$326 Find Cheap Flights from Grand Cayman to San Francisco

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to San Francisco departing on 5/23. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Cheap Flights from Grand Cayman to San Francisco

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Grand Cayman to San Francisco that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Grand Cayman to San Francisco

Wed, May 27 - Wed, Jun 3
Southwest Logo
1:05 pm - 10:45 pm
GCM
-
SFO
11h 40m
2 stops
Southwest Logo
10:40 pm - 11:50 am
SFO
-
GCM
11h 10m
2 stops
$516Southwest
Sun, May 24 - Sun, May 31
Southwest Logo
12:50 pm - 10:30 pm
GCM
-
SFO
11h 40m
2 stops
Southwest Logo
9:15 pm - 12:10 pm
SFO
-
GCM
12h 55m
2 stops
$575Southwest
Tue, Jun 30 - Sun, Jul 12
Multiple Airlines Logo
1:45 pm - 12:20 pm
GCM
-
SFO
24h 35m
1 stop
Multiple Airlines Logo
9:35 pm - 4:05 pm
SFO
-
GCM
40h 30m
2 stops
$700Multiple Airlines
Sat, May 16 - Wed, May 20
JetBlue Logo
1:25 pm - 11:51 pm
GCM
-
SFO
12h 26m
1 stop
JetBlue Logo
8:00 am - 12:45 pm
SFO
-
GCM
26h 45m
1 stop
$715JetBlue
Sat, May 16 - Wed, May 20
JetBlue Logo
1:25 pm - 11:51 pm
GCM
-
SFO
12h 26m
1 stop
JetBlue Logo
8:00 am - 12:45 pm
SFO
-
GCM
26h 45m
1 stop
$734JetBlue
Sat, Jun 13 - Wed, Jun 17
Air Canada Logo
10:55 am - 9:10 pm
GCM
-
SFO
12h 15m
1 stop
Air Canada Logo
4:30 pm - 11:25 am
SFO
-
GCM
16h 55m
1 stop
$745Air Canada
Sat, Jun 13 - Wed, Jun 17
Air Canada Logo
10:55 am - 9:10 pm
GCM
-
SFO
12h 15m
1 stop
Air Canada Logo
4:30 pm - 11:25 am
SFO
-
GCM
16h 55m
1 stop
$765Air Canada
Wed, May 27 - Wed, Jun 3
Delta Logo
1:19 pm - 11:24 pm
GCM
-
SFO
12h 05m
1 stop
Delta Logo
11:55 pm - 11:54 am
SFO
-
GCM
9h 59m
1 stop
$772Delta
Sat, Jun 13 - Wed, Jun 17
American Airlines Logo
11:55 am - 10:59 pm
GCM
-
SFO
13h 04m
1 stop
American Airlines Logo
9:50 pm - 4:11 pm
SFO
-
GCM
16h 21m
1 stop
$786American Airlines
Sat, Jun 13 - Wed, Jun 17
American Airlines Logo
12:31 pm - 10:49 pm
GCM
-
SFO
12h 18m
1 stop
American Airlines Logo
11:29 pm - 4:11 pm
SFO
-
GCM
14h 42m
2 stops
$791American Airlines
Useful Info

Good to know

Cheapest flight$291
Flight from George Town to San Francisco

FAQs for booking flights from Grand Cayman to San Francisco

  • How does KAYAK find such low prices on flights from Grand Cayman to San Francisco?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Grand Cayman to San Francisco.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Grand Cayman to San Francisco?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco from Grand Cayman is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Grand Cayman to San Francisco?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back to Grand Cayman with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Grand Cayman to San Francisco?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco from Grand Cayman up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Grand Cayman to San Francisco

 
Need help choosing which airline to fly with from Grand Cayman to San Francisco? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11568 reviews
6.9Entertainment
7.2Comfort
7.9Crew
7.5Boarding
6.4Food
Airline reviews

Wifi was spotty. Tray table was very dirty when I sat down.

4.0 OkayTimothy, Apr 2026
JFK - LAX
Read more American Airlines reviews

Wifi was spotty. Tray table was very dirty when I sat down.

The WiFi would not connect enough for me to do my actual work. It permaspooled, disconnected, said it was connected, then wouldn't open an email... it was frustrating. I am not a tall person, 5'4" - and I felt cramped with little room to reach into my bag under the seat in front of me. I feel sorry for anyone taller than me having to fly. the one positive thing I will add, is the overhead bins are roomy enough to manage more bags than other carriers.

Buying ticket from kayak instant booking was a huge mistake, never to be repeated again! The Kayak didn’t book the tickets directly, it handed it off to a third party Underpricer, that booked a code shared American Airlines flight operated by Cathay Pacific!! When managing the booking American Airlines would recognize the itinerary but wouldn’t let me do anything stating, the flight is operated by Cathay Pacific so go to their website. Cathay Pacific would recognize the itinerary, neither by reservation ID or ticket number…asking to reach out to the third party Underpricer….calling Underpricer resulted in no help like seat requests, mileage number or upgrade request, 15hr layover accommodation voucher guidance…so net in net avoid booking through three layers of intermediaries

Going non stop to lax like I paid for. Not stopping in MCI for gas. Too long of delays

Flight was on time. Cabin attendants made no recognition of my name or being an Advantage Executive Platinum member.

Delayed for mechanical and no updates on what was happening and how long the delay might be.

A first class seat should fit a fat person, and this doesn't. The trays in the armrest are less functional than an ordinary tray in the back of the seat.

The experience at checkin for my American Airlines flight from Sacramento to LAX was very good including the assistance I received in getting my bags checked in and boarding passes printed. Was pleasantly surprised the my bags were checked through all the way to my destination at Clark International Airport in Angeles, Philippines.

Smooth flight. From the early boarding and all were on board before departure time and arrived early in ONT. Great crew. Thank you!!!!

The flight was significantly delayed for 6.5 hours because of snow. There was no communication once the plane returned to the gate regarding when the flight would resume. Other flights were departing while our flight was being unloaded for reasons unknown. Our flight also seemed out of the queue regarding further deicing, refueling, and waiting to Taxi to the runway.

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