DSM - ECP

$219 Find Cheap Flights from Des Moines to Panama City - Compare and Save

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1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$335
Typical prices: $379-$560
Southwest
Mon 10/29Sun 11/4
DSM - ECP • 2 stops
Cheapest one-way
$219
Typical prices: $203-$343
Delta
Mon 11/19
DSM - ECP • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Des Moines and Panama City. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
September
Cheapest • 22% price drop
April
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Lambert-St Louis (STL)
Cheapest • Avg $300 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 4h 47m (one-way)
Insights
Insights
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Flight Deals

Cheap Flights from Des Moines to Panama City (DSM-ECP)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Panama City

Thu, Oct 29 - Wed, Nov 4
Southwest Logo
6:20 am - 2:30 pmDSM  Des Moines-ECP Panama City NW Florida Beaches
8h 10m2 stops Denver Intl Austin Bergstrom
Southwest Logo
10:05 am - 10:00 pmECP  Panama City NW Florida Beaches-DSM Des Moines
11h 55m2 stops Austin Bergstrom Chicago Midway
$335Southwest
Mon, Dec 7 - Mon, Dec 14
Southwest Logo
7:00 am - 6:10 pmDSM  Des Moines-ECP Panama City NW Florida Beaches
11h 10m2 stops Denver Intl Nashville Intl
Southwest Logo
10:05 am - 8:45 pmECP  Panama City NW Florida Beaches-DSM Des Moines
10h 40m2 stops Austin Bergstrom Denver Intl
$337Southwest
Fri, Oct 16 - Thu, Oct 22
American Airlines Logo
4:12 pm - 9:17 pmDSM  Des Moines-ECP Panama City NW Florida Beaches
5h 05m1 stop Dallas/Fort Worth
American Airlines Logo
6:42 pm - 11:58 pmECP  Panama City NW Florida Beaches-DSM Des Moines
5h 16m1 stop Charlotte Douglas
$340American Airlines
Sat, Oct 17 - Fri, Oct 23
United Airlines Logo
6:00 am - 11:06 amDSM  Des Moines-ECP Panama City NW Florida Beaches
5h 06m1 stop Houston George Bush Intcntl
United Airlines Logo
4:57 pm - 10:15 pmECP  Panama City NW Florida Beaches-DSM Des Moines
5h 18m1 stop Houston George Bush Intcntl
$340United Airlines
Thu, Oct 29 - Wed, Nov 4
Delta Logo
6:54 pm - 11:18 pmDSM  Des Moines-ECP Panama City NW Florida Beaches
4h 24m1 stop Atlanta Hartsfield-Jackson
Delta Logo
9:19 am - 3:16 pmECP  Panama City NW Florida Beaches-DSM Des Moines
5h 57m1 stop Atlanta Hartsfield-Jackson
$343Delta
Sat, Oct 17 - Fri, Oct 23
United Airlines Logo
6:00 am - 4:13 pmDSM  Des Moines-ECP Panama City NW Florida Beaches
10h 13m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
United Airlines Logo
4:57 pm - 10:15 pmECP  Panama City NW Florida Beaches-DSM Des Moines
5h 18m1 stop Houston George Bush Intcntl
$345United Airlines
Thu, Oct 29 - Wed, Nov 4
Southwest Logo
6:20 am - 5:05 pmDSM  Des Moines-ECP Panama City NW Florida Beaches
10h 45m1 stop Denver Intl
Southwest Logo
10:05 am - 10:00 pmECP  Panama City NW Florida Beaches-DSM Des Moines
11h 55m2 stops Austin Bergstrom Chicago Midway
$345Southwest
Wed, Dec 9 - Sun, Dec 13
Delta Logo
5:20 am - 10:34 amDSM  Des Moines-ECP Panama City NW Florida Beaches
5h 14m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:04 am - 2:13 pmECP  Panama City NW Florida Beaches-DSM Des Moines
7h 09m1 stop Atlanta Hartsfield-Jackson
$359Delta
Mon, Feb 22 - Sat, Feb 27
American Airlines Logo
7:29 am - 12:30 pmDSM  Des Moines-ECP Panama City NW Florida Beaches
5h 01m1 stop Chicago O'Hare Intl
American Airlines Logo
7:30 am - 2:49 pmECP  Panama City NW Florida Beaches-DSM Des Moines
7h 19m1 stop Dallas/Fort Worth
$387American Airlines
Mon, Feb 22 - Sat, Feb 27
American Airlines Logo
7:29 am - 12:30 pmDSM  Des Moines-ECP Panama City NW Florida Beaches
5h 01m1 stop Chicago O'Hare Intl
American Airlines Logo
7:30 am - 2:49 pmECP  Panama City NW Florida Beaches-DSM Des Moines
7h 19m1 stop Dallas/Fort Worth
$387American Airlines
Booking Insights

Price, demand and travel trends for Des Moines to Panama City flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Des Moines to Panama City with more confidence.

How much is a round-trip flight from Des Moines to Panama City?

Round-trip flights from Des Moines to Panama City start at $335. Prices are below average for this route right now, with typical round-trip fares ranging from $379 to $560. The lowest price found in the past 5 days was $335 on Southwest.

What's the cheapest day of the week to fly from Des Moines to Panama City?

Monday is the cheapest day of the week to fly from Des Moines to Panama City, it is 18% cheaper than the average day. Thursday is the most expensive day with flight prices 18% higher than average. Based on deals found by KAYAK users in the last 12 months.

What is the cheapest month to fly from Des Moines to Panama City?

  • September is the cheapest month to fly from Des Moines to Panama City at $354 round-trip.
  • December ($782) and July ($558) are the most expensive months.
  • The price difference between flying in the cheapest and most expensive months is 120% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for Des Moines to Panama City flights

Low season

November

Cheapest flight

$219
Best time to beat the crowds but there is an average 18% increase in price.
Most popular time to fly and prices are also 1% lower on average.
Flight from Des Moines to Panama City

When to book flights from Des Moines to Panama City

Are your dates flexible? Find out the best times to travel from Des Moines to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Des Moines to Panama City flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • Which airports can I use when flying from Des Moines to Panama City?

    Flights from Des Moines to Panama City usually depart from Des Moines (DSM) and arrive at Panama City NW Florida Beaches (ECP).

  • What cabin classes can I book on flights from Des Moines to Panama City?

    Two cabin classes are available on flights from Des Moines to Panama City:

    • Economy Class
    • First Class

  • Which airports do connecting flights from Des Moines to Panama City pass through?

    One-stop flights from Des Moines to Panama City most commonly connect through:

    • Atlanta Hartsfield-Jackson (ATL) - 49% of one-stop connections
    • Chicago O'Hare Intl (ORD) - 23% of one-stop connections
    • Chicago Midway (MDW) - 8% of one-stop connections
    • Charlotte Douglas (CLT) - 5% of one-stop connections

    Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.

  • Can I save money by using flexible dates for flights from Des Moines to Panama City?

    Yes. Being flexible with your travel dates can save you up to 31% on the Des Moines to Panama City route. Monday is the cheapest departure day at $374 round-trip on average, while Thursday is the most expensive at $538, a difference of $164. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How long is a flight from Des Moines to Panama City?

    A nonstop flight from Des Moines to Panama City takes 0h 00m, covering 887 miles.

  • Do I need a passport to fly from Des Moines to Panama City?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

  • Have flight prices from Des Moines to Panama City changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $335 to $1,034. That means the highest observed fare was about 3x higher than the lowest one.

  • How are flight prices from Des Moines to Panama City looking right now?

    One-way fares from Des Moines to Panama City are currently higher than usual. Average one-way flight prices are about $709, which is 191% above the typical average for this route.

  • How much time can I save by choosing a different layover airport from Des Moines to Panama City?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 47m, compared with 5h 19m via Lambert-St Louis (STL) and 5h 35m via Charlotte Douglas (CLT).

  • What car rental options are available at Panama City NW Florida Beaches Airport (ECP)?

    Panama City NW Florida Beaches Airport (ECP) hosts 5 major car rental companies, with daily rates starting from around $29 for economy cars. Top options include:
    • Dollar
    • Budget
    • Hertz
    • Alamo
    • Avis

  • How much should I expect to pay for a Des Moines to Panama City flight?

    Round-trip flights from Des Moines to Panama City range from $379 to $560, with an average of $454 over the past 12 months. Anything below $379 counts as a good deal.

Your guide to booking Des Moines to Panama City flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Monday departure instead of Thursday. On this route, Monday flights average $374 - about $164 less than Thursday (30% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Des Moines to Panama City trip for September. Fares historically average $354 round-trip in that month - typically $428 less than the most expensive month, which is December (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Panama City NW Florida Beaches Airport.
    - Hilton Garden Inn Panama City Airport

More options for your flight from Des Moines to Panama City

Complete your trip to Panama City with a hotel stay or car rental

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