$371 Find Cheap Flights from the Cayman Islands to San Francisco - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to San Francisco departing on 8/2. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to San Francisco

 
These are the airlines KAYAK users have selected most often from within our search results for flights to San Francisco, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results for flights to San Francisco, as well as popular online travel agencies
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Cheap Flights from the Cayman Islands to San Francisco

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from the Cayman Islands to San Francisco that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from the Cayman Islands to San Francisco

Mon, Jul 20 - Mon, Jul 27
Southwest Logo
12:50 pm - 9:35 pm
GCM
-
SFO
10h 45m
2 stops
Southwest Logo
6:10 pm - 11:55 am
SFO
-
GCM
15h 45m
2 stops
$654Southwest
Mon, Jul 13 - Sun, Jul 19
Southwest Logo
12:50 pm - 12:35 am
GCM
-
SFO
13h 45m
2 stops
Southwest Logo
7:10 pm - 11:55 am
SFO
-
GCM
14h 45m
2 stops
$693Southwest
Mon, Oct 5 - Thu, Oct 15
Delta Logo
12:55 pm - 11:57 pm
GCM
-
SFO
13h 02m
1 stop
Delta Logo
10:30 pm - 11:40 am
SFO
-
GCM
11h 10m
1 stop
$772Delta
Mon, Jul 20 - Mon, Jul 27
American Airlines Logo
2:41 pm - 12:43 am
GCM
-
SFO
12h 02m
1 stop
American Airlines Logo
5:01 pm - 1:36 pm
SFO
-
GCM
18h 35m
1 stop
$781American Airlines
Mon, Oct 5 - Thu, Oct 15
American Airlines Logo
9:25 am - 10:28 pm
GCM
-
SFO
15h 03m
2 stops
American Airlines Logo
11:36 pm - 11:00 am
SFO
-
GCM
9h 24m
1 stop
$786American Airlines
Mon, Jul 13 - Sun, Jul 19
American Airlines Logo
2:41 pm - 10:28 pm
GCM
-
SFO
9h 47m
1 stop
American Airlines Logo
9:49 pm - 11:00 am
SFO
-
GCM
11h 11m
1 stop
$826American Airlines
Mon, Jul 13 - Sun, Jul 19
American Airlines Logo
12:02 pm - 8:20 pm
GCM
-
SFO
10h 18m
1 stop
American Airlines Logo
11:49 pm - 4:10 pm
SFO
-
GCM
14h 21m
2 stops
$831American Airlines
Mon, Oct 5 - Thu, Oct 15
Multiple Airlines Logo
12:25 pm - 12:00 pm
GCM
-
SFO
25h 35m
3 stops
Multiple Airlines Logo
11:59 pm - 9:15 pm
SFO
-
GCM
19h 16m
2 stops
$1,007Multiple Airlines
Mon, Oct 5 - Thu, Oct 15
Multiple Airlines Logo
7:00 am - 12:00 pm
GCM
-
SFO
31h 00m
3 stops
Multiple Airlines Logo
11:10 am - 8:55 pm
SFO
-
GCM
31h 45m
3 stops
$1,358Multiple Airlines
Mon, Jul 13 - Sun, Jul 19
Multiple Airlines Logo
4:45 pm - 6:32 pm
GCM
-
SFO
27h 47m
3 stops
Multiple Airlines Logo
8:10 am - 11:25 am
SFO
-
GCM
25h 15m
2 stops
$1,530Multiple Airlines
Booking Insights

KAYAK's insights & trends for flights to San Francisco

Get data-powered insights and trends for flights to San Francisco to help you find the cheapest flights, the best time to fly and much more.

How long is the flight to San Francisco?

The duration of your flight to San Francisco depends on your departure and arrival airports. Obviously, any flights that include a layover will also be longer. The most popular route to San Francisco on KAYAK is from George Town, which takes 10h 45m.

How many direct flights to San Francisco are there each day?

There are around 1,874 direct flights from within Cayman Islands to San Francisco every day. Most flights depart in the morning, with 42% of flights departing in the morning.

Good to know

Cheapest flight$371
Flight from George Town to San Francisco

FAQs - booking San Francisco flights

  • How far is San Francisco Airport from central San Francisco?

    You’ll need to travel 11 miles to reach the San Francisco city center from San Francisco Airport.

  • What is the name of San Francisco’s airport?

    San Francisco is served by San Francisco Airport, also commonly referred to as San Francisco or San Francisco Intl. The airport code is SFO.

  • How does KAYAK find such low prices on flights to San Francisco?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights to San Francisco.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket to San Francisco?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights to San Francisco?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight to San Francisco?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • How many direct flights to San Francisco are there each week?

    Each week there are around 13,114 direct flights from within Cayman Islands to San Francisco. The most common day for departures is Sunday, with 16% of flights taking off on this day.

Top tips for finding cheap flights to San Francisco

  • Enter your preferred departure airport and travel dates into the search form above to unlock the latest San Francisco flight deals.

Reviews of the top airline flying from the Cayman Islands to San Francisco

 
See real verified KAYAK customer reviews for airlines flying to San Francisco. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline from the Cayman Islands to San Francisco. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with to San Francisco? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11670 reviews
7.9Crew
6.4Food
6.8Entertainment
7.5Boarding
7.2Comfort
Airline reviews

It was so much better than expected, Ohare is not such a pleasant experience but American Airlines with the new, clean aeroplane and free Wi-Fi was outstanding and the crew so pleasant and helpful.

10.0 ExcellentMark, Jun 2026
ORD - LAX
Read more American Airlines reviews

It was so much better than expected, Ohare is not such a pleasant experience but American Airlines with the new, clean aeroplane and free Wi-Fi was outstanding and the crew so pleasant and helpful.

This was my first flight on Aer Lingus and it was great. The plane wasn't full so I could move to a seat with extra room. The food was pretty good for airline food and the staff was nice and attentive. I enjoyed the media provided during my 10 hour flight. We arrived home early and it's always good to be home!

Was put into a seat right behind the toilet that had no entertainment possible but did have plenty of leg room over noisy part of plane.

The seat when "flat" was not flat and pad was too thin to cover it.

American delayed the flight for a crew rest period. The delay occurred late in the evening - the earliest i can find is 10:20 pm. With a 6 am flight anyone on the flight would have already have been asleep (unless you are insane, a vampire or on drugs) and at least for me i was already on the way to the airport at 445 am the next morning when i discovered they delayed the flight until 9 am. Given the incoming flight was in the air at 6 pm the evening before this should have been figured out a lot more timely that was there only crew to use. Just frustrating given there is no consideration for customer experience anymore in flying.

Flight: Started on time. Comfortable flight. Arrived on time. Crew: Very cordial and helpful. Drinks and snack was served with a smile. Overall enjoyed the trip. Regards, Hari Doss Chanchala Doss

To have arrived on time and not 3 hours late after having already spent $100 to change to an earlier flight, only to arrive back home close to the original flight time.

American Airlines is a miserable experience. It is predictably miserable, in the sense that every time I fly American, I brace myself for the certainty that it will be unpleasant and uncomfortable. But it is unpredictable in the sense that I never know if the flight will be on time or delayed nine hours (both happened to me this week). I never know if I will be able to sit in the seat that I selected when I purchased the ticket or if I will be told by Customer Service (!!!) that I must relocate from first class to a seat in the back of the aircraft with no explanation (both happened to me this week). Will the food be frozen and half defrosted, or scalding hot? Will the drinks be warm? Will the flight attendants be surly and mean? Will the toilets be cramped and foul? Will the seats be narrow and uncomfortable? Will there be a real electric outlet at the seat, or just an unreliable USB-2 port? Will there be enough seats in the boarding lounge or just a few? Will the boarding process be smooth and efficient, or will the gate agents mess it up and delay it needlessly for 30 or 40 minutes? Will the catering and cleaning crew be prompt or will they take an extra 30 minutes? Will the brakes on the aircraft work properly, or will the pilot delay takeoff for four hours while the ground crew attends to what can only be described as routine maintenance that should have been done the night before? I've eexperienced every one of these unpleasant things this year, 2026. The only thing I can reliably count on is that American will find a new way to make the experience of flying as miserable as they possibly can.

Wifi was spotty. Tray table was very dirty when I sat down.

The WiFi would not connect enough for me to do my actual work. It permaspooled, disconnected, said it was connected, then wouldn't open an email... it was frustrating. I am not a tall person, 5'4" - and I felt cramped with little room to reach into my bag under the seat in front of me. I feel sorry for anyone taller than me having to fly. the one positive thing I will add, is the overhead bins are roomy enough to manage more bags than other carriers.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Calistoga
Rohnert Park
Marina
Emeryville
Pacifica
Capitola
Millbrae
Campbell
Newark
Novato
Mill Valley
Windsor
Union City
West Sacramento
Belmont
Richmond
American Canyon
Corte Madera
Jenner
Los Altos

Everything you need to know for your flight to San Francisco

Information on the airport you'll fly into in San Francisco