$172 Find Cheap Flights from South America to Charlotte

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to Charlotte departing on 12/17. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$277
Typical prices: $371-$575
Spirit Airlines
Thu 1/22Sun 1/25
MDE - CLT • 1 stop
Cheapest one-way
$172
Typical prices: $237-$301
Spirit Airlines
Wed 12/17
MDE - CLT • 1 stop
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Flight Deals

Cheap Flights from South America to Charlotte

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from South America to Charlotte that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from South America to Charlotte

Thu, Jan 22 - Sun, Jan 25
Spirit Airlines Logo
3:15 pm - 8:11 amMDE-CLT
16h 56m1 stop
Spirit Airlines Logo
6:00 am - 2:15 pmCLT-MDE
8h 15m1 stop
$277Spirit Airlines
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Thu, Dec 18 - Fri, Jan 2
Spirit Airlines Logo
2:25 am - 9:39 amMDE-CLT
7h 14m1 stop
Spirit Airlines Logo
9:00 am - 1:28 amCLT-MDE
16h 28m1 stop
$278Spirit Airlines
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Fri, Jan 30 - Sat, Feb 7
Spirit Airlines Logo
3:15 pm - 12:40 amMDE-CLT
9h 25m1 stop
Spirit Airlines Logo
6:00 am - 2:15 pmCLT-MDE
8h 15m1 stop
$284Spirit Airlines
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Fri, Dec 19 - Fri, Jan 2
Spirit Airlines Logo
3:10 pm - 11:29 pmMDE-CLT
8h 19m1 stop
Spirit Airlines Logo
9:00 am - 1:28 amCLT-MDE
16h 28m1 stop
$285Spirit Airlines
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Tue, Feb 10 - Wed, Feb 18
United Airlines Logo
1:35 am - 5:24 pmUIO-CLT
39h 49m2 stops
United Airlines Logo
6:33 am - 12:30 amCLT-UIO
17h 57m1 stop
$612United Airlines
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Fri, Feb 13 - Sun, Feb 22
Delta Logo
11:45 pm - 1:39 pmUIO-CLT
13h 54m1 stop
Delta Logo
9:54 am - 5:17 amCLT-UIO
19h 23m2 stops
$636Delta
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Thu, Jan 22 - Tue, Jan 27
LATAM Airlines Logo
9:30 pm - 8:40 amSCL-CLT
13h 10m1 stop
LATAM Airlines Logo
2:25 pm - 7:00 amCLT-SCL
14h 35m2 stops
$689LATAM Airlines
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Tue, Jan 20 - Tue, Feb 3
Delta Logo
3:20 pm - 10:50 amCNF-CLT
21h 30m2 stops
Delta Logo
2:25 pm - 12:25 pmCLT-CNF
20h 00m2 stops
$876Delta
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Tue, Jan 20 - Tue, Feb 3
LATAM Airlines Logo
10:15 am - 8:40 amCNF-CLT
24h 25m2 stops
LATAM Airlines Logo
2:25 pm - 12:25 pmCLT-CNF
20h 00m2 stops
$885LATAM Airlines
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Mon, Jan 19 - Tue, Feb 3
American Airlines Logo
6:00 pm - 10:56 amCNF-CLT
18h 56m2 stops
American Airlines Logo
1:10 pm - 10:30 amCLT-CNF
19h 20m2 stops
$906American Airlines
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Good to know

Low seasonOctober
Cheapest flight$172
Best time to beat the crowds but there is an average 4% increase in price.
Most popular time to fly and prices are also 4% lower on average.
Flight from Medellín to Charlotte

FAQs for booking flights from South America to Charlotte

  • How does KAYAK find such low prices on flights from South America to Charlotte?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from South America to Charlotte.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from South America to Charlotte?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Charlotte from South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from South America to Charlotte?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Charlotte with an airline and back to South America with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from South America to Charlotte?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Charlotte from South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from South America to Charlotte

 
Need help choosing which airline to fly with from South America to Charlotte? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8010 reviews
7.9Comfort
8.5Crew
7.9Entertainment
7.3Food
8.1Boarding
Airline reviews

My flight was cancelled with no explanation after I had already cleared security. I was given 4 options to rebook, only one being non-stop like I had paid for. I grabbed it. It was 4 plus hours later and then took off even later. Biggest complaint is that I booked early and had an aisle seat. They gave me a "window" seat in front of the exit row, so the seat did not decline. I weigh all of 103 #s and it was tight for me! For what I paid, I feel I was kind of ripped off. I think they should have given me the empty comfort seat for the inconvenience. There was no apology nor any explanation as to why the flight was cancelled. My guess is it benefitted Delta in some way.

6.0 GoodMary Heather, Nov 2025LGA - MKE
Read more Delta reviews

My flight was cancelled with no explanation after I had already cleared security. I was given 4 options to rebook, only one being non-stop like I had paid for. I grabbed it. It was 4 plus hours later and then took off even later. Biggest complaint is that I booked early and had an aisle seat. They gave me a "window" seat in front of the exit row, so the seat did not decline. I weigh all of 103 #s and it was tight for me! For what I paid, I feel I was kind of ripped off. I think they should have given me the empty comfort seat for the inconvenience. There was no apology nor any explanation as to why the flight was cancelled. My guess is it benefitted Delta in some way.

Very smooth, on-time, and pleasantly uneventful flight. The team at the gate and on board were professional and genuinely courteous. The pilot kept us well updated throughout, and both takeoff and landing were steady and enjoyable without any drama. Just a good, solid flight. Thank you! 💗

Staff was exceptional! Everyone was kind, professional and friendly making the trip very pleasant. Thank you!

No lunch on a x-country flight scheduled for 10:50 am departure, arrived 5+ hrs later. That requires a black box label before you pay for the tickets. Worst, when I checked in online, it's specifically said that lunch was served on his flight for economy Plus passengers.

We had a lot of really rough weather but that was not Delta's fault. Pilot was amazing.

One of the best airlines that I flew on, the flight attendants were very attentive and professional.

First, Delta needs more flights to/from Miami. Second, a 1000pm leaving at 1230pm is unacceptable from their biggest airport world hub. Another aircraft could have been used such as the aircraft scheduled to be used in the morning for that exact same route. Yes, I did get me there but the lack of sleep the next day didn't help me enjoy my entire trip since I was busy with activities during the weekend. This can be and is expected from Spirit (going bankrupt) and Frontier (despite they're nickel and dimers). But from Delta's World Hub? That's totally unacceptable!

This flight was straightforward and without difficulty. Service was OK, but I continue to be underwhelmed by level of attention given to Sky Priority passengers.

It would’ve been nice for all that money to have a more substantial snack for free. I remember once upon a time getting a very nice turkey sandwich with Swiss cheese on whole wheat bread for no charge along with a drink. I guess those days are gone. it’s a little insulting being given a cookie or a bag of baked chips Going forward I’ll just bring my own.

Our flight from SFO to MSP was right on time on 11/15/2025. No delays. As we approached MSP at about 8 pm, we circled in the air until 8:40 pm so I don't call that efficient for MSP. I think the captain should announce the delay and why. (as if we all don't know that we are just circling around the area, slowing down, speeding up, slowing down.) Thank you. Marilyn Fischer

Wish the seats were a little more comfortable.. it was a 6 hrs nonstop trip. But the crew was courteous and w a smile

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor, the airline was not able to help me move flights.

Check in -- in business took over 30 mins as there was only one attendant. Boarding was also a mess. The seat was too narrow and was not working properly. Food was very bad and the entertainment very poor. Crew was very polite and helpful, in fairness.

The plane broke down at the Lima stopover and they offered to put me on a flight the be t day but I had to be back in LA that morning and so I had to buy another ticket from Avianca and United for $2k I asked LATAM for compensation and received none. Very bad experience

The flight was late. Please do not delay next time.

Boarding was confusing with a delayed flight because there was no English translation

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

My entertainment did not work. I was very tired from the botched connection, and the poor sleep

Very bad! They kept delaying my flight and wouldn’t do anything about it

They brought an empty plane to the gate. Then a flight delay was announced for maintenance and waiting on a part. I was then put on a flight to San Francisco instead with a connecting flight to my final destination. Arrived at my final destination 2 hours late.

The only downside was my cell phone charger wouldn’t work in the charging port but everyone else’s would work in them all. My cell phone cable works fine in my hotel room in Frankfurt.

Flight team stood out for perzonal attention, kindness at bright cheery attitudes at 8am. Very helpful.

Ot was overall fine. Left on time and had basic snacks. Weather was finicky but that’s not the airlines fault.

Quick and seamless boarding. No entertainment but fast Starlink wifi for this short trip and the staff was really friendly.

We boarded late. The crew at the airport was dismissive. The seat cushion on the plane was uncomfortable.

Very thoughtful flight attendant offered me water immediately since I had run to make my connection.

Door to door, the crew and staff were amazing. It was a stressful travel day with delays, but they were focused on customers and doing what they could to get us to our destinations.

I dread trans-Pacific flights. They are very long. This was my first time on Universal, and it was my best crossing ever. The staff were professional, the hospitality was great, and the food was delicious. The entertainment system filled the long flight hours. I will seek out Universal flights from now onwards. 🙂

I had a positive experience on American. I'm blind and traveling with a guide dog and the flight attendants were so kind, friendly, and helpful towards us. They checked in on us during the flight and they made us feel comfortable and welcomed. There was an hour delay before depature, but overall the flight was a smooth ride. I appreciate that there were no issues on this long flight back home.

Did not get any refreshments. Crew was very nice but limited. Small seats

The flight was flawless and we even arrived between 20 and 25 minutes early!

Typically flights with AA are good. The staff are pleasant, welcoming, and efficient.

Mostly good. Flight was crowded but Airline personnel were very friendly & accommodating. It would be good to have savory snacks rather than just sweet Biscoff cookies.

We had 3 flights. 1 & 2 were on the same plane but we had to de-board just to re-board 30 mins later. That may have been due to a crew change though. Our 3rd flight had a couple “maintenance” issues that held us up. They were quickly resolved but it took forever for someone to bring the paperwork needed so we could leave. Apparently there was a computer glitch so a driver had to bring a physical copy. It delayed us about 1 1/2 hrs. The flights themselves were smooth & no problems. For boarding, I don’t know why they don’t start with the back of the plane & move forward. It would eliminate the back up from people trying to find their seats & put their bags in the overhead bins. Unless you’re on an overseas flight, there is no food, you get a beverage & either a small bag of pretzels or a biscuit cookie. Take your own food or snacks of you want something more.

We spent too much time on board waiting for takeoff.

The actual trip was fine, however, the changes made to our flights and the layovers were had to endure were awful.

Most things were ok but the main problem was the cabin staff; they were very abrupt and not very friendly. They were busy and often rushed, snatching drinks off people before finished and bossing them about.

Given it’s a red-eye into Charolotte, we didn’t get any food. The survey does not include “N/A” so the rating will be skewed.

Excellent! No complaints! All the staff from the counter to the airplane crew, was just amazing and pleasing to talk to

My baby was crying uncontrollably for the longest time and the entire crew was SO supportive, I’m so appreciative of them. Thank you so much for the support during an exhausting moment. We got very lucky.

I didn't eat, so I can't rate the food. Delayed set off was beyond

No free snacks or drinks. Freezing. Uncomfortable. No plugs or entertainment. If you fly to LA the make you change terminals with a slow bus. Awful trip that took forever. Terrible airline- maybe the worst I’ve ever flown.

I hope you continue to be one of the great company

Crew are always very angry and dismissive like they seem they are being forced to work. In addition, there was a long line for the bathrooms, and only one was allowed to be used. No reason was given for only one bathroom being available; apparently, the stewardess was more interested in using the jumpseat instead of allowing the customers to use the bathroom.

Very positive in both directions. Safe travels, nice staff, lost and found in fact found my phone under my chair! I was out of cash after my NYC trip otherwise I would've offered a reward for helping my day out immensly! Thanks you so much Spirit staff!

I stopped flying spirit as much because they are crooks and thieves. It's not like other airlines where you can at least get credits they just take your money.

Flight was on time. Friendly crew. Gate agents in the other hand were very unfriendly.

Uncomfortable seats and tiny tray table. Expensive snacks. Flight was on time and crew was pleasant but take me back to Southwest!

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