BUF - TYS

$127 Find Cheap Flights from Buffalo to Knoxville - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$253
Typical prices: $356-$566
American Airlines
Sun 12/9Wed 12/12
BUF - TYS • 1 stop
Cheapest one-way
$127
Typical prices: $193-$289
United Airlines
Wed 12/5
BUF - TYS • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Buffalo and Knoxville. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
June
Cheapest • 16% price drop
July
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Chicago O'Hare Intl (ORD)
Cheapest • Avg $347 (round-trip)
Charlotte Douglas (CLT)
Shortest trip • 4h 11m (one-way)
Insights
Insights
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Flight Deals

Cheap Flights from Buffalo to Knoxville (BUF-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Buffalo to Knoxville

Wed, Dec 9 - Sat, Dec 12
American Airlines Logo
5:19 am - 10:52 amBUF  Buffalo-TYS Knoxville McGhee Tyson
5h 33m1 stop Washington, D.C. Reagan-National
American Airlines Logo
4:17 pm - 10:43 pmTYS  Knoxville McGhee Tyson-BUF Buffalo
6h 26m1 stop Charlotte Douglas
$253American Airlines
Sat, Dec 12 - Tue, Dec 15
American Airlines Logo
6:00 am - 11:20 amBUF  Buffalo-TYS Knoxville McGhee Tyson
5h 20m1 stop Philadelphia
American Airlines Logo
12:42 pm - 5:24 pmTYS  Knoxville McGhee Tyson-BUF Buffalo
4h 42m1 stop Philadelphia
$253American Airlines
Wed, Dec 9 - Sat, Dec 12
United Airlines Logo
7:12 am - 5:00 pmBUF  Buffalo-TYS Knoxville McGhee Tyson
9h 48m2 stops Newark Chicago O'Hare Intl
United Airlines Logo
6:00 am - 1:17 pmTYS  Knoxville McGhee Tyson-BUF Buffalo
7h 17m1 stop Chicago O'Hare Intl
$258United Airlines
Sat, Dec 12 - Tue, Dec 15
United Airlines Logo
10:00 am - 8:47 pmBUF  Buffalo-TYS Knoxville McGhee Tyson
10h 47m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
United Airlines Logo
2:07 pm - 7:19 pmTYS  Knoxville McGhee Tyson-BUF Buffalo
5h 12m1 stop Washington, D.C. Dulles Intl
$258United Airlines
Wed, Dec 9 - Sun, Dec 13
Delta Logo
10:00 am - 4:45 pmBUF  Buffalo-TYS Knoxville McGhee Tyson
6h 45m1 stop New York LaGuardia
Delta Logo
7:26 pm - 12:04 amTYS  Knoxville McGhee Tyson-BUF Buffalo
4h 38m1 stop Atlanta Hartsfield-Jackson
$298Delta
Wed, Jan 6 - Fri, Jan 8
Delta Logo
2:29 pm - 7:56 pmBUF  Buffalo-TYS Knoxville McGhee Tyson
5h 27m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:18 am - 11:54 amTYS  Knoxville McGhee Tyson-BUF Buffalo
4h 36m1 stop Detroit Metropolitan Wayne County
$303Delta
Wed, Jan 6 - Sat, Jan 9
American Airlines Logo
12:37 pm - 6:18 pmBUF  Buffalo-TYS Knoxville McGhee Tyson
5h 41m1 stop Washington, D.C. Reagan-National
American Airlines Logo
8:14 am - 12:06 pmTYS  Knoxville McGhee Tyson-BUF Buffalo
3h 52m1 stop Charlotte Douglas
$303American Airlines
Fri, Dec 25 - Wed, Dec 30
United Airlines Logo
7:52 pm - 12:15 amBUF  Buffalo-TYS Knoxville McGhee Tyson
4h 23m1 stop Washington, D.C. Dulles Intl
United Airlines Logo
5:30 am - 9:45 amTYS  Knoxville McGhee Tyson-BUF Buffalo
4h 15m1 stop Washington, D.C. Dulles Intl
$303United Airlines
Wed, Jan 6 - Fri, Jan 8
Southwest Logo
5:45 am - 12:15 pmBUF  Buffalo-TYS Knoxville McGhee Tyson
6h 30m2 stops Baltimore/Washington Nashville Intl
Southwest Logo
6:45 am - 3:00 pmTYS  Knoxville McGhee Tyson-BUF Buffalo
8h 15m2 stops Nashville Intl Baltimore/Washington
$313Southwest
Sat, Dec 12 - Wed, Mar 17
Southwest Logo
3:30 pm - 7:45 pmBUF  Buffalo-TYS Knoxville McGhee Tyson
4h 15m1 stop Baltimore/Washington
Southwest Logo
6:40 am - 3:20 pmTYS  Knoxville McGhee Tyson-BUF Buffalo
8h 40m2 stops Nashville Intl Chicago Midway
$325Southwest
Booking Insights

Price, demand and travel trends for Buffalo to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Buffalo to Knoxville?

Round-trip flights from Buffalo to Knoxville typically range from $356 to $566. The lowest price found in the past 5 days was $253, on American Airlines.

What's the cheapest day of the week to fly from Buffalo to Knoxville?

Based on deals KAYAK users found in the last 12 months, Wednesday is the cheapest day of the week to fly from Buffalo to Knoxville. It’s 16% cheaper than the average day, while Saturday is the most expensive, with prices 64% higher.

What’s the cheapest month to fly from Buffalo to Knoxville?

•June is the cheapest month to fly from Buffalo to Knoxville at $344 round-trip.
•December ($646) and February ($646) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 87% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for Buffalo to Knoxville flights

Low season

December

Cheapest flight

$127
Beat the crowds with an average 49% drop in travelers.
The most popular month to fly with an average 97% increase in travelers.
One-way flight from Buffalo to Knoxville

When to book flights from Buffalo to Knoxville

Are your dates flexible? Find out the best times to travel from Buffalo to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Buffalo to Knoxville flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Buffalo to Knoxville?

    Only Economy Class is available on flights from Buffalo to Knoxville.

  • How long is a flight from Buffalo to Knoxville?

    A nonstop flight from Buffalo to Knoxville takes 00m, covering 567 miles.

  • Do I need a passport to fly from Buffalo to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Buffalo to Knoxville flight?

    Round-trip flights from Buffalo to Knoxville range from $356 to $566, with an average of $411 over the past 12 months. Anything below $356 counts as a good deal.

  • Have flight prices from Buffalo to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $253 to $1,440. That means the highest observed fare was about 6x higher than the lowest one.

  • How are flight prices from Buffalo to Knoxville looking right now?

    One-way fares from Buffalo to Knoxville are currently lower than usual. Average one-way flight prices are about $189, which is 30% below the typical average for this route.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates averaging $80 for economy cars. Top options include:

    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Thrifty
    • Avis

  • Which airports can I use when flying from Buffalo to Knoxville?

    Flights from Buffalo to Knoxville usually depart from Buffalo (BUF) and arrive at Knoxville McGhee Tyson (TYS).

  • Which airports do connecting flights from Buffalo to Knoxville pass through?

    One-stop flights from Buffalo to Knoxville most commonly connect through:

    • Washington, D.C. Dulles Intl (IAD) - 28% of one-stop connections
    • Detroit Metropolitan Wayne County (DTW) - 19% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 14% of one-stop connections
    • Charlotte Douglas (CLT) - 14% of one-stop connections

  • Can I save money by using flexible dates for flights from Buffalo to Knoxville?

    Yes. Flexible dates can save you up to 49% on flights from Buffalo to Knoxville. Wednesday is the cheapest departure day at $346 round-trip on average, while Saturday is the most expensive at $678, a difference of $332.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Buffalo to Knoxville?

    Flying via Charlotte Douglas (CLT) gives the shortest average 1-stop total travel time at 4h 11m, compared with 4h 15m via Detroit Metropolitan Wayne County (DTW) and 4h 24m via Washington, D.C. Dulles Intl (IAD).

Your guide to booking Buffalo to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Wednesday departure and avoid flying on Saturday. On this route, Wednesday flights average $346, about $332 less than Saturday fares (49% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Buffalo to Knoxville trip for June. Fares historically average $344 round-trip in that month - typically $302 less than the most expensive month, which is February (based on the last 12 months).

More options for your flight from Buffalo to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

Car rentals in Knoxville
Hotels in Knoxville
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