$272 Find Cheap Flights from the Cayman Islands to San Francisco

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to San Francisco departing on 4/7. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to San Francisco

 
These are the airlines KAYAK users have selected most often from within our search results for flights to San Francisco, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results for flights to San Francisco, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$515
Southwest
Wed 4/8Sun 4/12
GCM - SFO • 2 stops
Cheapest one-way
$272
Typical prices: $508-$519
JetBlue
Tue 4/7
GCM - SFO • 1 stop
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to San Francisco!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from the Cayman Islands to San Francisco

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from the Cayman Islands to San Francisco that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from the Cayman Islands to San Francisco

Wed, Apr 8 - Sun, Apr 12
Southwest Logo
1:05 pm - 11:35 pm
GCM
-
SFO
12h 30m
2 stops
Southwest Logo
9:15 pm - 12:10 pm
SFO
-
GCM
12h 55m
2 stops
$515Southwest
Thu, Jun 11 - Mon, Aug 31
JetBlue Logo
2:55 pm - 11:55 pm
GCM
-
SFO
11h 00m
1 stop
JetBlue Logo
9:00 pm - 1:55 pm
SFO
-
GCM
14h 55m
1 stop
$536JetBlue
Mon, Mar 30 - Sat, Apr 11
Air Canada Logo
12:30 pm - 9:23 am
GCM
-
SFO
22h 53m
1 stop
Air Canada Logo
1:20 pm - 11:10 am
SFO
-
GCM
19h 50m
2 stops
$702Air Canada
Wed, Apr 8 - Sun, Apr 12
United Airlines Logo
1:50 pm - 12:03 pm
GCM
-
SFO
24h 13m
1 stop
United Airlines Logo
6:55 pm - 12:30 pm
SFO
-
GCM
15h 35m
1 stop
$722United Airlines
Mon, Mar 30 - Fri, Apr 10
American Airlines Logo
11:40 am - 11:10 pm
GCM
-
SFO
13h 30m
1 stop
American Airlines Logo
12:30 am - 3:03 pm
SFO
-
GCM
12h 33m
1 stop
$731American Airlines
Mon, Mar 30 - Fri, Apr 10
American Airlines Logo
12:00 pm - 12:48 am
GCM
-
SFO
14h 48m
2 stops
American Airlines Logo
12:59 am - 3:03 pm
SFO
-
GCM
12h 04m
2 stops
$736American Airlines
Sat, Jun 13 - Wed, Jun 17
Air Canada Logo
12:25 pm - 10:50 am
GCM
-
SFO
24h 25m
1 stop
Air Canada Logo
4:30 pm - 11:30 am
SFO
-
GCM
17h 00m
1 stop
$755Air Canada
Sat, Jun 13 - Wed, Jun 17
Air Canada Logo
12:25 pm - 11:25 am
GCM
-
SFO
25h 00m
2 stops
Air Canada Logo
4:30 pm - 11:30 am
SFO
-
GCM
17h 00m
1 stop
$758Air Canada
Sat, Jun 13 - Wed, Jun 17
Air Canada Logo
12:25 pm - 10:50 am
GCM
-
SFO
24h 25m
1 stop
Air Canada Logo
1:40 pm - 11:30 am
SFO
-
GCM
19h 50m
1 stop
$765Air Canada
Sat, Jun 13 - Wed, Jun 17
Air Canada Logo
12:25 pm - 11:25 am
GCM
-
SFO
25h 00m
2 stops
Air Canada Logo
1:40 pm - 11:30 am
SFO
-
GCM
19h 50m
1 stop
$769Air Canada
Booking Insights

KAYAK's insights & trends for flights to San Francisco

Get data-powered insights and trends for flights to San Francisco to help you find the cheapest flights, the best time to fly and much more.

How long is the flight to San Francisco?

The duration of your flight to San Francisco depends on your departure and arrival airports. Obviously any flights that include a layover will also be longer. The most popular route to San Francisco on KAYAK is from George Town, which takes 11h 00m.

How many direct flights to San Francisco are there each day?

There are around 539 direct flights from within Cayman Islands to San Francisco every day. Most flights depart in the morning, with 7:00 am the most common departure time and 46% of flights departing in the morning.

Good to know

Cheapest flight$272
Flight from George Town to San Francisco

FAQs - booking San Francisco flights

  • How far is San Francisco Airport from central San Francisco?

    You’ll need to travel 12 miles to reach the San Francisco city center from San Francisco Airport.

  • What is the name of San Francisco’s airport?

    San Francisco is served by San Francisco Airport, also commonly referred to as San Francisco or San Francisco Intl. The airport code is SFO.

  • How does KAYAK find such low prices on flights to San Francisco?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights to San Francisco.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket to San Francisco?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights to San Francisco?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight to San Francisco?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • How many direct flights to San Francisco are there each week?

    Each week there are around 3,770 direct flights from within Cayman Islands to San Francisco. The most common day for departures is Thursday, with 15% of flights taking off on this day.

Top tips for finding cheap flights to San Francisco

  • Enter your preferred departure airport and travel dates into the search form above to unlock the latest San Francisco flight deals.

Reviews of the top airline flying from the Cayman Islands to San Francisco

 
See real verified KAYAK customer reviews for airlines flying to San Francisco. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline from the Cayman Islands to San Francisco. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with to San Francisco? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11201 reviews
7.5Boarding
7.2Comfort
6.4Food
6.9Entertainment
8.0Crew
Airline reviews

We were upgraded to Business Class. So comfortable with great service and food options

10.0 ExcellentRobert, Jan 2026
AKL - LAX
Read more American Airlines reviews

We were upgraded to Business Class. So comfortable with great service and food options

The flight was completely full. Crew was not happy. Everyone was rude and brusque. Travelling with an arm in a cast and seating in the first row of economy cabin (in front of the separation) I needed help retrieving my tray for the meal. A staff member literally threw the tray on my lap, without helping to take out the tray. Boarding was messy, with 300 people waiting in an encloses space with low ceiling. I will try to avoid AA next time I have a long flight.

The comfort of Business Class made this trip far more comfortable. I was indeed surprised when I asked one of the flight attendant to help me set up my "bed", she responded that "We don't make beds in Business Class any longer...only First Class" I believe her name was Giselle, but I'm not certain. She did instruct me how to adjust the seat, place the hooded cover and I clearly understood how to place the blanket and the cover. Additionally, the meal I was served (a beef dish) was almost inedible. The beef was tough and odd tasting. I didn't mention it as I was hoping to quickly settle down and try to get some sleep.

Amazing I love American. I’ll never fly anyone else if I can help it.

Everything about the flight was lovely. My only suggestion would be to offer a few more options of tv series from Apple TV or HBO.

After the door had been closed, the cockpit makes an announcement that catering is running late and it is not the airline's fault. It is their fault in the sense that we had to sit for 2 hours or more when we could have stayed in the terminal. Poor communications between catering and airline. This caused a young man to lose his temper and he went storming out hitting objects. He had complained to the gate agent that he had already waited at the gate 7 hours and when can the airplane leave? Airilnes do a poor job of explaining delays, maintenance issues, etc. whereas being truthful may gain more sympathy or understanding.

We were told the flight was delayed 5 times, then it was moved to the next day.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

Loved the crew . Absolutely no complaints. Except for luggage lost

Wish some foods provided rather than just biscuit/cookie for flight more than 2 hours

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Calistoga
Rohnert Park
Marina
Emeryville
Capitola
Pacifica
Millbrae
Campbell
Mill Valley
Newark
Novato
Windsor
Union City
Richmond
Belmont
West Sacramento
Los Altos
Corte Madera
American Canyon
Jenner

Everything you need to know for your flight to San Francisco

Information on the airport you'll fly into in San Francisco