights between Knoxville and Santiago. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
November
Cheapest • 43% price drop
February
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Houston George Bush Intcntl (IAH)
Cheapest • Avg $1,041 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 12h 55m (one-way)
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Flight Deals

Cheap Flights from Knoxville to Santiago (TYS-SCL)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Santiago

Thu, Jan 21 - Wed, Feb 3
United Airlines Logo
7:35 pm - 8:50 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
35h 15m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl
United Airlines Logo
10:45 pm - 9:50 amSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
37h 05m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$1,008United Airlines
Thu, Jan 21 - Wed, Feb 3
United Airlines Logo
5:38 pm - 8:50 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
37h 12m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
United Airlines Logo
10:45 pm - 2:54 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
42h 09m3 stops Houston George Bush Intcntl Chicago O'Hare Intl Washington, D.C. Reagan-National
$1,016United Airlines
Sun, Jan 31 - Sun, Feb 14
American Airlines Logo
5:36 pm - 9:00 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
13h 24m1 stop Miami
American Airlines Logo
11:45 pm - 4:34 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
18h 49m1 stop Dallas/Fort Worth
$1,035American Airlines
Thu, Jan 21 - Wed, Feb 3
American Airlines Logo
11:41 am - 7:45 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
18h 04m1 stop Dallas/Fort Worth
American Airlines Logo
10:15 pm - 5:06 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
20h 51m1 stop Miami
$1,035American Airlines
Sun, Jan 31 - Sun, Feb 14
American Airlines Logo
4:00 pm - 9:00 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
15h 00m2 stops Charlotte Douglas Miami
American Airlines Logo
11:45 pm - 2:09 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
16h 24m1 stop Dallas/Fort Worth
$1,040American Airlines
Thu, Jan 21 - Wed, Feb 3
American Airlines Logo
11:41 am - 7:45 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
18h 04m1 stop Dallas/Fort Worth
American Airlines Logo
10:15 pm - 3:46 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
19h 31m2 stops Miami Washington, D.C. Reagan-National
$1,040American Airlines
Sun, Jan 31 - Sun, Feb 14
American Airlines Logo
11:35 am - 7:45 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
18h 10m2 stops Chicago O'Hare Intl Dallas/Fort Worth
American Airlines Logo
10:15 pm - 2:09 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
17h 54m2 stops Miami Dallas/Fort Worth
$1,040American Airlines
Mon, Oct 12 - Mon, Oct 19
American Airlines Logo
10:48 am - 8:10 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
20h 22m2 stops Charlotte Douglas Miami
American Airlines Logo
9:30 pm - 1:33 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
17h 03m2 stops Miami Charlotte Douglas
$1,046American Airlines
Fri, Nov 20 - Sun, Nov 29
Delta Logo
12:34 pm - 7:15 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
16h 41m2 stops Atlanta Hartsfield-Jackson Bogotá El Dorado
Delta Logo
11:10 pm - 3:15 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
18h 05m1 stop Atlanta Hartsfield-Jackson
$1,065Delta
Thu, Oct 1 - Wed, Oct 7
Delta Logo
11:00 am - 7:25 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
19h 25m1 stop New York LaGuardia
Delta Logo
8:40 pm - 10:54 amSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
15h 14m1 stop Atlanta Hartsfield-Jackson
$1,087Delta
Booking Insights

Price, demand and travel trends for Knoxville to Santiago flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Knoxville to Santiago with more confidence.

How much is a round-trip flight from Knoxville to Santiago?

Round-trip flights from Knoxville to Santiago start at $1,008. Prices are typical for this route right now, with typical round-trip fares ranging from $904 to $1,520. The lowest price found in the past 5 days was $1,008 on United Airlines.

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Key details for Knoxville to Santiago flights

Low season

May

Cheapest flight

$462
Best time to beat the crowds but there is an average 11% increase in price.
Most popular time to fly and prices are also 1% lower on average.
Flight from Knoxville to Santiago

When to book flights from Knoxville to Santiago

Are your dates flexible? Find out the best times to travel from Knoxville to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Knoxville to Santiago flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • Which airports can I use when flying from Knoxville to Santiago?

    Flights from Knoxville to Santiago usually depart from Knoxville McGhee Tyson (TYS) and arrive at Santiago Arturo Merino Benitez (SCL).

  • What cabin classes can I book on flights from Knoxville to Santiago?

    Only Economy Class is available on flights from Knoxville to Santiago.

  • Which airports do connecting flights from Knoxville to Santiago pass through?

    One-stop flights from Knoxville to Santiago most commonly connect through:

    • Atlanta Hartsfield-Jackson (ATL) - 63% of one-stop connections
    • Dallas/Fort Worth (DFW) - 31% of one-stop connections
    • Houston George Bush Intcntl (IAH) - 6% of one-stop connections

    Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.

  • Can I save money by using flexible dates for flights from Knoxville to Santiago?

    Yes. Being flexible with your travel dates can save you up to 44% on the Knoxville to Santiago route. Thursday is the cheapest departure day at $874 round-trip on average, while Friday is the most expensive at $1,545, a difference of $671. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • What popular places can I visit in Santiago?

    Some of the most popular sights in Santiago are Parque Arauco, University of Chile and Estadio Nacional Julio Martinez Pradanos. These are among the most viewed places in Santiago on KAYAK.

  • How long is a flight from Knoxville to Santiago?

    A nonstop flight from Knoxville to Santiago takes 0h 00m, covering 4,853 miles.

  • Do I need a passport to fly from Knoxville to Santiago?

    Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

  • Have flight prices from Knoxville to Santiago changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $1,008 to $2,232. That means the highest observed fare was about 2x higher than the lowest one.

  • How are flight prices from Knoxville to Santiago looking right now?

    One-way fares from Knoxville to Santiago are currently higher than usual. Average one-way flight prices are about $752, which is 25% above the typical average for this route.

  • How much time can I save by choosing a different layover airport from Knoxville to Santiago?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 12h 55m, compared with 14h 52m via Dallas/Fort Worth (DFW) and 15h 02m via Houston George Bush Intcntl (IAH).

  • What car rental options are available at Santiago Arturo Merino Benitez Airport (SCL)?

    Santiago Arturo Merino Benitez Airport (SCL) hosts 5 major car rental companies, with daily rates starting from around $6 for economy cars. Top options include:
    · Lucano
    · United Rent-A-Car
    · Rosselot
    · FlexWays
    · Alamo

  • How much should I expect to pay for a Knoxville to Santiago flight?

    Round-trip flights from Knoxville to Santiago range from $904 to $1,520, with an average of $1,255 over the past 12 months. Anything below $904 counts as a good deal.

Your guide to booking Knoxville to Santiago flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Thursday departure instead of Friday. On this route, Thursday flights average $874 - about $671 less than Friday (43% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Knoxville to Santiago trip for November. Fares historically average $714 round-trip in that month - typically $831 less than the most expensive month, which is March (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Santiago Arturo Merino Benitez Airport.
    - Holiday Inn Santiago - Airport Terminal By IHG

Everything you need to know for your flight from Knoxville to Santiago

Information on your arrival and departure airports

Knoxville (TYS)
Santiago (SCL)