$246 Find Cheap Flights from Grand Cayman to San Francisco

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to San Francisco departing on 2/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to San Francisco

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Everything you should know

Cheapest round-trip
$556
Multiple Airlines
Wed 3/4Wed 3/11
GCM - SFO • 1 stop
Cheapest one-way
$246
Typical prices: $650-$785
JetBlue
Tue 2/10
GCM - SFO • 1 stop
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to San Francisco!
Flight Deals
Useful Info
Flight Deals

Cheap Flights from Grand Cayman to San Francisco

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Grand Cayman to San Francisco that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Grand Cayman to San Francisco

Wed, Mar 4 - Wed, Mar 11
Multiple Airlines Logo
10:00 am - 3:18 pm
GCM
-
SFO
32h 18m
1 stop
Multiple Airlines Logo
10:38 pm - 9:15 pm
SFO
-
GCM
20h 37m
2 stops
$556Multiple Airlines
Wed, Mar 4 - Wed, Mar 11
Multiple Airlines Logo
10:00 am - 3:18 pm
GCM
-
SFO
32h 18m
1 stop
Multiple Airlines Logo
11:20 pm - 12:56 pm
SFO
-
GCM
11h 36m
1 stop
$568Multiple Airlines
Wed, Apr 8 - Sun, Apr 12
Southwest Logo
1:05 pm - 11:15 pm
GCM
-
SFO
12h 10m
2 stops
Southwest Logo
9:15 pm - 12:10 pm
SFO
-
GCM
12h 55m
2 stops
$610Southwest
Thu, Mar 5 - Thu, Mar 12
Multiple Airlines Logo
2:50 pm - 12:45 pm
GCM
-
SFO
24h 55m
1 stop
Multiple Airlines Logo
10:38 pm - 12:20 pm
SFO
-
GCM
35h 42m
2 stops
$618Multiple Airlines
Sat, Mar 14 - Fri, Mar 20
JetBlue Logo
3:00 pm - 10:43 am
GCM
-
SFO
21h 43m
1 stop
JetBlue Logo
11:14 pm - 12:48 pm
SFO
-
GCM
11h 34m
1 stop
$653JetBlue
Wed, Jul 1 - Wed, Jul 29
Southwest Logo
12:45 pm - 12:05 am
GCM
-
SFO
13h 20m
2 stops
Southwest Logo
7:20 pm - 11:50 am
SFO
-
GCM
14h 30m
2 stops
$662Southwest
Wed, Apr 8 - Sun, Apr 12
American Airlines Logo
12:00 pm - 10:45 pm
GCM
-
SFO
12h 45m
2 stops
American Airlines Logo
12:30 am - 11:32 am
SFO
-
GCM
9h 02m
1 stop
$720American Airlines
Wed, Apr 8 - Sun, Apr 12
United Airlines Logo
1:50 pm - 12:19 am
GCM
-
SFO
12h 29m
1 stop
United Airlines Logo
4:45 pm - 12:30 pm
SFO
-
GCM
17h 45m
1 stop
$722United Airlines
Wed, Jul 1 - Wed, Jul 29
American Airlines Logo
12:20 pm - 10:53 pm
GCM
-
SFO
12h 33m
1 stop
American Airlines Logo
11:53 pm - 11:20 am
SFO
-
GCM
9h 27m
1 stop
$731American Airlines
Wed, Mar 4 - Wed, Mar 11
American Airlines Logo
8:45 am - 9:13 pm
GCM
-
SFO
15h 28m
2 stops
American Airlines Logo
11:35 pm - 1:13 pm
SFO
-
GCM
11h 38m
2 stops
$736American Airlines
Useful Info

Good to know

Cheapest flight$246
Flight from George Town to San Francisco

FAQs for booking flights from Grand Cayman to San Francisco

  • How does KAYAK find such low prices on flights from Grand Cayman to San Francisco?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Grand Cayman to San Francisco.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Grand Cayman to San Francisco?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco from Grand Cayman is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Grand Cayman to San Francisco?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back to Grand Cayman with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Grand Cayman to San Francisco?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco from Grand Cayman up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Grand Cayman to San Francisco

 
Need help choosing which airline to fly with from Grand Cayman to San Francisco? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11160 reviews
8.0Crew
7.5Boarding
6.9Entertainment
6.4Food
7.2Comfort
Airline reviews

Amazing I love American. I’ll never fly anyone else if I can help it.

10.0 ExcellentRichard, Jan 2026
PHX - ONT
Read more American Airlines reviews

Amazing I love American. I’ll never fly anyone else if I can help it.

Everything about the flight was lovely. My only suggestion would be to offer a few more options of tv series from Apple TV or HBO.

After the door had been closed, the cockpit makes an announcement that catering is running late and it is not the airline's fault. It is their fault in the sense that we had to sit for 2 hours or more when we could have stayed in the terminal. Poor communications between catering and airline. This caused a young man to lose his temper and he went storming out hitting objects. He had complained to the gate agent that he had already waited at the gate 7 hours and when can the airplane leave? Airilnes do a poor job of explaining delays, maintenance issues, etc. whereas being truthful may gain more sympathy or understanding.

We were told the flight was delayed 5 times, then it was moved to the next day.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

Loved the crew . Absolutely no complaints. Except for luggage lost

Wish some foods provided rather than just biscuit/cookie for flight more than 2 hours

We are too tired and frustrated to comment politely at this point

The business class seats are dated and uncomfortable. The space is bare minimum and there is absolutely no privacy. For $4K, this is not what I expect.

The flight crew was rude. We were in first class and no one even offered water until an hour after we were in the air. Horrible experience

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Calistoga
Rohnert Park
Marina
Emeryville
Capitola
Pacifica
Millbrae
Campbell
Mill Valley
Newark
Novato
Windsor
Union City
Belmont
Richmond
West Sacramento
Los Altos
Corte Madera
American Canyon
Jenner

Everything you need to know for your flight to San Francisco

Information on the airport you'll fly into in San Francisco