FSD - ECP

$291 Find Cheap Flights from Sioux Falls to Panama City - Compare and Save

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Sioux Falls to Panama City departing on 9/22. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$291
Typical prices: $380-$385
Delta
Tue 9/22Sat 9/26
FSD - ECP • 1 stop
Cheapest one-way
$304
American Airlines
Wed 9/9
FSD - ECP • 1 stop
Top airlines
Cheapest • from $291 (round-trip)
Best reviews • 7.8 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Sioux Falls and Panama City. You'll need at least 1 connection.
Insights
Insights
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Insights
Top layover airports
Cheapest • Avg $409 (round-trip)
Shortest trip • 5h 56m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 100% price drop
Most popular
Good to know
Good to know
+1
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Good to know
Good to know
+1
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We hope you love your trip to Panama City!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Sioux Falls to Panama City (FSD-ECP)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Sioux Falls to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Sioux Falls to Panama City

Tue, Sep 22 - Sat, Sep 26
Delta Logo
5:30 am - 12:39 pm
FSD
-
ECP
7h 09m
1 stop
Delta Logo
1:46 pm - 7:49 pm
ECP
-
FSD
6h 03m
1 stop
$291Delta
Wed, Aug 26 - Sat, Sep 5
American Airlines Logo
12:57 pm - 10:40 pm
FSD
-
ECP
9h 43m
2 stops
American Airlines Logo
3:00 pm - 8:31 pm
ECP
-
FSD
5h 31m
1 stop
$296American Airlines
Wed, Aug 26 - Sat, Sep 5
American Airlines Logo
12:57 pm - 10:40 pm
FSD
-
ECP
9h 43m
2 stops
American Airlines Logo
7:10 am - 8:31 pm
ECP
-
FSD
13h 21m
2 stops
$301American Airlines
Tue, Sep 22 - Sat, Sep 26
Delta Logo
5:30 am - 12:39 pm
FSD
-
ECP
7h 09m
1 stop
Delta Logo
1:46 pm - 7:49 pm
ECP
-
FSD
6h 03m
1 stop
$305Delta
Wed, Aug 12 - Tue, Aug 18
American Airlines Logo
6:24 am - 2:30 pm
FSD
-
ECP
8h 06m
1 stop
American Airlines Logo
6:40 am - 4:53 pm
ECP
-
FSD
10h 13m
2 stops
$310American Airlines
Tue, Sep 22 - Sat, Sep 26
Delta Logo
1:05 pm - 11:05 pm
FSD
-
ECP
10h 00m
2 stops
Delta Logo
6:00 am - 12:19 pm
ECP
-
FSD
6h 19m
2 stops
$315Delta
Tue, Sep 22 - Sat, Sep 26
American Airlines Logo
6:00 am - 11:42 am
FSD
-
ECP
5h 42m
1 stop
American Airlines Logo
3:17 pm - 8:45 pm
ECP
-
FSD
5h 28m
1 stop
$330American Airlines
Tue, Sep 22 - Sat, Sep 26
Delta Logo
1:05 pm - 11:05 pm
FSD
-
ECP
10h 00m
2 stops
Delta Logo
1:46 pm - 7:49 pm
ECP
-
FSD
6h 03m
1 stop
$335Delta
Tue, Sep 22 - Sat, Sep 26
Delta Logo
1:05 pm - 11:05 pm
FSD
-
ECP
10h 00m
2 stops
Delta Logo
6:00 am - 12:19 pm
ECP
-
FSD
6h 19m
2 stops
$340Delta
Wed, Aug 12 - Tue, Aug 18
Delta Logo
5:30 am - 10:42 am
FSD
-
ECP
5h 12m
1 stop
Delta Logo
1:53 pm - 7:59 pm
ECP
-
FSD
6h 06m
1 stop
$344Delta
Booking Insights

KAYAK's insights & trends for Sioux Falls to Panama City flights

Get data-powered insights and trends into flights from Sioux Falls to Panama City to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Sioux Falls to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Sioux Falls to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Sioux Falls to Panama City is January, where tickets cost $0 (return) on average. On the other hand, the most expensive months are December and May, where the average cost of round-trip tickets is $1,362 and $1,136 respectively.

Good to know

Low season

October

Cheapest flight

$291
Best time to beat the crowds with an average 43% drop in price.
Most popular time to fly and prices are also 21% lower on average.
Flight from Sioux Falls to Panama City

When to book flights from Sioux Falls to Panama City

Are your dates flexible? Find out the best times to travel from Sioux Falls to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Sioux Falls to Panama City

  • What is the cheapest flight from Sioux Falls to Panama City?

    In the last 5 days, the lowest price for a flight from Sioux Falls to Panama City was $304 for a one-way ticket and $291 for a round-trip.

  • Do I need a passport to fly between Sioux Falls and Panama City?

    No

  • Which aircraft models fly most regularly from Sioux Falls to Panama City?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Sioux Falls to Panama City?

    SkyTeam, and oneworld are the airline alliances operating flights between Sioux Falls and Panama City, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Sioux Falls to Panama City, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Sioux Falls to Panama City are Delta and American Airlines. With an average price for the route of $418 and an overall rating of 7.8, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $398 and an overall rating of 7.1.

  • How does KAYAK find such low prices on flights from Sioux Falls to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Sioux Falls to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Sioux Falls to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from Sioux Falls is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Sioux Falls to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to Sioux Falls with another airline. Booking your flights between Sioux Falls and ECP can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Sioux Falls to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from Sioux Falls up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Sioux Falls to Panama City

 
See real verified KAYAK customer reviews for airlines flying from Sioux Falls to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Sioux Falls to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8469 reviews
7.8Entertainment
8.5Crew
7.2Food
7.8Comfort
8.1Boarding
Airline reviews

Flight was delayed and then "they did not have time to load food". No snack or drink at all for 1.5 how flight. Somebody wasn't prepared.

4.0 OkayAlexander, Jul 2026
ATL - TPA
Read more Delta reviews

Flight was delayed and then "they did not have time to load food". No snack or drink at all for 1.5 how flight. Somebody wasn't prepared.

It is usually very pleasant. Good service for the price, international flights are even better

New high end luggage ruined/zippers broken, items missing. All happened on return flight from msp to mso. Do better! Not store bought luggage but high end personalized ogio custom embroidered luggage. Total slap in the face ontop of an extra luggage fee that took me 3 hrs on chat to resolve.

Third flight in two months where the crew was not there. Comfort seating does not guarantee overhead bin space. Passengers with children are allowed on the plane first - if you are flying to and from Orlando, this means half the plane has boarded before you get on. And somehow all the bin space is taken up. 3 out of 5 flights have had issues with equipment or procedure. Some of these instances caused the flight to be delayed because of a "nuisance" light. One time it was a bag that had been brought on board but did not belong to anyone so we had to return to the gate. Last night we were told the "AC" on the plane doesn't work well and we're 10th for take off- because the crew was late - and that it will get cool when we're in the air. Not sure if this is usual, but I didn't think flight crew could jump seat in first class. Movie and TV selection has not been refreshed for several months- flying one to two round trips each month easily exhausts the list of content.

Definitely a southern flavor. Cordiality was evident even though no drinks or snacks were served.

No service flight that took 5 hrs and a stop at an unscheduled airport. Crew and pilots did their jobs

I continue to be satisfied with Delta’s excellent service out of LGA. The digit id works well and gets me through security in no time. Whenever possible, I choose Delta.

Was revoked with Jet Blue due to delay from Kenya Air

Overall Good! The weather delayed our takeoff from Atlanta and our arrival in Miami! If Mother Nature can mess up a flight she will do it every time!

We checked one bag. That was fast and the agent was fast and super nice. At the gate, boarding was fast and efficient. Flight was uneventful which was great because it was early in the morning and most folks were sleeping. Landing was great. Delta does a really good job of making the flying experience better all around considering you are sitting in such a small space on a plane for several hours. Flight from ALT to Panama City was short and uneventful as well. No entertainment but no need since it was such a short flight.

The departure and arrival was on time. The fact that I could load my boarding tickets on the American airlines app.

Horrible experience, delays after delays. A flight that should arrive 11:50pm just landed past 1 am, and another 30min waiting for the baggage to come out. Very disappointing.

The flight was delayed significantly. Communication during the flight was abrupt and caused some panic as we were navigating turbulence. It was also too loud and every announcement felt startling. The flight attendants did not offer any assurances and I felt unsettled most of the flight. The seats, floor and tray table was very dirty. The seat next to me was broken and the passenger sitting there was very uncomfortable. He had a spring in his back and his seat made terrible squeaking noises through the flight.

My experience with American Airlines was great. Unfortunately my stroller was not located and has not been given to me and or reached out in return for in regard to information.

It was awful. The communication between corporate and the crew on the ground left more to be desired. The crew even said that Corporate was waiting on answers because they themselves didn't know. Every hour, there was a new excuse. I also understood that passengers were angry, but the crew should have done a better job at crowd control. There was a racial exchange between passengers that could've been avoided has the crew acted sooner.

We sat on plane at gate delayed without communication as to why we were just sitting there

Flight was delayed by 6 hours... the level of incompetence was truly astounding. I won't be flying American Airlines again. I don't care if AA is direct and there is a layover with another airline, I'll take the layover.

Little time between flight from Dallas to flight to Gainesville. We chose this one, 43 minutes between, because the price for a connection with at least an hour between, was so much higher. Had to ask passengers on the Dallas flight to please allow us to deplane ahead of them. The economy passengers allowed this. We had to walk very fast to the next gate, 35 gates away. Thankfully all in the same terminal. Getting to the small Gainesville plane was a little confusing as you enter an area that is boarding many small planes at the same time. We stood in the wrong line for about 15 seconds before realizing it was not our Gainesville flight. Since I had boarded at this gate in the past, I knew to check the signs carefully so we weren’t lost. The first class seat experience was wonderful. I really enjoyed the upgrade. We were offered an alcohol drink as soon as we sat down. I got something different but it was a great gesture especially since we really had to hurry to make the flight. We had packed expecting we might miss this connection, but made it. Our luggage didn’t miss the flight. American Airlines delivered our bags to our home the next day. That was very convenient!

I had a carry on and a personal bag. I put my personal item under my seat and on way to the seat I put my bag up. I usually close my eyes and rest as I was on call for last 36 hours. I heard very loud announcements that someone needs to identify their bag. Pretty sure it was not mine until the hostess pointed out my jacket details attached to the bag. I asked why she got my bag out. I got berated and did not want to create a scene. But this person needs to be talked to.

Other than being delayed 5.5 hours and having to get a hotel because I missed my connecting flight, it was an okay flight. No in-flight Wi-Fi or entertainment.

Everything you need to know for your flight from Sioux Falls to Panama City

Information on your arrival and departure airports