TYS - SCL

$835 Find Cheap Flights from Knoxville to Santiago

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Santiago departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Santiago, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$835
LATAM Airlines
Wed 4/1Mon 4/6
TYS - SCL • 1 stop
Top airlines
LATAM Airlines
Cheapest • from $835 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Knoxville and Santiago. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Dallas (DFW)
Cheapest • Avg $950 (round-trip)
Atlanta (ATL)
Shortest trip • 13h 00m (one-way)
Insights
Insights
Insights
Insights
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Santiago!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Santiago (TYS-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Santiago

Wed, Apr 1 - Mon, Apr 6
LATAM Airlines Logo
5:10 pm - 8:15 am
TYS
-
SCL
14h 05m
1 stop
LATAM Airlines Logo
7:50 am - 11:57 pm
SCL
-
TYS
16h 07m
2 stops
$835LATAM Airlines
Sun, Apr 12 - Sun, Apr 19
LATAM Airlines Logo
6:38 pm - 6:00 am
TYS
-
SCL
35h 22m
2 stops
LATAM Airlines Logo
4:30 pm - 6:14 pm
SCL
-
TYS
25h 44m
2 stops
$856LATAM Airlines
Sun, Apr 12 - Sun, Apr 19
LATAM Airlines Logo
6:38 pm - 7:15 am
TYS
-
SCL
12h 37m
1 stop
LATAM Airlines Logo
11:05 pm - 6:14 pm
SCL
-
TYS
19h 09m
2 stops
$860LATAM Airlines
Sun, Apr 12 - Sun, Apr 19
Delta Logo
6:38 pm - 7:15 am
TYS
-
SCL
12h 37m
1 stop
Delta Logo
8:40 pm - 5:08 pm
SCL
-
TYS
20h 28m
1 stop
$900Delta
Sun, Apr 12 - Sun, Apr 19
LATAM Airlines Logo
6:38 pm - 6:00 am
TYS
-
SCL
35h 22m
2 stops
LATAM Airlines Logo
8:30 am - 11:17 am
SCL
-
TYS
26h 47m
3 stops
$901LATAM Airlines
Sun, Apr 12 - Sun, Apr 19
LATAM Airlines Logo
7:13 am - 1:05 pm
TYS
-
SCL
29h 52m
3 stops
LATAM Airlines Logo
8:30 am - 11:17 am
SCL
-
TYS
26h 47m
3 stops
$1,203LATAM Airlines
Wed, Apr 1 - Mon, Apr 6
LATAM Airlines Logo
5:10 pm - 2:05 pm
TYS
-
SCL
19h 55m
3 stops
LATAM Airlines Logo
5:40 am - 11:57 pm
SCL
-
TYS
18h 17m
2 stops
$2,285LATAM Airlines
Tue, May 12 - Tue, May 26
GOL Logo
8:48 pm - 7:05 am
TYS
-
SCL
34h 17m
2 stops
GOL Logo
8:30 pm - 5:37 pm
SCL
-
TYS
21h 07m
2 stops
$2,975GOL
Tue, May 12 - Tue, May 26
GOL Logo
8:48 pm - 7:05 am
TYS
-
SCL
34h 17m
2 stops
GOL Logo
8:30 pm - 11:59 pm
SCL
-
TYS
27h 29m
1 stop
$2,998GOL
Tue, May 12 - Tue, May 26
LATAM Airlines Logo
3:30 pm - 7:15 am
TYS
-
SCL
15h 45m
1 stop
LATAM Airlines Logo
8:40 pm - 2:33 pm
SCL
-
TYS
17h 53m
1 stop
$3,173LATAM Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Santiago flights

Get data-powered insights and trends into flights from Knoxville to Santiago to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Knoxville to Santiago?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Knoxville to Santiago were found on LATAM Airlines ($835) and Delta ($900).

Good to know

Cheapest flight$835
Flight from Knoxville to Santiago

When to book flights from Knoxville to Santiago

Are your dates flexible? Find out the best times to travel from Knoxville to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Santiago

  • What is the cheapest flight from Knoxville to Santiago?

    In the last 3 days, the lowest price for a flight from Knoxville to Santiago was $835 for a round-trip ticket.

  • Do I need a passport to fly between Knoxville and Santiago?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Knoxville and on arrival in Santiago.

  • Which aircraft models fly most regularly from Knoxville to Santiago?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Santiago?

    SkyTeam, and oneworld are the airline alliances operating flights between Knoxville and Santiago, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Knoxville to Santiago, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Knoxville to Santiago are Delta and American Airlines. With an average price for the route of $1,313 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $931 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Knoxville to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Knoxville to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8242 reviews
8.5Crew
7.9Comfort
8.1Boarding
7.8Entertainment
7.2Food
Airline reviews

Everything was good except wifi and a leaking drink chiller. The floor was all wet and my bag was soaked. Did not notice until debarking. Have not heard back from Delta. Even though this was leg one of an international flight in first class, they denied access to their Sky Club - very disappointing!

6.0 GoodAnonymous, Feb 2026
RDU - SEA
Read more Delta reviews

Everything was good except wifi and a leaking drink chiller. The floor was all wet and my bag was soaked. Did not notice until debarking. Have not heard back from Delta. Even though this was leg one of an international flight in first class, they denied access to their Sky Club - very disappointing!

The staff was fine. The plane was extremely tight, and I paid for the wifi and it did not work at all. I was actually going to ask for a refund.

two hour delay and the Delta representative on the PA system was unable to understand

An awesome flight crew. FC seat cushion just doesn’t cut it for a 3+ hour flight.

2+hrs delay without any reason provided and a cramped flight

We waited an hour on the runway to get a gate in Orlando

Flight was delayed by 3-hours and their fix was… complimentary pretzels.

Flight was delayed due to crew being not on time

Flight crew issues delayed my flight by 2 1/2 hours. Causing me to miss my connection.

The staff on board and gate was nice - a welcome change from the usual. We also arrived early, which was a great benefit, given that it takes 30 minutes plus to get bags at SRQ.

It's very confusing because Kayak has it as American Airlines, but it was Hawaiian Airlines, but operated by Alaska Airlines. I had to go to the airport for my boarding pass because American said I didn't have any trips.

Smooth flight. From the early boarding and all were on board before departure time and arrived early in ONT. Great crew. Thank you!!!!

Small plane, poor meal choices for first class, bad terminal and boarding experience at LAX

Lack of gluten free options in food service. I have Celiac disease and it appears you no longer offer special meals for people with dietary restrictions. I am a frequent flyer traveling into and out of Omaha airport. I have noticed over the course of several months that although our flight typically arrives ahead of schedule (awesome job AA!) - we typically sit on the runway for several minutes waiting for the ground crew to get in place. Not sure if it is a ground crew issue or a gate availability issue (due to construction at this airport). Seems to be more of a ground crew being on time issue.

Arrived early picked up my bag in a few minutes- great trip - thank you

Flight boarded, departed and landed on time. Excellent service from flight attendant in FIRST

Boarding is always an ordeal. Less dogs on flights. I am highly allergic to dogs and cats. Why are there so many animals these days?

Flight to Tampa was delayed taking off due to plane arriving late but no other issues

There was a delay with the plan which cause the flight to leave later and once arrived in Chicago there was another delay and some passengers missed their connecting flights

Massimo, flight attendant was very authentic, attentive - wonderful. Food/wrap was just okay.

Everything you need to know for your flight from Knoxville to Santiago

Information on your arrival and departure airports