TYS - SCL

$396 Find Cheap Flights from Knoxville to Santiago - Compare and Save

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1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$1,167
Typical prices: $1,041-$1,341
United Airlines
Sun 12/2Sun 12/9
TYS - SCL • 1 stop
Cheapest one-way
$396
Typical prices: $438-$438
Multiple Airlines
Tue 1/2
TYS - SCL • 2 stops
Nonstop flights
Not available
There are currently no direct flights between Knoxville and Santiago. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
January
Cheapest • 27% price drop
November
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Houston George Bush Intcntl (IAH)
Cheapest • Avg $1,041 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 13h 20m (one-way)
Insights
Insights
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We hope you love your trip to Santiago!

Cheap Flights from Knoxville to Santiago (TYS-SCL)

 

Cheap flights from Knoxville to Santiago with top airlines, updated regularly. Compare round-trip, one-way, direct and last-minute deals.

Wed, Dec 2 - Wed, Dec 9
United Airlines Logo
5:00 pm - 8:50 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
13h 50m1 stop Houston George Bush Intcntl
United Airlines Logo
10:45 pm - 6:18 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
21h 33m1 stop Houston George Bush Intcntl
$1,167United Airlines
Wed, Dec 2 - Wed, Dec 9
United Airlines Logo
6:00 am - 8:50 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
24h 50m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
United Airlines Logo
10:45 pm - 5:00 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
20h 15m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$1,171United Airlines
Wed, Dec 2 - Wed, Dec 9
United Airlines Logo
5:00 pm - 8:50 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
13h 50m1 stop Houston George Bush Intcntl
United Airlines Logo
10:45 pm - 11:59 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
27h 14m2 stops Houston George Bush Intcntl Washington, D.C. Dulles Intl
$1,171United Airlines
Mon, Nov 30 - Mon, Dec 7
American Airlines Logo
7:22 pm - 9:25 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
12h 03m1 stop Miami
American Airlines Logo
11:15 pm - 2:02 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
16h 47m1 stop Dallas/Fort Worth
$1,177American Airlines
Mon, Nov 30 - Mon, Dec 7
American Airlines Logo
3:47 pm - 9:25 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
15h 38m2 stops Charlotte Douglas Miami
American Airlines Logo
11:15 pm - 12:11 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
14h 56m1 stop Dallas/Fort Worth
$1,181American Airlines
Mon, Nov 30 - Mon, Dec 7
American Airlines Logo
2:54 pm - 9:25 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
16h 31m2 stops Dallas/Fort Worth Miami
American Airlines Logo
11:15 pm - 3:26 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
18h 11m2 stops Dallas/Fort Worth Charlotte Douglas
$1,181American Airlines
Wed, Dec 16 - Thu, Jan 7
Copa Airlines Logo
11:53 am - 5:52 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
15h 59m2 stops Houston George Bush Intcntl Panama City Tocumen Intl
Copa Airlines Logo
12:20 pm - 10:10 amSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
23h 50m2 stops Panama City Tocumen Intl Chicago O'Hare Intl
$1,194Copa Airlines
Mon, Nov 30 - Mon, Dec 7
United Airlines Logo
7:35 pm - 8:50 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
35h 15m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl
United Airlines Logo
10:45 pm - 8:37 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
23h 52m3 stops Houston George Bush Intcntl Washington, D.C. Reagan-National Newark
$1,195United Airlines
Thu, Nov 12 - Wed, Nov 18
United Airlines Logo
9:45 am - 8:50 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
21h 05m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl
United Airlines Logo
10:45 pm - 11:12 amSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
14h 27m1 stop Houston George Bush Intcntl
$1,218United Airlines
Thu, Nov 12 - Wed, Nov 18
United Airlines Logo
7:00 am - 8:50 amTYS  Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez
23h 50m1 stop Houston George Bush Intcntl
United Airlines Logo
10:45 pm - 5:54 pmSCL  Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson
21h 09m1 stop Houston George Bush Intcntl
$1,218United Airlines

Price, demand and travel trends for Knoxville to Santiago flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Knoxville to Santiago?

Round-trip flights from Knoxville to Santiago typically range from $1,041 to $1,341. The lowest price found in the past 5 days was $1,167, on United Airlines.

Find deals

Key details for Knoxville to Santiago flights

Low season

May

Cheapest flight

$396
Beat the crowds with an average 86% drop in travelers.
The most popular month to fly with an average 29% increase in travelers.
One-way flight from Knoxville to Santiago

When to book flights from Knoxville to Santiago

Are your dates flexible? Find out the best times to travel from Knoxville to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Knoxville to Santiago flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Knoxville to Santiago?

    Only Economy Class is available on flights from Knoxville to Santiago.

  • How long is a flight from Knoxville to Santiago?

    A nonstop flight from Knoxville to Santiago takes 00m, covering 4,853 miles.

  • Do I need a passport to fly from Knoxville to Santiago?

    Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

  • How much should I expect to pay for a Knoxville to Santiago flight?

    Round-trip flights from Knoxville to Santiago range from $1,041 to $1,341, with an average of $1,236 over the past 12 months. Anything below $1,041 counts as a good deal.

  • Have flight prices from Knoxville to Santiago changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route varied from about $1,167 to $1,820. That means the highest observed fare was about 55% higher than the lowest one.

  • How are flight prices from Knoxville to Santiago looking right now?

    One-way fares from Knoxville to Santiago are currently higher than usual. Average one-way flight prices are about $647, which is 47% above the typical average for this route.

  • What car rental options are available at Santiago Arturo Merino Benitez Airport (SCL)?

    Santiago Arturo Merino Benitez Airport (SCL) hosts 5 major car rental companies, with daily rates starting from around $6 for economy cars. Top options include:

    • Lucano
    • United Rent-A-Car
    • Rosselot
    • FlexWays
    • Alamo

  • Which airports can I use when flying from Knoxville to Santiago?

    Flights from Knoxville to Santiago usually depart from Knoxville McGhee Tyson (TYS) and arrive at Santiago Arturo Merino Benitez (SCL).

  • Which airports do connecting flights from Knoxville to Santiago pass through?

    One-stop flights from Knoxville to Santiago most commonly connect through:

    • Atlanta Hartsfield-Jackson (ATL) - 69% of one-stop connections
    • Dallas/Fort Worth (DFW) - 25% of one-stop connections
    • Houston George Bush Intcntl (IAH) - 6% of one-stop connections

  • Can I save money by using flexible dates for flights from Knoxville to Santiago?

    Yes. Flexible dates can save you up to 30% on flights from Knoxville to Santiago. Monday is the cheapest departure day at $1,087 round-trip on average, while Friday is the most expensive at $1,545, a difference of $458.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Knoxville to Santiago?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 13h 20m, compared with 14h 39m via Dallas/Fort Worth (DFW) and 15h 02m via Houston George Bush Intcntl (IAH).

  • What is the time difference between Knoxville and Santiago?

    Santiago is 1 hour ahead of Knoxville (Chile Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in Santiago?

    Some of the most popular sights in Santiago are Estadio Nacional Julio Martinez Pradanos, Espacio Riesco Convention and Exhibition Center and Costanera Center. These are among the most viewed places in Santiago on KAYAK.

Your guide to booking Knoxville to Santiago flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Monday departure and avoid flying on Friday. On this route, Monday flights average $1,087, about $458 less than Friday fares (30% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Knoxville to Santiago trip for January. Fares historically average $904 round-trip in that month - typically $641 less than the most expensive month, which is March (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Santiago Arturo Merino Benitez Airport.

    • Holiday Inn Santiago - Airport Terminal By IHG

More options for your flight from Knoxville to Santiago

Complete your trip to Santiago with a hotel stay or car rental

Car rentals in Santiago
Hotels in Santiago
Vacations in Santiago