$187 Find Cheap Flights from Knoxville to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to South America departing on 2/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Knoxville to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima2 stops$589
Santiago
Santiago2 stops$950
Cartagena
Cartagena1 stop$462
Montevideo
Montevideo3 stops$1,145
Lima
Lima2 stops$589
Santiago
Santiago2 stops$950
Cartagena
Cartagena1 stop$462
Montevideo
Montevideo3 stops$1,145

Book Cheap Knoxville to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to South America

Wed, May 6 - Fri, May 8
Multiple Airlines Logo
4:25 pm - 12:13 pm
TYS
-
CTG
20h 48m
1 stop
Multiple Airlines Logo
1:21 pm - 11:06 am
CTG
-
TYS
20h 45m
1 stop
$462Multiple Airlines
Mon, Feb 9 - Fri, Feb 20
Multiple Airlines Logo
6:18 pm - 12:25 pm
TYS
-
LIM
42h 07m
2 stops
Multiple Airlines Logo
11:30 pm - 1:04 pm
LIM
-
TYS
13h 34m
1 stop
$589Multiple Airlines
Wed, May 6 - Fri, May 8
American Airlines Logo
6:54 pm - 2:04 pm
TYS
-
CTG
20h 10m
2 stops
American Airlines Logo
3:10 pm - 11:15 am
CTG
-
TYS
19h 05m
2 stops
$609American Airlines
Wed, May 6 - Fri, May 8
United Airlines Logo
7:00 am - 11:01 pm
TYS
-
CTG
17h 01m
3 stops
United Airlines Logo
3:05 pm - 7:56 pm
CTG
-
TYS
27h 51m
2 stops
$634United Airlines
Sun, May 24 - Sun, May 31
LATAM Airlines Logo
5:30 pm - 3:00 pm
TYS
-
LIM
46h 30m
2 stops
LATAM Airlines Logo
3:50 pm - 11:46 pm
LIM
-
TYS
30h 56m
2 stops
$652LATAM Airlines
Sat, Mar 14 - Sat, Mar 21
Delta Logo
5:13 pm - 5:00 am
TYS
-
LIM
12h 47m
1 stop
Delta Logo
10:45 am - 9:16 am
LIM
-
TYS
21h 31m
2 stops
$655Delta
Sat, Mar 14 - Sat, Mar 21
LATAM Airlines Logo
5:13 pm - 10:10 pm
TYS
-
LIM
53h 57m
2 stops
LATAM Airlines Logo
10:45 am - 9:16 am
LIM
-
TYS
21h 31m
2 stops
$684LATAM Airlines
Sun, May 24 - Sat, May 30
Delta Logo
2:30 pm - 5:00 am
TYS
-
LIM
15h 30m
1 stop
Delta Logo
12:05 am - 6:15 pm
LIM
-
TYS
17h 10m
2 stops
$717Delta
Mon, Feb 23 - Thu, Feb 26
United Airlines Logo
9:10 am - 11:35 pm
TYS
-
PEI
38h 25m
2 stops
United Airlines Logo
8:20 am - 1:46 pm
PEI
-
TYS
53h 26m
2 stops
$752United Airlines
Wed, Mar 4 - Wed, Apr 8
American Airlines Logo
8:50 am - 7:05 am
TYS
-
EZE
20h 15m
2 stops
American Airlines Logo
8:25 pm - 11:15 am
EZE
-
TYS
15h 50m
2 stops
$1,076American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to South America flights

Get data-powered insights and trends into flights from Knoxville to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to South America is September, when tickets cost $619 (return) on average. On the other hand, the most expensive months are November and April, when the average cost of round-trip tickets is $1,071 and $880 respectively.

Good to know

Low seasonJanuary
Best time to beat the crowds but there is an average 7% increase in price.
Most popular time to fly with an average 10% increase in price.

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Knoxville to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Knoxville to South America

 
Need help choosing which airline to fly with from Knoxville to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8128 reviews
8.1Boarding
7.2Food
7.9Comfort
8.5Crew
7.8Entertainment
Airline reviews

Timing, quality of service, promptness and courtesy of the staff

10.0 ExcellentAjai, Jan 2026
DFW - ATL
Read more Delta reviews

Timing, quality of service, promptness and courtesy of the staff

It was last minute due to weather - considering - it was amazing! Good smiles, friendly staff and they were making sure we knew what was going on when and where.

delta last minute gave me a boarding pass for a different flight with no confirmation that they were changing it

The flight was comfortable and uneventful, which is what I desire

The service from the flight attendants were of supreme quality. They greeted and treated everyone with a wide smile. This is totally absent nowadays. Kudos to them!!!!

Excellent flight and got us around tough weather. Only issue was seat TV did not work and crew tried to reboot.

Very large passenger too space from my own seat. Arm board couldn’t be lowered because of his size. It wads very uncomfortable trip, as the flight was full couldn’t move anywhere having back pain because of the position in which I was the entire flight.

was sitting in the jet bridge for 10 minutes in -20 degree weather waiting for my bag

Outdated equipment in disrepair, wifi inoperable. Broken seats, taped air vents, generally poor condition, the 717 showed its age and lack of upkeep.

My flight out of Baton Rouge to Atlanta was delayed by a half hour. This got us into Atlanta airport 30 minutes late. I ran through the airport to get to my connecting flight. As I approached the boarding gate, I saw the boarding door was still open and a passenger was being checked in. But when I got to the gate, the boarding agent told me they had already given away my seat and there were no empty seats on that flight. So I had to take a later flight. That has never happened to me before. Very frustrating.

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

There was a mechanical issue with the plane that they had to work on before we could take off. That's fine, by all means, PLEASE make sure the mechanics are functioning properly. What was a problem was the fact that we sat on the tarmac for 4.5 hours without moving, without letting us off the plane, and without climate control and air running through the plane. There was no explanation as to what was going on; they just kept promising that it would be "15 minutes, then we are on our way." At one point, they even switched the entire crew out and told everyone we just needed to wait for new employees to show up. Then, as the 4 hours were not moving, an hour before the full refund, they made a big show about "the flight starting and the doors are locked, so you have to sit down." We didn't move for another 40 minutes; they were just trying to skirt around legalities that entitled us to restitution. When the flight finally was underway, the plane was gigantic but cramped in design, my entertainment screen kept freezing and glitching, and subtitles didn't work, and the crew was passive-aggressive. Terrible flight.

LATAM’s crews are fine, but God help you if you need any customer service. Their app and website never work, with error after error. Trying to solve anything over the phone is painful, and lastly, the boarding pass LATAM gave me to board the flight with Delta was invalid and I had to purchase an emergency one-way ticket at the last minute to get home.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Good flight, boarding ok and crew very nice. Flight was not full so I was able to be very comfortable. Blanket and pillow provided with was good as it was very cold during the flight . Food was very good(small snack sandwich and an excellent piece of orange cake). Overall good flight, no complaints.

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Check in -- in business took over 30 mins as there was only one attendant. Boarding was also a mess. The seat was too narrow and was not working properly. Food was very bad and the entertainment very poor. Crew was very polite and helpful, in fairness.

The flight was late. Please do not delay next time.

Crew was helpful and cheerful especially when they had no refreshments to work with. The plane was never serviced and had nothing but limited water and coffee onboard. For the price point, a concern of services.

Flight was smooth, quick and felt safe. The 2 delays not happening would have been better but I guess that happens in the airline industry

Flight was canceled. I asked to be rerouted to OKC and then took an Uber.

AA did not allow to board a flight because my connecting flight from DFW had been canceled. I got on another flight to another city. No service on the plane and I did not use their entertainment system.

On time on a day with lots of weather cancellations on other flights. Thank you for getting me home during a winter storm!

Don't change gate multiple times make people run across the airport. Announce delays in a timely manner. Have maintenance crew ready. Don't delay and keep passengers on the plane for 3 hrs. on tarmac.

The plane was experiencing problems with the HVAC system, it was very cold in the front of the plane and very hot in the back.

My flight to London from Philadelphia was cancelled due to weather.

The attendants were kind and helpful. A sugar-free drink would have been very welcome.

Pilot navigated severe weather/snow storm with skill. Described his intentions clearly

Everything you need to know for your flight to South America

Information on your arrival and departure airports