$278 Find Cheap Flights from Knoxville to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to South America departing on 6/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Knoxville to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$641
Bogotá
Bogotá1 stop$400
Santiago
Santiago1 stop$920
Cartagena
Cartagena1 stop$437
Lima
Lima1 stop$641
Bogotá
Bogotá1 stop$400
Santiago
Santiago1 stop$920
Cartagena
Cartagena1 stop$437

Book Cheap Knoxville to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to South America

Sun, May 3 - Sun, May 10
Multiple Airlines Logo
9:25 pm - 12:06 pm
TYS
-
CTG
15h 41m
1 stop
Multiple Airlines Logo
1:11 pm - 12:25 pm
CTG
-
TYS
22h 14m
1 stop
$437Multiple Airlines
Fri, May 1 - Fri, May 8
Multiple Airlines Logo
1:15 pm - 8:29 am
TYS
-
CTG
44h 14m
2 stops
Multiple Airlines Logo
1:11 pm - 11:06 am
CTG
-
TYS
20h 55m
1 stop
$497Multiple Airlines
Sat, May 23 - Sat, May 30
American Airlines Logo
7:59 pm - 2:13 pm
TYS
-
CTG
19h 14m
2 stops
American Airlines Logo
1:35 pm - 10:48 am
CTG
-
TYS
20h 13m
2 stops
$567American Airlines
Sat, May 23 - Sat, May 30
American Airlines Logo
7:46 pm - 12:35 pm
TYS
-
CTG
17h 49m
1 stop
American Airlines Logo
3:13 pm - 11:59 pm
CTG
-
TYS
7h 46m
1 stop
$574American Airlines
Mon, Jun 1 - Mon, Jun 8
LATAM Airlines Logo
3:30 pm - 5:00 am
TYS
-
LIM
14h 30m
1 stop
LATAM Airlines Logo
12:15 am - 5:19 pm
LIM
-
TYS
16h 04m
2 stops
$709LATAM Airlines
Mon, Jun 1 - Mon, Jun 8
Delta Logo
1:59 pm - 5:00 am
TYS
-
LIM
16h 01m
2 stops
Delta Logo
12:15 am - 3:06 pm
LIM
-
TYS
13h 51m
2 stops
$732Delta
Fri, May 8 - Sun, May 10
United Airlines Logo
11:40 am - 11:35 pm
TYS
-
PEI
12h 55m
2 stops
United Airlines Logo
5:15 am - 11:44 pm
PEI
-
TYS
17h 29m
2 stops
$792United Airlines
Fri, May 8 - Sun, May 10
United Airlines Logo
11:40 am - 11:35 pm
TYS
-
PEI
12h 55m
2 stops
United Airlines Logo
5:15 am - 11:44 pm
PEI
-
TYS
17h 29m
2 stops
$863United Airlines
Thu, Apr 30 - Thu, May 7
Delta Logo
4:38 pm - 7:15 am
TYS
-
SCL
14h 37m
1 stop
Delta Logo
8:40 pm - 1:10 pm
SCL
-
TYS
16h 30m
1 stop
$920Delta
Thu, Apr 30 - Thu, May 7
LATAM Airlines Logo
4:38 pm - 1:25 pm
TYS
-
SCL
20h 47m
3 stops
LATAM Airlines Logo
8:30 am - 11:11 am
SCL
-
TYS
26h 41m
3 stops
$955LATAM Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to South America flights

Get data-powered insights and trends into flights from Knoxville to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to South America is August, when tickets cost $488 (return) on average. On the other hand, the most expensive months are November and May, when the average cost of round-trip tickets is $1,071 and $943 respectively.

Good to know

Low seasonFebruary
Cheapest flight$278
Best time to beat the crowds with an average 21% drop in price.
Most popular time to fly with an average 18% increase in price.
Flight from Knoxville to Santiago

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Knoxville to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Knoxville to South America

 
Need help choosing which airline to fly with from Knoxville to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8303 reviews
7.8Entertainment
8.5Crew
7.9Comfort
7.2Food
8.1Boarding
Airline reviews

My recent experience was excellent on Delta! I flew with Delta Comfort and I was really comfortable in my seat. I enjoyed the in-flight service. The flight attendants were so friendly and hospitable. I love the snack on the flight as well. This was my first time flying on Delta and I will definitely consider flying with them again.

10.0 ExcellentShirley, Mar 2026
LAX - ATL
Read more Delta reviews

My recent experience was excellent on Delta! I flew with Delta Comfort and I was really comfortable in my seat. I enjoyed the in-flight service. The flight attendants were so friendly and hospitable. I love the snack on the flight as well. This was my first time flying on Delta and I will definitely consider flying with them again.

My flight was cencaled due with the bad weather on Sunday the crew was poorly mistaken my luggage supposed depart with my flight instead I didn’t have my luggage for almost 3 days the website is poorly respond to my complain until I have someone to do it my connection smooth their not even respon or email me even the have my luggage

Delta needs to step its game up get a more reliable internet service. Internet service was non-existent for this flight.

Mechanical Delay of over an hour with multiple gate changes. Entertainment system down for rejuvenation.

This was a Latam operated flight. Seats seemed a bit narrow in business class. Older aircraft.

I had a flight cancel and had it rerouted. When the rerouted they put me at a window seat instead of an isle. It was hard sitting by the window because the couple with masks on were making out. I get motion sickness which is why I need to have the isle seat.

NEVER MADE THE FLIGHT BECAUSE DELTA SAID THEY CAN NOT

THEY FAILED ME AND I NEVER GOT ON THE FLIGHT BECAUSE IT WAS SO DELAYED! I ENDED UP HAVING TO PAY OUT OF POCKET FOR A HOTEL AND STAY IN NASHVILLE TO CATCH A FLIGHT FOR THE FOLLOWING DAY. DELTA IS POOR CUSTOMER SERVICE>

8 hours late and the plane smelled like urine, that smell in the morning when your child wet the bed in the night.

My flight was canceled on Sunday. Rebooking took three hours. Had to pay for accommodations another night. New flight was delayed for 5 hours, all that was sent was a 12 dollar food voucher, which doesn’t tell you how to use it. Then when we landed we had to sit on the plane for an hour before we could get off.

LATAM is a great airline who takes care of there guests. They consistently walk around and see if you need water in addition to taking care of all the passengers. The chicken in process is really easy and I’m always offered a chance for an upgrade which I appreciate.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

There was a mechanical issue with the plane that they had to work on before we could take off. That's fine, by all means, PLEASE make sure the mechanics are functioning properly. What was a problem was the fact that we sat on the tarmac for 4.5 hours without moving, without letting us off the plane, and without climate control and air running through the plane. There was no explanation as to what was going on; they just kept promising that it would be "15 minutes, then we are on our way." At one point, they even switched the entire crew out and told everyone we just needed to wait for new employees to show up. Then, as the 4 hours were not moving, an hour before the full refund, they made a big show about "the flight starting and the doors are locked, so you have to sit down." We didn't move for another 40 minutes; they were just trying to skirt around legalities that entitled us to restitution. When the flight finally was underway, the plane was gigantic but cramped in design, my entertainment screen kept freezing and glitching, and subtitles didn't work, and the crew was passive-aggressive. Terrible flight.

LATAM’s crews are fine, but God help you if you need any customer service. Their app and website never work, with error after error. Trying to solve anything over the phone is painful, and lastly, the boarding pass LATAM gave me to board the flight with Delta was invalid and I had to purchase an emergency one-way ticket at the last minute to get home.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Good flight, boarding ok and crew very nice. Flight was not full so I was able to be very comfortable. Blanket and pillow provided with was good as it was very cold during the flight . Food was very good(small snack sandwich and an excellent piece of orange cake). Overall good flight, no complaints.

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Rough flight No beverage service due to turbulence Bottom Seat cushion was non existent

Great experience. Good dinner and service. FA's were very nice and attentive.

It was great. Smooth flight, comfortable, left on time and landed on time.

Perhaps this is an airport issue, but being in a takeoff queue for over an hour in the taxiing lane is unacceptable. We will definitely be seeking alternative avenues for air travel in the future.

We hoarded. Then we deplaned. Then we waited for 10 hours in the MSP airport due to a wheel misfunction. We understand safety but communication between crew and airport staff was horrible. When we did finally board, we were rushed on and because we were waiting for a “fresh” pilot and crew, we sat in a roasting plane with no A/C for an hour. My question is why was this flight not cancelled right away when they knew this would be a huge issue OR, why did AA not get a substitute plane, considering this was already a full flight? To me, this appears to be a complete breakdown in leadership and utter systems failure. The compensation for completely disrupting travel plans for hundreds, which we paid dearly for, was measly. While we appreciated the lodging for the night, $12 in meal vouchers isn’t going to sustain anyone for over 12 hours. “We apologize; our hands are tied” is no longer an acceptable explanation. We are so completely turned off by this experience and will definitely seek alternative avenues when we need to fly.

Mostly good. The WiFi wasn’t working so that was not great.

I rated the experience "mediocre" because of the 2 hour delay in take off. This is the 4th flight from DFW on AA where there was a delay and in one of the instances (after 13 delays), the flight was cancelled. I understand weather but for the March 18th flight, there was no weather issue in Dallas or Detroit. I called Concierge Key and they were wonderful, booking me on a later flight in case my flight was cancelled. I have flown with American for many years and never has there been this consistent pattern of delays. Very disappointing.

They put me on an earlier and I got home sooner

Not good. One of my luggage is missing. And until now they can’t find it

Horrible experience upon landing. Probably more due to DCA utter incompetence than AA.

Everything you need to know for your flight to South America

Information on your arrival and departure airports