$246 Find Cheap Flights from Grand Cayman to San Francisco

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to San Francisco departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$386
JetBlue
Thu 4/9Mon 4/13
GCM - SFO • 1 stop
Cheapest one-way
$246
Typical prices: $500-$609
JetBlue
Thu 4/23
GCM - SFO • 1 stop
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Flight Deals
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Flight Deals

Cheap Flights from Grand Cayman to San Francisco

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Grand Cayman to San Francisco that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Grand Cayman to San Francisco

Thu, Apr 9 - Mon, Apr 13
JetBlue Logo
2:05 pm - 12:58 am
GCM
-
SFO
12h 53m1 stop
JetBlue Logo
11:59 pm - 12:39 pm
SFO
-
GCM
10h 40m1 stop
$386JetBlue
Wed, Apr 8 - Mon, Apr 13
Southwest Logo
1:05 pm - 11:15 pm
GCM
-
SFO
12h 10m2 stops
Southwest Logo
7:15 pm - 12:10 pm
SFO
-
GCM
14h 55m2 stops
$600Southwest
Sun, Apr 5 - Sat, Apr 11
Multiple Airlines Logo
1:50 pm - 12:45 pm
GCM
-
SFO
24h 55m1 stop
Multiple Airlines Logo
9:07 pm - 12:44 pm
SFO
-
GCM
37h 37m2 stops
$651Multiple Airlines
Wed, Apr 8 - Mon, Apr 13
United Airlines Logo
1:50 pm - 12:19 am
GCM
-
SFO
12h 29m1 stop
United Airlines Logo
9:15 pm - 11:45 am
SFO
-
GCM
12h 30m1 stop
$702United Airlines
Sun, Apr 5 - Sat, Apr 11
JetBlue Logo
4:40 pm - 10:47 pm
GCM
-
SFO
32h 07m1 stop
JetBlue Logo
11:25 pm - 1:48 pm
SFO
-
GCM
12h 23m1 stop
$726JetBlue
Fri, Feb 20 - Fri, Feb 27
United Airlines Logo
2:50 pm - 11:24 pm
GCM
-
SFO
11h 34m1 stop
United Airlines Logo
11:20 pm - 4:35 pm
SFO
-
GCM
14h 15m1 stop
$727United Airlines
Wed, Apr 8 - Mon, Apr 13
American Airlines Logo
12:00 pm - 8:49 pm
GCM
-
SFO
10h 49m1 stop
American Airlines Logo
10:58 pm - 1:11 pm
SFO
-
GCM
12h 13m2 stops
$742American Airlines
Sat, Jun 13 - Wed, Jun 17
Air Canada Logo
12:25 pm - 10:50 am
GCM
-
SFO
24h 25m1 stop
Air Canada Logo
4:35 pm - 11:30 am
SFO
-
GCM
16h 55m2 stops
$745Air Canada
Sat, Jun 13 - Wed, Jun 17
Air Canada Logo
12:25 pm - 11:17 am
GCM
-
SFO
24h 52m2 stops
Air Canada Logo
4:35 pm - 11:30 am
SFO
-
GCM
16h 55m2 stops
$748Air Canada
Sun, Apr 5 - Sat, Apr 11
Multiple Airlines Logo
1:50 pm - 12:32 pm
GCM
-
SFO
24h 42m3 stops
Multiple Airlines Logo
1:20 pm - 11:10 am
SFO
-
GCM
19h 50m2 stops
$778Multiple Airlines
Useful Info

Good to know

Cheapest flight$246
Flight from George Town to San Francisco

FAQs for booking flights from Grand Cayman to San Francisco

  • How does KAYAK find such low prices on flights from Grand Cayman to San Francisco?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Grand Cayman to San Francisco.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Grand Cayman to San Francisco?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco from Grand Cayman is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Grand Cayman to San Francisco?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back to Grand Cayman with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Grand Cayman to San Francisco?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco from Grand Cayman up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Grand Cayman to San Francisco

 
Need help choosing which airline to fly with from Grand Cayman to San Francisco? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11088 reviews
7.5Boarding
7.2Comfort
8.0Crew
6.9Entertainment
6.4Food
Airline reviews

Everything about the flight was lovely. My only suggestion would be to offer a few more options of tv series from Apple TV or HBO.

10.0 ExcellentJill, Jan 2026
PHL - LAX
Read more American Airlines reviews

Everything about the flight was lovely. My only suggestion would be to offer a few more options of tv series from Apple TV or HBO.

After the door had been closed, the cockpit makes an announcement that catering is running late and it is not the airline's fault. It is their fault in the sense that we had to sit for 2 hours or more when we could have stayed in the terminal. Poor communications between catering and airline. This caused a young man to lose his temper and he went storming out hitting objects. He had complained to the gate agent that he had already waited at the gate 7 hours and when can the airplane leave? Airilnes do a poor job of explaining delays, maintenance issues, etc. whereas being truthful may gain more sympathy or understanding.

We were told the flight was delayed 5 times, then it was moved to the next day.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

Loved the crew . Absolutely no complaints. Except for luggage lost

Wish some foods provided rather than just biscuit/cookie for flight more than 2 hours

We are too tired and frustrated to comment politely at this point

The business class seats are dated and uncomfortable. The space is bare minimum and there is absolutely no privacy. For $4K, this is not what I expect.

The flight crew was rude. We were in first class and no one even offered water until an hour after we were in the air. Horrible experience

Great. Quick and quiet and east. The breakfast choices were a welcome surprise!

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