Which airports can I use when flying from Buffalo to Knoxville?

Flights from Buffalo to Knoxville usually depart from Buffalo (BUF) and arrive at Knoxville McGhee Tyson (TYS).

What cabin classes can I book on flights from Buffalo to Knoxville?

Two cabin classes are available on flights from Buffalo to Knoxville: • Economy Class • First Class

Which airports do connecting flights from Buffalo to Knoxville pass through?

One-stop flights from Buffalo to Knoxville most commonly connect through: • Charlotte Douglas (CLT) - 25% of one-stop connections • Washington, D.C. Dulles Intl (IAD) - 18% of one-stop connections • Detroit Metropolitan Wayne County (DTW) - 16% of one-stop connections • Chicago O'Hare Intl (ORD) - 16% of one-stop connections Charlotte Douglas (CLT) handles the largest share of one-stop connections on this route.

Can I save money by using flexible dates for flights from Buffalo to Knoxville?

Yes. Being flexible with your travel dates can save you up to 33% on the Buffalo to Knoxville route. Wednesday is the cheapest departure day at $337 round-trip on average, while Sunday is the most expensive at $496, a difference of $159. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

How long is a flight from Buffalo to Knoxville?

A nonstop flight from Buffalo to Knoxville takes 0h 00m, covering 567 miles.

Do I need a passport to fly from Buffalo to Knoxville?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

Have flight prices from Buffalo to Knoxville changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $287 to $930. That means the highest observed fare was about 3x higher than the lowest one.

How are flight prices from Buffalo to Knoxville looking right now?

One-way fares from Buffalo to Knoxville are currently higher than usual. Average one-way flight prices are about $294, which is 23% above the typical average for this route.

How much time can I save by choosing a different layover airport from Buffalo to Knoxville?

Flying via Detroit Metropolitan Wayne County (DTW) gives the shortest average 1-stop total travel time at 4h 14m, compared with 4h 16m via Charlotte Douglas (CLT) and 4h 21m via Washington, D.C. Dulles Intl (IAD).

What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include: • Budget • Alamo • Thrifty • Enterprise Rent-A-Car • Payless

How much should I expect to pay for a Buffalo to Knoxville flight?

Round-trip flights from Buffalo to Knoxville range from $337 to $488, with an average of $388 over the past 12 months. Anything below $337 counts as a good deal.

What is the cheapest airline to fly from Buffalo to Knoxville?

American Airlines ($287) and Delta ($287) are the cheapest airlines to fly round-trip from Buffalo to Knoxville according to KAYAK data over the last 5 days.

What is the most popular layover airport when flying from Buffalo to Knoxville?

Charlotte Douglas (CLT) is the most popular layover for the Buffalo to Knoxville route. 25% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via CLT.

What is the cheapest layover airport when flying from Buffalo to Knoxville?

Flights via Chicago O'Hare Intl (ORD) offer the most affordable fares, with an average round-trip price of $358. Based on KAYAK data over the past 3 months.

When flying from Buffalo to Knoxville which airport offers the shortest layover?

Charlotte Douglas (CLT) had the shortest average connection time for Buffalo to Knoxville layovers at 156 minutes over the past 3 months.

$127 CHEAP FLIGHTS from Buffalo to Knoxville (BUF - TYS)

Save 21% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$287

Typical prices: $337-$488

American Airlines

Fri 10/26Wed 10/31

BUF - TYS • 1 stop

Cheapest one-way

$127

Typical prices: $169-$278

Multiple Airlines

Wed 10/24

BUF - TYS • 2 stops

Nonstop flights

Not available

There are currently no direct flights between Buffalo and Knoxville. You'll need to take a connecting flight to reach the destination.

Insights

When to travel

August

Cheapest • 12% price drop

October

Most popular

Good to know

Top layover airports

Chicago O'Hare Intl (ORD)

Cheapest • Avg $358 (round-trip)

Detroit Metropolitan Wayne County (DTW)

Shortest trip • 4h 14m (one-way)

Insights

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We hope you love your trip to Knoxville!

Flight Deals

Cheap Flights from Buffalo to Knoxville (BUF-TYS)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Recent round-trip flight deals from Buffalo to Knoxville

Mon, Oct 26 - Sat, Oct 31

7:53 pm - 11:55 pmBUF Buffalo-TYS Knoxville McGhee Tyson

4h 02m1 stop Charlotte Douglas

6:00 am - 10:18 amTYS Knoxville McGhee Tyson-BUF Buffalo

4h 18m1 stop Philadelphia

$287American Airlines

Mon, Nov 9 - Sat, Nov 14

12:58 pm - 6:44 pmBUF Buffalo-TYS Knoxville McGhee Tyson

5h 46m1 stop Charlotte Douglas

7:50 am - 3:01 pmTYS Knoxville McGhee Tyson-BUF Buffalo

7h 11m1 stop Philadelphia

$287American Airlines

Thu, Oct 1 - Mon, Oct 5

6:00 am - 11:04 amBUF Buffalo-TYS Knoxville McGhee Tyson

5h 04m1 stop New York LaGuardia

7:25 pm - 11:52 pmTYS Knoxville McGhee Tyson-BUF Buffalo

4h 27m1 stop Atlanta Hartsfield-Jackson

$287Delta

Mon, Nov 9 - Sat, Nov 14

7:52 pm - 11:59 pmBUF Buffalo-TYS Knoxville McGhee Tyson

4h 07m1 stop Washington, D.C. Dulles Intl

1:56 pm - 11:49 pmTYS Knoxville McGhee Tyson-BUF Buffalo

9h 53m2 stops Chicago O'Hare Intl Newark

$292United Airlines

Thu, Feb 4 - Sun, Feb 7

12:39 pm - 6:03 pmBUF Buffalo-TYS Knoxville McGhee Tyson

5h 24m1 stop Washington, D.C. Reagan-National

6:33 pm - 11:59 pmTYS Knoxville McGhee Tyson-BUF Buffalo

5h 26m1 stop Washington, D.C. Reagan-National

$319American Airlines

Thu, Feb 4 - Sun, Feb 7

10:25 am - 6:40 pmBUF Buffalo-TYS Knoxville McGhee Tyson

8h 15m1 stop Nashville Intl

6:50 am - 2:15 pmTYS Knoxville McGhee Tyson-BUF Buffalo

7h 25m2 stops Nashville Intl Baltimore/Washington

$330Southwest

Mon, Oct 26 - Sat, Oct 31

5:45 pm - 9:35 pmBUF Buffalo-TYS Knoxville McGhee Tyson

3h 50m1 stop Baltimore/Washington

8:25 am - 5:55 pmTYS Knoxville McGhee Tyson-BUF Buffalo

9h 30m2 stops Baltimore/Washington Orlando

$332Southwest

Sat, Oct 31 - Tue, Nov 3

3:01 pm - 7:36 pmBUF Buffalo-TYS Knoxville McGhee Tyson

4h 35m1 stop Washington, D.C. Dulles Intl

5:45 am - 9:54 amTYS Knoxville McGhee Tyson-BUF Buffalo

4h 09m1 stop Washington, D.C. Dulles Intl

$367United Airlines

Mon, Oct 12 - Sat, Oct 17

6:00 am - 11:02 amBUF Buffalo-TYS Knoxville McGhee Tyson

5h 02m1 stop New York LaGuardia

7:26 am - 11:35 amTYS Knoxville McGhee Tyson-BUF Buffalo

4h 09m1 stop Detroit Metropolitan Wayne County

$387Delta

Thu, Oct 29 - Sun, Nov 1

6:15 am - 10:20 amBUF Buffalo-TYS Knoxville McGhee Tyson

4h 05m1 stop Detroit Metropolitan Wayne County

5:40 am - 11:35 amTYS Knoxville McGhee Tyson-BUF Buffalo

5h 55m2 stops Atlanta Hartsfield-Jackson Detroit Metropolitan Wayne County

$781Delta

Recent last minute flight deals from Buffalo to Knoxville

Fri, Sep 18 - Sun, Sep 20

6:00 am - 5:10 pmBUF Buffalo-TYS Knoxville McGhee Tyson

11h 10m1 stop Orlando

8:30 am - 12:15 pmTYS Knoxville McGhee Tyson-BUF Buffalo

3h 45m1 stop Baltimore/Washington

$899Southwest

Fri, Sep 18 - Sun, Sep 20

7:59 pm - 11:59 pmBUF Buffalo-TYS Knoxville McGhee Tyson

4h 00m1 stop Washington, D.C. Dulles Intl

9:45 am - 2:18 pmTYS Knoxville McGhee Tyson-BUF Buffalo

4h 33m1 stop Washington, D.C. Dulles Intl

$925United Airlines

Fri, Sep 18 - Sun, Sep 20

11:45 am - 8:00 pmBUF Buffalo-TYS Knoxville McGhee Tyson

8h 15m2 stops Chicago Midway Baltimore/Washington

8:30 am - 12:15 pmTYS Knoxville McGhee Tyson-BUF Buffalo

3h 45m1 stop Baltimore/Washington

$969Southwest

Fri, Sep 18 - Sun, Sep 20

7:59 pm - 2:37 pmBUF Buffalo-TYS Knoxville McGhee Tyson

18h 38m1 stop Washington, D.C. Dulles Intl

5:45 am - 9:48 amTYS Knoxville McGhee Tyson-BUF Buffalo

4h 03m1 stop Washington, D.C. Dulles Intl

$980United Airlines

Fri, Sep 18 - Sun, Sep 20

7:59 pm - 10:49 pmBUF Buffalo-TYS Knoxville McGhee Tyson

26h 50m3 stops Washington, D.C. Dulles Intl Newark Chicago O'Hare Intl

9:45 am - 2:18 pmTYS Knoxville McGhee Tyson-BUF Buffalo

4h 33m1 stop Washington, D.C. Dulles Intl

$1,009United Airlines

Fri, Sep 18 - Sun, Sep 20

9:40 am - 5:10 pmBUF Buffalo-TYS Knoxville McGhee Tyson

7h 30m2 stops Baltimore/Washington Orlando

1:15 pm - 10:55 pmTYS Knoxville McGhee Tyson-BUF Buffalo

9h 40m2 stops Orlando Baltimore/Washington

$1,054Southwest

Fri, Sep 18 - Sun, Sep 20

6:00 am - 11:59 pmBUF Buffalo-TYS Knoxville McGhee Tyson

17h 59m2 stops Newark Washington, D.C. Dulles Intl

5:45 am - 9:48 amTYS Knoxville McGhee Tyson-BUF Buffalo

4h 03m1 stop Washington, D.C. Dulles Intl

$1,070United Airlines

Fri, Sep 18 - Sun, Sep 20

7:59 pm - 2:37 pmBUF Buffalo-TYS Knoxville McGhee Tyson

18h 38m1 stop Washington, D.C. Dulles Intl

5:45 am - 9:48 amTYS Knoxville McGhee Tyson-BUF Buffalo

4h 03m1 stop Washington, D.C. Dulles Intl

$1,095United Airlines

Fri, Sep 18 - Sun, Sep 20

7:59 pm - 2:37 pmBUF Buffalo-TYS Knoxville McGhee Tyson

18h 38m1 stop Washington, D.C. Dulles Intl

5:45 am - 9:48 amTYS Knoxville McGhee Tyson-BUF Buffalo

4h 03m1 stop Washington, D.C. Dulles Intl

$1,127United Airlines

Fri, Sep 18 - Sun, Sep 20

7:59 pm - 10:49 pmBUF Buffalo-TYS Knoxville McGhee Tyson

26h 50m3 stops Washington, D.C. Dulles Intl Newark Chicago O'Hare Intl

5:45 am - 9:48 amTYS Knoxville McGhee Tyson-BUF Buffalo

4h 03m1 stop Washington, D.C. Dulles Intl

$1,135United Airlines

Booking Insights

Price, demand and travel trends for Buffalo to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Buffalo to Knoxville with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from Buffalo to Knoxville?

Round-trip flights from Buffalo to Knoxville start at $287. Prices are below average for this route right now, with typical round-trip fares ranging from $337 to $488. The lowest price found in the past 5 days was $287 on American Airlines.

What's the cheapest day of the week to fly from Buffalo to Knoxville?

Wednesday is the cheapest day of the week to fly from Buffalo to Knoxville, it is 14% cheaper than the average day. Sunday is the most expensive day with flight prices 27% higher than average. Based on deals found by KAYAK users in the last 12 months.

What is the cheapest month to fly from Buffalo to Knoxville?

August is the cheapest month to fly from Buffalo to Knoxville at $343 round-trip.
February ($646) and January ($637) are the most expensive months.
The price difference between flying in the cheapest and most expensive months is 88% on average.

This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Low season	February
High season	October
Cheapest flight	$127

Best time to beat the crowds but there is an average 66% increase in price.

Most popular time to fly with an average 17% increase in price.

Flight from Buffalo to Knoxville

When to book flights from Buffalo to Knoxville

Are your dates flexible? Find out the best times to travel from Buffalo to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

Which airports can I use when flying from Buffalo to Knoxville?
Flights from Buffalo to Knoxville usually depart from Buffalo (BUF) and arrive at Knoxville McGhee Tyson (TYS).
What cabin classes can I book on flights from Buffalo to Knoxville?
Two cabin classes are available on flights from Buffalo to Knoxville:

• Economy Class
• First Class
Which airports do connecting flights from Buffalo to Knoxville pass through?
One-stop flights from Buffalo to Knoxville most commonly connect through:

• Charlotte Douglas (CLT) - 25% of one-stop connections
• Washington, D.C. Dulles Intl (IAD) - 18% of one-stop connections
• Detroit Metropolitan Wayne County (DTW) - 16% of one-stop connections
• Chicago O'Hare Intl (ORD) - 16% of one-stop connections

Charlotte Douglas (CLT) handles the largest share of one-stop connections on this route.
Can I save money by using flexible dates for flights from Buffalo to Knoxville?
Yes. Being flexible with your travel dates can save you up to 33% on the Buffalo to Knoxville route. Wednesday is the cheapest departure day at $337 round-trip on average, while Sunday is the most expensive at $496, a difference of $159. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.
How long is a flight from Buffalo to Knoxville?
A nonstop flight from Buffalo to Knoxville takes 0h 00m, covering 567 miles.
Do I need a passport to fly from Buffalo to Knoxville?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.
Have flight prices from Buffalo to Knoxville changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $287 to $930. That means the highest observed fare was about 3x higher than the lowest one.
How are flight prices from Buffalo to Knoxville looking right now?
One-way fares from Buffalo to Knoxville are currently higher than usual. Average one-way flight prices are about $294, which is 23% above the typical average for this route.
How much time can I save by choosing a different layover airport from Buffalo to Knoxville?
Flying via Detroit Metropolitan Wayne County (DTW) gives the shortest average 1-stop total travel time at 4h 14m, compared with 4h 16m via Charlotte Douglas (CLT) and 4h 21m via Washington, D.C. Dulles Intl (IAD).
What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?
Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:
• Budget
• Alamo
• Thrifty
• Enterprise Rent-A-Car
• Payless
How much should I expect to pay for a Buffalo to Knoxville flight?
Round-trip flights from Buffalo to Knoxville range from $337 to $488, with an average of $388 over the past 12 months. Anything below $337 counts as a good deal.

If your dates can be flexible, aim for a Wednesday departure instead of Sunday. On this route, Wednesday flights average $337 - about $159 less than Sunday (32% savings) based on the last 12 months.
If you can choose when to travel, plan your Buffalo to Knoxville trip for August. Fares historically average $343 round-trip in that month - typically $303 less than the most expensive month, which is February (based on the last 12 months).

More options for your flight from Buffalo to Knoxville

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BUF - TYS

$127 Find Cheap Flights from Buffalo to Knoxville - Compare and Save

Everything you should know

Cheap Flights from Buffalo to Knoxville (BUF-TYS)

Recent round-trip flight deals from Buffalo to Knoxville

Recent one-way flight deals from Buffalo to Knoxville

Recent last minute flight deals from Buffalo to Knoxville

Price, demand and travel trends for Buffalo to Knoxville flights

How much is a round-trip flight from Buffalo to Knoxville?

What's the cheapest day of the week to fly from Buffalo to Knoxville?

What is the cheapest month to fly from Buffalo to Knoxville?

What is the cheapest airline to fly from Buffalo to Knoxville?

What is the most popular layover airport when flying from Buffalo to Knoxville?

What is the cheapest layover airport when flying from Buffalo to Knoxville?

When flying from Buffalo to Knoxville which airport offers the shortest layover?

Key details for Buffalo to Knoxville flights

Low season

High season

Cheapest flight

When to book flights from Buffalo to Knoxville

Your Buffalo to Knoxville flight questions, answered

Your guide to booking Buffalo to Knoxville flights

More options for your flight from Buffalo to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

Information on your arrival and departure airports

Cabin class types available on flights from Buffalo to Knoxville

Find direct flights to and from Buffalo and Knoxville

Flights from domestic origins to Knoxville

Flights to other popular destinations

Find deals for your return flight