What is the difference between the most popular and the most frequent airline at Mytilene?

American Airlines operates the most flights from the United States to Mytilene at 0 per week, while Brussels Airlines is the airline most often selected by KAYAK users searching for flights from the United States to Mytilene. The two are often different because flight volume reflects an airline's schedule, while popularity reflects traveler choice.

Which city has the cheapest flights to Mytilene?

Based on fares booked in the past 5 days, the cheapest flights to Mytilene are from New York, starting at $823 round-trip.

How do I know if a flight to Mytilene is a good deal?

A good deal on a flight to Mytilene is around $1,188 round-trip. This fare is in the lowest 25% of round-trip prices searched on KAYAK, averaged across the cities most often searched as origins by KAYAK users.

Which airlines should I consider for flights to Mytilene?

Brussels Airlines is the most popular airline with KAYAK users flying to Mytilene, and has the best on-time record at the destination's main airport.

What are the most popular airlines flying to Mytilene?

Brussels Airlines is the only airline flying to Mytilene on KAYAK.

$2,145 CHEAP FLIGHTS to Mytilene in 2026/27

Save 21% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$823

Typical prices: $1,188-$1,736

Multiple Airlines

Mon 11/5Mon 11/12

EWR - MJT • 2 stops

Cheapest one-way

$377

Typical prices: $552-$687

Multiple Airlines

Wed 10/31

BOS - MJT • 3 stops

Top airlines

Brussels Airlines

Best reviews • 7.2 score

Airline reviews

Top routes

TPA - MJT

Cheapest • 11% average savings

NYC - MJT

Most popular

Insights

When to travel

October

Cheapest • 32% price drop

July

Most popular

Good to know

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We hope you love your trip to Mytilene!

Flight Deals

Cheap Flights to Mytilene

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

All Flight Deals

Recent round-trip flight deals to Mytilene

Thu, Nov 5 - Thu, Nov 12

10:00 pm - 9:10 pmEWR Newark-MJT Mytilene

16h 10m2 stops Zurich Athens Eleftherios V.

8:30 am - 7:40 pmMJT Mytilene-EWR Newark

18h 10m2 stops Athens Eleftherios V. Toronto Pearson Intl

$823Multiple Airlines

Thu, Nov 5 - Thu, Nov 12

5:30 pm - 4:25 pmJFK New York John F Kennedy Intl-MJT Mytilene

15h 55m2 stops Munich Franz Josef Strauss Athens Eleftherios V.

9:55 pm - 1:35 pmMJT Mytilene-JFK New York John F Kennedy Intl

22h 40m2 stops Athens Eleftherios V. Frankfurt am Main

$826Multiple Airlines

Tue, Nov 3 - Tue, Nov 10

10:00 pm - 8:00 amEWR Newark-MJT Mytilene

27h 00m3 stops Zurich Bucharest Otopeni Intl Athens Eleftherios V.

9:55 pm - 7:05 pmMJT Mytilene-EWR Newark

28h 10m3 stops Athens Eleftherios V. Bucharest Otopeni Intl Munich Franz Josef Strauss

$833Multiple Airlines

Thu, Nov 5 - Thu, Nov 12

6:55 am - 4:25 pmEWR Newark-MJT Mytilene

26h 30m3 stops Montreal Pierre Elliott Trudeau Intl Zurich Athens Eleftherios V.

8:30 am - 10:50 pmMJT Mytilene-EWR Newark

21h 20m2 stops Athens Eleftherios V. Toronto Pearson Intl

$899Multiple Airlines

Sun, Jan 17 - Sun, Jan 31

9:05 pm - 9:10 pmJFK New York John F Kennedy Intl-MJT Mytilene

17h 05m2 stops Rome Fiumicino Athens Eleftherios V.

9:40 pm - 2:15 pmMJT Mytilene-JFK New York John F Kennedy Intl

23h 35m2 stops Athens Eleftherios V. Rome Fiumicino

$911Multiple Airlines

Sat, Nov 7 - Sat, Nov 14

4:40 pm - 9:10 pmJFK New York John F Kennedy Intl-MJT Mytilene

21h 30m2 stops Rome Fiumicino Athens Eleftherios V.

8:40 am - 6:55 pmMJT Mytilene-JFK New York John F Kennedy Intl

17h 15m2 stops Athens Eleftherios V. Rome Fiumicino

$919Multiple Airlines

Sun, Jan 17 - Sun, Jan 31

9:05 pm - 9:10 pmJFK New York John F Kennedy Intl-MJT Mytilene

17h 05m2 stops Rome Fiumicino Athens Eleftherios V.

9:40 pm - 2:15 pmMJT Mytilene-JFK New York John F Kennedy Intl

23h 35m2 stops Athens Eleftherios V. Rome Fiumicino

$927Multiple Airlines

Thu, Nov 5 - Thu, Nov 12

5:30 pm - 4:25 pmJFK New York John F Kennedy Intl-MJT Mytilene

15h 55m2 stops Munich Franz Josef Strauss Athens Eleftherios V.

3:05 pm - 1:35 pmMJT Mytilene-JFK New York John F Kennedy Intl

29h 30m3 stops Chios Athens Eleftherios V. Frankfurt am Main

$929Multiple Airlines

Sat, Nov 7 - Sat, Nov 14

7:35 pm - 11:25 amJFK New York John F Kennedy Intl-MJT Mytilene

32h 50m3 stops Geneva Geneve-Cointrin Athens Eleftherios V. Chios

9:40 pm - 4:40 pmMJT Mytilene-JFK New York John F Kennedy Intl

26h 00m2 stops Athens Eleftherios V. Zurich

$932Multiple Airlines

Tue, Oct 20 - Tue, Nov 10

9:10 pm - 9:20 pmJFK New York John F Kennedy Intl-MJT Mytilene

17h 10m2 stops Rome Fiumicino Athens Eleftherios V.

9:40 pm - 2:15 pmMJT Mytilene-JFK New York John F Kennedy Intl

23h 35m2 stops Athens Eleftherios V. Rome Fiumicino

$979Multiple Airlines

All round-trip flight deals to Mytilene

Thu, Nov 5 - Thu, Nov 12

10:00 pm - 9:10 pmEWR Newark-MJT Mytilene

16h 10m2 stops Zurich Athens Eleftherios V.

8:30 am - 7:40 pmMJT Mytilene-EWR Newark

18h 10m2 stops Athens Eleftherios V. Toronto Pearson Intl

$823Multiple Airlines

Thu, Nov 5 - Thu, Nov 12

5:30 pm - 4:25 pmJFK New York John F Kennedy Intl-MJT Mytilene

15h 55m2 stops Munich Franz Josef Strauss Athens Eleftherios V.

9:55 pm - 1:35 pmMJT Mytilene-JFK New York John F Kennedy Intl

22h 40m2 stops Athens Eleftherios V. Frankfurt am Main

$826Multiple Airlines

Tue, Nov 3 - Tue, Nov 10

10:00 pm - 8:00 amEWR Newark-MJT Mytilene

27h 00m3 stops Zurich Bucharest Otopeni Intl Athens Eleftherios V.

9:55 pm - 7:05 pmMJT Mytilene-EWR Newark

28h 10m3 stops Athens Eleftherios V. Bucharest Otopeni Intl Munich Franz Josef Strauss

$833Multiple Airlines

Thu, Nov 5 - Thu, Nov 12

6:55 am - 4:25 pmEWR Newark-MJT Mytilene

26h 30m3 stops Montreal Pierre Elliott Trudeau Intl Zurich Athens Eleftherios V.

8:30 am - 10:50 pmMJT Mytilene-EWR Newark

21h 20m2 stops Athens Eleftherios V. Toronto Pearson Intl

$899Multiple Airlines

Sun, Jan 17 - Sun, Jan 31

9:05 pm - 9:10 pmJFK New York John F Kennedy Intl-MJT Mytilene

17h 05m2 stops Rome Fiumicino Athens Eleftherios V.

9:40 pm - 2:15 pmMJT Mytilene-JFK New York John F Kennedy Intl

23h 35m2 stops Athens Eleftherios V. Rome Fiumicino

$911Multiple Airlines

Sat, Nov 7 - Sat, Nov 14

4:40 pm - 9:10 pmJFK New York John F Kennedy Intl-MJT Mytilene

21h 30m2 stops Rome Fiumicino Athens Eleftherios V.

8:40 am - 6:55 pmMJT Mytilene-JFK New York John F Kennedy Intl

17h 15m2 stops Athens Eleftherios V. Rome Fiumicino

$919Multiple Airlines

Sun, Jan 17 - Sun, Jan 31

9:05 pm - 9:10 pmJFK New York John F Kennedy Intl-MJT Mytilene

17h 05m2 stops Rome Fiumicino Athens Eleftherios V.

9:40 pm - 2:15 pmMJT Mytilene-JFK New York John F Kennedy Intl

23h 35m2 stops Athens Eleftherios V. Rome Fiumicino

$927Multiple Airlines

Thu, Nov 5 - Thu, Nov 12

5:30 pm - 4:25 pmJFK New York John F Kennedy Intl-MJT Mytilene

15h 55m2 stops Munich Franz Josef Strauss Athens Eleftherios V.

3:05 pm - 1:35 pmMJT Mytilene-JFK New York John F Kennedy Intl

29h 30m3 stops Chios Athens Eleftherios V. Frankfurt am Main

$929Multiple Airlines

Sat, Nov 7 - Sat, Nov 14

7:35 pm - 11:25 amJFK New York John F Kennedy Intl-MJT Mytilene

32h 50m3 stops Geneva Geneve-Cointrin Athens Eleftherios V. Chios

9:40 pm - 4:40 pmMJT Mytilene-JFK New York John F Kennedy Intl

26h 00m2 stops Athens Eleftherios V. Zurich

$932Multiple Airlines

Tue, Oct 20 - Tue, Nov 10

9:10 pm - 9:20 pmJFK New York John F Kennedy Intl-MJT Mytilene

17h 10m2 stops Rome Fiumicino Athens Eleftherios V.

9:40 pm - 2:15 pmMJT Mytilene-JFK New York John F Kennedy Intl

23h 35m2 stops Athens Eleftherios V. Rome Fiumicino

$979Multiple Airlines

Booking Insights

Price, demand and travel trends for flights to Mytilene

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Prices

Airlines

What is the cheapest flight to Mytilene?

Newark Airport to Mytilene is the cheapest route at $823 round-trip, found in the past 5 days on KAYAK. KAYAK data shows this is also the most popular route.

How much is a flight to Mytilene?

On average, a round-trip flight from the United States to Mytilene costs $1,480, based on KAYAK data over the past 12 months. Round-trip fares from Tampa average $1,211, while New York runs a bit higher at $1,412.

What is the cheapest day to fly to Mytilene?

Tuesday is the cheapest day to fly to Mytilene at $1,115 round-trip on average over the past 12 months on KAYAK. Friday is the most expensive at $1,826.

What is the cheapest time of day to fly to Mytilene?

Evening flights to Mytilene are the cheapest at $1,379 round-trip on average. Morning flights are the most expensive at $1,826.

What is a good deal for flights to Mytilene?

Flights under $1,188 are considered a good deal. 25% of KAYAK users found round-trip flights to Mytilene at or below these prices, with the lowest fares from:
•New York $1,003
•Tampa $1,066.

Find deals

Low season	February
High season	July
Cheapest flight	$377

The most popular month to fly with an average 129% increase in travelers.

One-way flight from Boston to Mytilene

When to book flights to Mytilene

Are your dates flexible? Find out the best times to travel to Mytilene based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. The information is for flights to Mytilene based on your location. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

How do I know if a flight to Mytilene is a good deal?
A good deal on a flight to Mytilene is around $1,188 round-trip. This fare is in the lowest 25% of round-trip prices searched on KAYAK, averaged across the cities most often searched as origins by KAYAK users.
Which city has the cheapest flights to Mytilene?
Based on fares booked in the past 5 days, the cheapest flights to Mytilene are from New York, starting at $823 round-trip.
What is the difference between the most popular and the most frequent airline at Mytilene?
American Airlines operates the most flights from the United States to Mytilene at 0 per week, while Brussels Airlines is the airline most often selected by KAYAK users searching for flights from the United States to Mytilene. The two are often different because flight volume reflects an airline's schedule, while popularity reflects traveler choice.
Which airlines should I consider for flights to Mytilene?
Brussels Airlines is the most popular airline with KAYAK users flying to Mytilene, and has the best on-time record at the destination's main airport.

For flights to Mytilene, a good round-trip fare is around $1,188. If you find a fare below that, you're getting a strong deal.
If your travel dates are flexible, consider flying to Mytilene in October. Round-trip fares historically average $1,003, making October the cheapest month to travel based on KAYAK data from the last 12 months.
Before you book:

• Check the route's typical price range so you can spot a deal.
• Confirm baggage fees and seat-selection costs on budget carriers.
• Verify whether you need any travel documents beyond ID.
• Pick a departure airport, since your nearest may not be the cheapest origin.
Shift your departure to afternoon to save up to $447 per round-trip. Afternoon flights to Mytilene average $1,379 compared to $1,826 for morning flights.