TYS - BUF

$125 Find Cheap Flights from Knoxville to Buffalo - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Buffalo departing on 9/6. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$260
Typical prices: $263-$390
Multiple Airlines
Thu 8/27Thu 9/3
TYS - BUF • 2 stops
Cheapest one-way
$125
Typical prices: $125-$293
Multiple Airlines
Sun 9/6
TYS - BUF • 2 stops
Top airlines
Cheapest • from $287 (round-trip)
Best reviews • 8.0 score
Airline reviews
Airline reviews
+1
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Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Knoxville and Buffalo. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $232 (round-trip)
Shortest trip • 4h 00m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 38% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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We hope you love your trip to Buffalo!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Buffalo (TYS-BUF)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Buffalo that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Buffalo

Thu, Aug 27 - Thu, Sep 3
Multiple Airlines Logo
12:55 pm - 10:29 am
TYS
-
BUF
21h 34m
2 stops
Multiple Airlines Logo
9:29 pm - 10:56 pm
BUF
-
TYS
25h 27m
1 stop
$260Multiple Airlines
Sat, Sep 19 - Tue, Sep 22
Delta Logo
7:33 am - 11:22 am
TYS
-
BUF
3h 49m
1 stop
Delta Logo
6:05 am - 11:18 am
BUF
-
TYS
5h 13m
1 stop
$287Delta
Thu, Aug 27 - Thu, Sep 3
American Airlines Logo
6:32 pm - 11:56 pm
TYS
-
BUF
5h 24m
1 stop
American Airlines Logo
4:49 pm - 10:58 pm
BUF
-
TYS
6h 09m
1 stop
$287American Airlines
Mon, Aug 24 - Mon, Aug 31
American Airlines Logo
7:31 pm - 11:36 pm
TYS
-
BUF
4h 05m
1 stop
American Airlines Logo
5:00 am - 10:45 am
BUF
-
TYS
5h 45m
1 stop
$287American Airlines
Sat, Sep 19 - Tue, Sep 22
Delta Logo
11:45 am - 3:13 pm
TYS
-
BUF
3h 28m
1 stop
Delta Logo
6:20 am - 10:18 am
BUF
-
TYS
3h 58m
1 stop
$287Delta
Thu, Dec 3 - Mon, Dec 7
Delta Logo
6:00 am - 11:23 am
TYS
-
BUF
5h 23m
1 stop
Delta Logo
7:05 pm - 11:57 pm
BUF
-
TYS
4h 52m
1 stop
$287Delta
Mon, Sep 28 - Fri, Oct 2
Multiple Airlines Logo
5:33 pm - 5:49 pm
TYS
-
BUF
24h 16m
1 stop
Multiple Airlines Logo
1:40 pm - 8:35 am
BUF
-
TYS
18h 55m
2 stops
$288Multiple Airlines
Thu, Aug 20 - Mon, Aug 24
Multiple Airlines Logo
12:55 pm - 10:29 am
TYS
-
BUF
21h 34m
2 stops
Multiple Airlines Logo
6:54 pm - 2:35 pm
BUF
-
TYS
19h 41m
1 stop
$288Multiple Airlines
Tue, Aug 18 - Tue, Aug 25
Southwest Logo
8:05 am - 2:20 pm
TYS
-
BUF
6h 15m
1 stop
Southwest Logo
8:55 am - 6:55 pm
BUF
-
TYS
10h 00m
2 stops
$292Southwest
Thu, Sep 10 - Mon, Sep 14
Southwest Logo
1:00 pm - 9:55 pm
TYS
-
BUF
8h 55m
2 stops
Southwest Logo
6:00 am - 5:10 pm
BUF
-
TYS
11h 10m
1 stop
$298Southwest
Booking Insights

KAYAK's insights & trends for Knoxville to Buffalo flights

Get data-powered insights and trends into flights from Knoxville to Buffalo to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Knoxville to Buffalo?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Buffalo, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Buffalo is November, where tickets cost $283 (return) on average. On the other hand, the most expensive months are December and March, where the average cost of round-trip tickets is $798 and $682 respectively.

Good to know

Low season

February

Cheapest flight

$125
Best time to beat the crowds with an average 15% drop in price.
Most popular time to fly and prices are also 13% lower on average.
Flight from Knoxville to Buffalo

When to book flights from Knoxville to Buffalo

Are your dates flexible? Find out the best times to travel from Knoxville to Buffalo based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Buffalo

  • What is the cheapest flight from Knoxville to Buffalo?

    In the last 5 days, the lowest price for a flight from Knoxville to Buffalo was $125 for a one-way ticket and $260 for a round-trip.

  • Do I need a passport to fly between Knoxville and Buffalo?

    No

  • Which airports will I be using when flying from Knoxville to Buffalo?

    On your way to Buffalo, you’ll fly out from Knoxville McGhee Tyson. You’ll be landing at Buffalo.

  • Which aircraft models fly most regularly from Knoxville to Buffalo?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Buffalo?

    SkyTeam, and oneworld are the airline alliances operating flights between Knoxville and Buffalo, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Knoxville to Buffalo, Southwest or Delta?

    The two airlines most popular with KAYAK users for flights from Knoxville to Buffalo are Southwest and Delta. With an average price for the route of $397 and an overall rating of 8.0, Southwest is the most popular choice. Delta is also a great choice for the route, with an average price of $300 and an overall rating of 7.8.

  • How does KAYAK find such low prices on flights from Knoxville to Buffalo?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Buffalo.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Buffalo?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Buffalo from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Buffalo?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Buffalo with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and BUF can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Buffalo?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Buffalo from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Knoxville to Buffalo

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Buffalo. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Buffalo? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4227 reviews
7.5Entertainment
8.1Boarding
8.6Crew
7.0Food
8.0Comfort
Airline reviews

Had a great flight. Delayed takeoff, but comfortable. Snacks were good.

10.0 ExcellentMelissa, Mar 2026
MSY - LGA
Read more Southwest reviews

Had a great flight. Delayed takeoff, but comfortable. Snacks were good.

Pretty seamless, just a tad bit late in taking off and landing.

after landing, we stay 2 hours on the taxi way before reaching the gate The airline and the crew were good though

My flight to Chicago left and landed early. My return flight left two minutes late and arrived 2 minutes late. My seat selections were ideal! There were no snacks going to Chicago and no snacks on the return trip. There are no charging outlets on board.

Gate agents were informative and friendly… flight attendants were as well. Had a fun time chatting about their legacy AirTran experiences as a former fan of the airline that Southwest acquired.

The fluidity of the entire process of boarding the plane the flight attendants attentiveness. The flight attendants also provided coloring books for my kids who loved it.

It good. Just not that plane didn’t have power outlets to charge devices etc.

We stood on the tarmac for over an hour. Very bad turbulence the whole ride. Very to get to the restroom.

C Am handicapped and couldn't get help with my luggage.

Healthier snack would be much appreciated. Love traveling on Southwest!

Flight from Savannah arrived very late and we did not take off till 2 hours after scheduled departure!

My flight was canceled, and instead of rebooking me on a non-stop first-class flight for the same day, which I originally had, Delta rebooked me on a one-stop flight for the following day. When I checked the Delta app, I noticed that there were available flights for both the same day and the next day. I believe this indicates poor management on their part.

My flight home from Knoxville, TN, included a layover in Atlanta. I boarded the aircraft in Zone 5 and although there was limited overhead space, I was able to put my 'backpack' style roller-bag above my seat. Unfortunately, due to continued bad weather, we had to deplane. There were many people who would have missed their connection, so they rebooked. When we were re-boarding, the gate agent welcomed zone 5 and then made an announcement: All roller-bags for zone 5 passengers and higher will need to be gate checked. I promptly pushed the telescoping handle in and held my bag like a backpack. I was able to bring it on board, which was a relief. Upon entering the aircraft it became apparent that there was easily 40% open overhead space. There were audible signs of angry passengers who felt duped into checking their bags when in fact there were noticeably LESS passengers on the aircraft and TONS of overhead space. I'm not sure what kinds of parameters are used to determine when to cut off roller-bags from being brought on board, but it seemed deceptive and underhanded to have so many people get stuck checking their bags when clearly there was ample room for at least one more zone.

So terrible. My flight was 4 hours delayed and we weren't notified til last second within an hour of boarding. WE had to sit on the plane for 4 hours. ridiculous.

The CRJ-900 was clean but the overhead air vents were broken in our First Class row, making the cabin very hot until about 30 mins into the flight. The flight attendants were both extremely apologetic and accommodating though so that is why I rated the flight as very good. They checked on us many times and truly showed they cared. The snacks for an hour and a half flight could be better. Would be nice if there was a small plated meal over convenient store snacks. WiFi also was not working. And it would be nice if Delta had adjustable headrests on these planes.

The plane was old and thus the seats were not good. No cushion left whatsoever, and it all was a bit worn out.

flight was delayed 4+ hours. there was really no understanding of why? weather? the last hour of delay was post boarding. pilot seat was broken. was that the real reason? nonetheless, long day of inconveniences.

Great overall. There was a bit of turbulence so they could only serve water because too much turbulence for the carts. Was glad they prioritized safety though

From Atlanta to Cabo I would have hoped on a plane that size I would have been able to breathe and wiggle my feet a little! The leg room in that plane is non existent and I am only 5”4’. And the air vent either wasn’t working very well or just could not blow air from the ceiling to the seat area as I was suffocating through the entire flight! And please don’t say I would have been more comfortable in first class because I cannot afford those rates and have always travelled Main Cabin without issues !

We flew early evening on New Year's Eve. Our plane was less than half full... Great for the passenger experience -- not so much for the airline lol. Comfortable, spacious, smooth flight -- and early arrival!

Terrible boarding and first class experience. Nice staff but overall disorganized, dirty plane.

I almost missed my flight and they helped me out enormously

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

I didn’t like anything, being platinum pro get you absolutely nowhere and does not increase the customer service treatment whatsoever anymore. My flight was canceled and they put me on a flight eight hours later that would’ve got me back in the middle of the night. They could’ve easily move me up to an hour Prior on an earlier flight. My second flight was unreasonable to take, the third flight was also canceled due to mechanical issues like the first flight. I don’t know what’s going on with American, but they are falling apart, after seven flight changes I finally got home, Unreasonable.

This was a horrible American Airlines experience, and it discourages me from flying with them again. It may have stemmed from a mechanical delay, but it appeared that the team was unprepared to respond to the delay. After boarding, we waited an hour before finally taking off. After landing at our destination, we waited an additional hour on the tarmac waiting for a gate (at 8:00pm) to be assigned and cleared. The flight crew did their best, but they were clearly tired and also ready to be done for the day. Because of the delay, I missed a connecting flight. It was a very poor experience.

Fantastic! If it had not been for a check-in agent in Knoxville I may have not gotten my passes on British Airways. I couldn’t check-in online because British Airways had messed us the info on my tickets to London & Inverness. AA’s was great! British Airways was a continuous series of delays and frustrations.

We liked quick boarding and on time departure. Seats were very uncomfortable.

Wheelchair was waiting for me,changed to a better seat which was great as it's hard for me to walk

Everything you need to know for your flight from Knoxville to Buffalo

Information on your arrival and departure airports