$304 Find Cheap Flights from Santo Domingo to Panama City - Compare and Save

Among airlines operating Santo Domingo to Panama City flights:

• Copa Airlines: offers free seat selection

Extra legroom and free seat selection availability depends on fare class and route.

Only Copa Airlines operates flights between Santo Domingo and Panama City.

Flights from Santo Domingo to Panama City usually depart from Santo Domingo Las Americas (SDQ) and arrive at Panama City Tocumen Intl (PTY).

Here are some options for this route, based on selected ticket types and cabin classes:

• Copa Airlines: a cabin bag and a checked bag in Economy Class

Bag allowance can vary by ticket type, cabin class, route and airline, so travelers should check the fare details before booking.

Two cabin classes are available on flights from Santo Domingo to Panama City:

• Economy Class
• Business Class

On this route, layover flights are cheaper than nonstop options on average. Layover fares average $556 round-trip via Bogotá El Dorado (BOG), compared to $619 for nonstop.

There is no standard. Checked-bag policies vary by airline on this route. Most carriers charge $59–$100 for the first checked bag in economy. Premium fares and elite-status bookings typically include a free checked bag.

The Boeing 737 MAX 8 family is used most often on this route, operated mainly by Arajet and WorldTicket. Other aircraft seen on the route include Boeing 737-800 variants.

One-stop flights from Santo Domingo to Panama City most commonly connect through:

• Bogotá El Dorado (BOG) - 98% of one-stop connections
• Medellín Jose Maria Cordova Intl (MDE) - 1% of one-stop connections
• Miami (MIA) - 0% of one-stop connections
• San José Juan Santamaria Intl (SJO) - 0% of one-stop connections

Bogotá El Dorado (BOG) handles the largest share of one-stop connections on this route.

Yes. Being flexible with your travel dates can save you up to 10% on the Santo Domingo to Panama City route. Tuesday is the cheapest departure day at $572 round-trip on average, while Sunday is the most expensive at $630, a difference of $58. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

A flight is considered delayed when it departs 15 minutes or more after its scheduled time. This is the standard used by the US Department of Transportation and most airline industry reporting. On the Santo Domingo to Panama City route, 5% of flights were delayed in the past 3 months, with delays averaging 1 hour 46 minutes.

Afternoon is the busiest departure period on Santo Domingo to Panama City flights, with 60% of flights leaving in that window. Morning departures account for 20%, evening flights for 20%, and night flights for 0%.

Some of the most popular sights in Panama City are Avenida Balboa, Panama City Centre and Multiplaza Pacific. These are among the most viewed places in Panama City on KAYAK.

These are the earliest and latest flight times available from Santo Domingo to Panama City:

• Earliest: departs at 5:53 am and lands at 8:27 am
• Latest: departs at 7:07 pm and lands at 9:41 pm.

The flight takes about 2h 34m.

Last-minute fares on this route - booked within 2 weeks of departure - run 22% above the route average of $608. Book 7 weeks before departure for the lowest fares.

A nonstop flight from Santo Domingo to Panama City takes 2h 34m, covering 917 miles.

Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $557 to $2,621. That means the highest observed fare was about 5x higher than the lowest one.

One-way fares from Santo Domingo to Panama City are currently lower than usual. Average one-way flight prices are about $411, which is 16% below the typical average for this route.

Copa Airlines is the only airline operating Santo Domingo to Panama City flights. 95% of its flights are on time.

Night flights have the fewest delays on this route. Delays tend to pile up throughout the day as one late flight pushes the next, so earlier departures are usually more reliable.

Flying via Bogotá El Dorado (BOG) gives the shortest average 1-stop total travel time at 6h 50m, compared with 7h 24m via Medellín Jose Maria Cordova Intl (MDE) and 7h 56m via Miami (MIA).

Panama City is 1 hour behind Santo Domingo (Eastern Time vs Atlantic Time). Plan for the time shift when scheduling connections or first-day activities.

Panama City Tocumen Intl Airport (PTY) hosts 5 major car rental companies, with daily rates starting from around $1 for economy cars. Top options include:
• Avis
• Europcar
• Ace
• Budget
• Hertz

Round-trip flights from Santo Domingo to Panama City range from $524 to $676, with an average of $608 over the past 12 months. Anything below $524 counts as a good deal.