$407 Find Cheap Flights from Santiago to Missouri

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santiago to Missouri departing on 8/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Missouri

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santiago to Missouri, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santiago to Missouri, as well as popular online travel agencies
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Cheap Flights from Santiago to Missouri

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
St. Louis
St. Louis2 stops$920
Kansas City
Kansas City1 stop$907
St. Louis
St. Louis2 stops$920
Kansas City
Kansas City1 stop$907

Book Cheap Santiago to Missouri Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santiago to Missouri that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santiago to Missouri

Mon, May 25 - Mon, Jun 1
Multiple Airlines Logo
11:05 pm - 11:57 pm
SCL
-
STL
25h 52m
2 stops
Multiple Airlines Logo
4:19 pm - 8:55 pm
STL
-
SCL
51h 36m
3 stops
$920Multiple Airlines
Wed, Jul 15 - Wed, Aug 5
American Airlines Logo
8:30 pm - 10:53 pm
SCL
-
STL
27h 23m
1 stop
American Airlines Logo
5:18 am - 6:50 am
STL
-
SCL
24h 32m
1 stop
$973American Airlines
Wed, Jul 15 - Wed, Aug 5
American Airlines Logo
8:30 pm - 10:24 am
SCL
-
STL
14h 54m
1 stop
American Airlines Logo
5:18 am - 6:50 am
STL
-
SCL
24h 32m
1 stop
$975American Airlines
Wed, Jul 15 - Wed, Aug 5
American Airlines Logo
8:30 pm - 10:24 am
SCL
-
STL
14h 54m
1 stop
American Airlines Logo
10:14 am - 6:50 am
STL
-
SCL
19h 36m
2 stops
$978American Airlines
Wed, Jul 15 - Wed, Aug 5
American Airlines Logo
8:30 pm - 10:53 pm
SCL
-
STL
27h 23m
1 stop
American Airlines Logo
10:16 am - 6:50 am
STL
-
SCL
19h 34m
2 stops
$980American Airlines
Wed, Jul 15 - Wed, Aug 5
American Airlines Logo
8:30 pm - 10:24 am
SCL
-
STL
14h 54m
1 stop
American Airlines Logo
1:01 pm - 6:50 am
STL
-
SCL
16h 49m
2 stops
$982American Airlines
Wed, Jun 24 - Thu, Jul 2
LATAM Airlines Logo
11:00 pm - 6:07 pm
SCL
-
STL
20h 07m
2 stops
LATAM Airlines Logo
1:39 pm - 6:55 am
STL
-
SCL
16h 16m
2 stops
$1,004LATAM Airlines
Wed, Jun 3 - Wed, Jul 15
LATAM Airlines Logo
10:30 am - 9:44 am
SCL
-
STL
24h 14m
2 stops
LATAM Airlines Logo
1:22 pm - 6:55 am
STL
-
SCL
16h 33m
2 stops
$1,010LATAM Airlines
Tue, Jul 14 - Wed, Aug 5
Delta Logo
12:40 am - 5:53 pm
SCL
-
STL
18h 13m
2 stops
Delta Logo
1:22 pm - 7:15 am
STL
-
SCL
16h 53m
1 stop
$1,016Delta
Wed, Jun 3 - Wed, Jul 15
LATAM Airlines Logo
11:00 pm - 5:56 pm
SCL
-
STL
19h 56m
2 stops
LATAM Airlines Logo
1:22 pm - 6:55 am
STL
-
SCL
16h 33m
2 stops
$1,027LATAM Airlines
Booking Insights

KAYAK's insights & trends for Santiago to Missouri flights

Get data-powered insights and trends into flights from Santiago to Missouri to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Santiago to Missouri?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Santiago to Missouri departing in May.

What is the cheapest month to fly from Santiago to Missouri?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santiago to Missouri, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Santiago to Missouri is December, when tickets cost $795 (return) on average. On the other hand, the most expensive months are May and January, when the average cost of round-trip tickets is $1,222 and $1,150 respectively.

Good to know

Low seasonApril
Cheapest flight$407
Best time to beat the crowds but there is an average 13% increase in price.
Most popular time to fly with an average 5% increase in price.
Flight from Santiago to St. Louis

FAQs - booking Missouri flights

  • How does KAYAK find such low prices on flights from Santiago to Missouri?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Santiago to Missouri.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Santiago to Missouri?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Santiago to Missouri is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Santiago to Missouri?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Santiago to Missouri with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Santiago to Missouri?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Santiago to Missouri up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Santiago to Missouri

 
See real verified KAYAK customer reviews for airlines flying from Santiago to Missouri. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santiago to Missouri? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8399 reviews
8.1Boarding
7.2Food
8.5Crew
7.8Entertainment
7.9Comfort
Airline reviews

The flight was smooth, the crew was great but the plane was quite old

8.0 ExcellentDimitrina, Apr 2026
BOS - DCA
Read more Delta reviews

The flight was smooth, the crew was great but the plane was quite old

Everything was great until I lost my water bottle and they can’t seem to locate it. I know I left it on the plane though.

WiFi didn’t work most of the time. The usb chargers would work only occasionally for 5 mins and wouldn’t charge after that. Had to keep trying repeatedly at each of the seats in the row.

The crew bent over backwards to thank us for flying and make us comfortable. The food service was quick and efficient. The Captain communicated and said goodbye and thank you as we departed. They really stood out!

Okay considering we had weather delays which the Pilot notified us of immediately!

Generally on time departures and arrivals, clean planes, sky miles membership provides great benefits (complimentary upgrades, etc).

Flight from Fort Wayne to Atlanta was the smallest in terms of cabin space that I've ever seen. A carry on I've used for 20 years BARELY fit in overhead compartment. I'm 5'10" and felt very cramped. Not the best experience.

I am writing to express my dissatisfaction with the poor service and unprofessional staff we encountered when traveling with an infant. Our flight was delayed, and the gate staff failed to manage the boarding process appropriately. Due to incorrect, unavailable, or missing 'pink tag' stroller and car seat check-in procedures at the gate, we were forced to board last. Furthermore, the gate staff was rude and dismissive, causing significant distress to our infant. To make matters worse, one of our checked items—an infant sleeper/lounger—was returned to us broken. Given the unsafe handling of essential equipment and unprofessional treatment, I expect a prompt resolution regarding compensation for the damaged items.

We departed and landed early which was a nice surprise. The boarding process was slow.

N Everything was perfect from boarding to assistance to baggage in Tampa

THe flight was an hour late. You got us on the plan and we sat on the ground for 45 minutes with no information from the pilot whatsoever. Worst flight this year.

Boarding was quick and efficient. We arrived at our destination early.

I'm not sure American is capable of on-time arrivals and departures. When you land at ORD, you almost always get held on the tarmac because your gate is still occupied. I may have missed my connection, but that ended up up being significantly delayed as well. Once again, I finally got home well after midnight.

Same plane as RDU to LGA — internet not working. Pilot issue of some sort at end of prior flight - I was on same plane for my connection. Late/delayed —

Good flight, seated and had a water within 5 minutes. Crew was hospitable.

Didn't make it back on American Airlines due to a maintenance issue. The communication and updates were terrible. I ended up returning on Aero Mexico which had a much nicer aircraft with a large entertainment screen with movies and shows AND they had a nice inflight meal. That was a treat after being delayed 26 hours! I think some additional flight miles, or something should be offered for that long of a delay ---it was not pleasant at all---very physical and emotional experience.

Message about flight cancelation was received late due to being in the air. No explanation, just canceled and booked on morning flight. We had to stay in the airport overnight because there was no transportation offered to get to the hotel that AA had available. Actual inflight was fine.

Buying ticket from kayak instant booking was a huge mistake, never to be repeated again! The Kayak didn’t book the tickets directly, it handed it off to a third party Underpricer, that booked a code shared American Airlines flight operated by Cathay Pacific!! When managing the booking American Airlines would recognize the itinerary but wouldn’t let me do anything stating, the flight is operated by Cathay Pacific so go to their website. Cathay Pacific would recognize the itinerary, neither by reservation ID or ticket number…asking to reach out to the third party Underpricer….calling Underpricer resulted in no help like seat requests, mileage number or upgrade request, 15hr layover accommodation voucher guidance…so net in net avoid booking through three layers of intermediaries

I didn't go from Reno to Phoenix I ended up going from Reno to Dallas to Tucson because my flight rebooked because my Amtrak was late I tried notifying you guys I also don't know what you ask me about my flight because you guys didn't book my flight

A chaotic and uncomfortable experience from start to finish. The boarding process was a disaster; despite group numbers, it was a free-for-all that the staff failed to manage (especially after group 5). Once on board, the "entertainment" was non-existent. There are no seatback screens, and the mobile app selection is incredibly thin. The hardware is severely dated. My seat had zero cushioning left—it felt like sitting on a hard board for the entire flight—and the legroom was cramped. To make matters worse, the bathroom was repulsive, with toilet paper, soiled paper towels and liquid/pee all over the floor. When I did interact with the crew, they provided the absolute bare minimum and made me feel like an inconvenience for asking for anything. Avoid this flight if you can.

Everything you need to know for your flight from Santiago to Missouri

Information on your arrival and departure airports