DSM - ECP

$183 Find Cheap Flights from Des Moines to Panama City - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$325
Typical prices: $301-$666
Southwest
Mon 9/21Sat 9/26
DSM - ECP • 1 stop
Cheapest one-way
$183
American Airlines
Tue 10/27
DSM - ECP • 1 stop
Top airlines
Cheapest • from $325 (round-trip)
Best reviews • 8.0 score
Airline reviews
Airline reviews
+1
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Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Des Moines and Panama City. You'll need at least 1 connection.
Insights
Insights
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Insights
Top layover airports
Cheapest • Avg $300 (round-trip)
Shortest trip • 4h 05m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 26% price drop
Most popular
Good to know
Good to know
+1
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Good to know
+1
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We hope you love your trip to Panama City!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to Panama City (DSM-ECP)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Panama City

Mon, Sep 21 - Sat, Sep 26
Southwest Logo
2:25 pm - 9:40 pm
DSM
-
ECP
7h 15m
1 stop
Southwest Logo
2:45 pm - 7:30 pm
ECP
-
DSM
4h 45m
1 stop
$325Southwest
Wed, Aug 26 - Wed, Sep 2
American Airlines Logo
6:55 am - 2:30 pm
DSM
-
ECP
7h 35m
1 stop
American Airlines Logo
12:25 pm - 5:52 pm
ECP
-
DSM
5h 27m
1 stop
$325American Airlines
Tue, Sep 22 - Sat, Sep 26
Delta Logo
2:34 pm - 7:08 pm
DSM
-
ECP
4h 34m
1 stop
Delta Logo
5:30 pm - 10:26 pm
ECP
-
DSM
4h 56m
1 stop
$325Delta
Thu, Aug 20 - Mon, Aug 24
American Airlines Logo
5:10 pm - 10:40 pm
DSM
-
ECP
5h 30m
1 stop
American Airlines Logo
6:40 am - 12:24 pm
ECP
-
DSM
5h 44m
1 stop
$325American Airlines
Wed, Aug 26 - Wed, Sep 2
United Airlines Logo
6:00 am - 1:06 pm
DSM
-
ECP
7h 06m
1 stop
United Airlines Logo
6:30 am - 4:19 pm
ECP
-
DSM
9h 49m
2 stops
$330United Airlines
Thu, Aug 27 - Mon, Aug 31
Southwest Logo
2:25 pm - 9:35 pm
DSM
-
ECP
7h 10m
1 stop
Southwest Logo
1:30 pm - 10:10 pm
ECP
-
DSM
8h 40m
2 stops
$330Southwest
Thu, Aug 20 - Mon, Aug 24
Southwest Logo
2:25 pm - 9:35 pm
DSM
-
ECP
7h 10m
1 stop
Southwest Logo
5:10 am - 1:45 pm
ECP
-
DSM
8h 35m
2 stops
$330Southwest
Thu, Sep 17 - Tue, Sep 22
Delta Logo
6:54 pm - 11:25 pm
DSM
-
ECP
4h 31m
1 stop
Delta Logo
9:23 am - 1:49 pm
ECP
-
DSM
4h 26m
1 stop
$339Delta
Sat, Sep 12 - Tue, Sep 15
American Airlines Logo
4:14 pm - 9:07 pm
DSM
-
ECP
4h 53m
1 stop
American Airlines Logo
7:34 am - 3:10 pm
ECP
-
DSM
7h 36m
1 stop
$346American Airlines
Sun, Aug 30 - Sun, Sep 6
United Airlines Logo
6:15 am - 1:52 pm
DSM
-
ECP
7h 37m
1 stop
United Airlines Logo
6:30 am - 2:14 pm
ECP
-
DSM
7h 44m
1 stop
$371United Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to Panama City flights

Get data-powered insights and trends into flights from Des Moines to Panama City to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Des Moines to Panama City, Florida?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Des Moines to Panama City, Florida departing in August.

Flight prices are below average for this route right now.

Flights to Panama City, Florida from Des Moines usually cost between $422 and $787 in August.
The lowest price found in the past 5 days was $325 on American Airlines (Aug 20-Aug 24).

What is the cheapest month to fly from Des Moines to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Panama City is September, where tickets cost $354 (return) on average. On the other hand, the most expensive months are December and July, where the average cost of round-trip tickets is $782 and $558 respectively.

Good to know

Low season

December

Cheapest flight

$183
Best time to beat the crowds but there is an average 63% increase in price.
Most popular time to fly with an average 5% increase in price.
Flight from Des Moines to Panama City

When to book flights from Des Moines to Panama City

Are your dates flexible? Find out the best times to travel from Des Moines to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Panama City

  • What is the cheapest flight from Des Moines to Panama City?

    In the last 5 days, the lowest price for a flight from Des Moines to Panama City was $183 for a one-way ticket and $325 for a round-trip.

  • Do I need a passport to fly between Des Moines and Panama City?

    No

  • Which airports will I be using when flying from Des Moines to Panama City?

    When flying out of Des Moines you will be using Des Moines. You will be landing at Panama City, also known as Panama City NW Florida Beaches.

  • Which aircraft models fly most regularly from Des Moines to Panama City?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Des Moines to Panama City?

    Star Alliance, oneworld, and SkyTeam are the airline alliances operating flights between Des Moines and Panama City, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from Des Moines to Panama City, Southwest or Delta?

    The two airlines most popular with KAYAK users for flights from Des Moines to Panama City are Southwest and Delta. With an average price for the route of $398 and an overall rating of 8.0, Southwest is the most popular choice. Delta is also a great choice for the route, with an average price of $478 and an overall rating of 7.8.

  • How does KAYAK find such low prices on flights from Des Moines to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and ECP can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Des Moines to Panama City

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4229 reviews
8.1Boarding
7.5Entertainment
8.6Crew
8.0Comfort
7.0Food
Airline reviews

Red eye from San Diego. Temperature of the cabin was way too warm and the air duct flowed very little air.

6.0 GoodGordon, Jul 2026
SAN - MCO
Read more Southwest reviews

Red eye from San Diego. Temperature of the cabin was way too warm and the air duct flowed very little air.

Over a 3 hour flight. The turbulence was almost imperceptible except for 2 short periods which were not bad and over quickly. The attendants claimed "Safety first" and sat looking at their phones for 3 hours with no drink or snack service. This isn't the first time with Southwest. I thinkit may be there new plan of operation. Oh, and it was June 18, Southwest's Birthday which offered free drinks. NOT.

The flight was okay. The pilots did an amazing job and kept us updated on the flight. The flight attendants were okay. They found time to be chatty with each other rather than focus on the guests. One of the attendants was a little less warm when asking about my bag I had on my lap that I was using during latter part of the mid- flight. Mind you, it was not the departure descent. I’m respectful to each and every attendant, it was the tone in her voice reminding me to place my carryon bag on the floor. I hope to have a better experience next time.

Terrible. Even though there’s assigned seating now, they are still the slowest boarding airline of anyone.

It was canceled. Supposedly weather. But there was no snow in Baltimore. At least we found out before driving to airport

Okay, not wonderful. Short flight. Wi-fi didn't work properly. Stuck waiting for a gate to open upon arrival for 20 or so minutes.

They sent a notice that they were boarding an hour early. We had to leave the club and run to the gate. They said sorry, that came from corporate and was a mistake. They did not have enough seating because the flight before it had not taken off on time. They moved our gate and delayed it for an hour.

The quality of Southwest Airlines continues to degrade each time I fly with them. If it were not for the free luggage, I would probably choose another airline. Their prices are a little bit competitive, but way too high for the quality of the service. Southwest is not unique in this way. Domestic flight in the United States of America has continued to be a lower and lower quality product. Very sad when you compare the quality of domestic airlines to that of many international airlines around the world.

I'm not a fan of Southwest's model. I don't like the herding style of boarding.

It is southwest seat was ok. Not the most comfortable seat

We were skipped when the snack cart passed and then the attendant said we weren’t . I am disabled and was in a row toward the back of the plane which was very difficult for me to navigate. Disabled people should not be forced to walk the plank.

Flight was delayed and then "they did not have time to load food". No snack or drink at all for 1.5 how flight. Somebody wasn't prepared.

It is usually very pleasant. Good service for the price, international flights are even better

New high end luggage ruined/zippers broken, items missing. All happened on return flight from msp to mso. Do better! Not store bought luggage but high end personalized ogio custom embroidered luggage. Total slap in the face ontop of an extra luggage fee that took me 3 hrs on chat to resolve.

Third flight in two months where the crew was not there. Comfort seating does not guarantee overhead bin space. Passengers with children are allowed on the plane first - if you are flying to and from Orlando, this means half the plane has boarded before you get on. And somehow all the bin space is taken up. 3 out of 5 flights have had issues with equipment or procedure. Some of these instances caused the flight to be delayed because of a "nuisance" light. One time it was a bag that had been brought on board but did not belong to anyone so we had to return to the gate. Last night we were told the "AC" on the plane doesn't work well and we're 10th for take off- because the crew was late - and that it will get cool when we're in the air. Not sure if this is usual, but I didn't think flight crew could jump seat in first class. Movie and TV selection has not been refreshed for several months- flying one to two round trips each month easily exhausts the list of content.

Definitely a southern flavor. Cordiality was evident even though no drinks or snacks were served.

No service flight that took 5 hrs and a stop at an unscheduled airport. Crew and pilots did their jobs

I continue to be satisfied with Delta’s excellent service out of LGA. The digit id works well and gets me through security in no time. Whenever possible, I choose Delta.

Was revoked with Jet Blue due to delay from Kenya Air

We checked one bag. That was fast and the agent was fast and super nice. At the gate, boarding was fast and efficient. Flight was uneventful which was great because it was early in the morning and most folks were sleeping. Landing was great. Delta does a really good job of making the flying experience better all around considering you are sitting in such a small space on a plane for several hours. Flight from ALT to Panama City was short and uneventful as well. No entertainment but no need since it was such a short flight.

The experience with United Airlines was excellent; however, the experience with Houston Intercontinental Airport (IAH) was horrible. Although our flight departed from Terminal B, we had to go through security in Terminal C and then get on a train for travel to Terminal B. Additionally, there was significant walking required to get to the boarding location.

Flight was delayed 5 hours. Updates kept changing. Sears were extremely cramped. Very little leg room. Flight attendant was rushing through with drinks and hit me in the knee either the cart and didn’t apologize. They gave a 15 dollar voucher in airport which doesn’t buy. Much and it was so late that choices were limited.

Always pretty good as far as I see it. Staff was friendly and process was quick to get on and off.

The flight was delayed because they closed several flight ways because of air shows, fire works, etc.

Lost one piece of luggage even though I checked in 2.5 hours before the flight

Horrifying Almost 2 million miles. Bring your own food and drink. One coffee or drink every three hours. Have to order meals on app more than 24 hours ahead Tiny and dirty bathrooms

Left an hour and a half after the listed time. Up side was it had TV screens on the seat.

Very rough getting into denver. my kid threw up it was so rough.

Liked that we left on time for each flight. Snacks not the best, but we're okay.

Delayed over an hour due to paperwork not being filed correctly. Forced to change planes.

Bad experience going to DFW with an IT outage then bad on the way back with a nearly 5 hour delay that’s started as maintenance then caused us to wait further due to weather - which would not have happened if we had left on time.

Quick flight. No time to stress over it. Over before it begins.

Very good, boarded and took off on time and landed early

Delayed boarding because a flight attendant couldn't find the gate...sat on the plane for over an hour at the gate because AA couldn't get one of the planes behind us to move

It was awful. My first flight was delayed and as a consequence I lost my second flight to Greensboro. I did not know what to do so I rebook myself a flight to Charlotte . It was very inconvenient I not to have anybody form corporate assisting me either from PwC or from kayak . It is a very disappointing experience that American did not wait 1 minute or told me to rebook before making the first flight

The departure and arrival was on time. The fact that I could load my boarding tickets on the American airlines app.

In flight connectivity (via T-Mobile) was often not working.

Terrible. Internet/kiosk glitch prevented baggage checkin. Line at ticket co in Ter was under serviced and did not move. Agents did not call for flight but rather allowed time to pass. Then told each person as they reached the front if line that it was too late to check bags so they’d have to rebook flights. At least 15 people missed the flight as a result of this incompetence.

It was exactly what I expected, actually arriving sooner than scheduled.

Terrible, they canceled my flight due to an issue they had, couldn't fly me into the same place within 24 hrs so had to fly in 2.5 hrs away from my destination and spend even more money. The customer service was terrible (except at the airport in Charleston). Had to call to get my checked baggage fees reimbursed 2 wks later in which one customer service agent was very rude, wouldn't listen and then hung up on me. The second lady I spoke with was actually able to help me with that part thankfully. Would not recommend flying AA.

Everything you need to know for your flight from Des Moines to Panama City

Information on your arrival and departure airports