$366 Find Cheap Flights from Santiago to Missouri

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santiago to Missouri departing on 2/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Missouri

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santiago to Missouri, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santiago to Missouri, as well as popular online travel agencies
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Cheap Flights from Santiago to Missouri

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
St. Louis
St. Louis2 stops$755
Kansas City
Kansas City1 stop$764
St. Louis
St. Louis2 stops$755
Kansas City
Kansas City1 stop$764

Book Cheap Santiago to Missouri Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santiago to Missouri that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santiago to Missouri

Sun, Feb 22 - Thu, Mar 26
Delta Logo
12:20 am - 8:41 pmSCL-STL
23h 21m2 stops
Delta Logo
10:02 am - 7:40 amSTL-SCL
19h 38m1 stop
$755Delta
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Thu, Dec 4 - Mon, Dec 8
LATAM Airlines Logo
11:10 pm - 10:45 amSCL-STL
14h 35m1 stop
LATAM Airlines Logo
9:30 am - 7:40 amSTL-SCL
19h 10m1 stop
$764LATAM Airlines
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Thu, Dec 4 - Mon, Dec 8
LATAM Airlines Logo
7:15 am - 11:42 pmSCL-STL
19h 27m3 stops
LATAM Airlines Logo
9:30 am - 5:35 amSTL-SCL
17h 05m2 stops
$769LATAM Airlines
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Mon, Feb 23 - Thu, Mar 26
Multiple Airlines Logo
6:47 pm - 3:26 pmSCL-STL
47h 39m3 stops
Multiple Airlines Logo
5:24 pm - 6:25 amSTL-SCL
35h 01m2 stops
$879Multiple Airlines
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Thu, Dec 4 - Mon, Dec 8
Multiple Airlines Logo
8:55 pm - 3:29 pmSCL-STL
21h 34m1 stop
Multiple Airlines Logo
4:05 pm - 4:00 amSTL-SCL
32h 55m3 stops
$981Multiple Airlines
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Thu, Dec 4 - Mon, Dec 8
United Airlines Logo
10:45 pm - 10:04 amSCL-STL
14h 19m1 stop
United Airlines Logo
10:00 am - 8:50 amSTL-SCL
19h 50m2 stops
$1,062United Airlines
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Thu, Dec 4 - Mon, Dec 8
Multiple Airlines Logo
6:40 am - 3:29 pmSCL-STL
35h 49m3 stops
Multiple Airlines Logo
4:05 pm - 4:00 amSTL-SCL
32h 55m3 stops
$1,068Multiple Airlines
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Thu, Dec 4 - Mon, Dec 8
American Airlines Logo
11:55 pm - 4:06 pmSCL-STL
19h 11m1 stop
American Airlines Logo
3:59 pm - 7:45 amSTL-SCL
12h 46m1 stop
$1,071American Airlines
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Thu, Dec 4 - Mon, Dec 8
Multiple Airlines Logo
8:55 pm - 9:40 pmSCL-STL
27h 45m2 stops
Multiple Airlines Logo
4:05 pm - 4:00 amSTL-SCL
32h 55m3 stops
$1,103Multiple Airlines
Find Deal
Wed, Dec 3 - Mon, Dec 8
LATAM Airlines Logo
12:20 am - 5:56 pmSCL-STL
20h 36m2 stops
LATAM Airlines Logo
9:30 am - 5:50 amSTL-SCL
17h 20m2 stops
$1,801LATAM Airlines
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Booking Insights

KAYAK's insights & trends for Santiago to Missouri flights

Get data-powered insights and trends into flights from Santiago to Missouri to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Santiago to Missouri?

The average price of all round-trip flights from Santiago to Missouri clicked on KAYAK for each day over the last 12 months.

If you are looking for a flight deal from Santiago to Missouri, look for departures on Tuesdays and avoid leaving on a Friday, as it's usually the priciest day. When flying back from Missouri, Wednesday is the cheapest day to fly and Saturday is the most expensive.

Good to know

Low seasonApril
Cheapest flight$366
Best time to beat the crowds but there is an average 8% increase in price.
Most popular time to fly and prices are also 3% lower on average.
Flight from Santiago to St. Louis

FAQs - booking Missouri flights

  • How does KAYAK find such low prices on flights from Santiago to Missouri?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Santiago to Missouri.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Santiago to Missouri?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Santiago to Missouri is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Santiago to Missouri?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Santiago to Missouri with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Santiago to Missouri?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Santiago to Missouri up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Missouri?

    The cheapest time of day to fly to Missouri is generally at night, when round-trip flights cost $889 on average. The most expensive time of day to fly to Missouri is generally at night, which is peak travel time and where the average cost of a ticket is $889.

Reviews of the top airlines flying from Santiago to Missouri

 
See real verified KAYAK customer reviews for airlines flying from Santiago to Missouri. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santiago to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8011 reviews
7.9Comfort
8.1Boarding
7.9Entertainment
7.3Food
8.5Crew
Airline reviews

Very smooth, on-time, and pleasantly uneventful flight. The team at the gate and on board were professional and genuinely courteous. The pilot kept us well updated throughout, and both takeoff and landing were steady and enjoyable without any drama. Just a good, solid flight. Thank you! 💗

10.0 ExcellentHartaj, Nov 2025LGA - RDU
Read more Delta reviews

Very smooth, on-time, and pleasantly uneventful flight. The team at the gate and on board were professional and genuinely courteous. The pilot kept us well updated throughout, and both takeoff and landing were steady and enjoyable without any drama. Just a good, solid flight. Thank you! 💗

Staff was exceptional! Everyone was kind, professional and friendly making the trip very pleasant. Thank you!

No lunch on a x-country flight scheduled for 10:50 am departure, arrived 5+ hrs later. That requires a black box label before you pay for the tickets. Worst, when I checked in online, it's specifically said that lunch was served on his flight for economy Plus passengers.

We had a lot of really rough weather but that was not Delta's fault. Pilot was amazing.

One of the best airlines that I flew on, the flight attendants were very attentive and professional.

First, Delta needs more flights to/from Miami. Second, a 1000pm leaving at 1230pm is unacceptable from their biggest airport world hub. Another aircraft could have been used such as the aircraft scheduled to be used in the morning for that exact same route. Yes, I did get me there but the lack of sleep the next day didn't help me enjoy my entire trip since I was busy with activities during the weekend. This can be and is expected from Spirit (going bankrupt) and Frontier (despite they're nickel and dimers). But from Delta's World Hub? That's totally unacceptable!

This flight was straightforward and without difficulty. Service was OK, but I continue to be underwhelmed by level of attention given to Sky Priority passengers.

It would’ve been nice for all that money to have a more substantial snack for free. I remember once upon a time getting a very nice turkey sandwich with Swiss cheese on whole wheat bread for no charge along with a drink. I guess those days are gone. it’s a little insulting being given a cookie or a bag of baked chips Going forward I’ll just bring my own.

Our flight from SFO to MSP was right on time on 11/15/2025. No delays. As we approached MSP at about 8 pm, we circled in the air until 8:40 pm so I don't call that efficient for MSP. I think the captain should announce the delay and why. (as if we all don't know that we are just circling around the area, slowing down, speeding up, slowing down.) Thank you. Marilyn Fischer

Service in business class was not impressive. I ordered coffee with dinner and then watched other people get 2 refills before I got my 1 cup of coffee, and only after I pressed the attendant button overhead. Furthermore, the seats in the forward cabin need maintenance on this 737-800: the upholstery is detaching from the seat frame, at least on the backs of seats 1C, 1D.

I like that the crew kept us informed but we moved back and forth from gate to gate before the aircraft arrived.

I like how the crew and pilot kept us updated Even though our flight was slightly delayed. We made up time for it in the air. I really did enjoy my seat and amenities and my trip and value overall.

The flight was delayed multiple times, again no fault of American but again the extra cost, for everything makes it feel like a cheap airline! Especially when flights are outrageously expensive already

The inflight staff is never the issue always the extra and charges american charges! Literally 30 bucks for WiFi! Is insane and then it’s choppy and slow. If you pay for it once you don’t need to pay again for switching aircraft especially when there is flight delays

Horrible. Both legs of my flight were delayed more than 6 hours. No compensation, no screens on the plane, and the plane was not clean.

I had a positive experience on American. I'm blind and traveling with a guide dog and the flight attendants were so kind, friendly, and helpful towards us. They checked in on us during the flight and they made us feel comfortable and welcomed. There was an hour delay before depature, but overall the flight was a smooth ride. I appreciate that there were no issues on this long flight back home.

We were told the flight was delayed 5 times, then it was moved to the next day.

More choices on snacks. Built-in video screen to enjoy entertainment choices.

we landed at cmh ten minutes early but had to sit on tarmac for twenty minutes because a plane was at our gate despite the fact that 3 other gates were open.

flight was good until we arrived at cmh ten minutes early but then sat on tarmac for twenty minutes because a plane was at our gate, so we had to wait despite the pilot tellling us that 3 other gates were open.

Everything you need to know for your flight from Santiago to Missouri

Information on your arrival and departure airports