DSM - ECP

$122 Find Cheap Flights from Des Moines to Panama City

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 1/24. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Panama City

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Panama City, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Panama City, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$181
Overall average: $426
American Airlines
Tue 2/3Tue 2/10
DSM - ECP • 1 stop
Cheapest one-way
$122
Typical prices: $176-$286
Delta
Sat 1/24
DSM - ECP • 2 stops
Top airlines
American Airlines
Cheapest • from $207 (round-trip)
Southwest
Best reviews • 8.0 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to book
5 weeks
in advance
Our data shows that travelers who book at least 5 weeks in advance save around 47% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
August
Cheapest • 25% price drop
March
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Panama City!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to Panama City (DSM-ECP)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Panama City

Tue, Feb 3 - Tue, Feb 10
American Airlines Logo
4:00 pm - 9:19 pmDSM-ECP
5h 19m1 stop
American Airlines Logo
6:03 pm - 11:08 pmECP-DSM
5h 05m1 stop
$181American Airlines
Find Deal
Tue, Feb 3 - Tue, Feb 10
American Airlines Logo
7:43 am - 5:33 pmDSM-ECP
9h 50m2 stops
American Airlines Logo
6:03 pm - 11:08 pmECP-DSM
5h 05m1 stop
$186American Airlines
Find Deal
Tue, Feb 3 - Tue, Feb 10
Southwest Logo
6:10 am - 2:55 pmDSM-ECP
8h 45m2 stops
Southwest Logo
10:30 am - 7:20 pmECP-DSM
8h 50m2 stops
$194Southwest
Find Deal
Tue, Jan 27 - Mon, Feb 2
American Airlines Logo
6:00 am - 1:04 pmDSM-ECP
7h 04m1 stop
American Airlines Logo
1:34 pm - 10:11 pmECP-DSM
8h 37m1 stop
$207American Airlines
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Sat, Jan 24 - Wed, Jan 28
Delta Logo
1:03 pm - 6:12 pmDSM-ECP
5h 09m1 stop
Delta Logo
6:00 am - 10:41 amECP-DSM
4h 41m1 stop
$215Delta
Find Deal
Tue, Feb 3 - Tue, Feb 10
Delta Logo
5:16 pm - 10:40 pmDSM-ECP
5h 24m1 stop
Delta Logo
6:00 am - 10:41 amECP-DSM
4h 41m1 stop
$219Delta
Find Deal
Sat, Jan 24 - Wed, Jan 28
Delta Logo
6:24 am - 6:12 pmDSM-ECP
11h 48m2 stops
Delta Logo
12:15 pm - 4:28 pmECP-DSM
4h 13m1 stop
$220Delta
Find Deal
Tue, Jan 27 - Mon, Feb 2
Southwest Logo
8:35 am - 6:10 pmDSM-ECP
9h 35m2 stops
Southwest Logo
10:30 am - 9:10 pmECP-DSM
10h 40m2 stops
$221Southwest
Find Deal
Tue, Feb 3 - Tue, Feb 10
Delta Logo
6:24 am - 6:14 pmDSM-ECP
11h 50m2 stops
Delta Logo
12:15 pm - 4:28 pmECP-DSM
4h 13m1 stop
$224Delta
Find Deal
Sat, Jan 24 - Wed, Jan 28
Delta Logo
6:24 am - 3:47 pmDSM-ECP
9h 23m2 stops
Delta Logo
12:15 pm - 8:54 pmECP-DSM
8h 39m2 stops
$225Delta
Find Deal
Booking Insights

KAYAK's insights & trends for Des Moines to Panama City flights

Get data-powered insights and trends into flights from Des Moines to Panama City to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Des Moines to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Panama City is August, where tickets cost $342 (return) on average. On the other hand, the most expensive months are December and March, where the average cost of round-trip tickets is $734 and $647 respectively.

How far in advance should I book a flight from Des Moines to Panama City?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Des Moines to Panama City, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Des Moines to Panama City, you should book around 5 weeks before departure, which saves you about 47% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 10 weeks before departure.

Good to know

Low seasonSeptember
Cheapest flight$122
Best time to beat the crowds with an average 20% drop in price.
Most popular time to fly with an average 42% increase in price.
Flight from Des Moines to Panama City

When to book flights from Des Moines to Panama City

Are your dates flexible? Find out the best times to travel from Des Moines to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Panama City

  • What is the cheapest flight from Des Moines to Panama City?

    In the last 3 days, the lowest price for a flight from Des Moines to Panama City was $122 for a one-way ticket and $181 for a round-trip.

  • Do I need a passport to fly between Des Moines and Panama City?

    No

  • Which airports will I be using when flying from Des Moines to Panama City?

    When flying out of Des Moines you will be using Des Moines. You will be landing at Panama City, also known as Panama City NW Florida Beaches.

  • Which aircraft models fly most regularly from Des Moines to Panama City?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Des Moines to Panama City?

    Star Alliance, oneworld, and SkyTeam are the airline alliances operating flights between Des Moines and Panama City, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from Des Moines to Panama City, Southwest or Delta?

    The two airlines most popular with KAYAK users for flights from Des Moines to Panama City are Southwest and Delta. With an average price for the route of $397 and an overall rating of 8.0, Southwest is the most popular choice. Delta is also a great choice for the route, with an average price of $422 and an overall rating of 7.9.

  • How does KAYAK find such low prices on flights from Des Moines to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and ECP can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Des Moines to Panama City

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4254 reviews
7.5Entertainment
8.0Comfort
7.0Food
8.6Crew
8.1Boarding
Airline reviews

Airline travel is always too cramped to really be pleasant, but the cabin crew on this flight did a pretty good job of making up for it by putting on some music during boarding and sprinkling a few funny remarks into the safety briefing and announcements, and just generally being friendly and helpful. It definitely reminded me of why I prefer the in-flight experience on Southwest!

10.0 ExcellentDavid, Nov 2025BUF - PHX
Read more Southwest reviews

Airline travel is always too cramped to really be pleasant, but the cabin crew on this flight did a pretty good job of making up for it by putting on some music during boarding and sprinkling a few funny remarks into the safety briefing and announcements, and just generally being friendly and helpful. It definitely reminded me of why I prefer the in-flight experience on Southwest!

No delays and arrived to destination 30 min early. Staff was super friendly.

San Diego airport is brand new, spacious, airy and very smooth checkin at SW baggage drop.

It was rough. The staff was unprofessional, the choice of on board drinks terrible, it was cramped in space at every airport, they always ran out of overhead bin space so they pressured people to check bags for free or we couldn’t leave on the plane— so I did check my bag to help, and they nearly lost my bag. My bag did not arrive on the luggage belt, another man on my flight and I had to waste our time going to the baggage office to search for our bags. I would only fly southwest again if it was my last choice. Also, my flights were consistently delayed over and over again— at one point they straight up told us we were waiting for the pilot to arrive.

Crew could have been friendlier, maybe I'm spoiled by SW crews. In flight wifi was good. Would be nice to have more food offerings on a 4 plus hour flight

Had to get off plane from prior flight even though I had to reboard same plane to continue to my final destination.

Everything a cheap airline should be at normal airline rates.

Plane crashed into a bus or some other vehicle on the ground while pulling out of the gate. No injuries, but wing tip was damaged and returned to gate for “maintenance issues” and we departed 5 hours later because the plane went out of service and new plane was flown in from a nearby airport, Midway.

Ever since Southwest starting charging for bags, passengers don't want to pay to check their bags, so the gate agents have to beg people to check their roller bags now because there's "not enough space". This was a terrible business move by Southwest.

Full cans of soda would be nice. A choice between two snacks would be appreciated.

I fly Delta all the time, have Platinum Medallion status. But this route seems to have major problems with delays and seems to never leave on time! Have only taken it twice in the last two weeks, and each time it had delays of more than 1 hour... very disappointed!!!!

Good seats in Main cabin, excellent service and excellent landing

My flight was cancelled with no explanation after I had already cleared security. I was given 4 options to rebook, only one being non-stop like I had paid for. I grabbed it. It was 4 plus hours later and then took off even later. Biggest complaint is that I booked early and had an aisle seat. They gave me a "window" seat in front of the exit row, so the seat did not decline. I weigh all of 103 #s and it was tight for me! For what I paid, I feel I was kind of ripped off. I think they should have given me the empty comfort seat for the inconvenience. There was no apology nor any explanation as to why the flight was cancelled. My guess is it benefitted Delta in some way.

First, Delta needs more flights to/from Miami. Second, a 1000pm leaving at 1230pm is unacceptable from their biggest airport world hub. Another aircraft could have been used such as the aircraft scheduled to be used in the morning for that exact same route. Yes, I did get me there but the lack of sleep the next day didn't help me enjoy my entire trip since I was busy with activities during the weekend. This can be and is expected from Spirit (going bankrupt) and Frontier (despite they're nickel and dimers). But from Delta's World Hub? That's totally unacceptable!

Service in business class was not impressive. I ordered coffee with dinner and then watched other people get 2 refills before I got my 1 cup of coffee, and only after I pressed the attendant button overhead. Furthermore, the seats in the forward cabin need maintenance on this 737-800: the upholstery is detaching from the seat frame, at least on the backs of seats 1C, 1D.

I truly love flying with Delta. They have always treated me with the upmost respect

Our flight attendant in FIRST CLASS was one of the worst I’ve ever had. She was not at all pleasant, nor particularly good at her service.

The flight was an hour and a half late departing which was inconvenient

The flight was great. The gate location was way to far away!!!

The flight attendant in first class was beyond rude and didn't care at all about her job. AND the gate agent was even worse than the flight attendant for rudeness. She was awful.

Flight was delayed 8 times. We were sitting at the airport for 14 hours. We got 2 hours of sleep (if that) on what was not meant to be a red-eye.

After a delay at the gate, C3, at Ohare on Sunday, I left my Blk ski coat on the bench at the gate, lost! Please review my lob claim, thx.

Very bad! They kept delaying my flight and wouldn’t do anything about it

They brought an empty plane to the gate. Then a flight delay was announced for maintenance and waiting on a part. I was then put on a flight to San Francisco instead with a connecting flight to my final destination. Arrived at my final destination 2 hours late.

The only downside was my cell phone charger wouldn’t work in the charging port but everyone else’s would work in them all. My cell phone cable works fine in my hotel room in Frankfurt.

Flight team stood out for perzonal attention, kindness at bright cheery attitudes at 8am. Very helpful.

Ot was overall fine. Left on time and had basic snacks. Weather was finicky but that’s not the airlines fault.

Very thoughtful flight attendant offered me water immediately since I had run to make my connection.

Door to door, the crew and staff were amazing. It was a stressful travel day with delays, but they were focused on customers and doing what they could to get us to our destinations.

Even though we were delayed, we were able to make our connection

Delays to take off and to leave the plane after landing added a lot of time to this flight.

It was a red eye flight, so no meals were provided, but it was fine with snacks. The seats felt cramped and almost too narrow.

We didn't take off until an hour after we boarded.

Wish they had the seat-back video screens for watching movies or playing games.

Very good but wish they had the seat-back video screens for movies & games

Flight was delayed not sure why no explanation given and no apologies either. Otherwise the flight was fine

While waiting to claim my checked luggage, I discovered the airline had lost it. After a long wait and inquiries, I discovered it was on another flight. Fortunately, the airline finally sent my luggage home.

Flight delays numerous times. Everytime we would get close to boarding it would be delayed again. Strung along the entire time.

This flight never occurred because AA couldn’t get their act together.

During service there was a garbage/beverage spill near our seats that never was cleaned up. On a relatively short flight when we’re fortunate enough to actually have in flight movies available, the flight attendants pitching the AADVANTAGE credit card shouldn’t talk for the last 10 minutes of the flight so that we miss the end of the movie.

Everything you need to know for your flight from Des Moines to Panama City

Information on your arrival and departure airports