$335 Find Cheap Flights from Santo Domingo to Panama City - Compare and Save

These are the earliest and latest flight times available from Santo Domingo to Panama City:

• Earliest: departs at 5:50 am and lands at 8:27 am
• Latest: departs at 7:28 pm and lands at 10:05 pm.

The flight takes about 2h 37m.

Two cabin classes are available on flights from Santo Domingo to Panama City:

• Economy Class
• Business Class

A nonstop flight from Santo Domingo to Panama City takes 2h 37m, covering 917 miles.

Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

Round-trip flights from Santo Domingo to Panama City range from $536 to $677, with an average of $618 over the past 12 months. Anything below $536 counts as a good deal.

Last-minute fares on this route (booked within two weeks of departure) run 21% above the $618 route average. Book 8 weeks before departure for the lowest fares.

On this route, layover flights are cheaper than nonstop options on average. Layover fares average $567 round-trip via Bogotá El Dorado (BOG), compared to $629 for nonstop.

Copa Airlines is the only airline operating Santo Domingo to Panama City flights. 95% of its flights are on time.

There is no standard. Checked-bag policies vary by airline on this route. Most carriers charge $100–$100 for the first checked bag in economy. Premium fares and elite-status bookings typically include a free checked bag.

The Boeing 737 MAX 8 family is used most often on this route, operated mainly by Copa Airlines and Arajet. Other aircraft seen on the route include Boeing 737-800 variants.

Afternoon is the busiest departure period on Santo Domingo to Panama City flights, with 50% of flights leaving in that window. Morning departures account for 25%, evening flights for 25%, and night flights for 0%.

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $481 to $2,805. That means the highest observed fare was about 6x higher than the lowest one.

One-way fares from Santo Domingo to Panama City are currently lower than usual. Average one-way flight prices are about $433, which is 10% below the typical average for this route.

Panama City Tocumen Intl Airport (PTY) hosts 5 major car rental companies, with daily rates starting from around $1 for economy cars. Top options include:

• Avis
• Ace
• Europcar
• Budget
• Thrifty

Flights from Santo Domingo to Panama City usually depart from Santo Domingo Las Americas (SDQ) and arrive at Panama City Tocumen Intl (PTY).

Night flights have the fewest delays on this route, while afternoon departures tend to have the most.

A flight is considered delayed when it departs 15 minutes or more after its scheduled time. This is the standard used by the US Department of Transportation and most airline industry reporting. On the Santo Domingo to Panama City route, 5% of flights were delayed in the past 3 months, with delays averaging 1h 49m.

One-stop flights from Santo Domingo to Panama City most commonly connect through:

• Bogotá El Dorado (BOG) - 97% of one-stop connections
• Medellín Jose Maria Cordova Intl (MDE) - 2% of one-stop connections
• San José Juan Santamaria Intl (SJO) - 1% of one-stop connections
• Mexico City Benito Juarez (MEX) - 0% of one-stop connections

Yes. Flexible dates can save you up to 6% on flights from Santo Domingo to Panama City. Friday is the cheapest departure day at $599 round-trip on average, while Sunday is the most expensive at $637, a difference of $38.

KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

Only Copa Airlines operates flights between Santo Domingo and Panama City.

Flying via Bogotá El Dorado (BOG) gives the shortest average 1-stop total travel time at 7h 01m, compared with 7h 56m via Miami (MIA) and 8h 34m via Medellín Jose Maria Cordova Intl (MDE).

Panama City is 1 hour behind Santo Domingo (Eastern Time vs Atlantic Time). Plan for the time shift when scheduling connections or first-day activities.

Some of the most popular sights in Panama City are ATLAPA Conventions Center, Panama Old Cathedral and Veneto Casino. These are among the most viewed places in Panama City on KAYAK.

Among airlines operating Santo Domingo to Panama City flights:

• Copa Airlines: offers extra legroom; offers free seat selection

Extra legroom and free seat selection availability depends on fare class and route.

Here are some options for this route, based on selected ticket types and cabin classes:

• Copa Airlines: a cabin bag and a checked bag in Economy Class

Bag allowance can vary by ticket type, cabin class, route and airline, so always check the fare details before booking.