$290 Find Cheap Flights from Columbus to Panama - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Columbus to Panama departing on 9/14. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Book Cheap Columbus to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Columbus to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Columbus to Panama

Tue, Sep 29 - Mon, Oct 5
Delta Logo
6:00 am - 12:58 pmCMH  Columbus-PTY Panama City Tocumen Intl
7h 58m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:23 pm - 12:15 amPTY  Panama City Tocumen Intl-CMH Columbus
8h 52m1 stop Atlanta Hartsfield-Jackson
$645Delta
Thu, Oct 15 - Mon, Oct 19
Delta Logo
7:00 am - 12:59 pmCMH  Columbus-PTY Panama City Tocumen Intl
6h 59m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:24 pm - 12:44 amPTY  Panama City Tocumen Intl-CMH Columbus
9h 20m1 stop Atlanta Hartsfield-Jackson
$645Delta
Tue, Sep 29 - Wed, Oct 7
United Airlines Logo
6:30 am - 2:14 pmCMH  Columbus-PTY Panama City Tocumen Intl
8h 44m1 stop Houston George Bush Intcntl
United Airlines Logo
9:45 am - 10:05 pmPTY  Panama City Tocumen Intl-CMH Columbus
11h 20m1 stop Newark
$645United Airlines
Wed, Jan 20 - Thu, Jan 28
United Airlines Logo
6:45 am - 2:45 pmCMH  Columbus-PTY Panama City Tocumen Intl
8h 00m1 stop Houston George Bush Intcntl
United Airlines Logo
4:41 pm - 10:59 amPTY  Panama City Tocumen Intl-CMH Columbus
18h 18m1 stop Houston George Bush Intcntl
$645United Airlines
Mon, Sep 28 - Mon, Oct 5
Delta Logo
6:00 am - 12:58 pmCMH  Columbus-PTY Panama City Tocumen Intl
7h 58m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:23 pm - 12:15 amPTY  Panama City Tocumen Intl-CMH Columbus
8h 52m1 stop Atlanta Hartsfield-Jackson
$645Delta
Mon, Sep 28 - Tue, Oct 6
United Airlines Logo
6:30 am - 2:14 pmCMH  Columbus-PTY Panama City Tocumen Intl
8h 44m1 stop Houston George Bush Intcntl
United Airlines Logo
10:00 am - 11:44 pmPTY  Panama City Tocumen Intl-CMH Columbus
12h 44m1 stop Houston George Bush Intcntl
$645United Airlines
Thu, Sep 24 - Thu, Oct 1
American Airlines Logo
8:50 pm - 12:16 pmCMH  Columbus-PTY Panama City Tocumen Intl
16h 26m2 stops Chicago O'Hare Intl Miami
American Airlines Logo
1:16 pm - 10:45 pmPTY  Panama City Tocumen Intl-CMH Columbus
8h 29m1 stop Miami
$649American Airlines
Thu, Nov 5 - Tue, Nov 10
American Airlines Logo
7:25 pm - 2:13 pmCMH  Columbus-PTY Panama City Tocumen Intl
18h 48m2 stops Chicago O'Hare Intl Miami
American Airlines Logo
3:13 pm - 10:56 amPTY  Panama City Tocumen Intl-CMH Columbus
19h 43m2 stops Miami Chicago O'Hare Intl
$649American Airlines
Wed, Jan 20 - Thu, Jan 28
Avianca Logo
7:45 pm - 10:30 amCMH  Columbus-PTY Panama City Tocumen Intl
14h 45m2 stops Washington, D.C. Dulles Intl San Salvador El Salvador Intl
Avianca Logo
7:50 pm - 9:35 amPTY  Panama City Tocumen Intl-CMH Columbus
13h 45m2 stops San Salvador El Salvador Intl Washington, D.C. Dulles Intl
$659Avianca
Thu, Nov 5 - Mon, Nov 9
Avianca Logo
7:56 pm - 10:30 amCMH  Columbus-PTY Panama City Tocumen Intl
14h 34m2 stops Washington, D.C. Dulles Intl San Salvador El Salvador Intl
Avianca Logo
3:50 pm - 9:55 amPTY  Panama City Tocumen Intl-CMH Columbus
18h 05m2 stops San Salvador El Salvador Intl Washington, D.C. Dulles Intl
$659Avianca
Booking Insights

KAYAK's insights & trends for Columbus to Panama flights

Get data-powered insights and trends into flights from Columbus to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Columbus Airport to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Columbus Airport to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Columbus Airport to Panama is October, when tickets cost $527 (return) on average. On the other hand, the most expensive months are December and July, when the average cost of round-trip tickets is $1,505 and $762 respectively.

Good to know

Low season

September

Cheapest flight

$290
Best time to beat the crowds with an average 24% drop in price.
Most popular time to fly with an average 113% increase in price.
Flight from Columbus to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Columbus to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Columbus to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Columbus to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Columbus to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Columbus to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Columbus to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Columbus to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Columbus to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Columbus to Panama

 
Need help choosing which airline to fly with from Columbus to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8499 reviews
8.1Boarding
7.2Food
7.8Comfort
8.5Crew
7.8Entertainment
Airline reviews

The flight was over 2 hours late.. once we finally got boarded things were fine

6.0 GoodColin, Jul 2026
Read more Delta reviews

The flight was over 2 hours late.. once we finally got boarded things were fine

Didn't like sitting on the waiting pad for 30 minutes right after departing the gate. If you're going to do that, just don't board so people can still get up and walk around in the terminal. My luggage was damaged by the baggage handlers.

Absolutely no communication on why there's a delay and multiple flight time reschedules. I would have canceled the flight and drove back home if I known it was going to be rescheduled 3 or 4 times.

Good flight. Connector flight was delayed so made a short turnaround in Atlanta which was stressful. Otherwise, great crew, Staff in ATL was very informative about the delay and ensured people their connections were fine. Notified the ones that were not. Great communication.

Seat was extremely hard which made even a short 1 hour 20 minute flight fairly uncomfortable.

Only water, tea or coffee served midflight, even to comfort seating. Man next to me needed two seats and took up a portion of my seat and Delta did nothing.

was sitting in the jet bridge for 10 minutes in -20 degree weather waiting for my bag

I like for how they process during check in. It was very smoothly.

Boarding was somewhat chaotic. Unable to evaluate crew or food/drink because captain kept them seated due to turbulence. Have no idea if entertainment was offered.

I liked the piloting of the aircraft. Very disappointed about lack of electrical ports. Also, although a short flight. there was enough time to hand out snacks to comfort + seats as was done for first class.

Flight was delayed 14 hours due to DC air show and weather. Missed connection to MUC.

The entertainment options on the seat back video boards were nice.

There was no WiFi available, there were mechanical problems with the plane and we landed at C 124, then the gate was switched to A 26, then all the way back to C126! For a 75 yo woman traveling alone, this was a difficult journey, indeed!

Teeny tiny bathrooms, crew was not realistic about when we'd arrive.

Very bad! They kept delaying my flight and wouldn’t do anything about it

IAD with the archaic people movers is just a place to be avoided.

Cabin was pitch black, even during meal service. The reading lights for seat 2E/F did not work, and seat 2E did not recline.

The flight from Cleveland to Newark was great. The connecting flight wasn’t so good.

Check in and boarding were very easy. Quite good food and a complimentary glass of wine with dinner. The acoustics on the TV difficult at times, and the options extensive though not very updated.

Crew did not arrive for their shift and flight delayed for 2 1/2 hours whilst new pilots were found. The man at the boarding gate did a great job keeping us informed and the eventual flight was good. It was just the long delay waiting…….

Flight canceled because they didn’t have enough flight attendants. No refunds or credits for future flights

Flights on time w/o delays. However, my baggage was damaged. Ground crew, throws baggage from plane to the baggage carrier, carelessly.

On time flight, good communication about boarding, lines didn't form unnecessarily for boarding before their group was announced (kept aisles clear), friendly flight attendants and service

They put me on an earlier and I got home sooner

I love American. I’ll never fly anyone else if I can help it.

Any flight to ORD after about 2pm this summer has been challenging. Flight was delayed getting in (coming from ORD) and that led to it not leaving before a ground stop due to lightening before they could fuel the plane, and so forth. They made up some time but we were still late in arriving at ORD, and that led to missed connections.

Couldn’t get the door on the plane to close leading to a nearly 2 hour delay. But, hey at least they didn’t cancel the flight.

The flight was fine and the crew awesome. The problem is ORD and AA. Computers went down, ORD fell apart and a 40 min flight turned into a 3 hour trip. Guess the answer is to not try and fly to ORD after noon. But, as I said, crew was awesome and did everything they could to lesson the flight time.

Boarded over an hour late, no communication, the sign just changed, no attendant to answer questions - she disappeared forever (hiding). Small plane and couldn’t hear the overhead nor understand.

Was supposedly in main extra (row 10), but the seat spacing appeared to be regular economy (the head rest was blue, as well - same as economy, the seats in front of us had red head rests). Otherwise the flight was good and got in well ahead of schedule.

Everything you need to know for your flight from Columbus to Panama

Information on your arrival and departure airports