$209 Find Cheap Flights from Des Moines to Panama

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Panama departing on 3/8. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Book Cheap Des Moines to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Panama

Tue, Mar 3 - Tue, Mar 10
American Airlines Logo
3:26 pm - 1:40 pm
DSM
-
PTY
21h 14m
2 stops
American Airlines Logo
1:40 pm - 11:56 pm
PTY
-
DSM
10h 16m
1 stop
$477American Airlines
Tue, Feb 24 - Fri, Mar 6
United Airlines Logo
7:52 am - 7:38 pm
DSM
-
PTY
10h 46m
1 stop
United Airlines Logo
8:55 am - 10:44 pm
PTY
-
DSM
14h 49m
1 stop
$483United Airlines
Fri, Mar 6 - Fri, Mar 13
United Airlines Logo
2:04 pm - 5:10 am
DSM
-
PTY
14h 06m
2 stops
United Airlines Logo
10:55 pm - 9:40 pm
PTY
-
DSM
22h 45m
2 stops
$487United Airlines
Mon, Feb 9 - Fri, Feb 13
United Airlines Logo
8:10 am - 5:07 pm
DSM
-
PTY
7h 57m
1 stop
United Airlines Logo
4:41 pm - 2:17 pm
PTY
-
DSM
22h 36m
1 stop
$492United Airlines
Sat, Feb 7 - Sat, Feb 14
United Airlines Logo
3:04 pm - 5:07 pm
DSM
-
PTY
25h 03m
1 stop
United Airlines Logo
4:41 pm - 2:27 pm
PTY
-
DSM
22h 46m
2 stops
$497United Airlines
Wed, Apr 22 - Sun, Apr 26
United Airlines Logo
8:20 am - 6:37 pm
DSM
-
PTY
10h 17m
1 stop
United Airlines Logo
10:00 am - 10:43 pm
PTY
-
DSM
12h 43m
1 stop
$515United Airlines
Wed, Apr 22 - Sun, Apr 26
United Airlines Logo
1:10 pm - 4:04 am
DSM
-
PTY
14h 54m
2 stops
United Airlines Logo
10:00 am - 10:43 pm
PTY
-
DSM
12h 43m
1 stop
$519United Airlines
Wed, Apr 22 - Sun, Apr 26
United Airlines Logo
8:20 am - 4:12 pm
DSM
-
PTY
7h 52m
1 stop
United Airlines Logo
3:30 pm - 12:29 pm
PTY
-
DSM
20h 59m
2 stops
$529United Airlines
Sat, Feb 28 - Thu, Mar 5
United Airlines Logo
2:59 pm - 2:45 pm
DSM
-
PTY
22h 46m
1 stop
United Airlines Logo
8:55 am - 10:44 pm
PTY
-
DSM
14h 49m
1 stop
$534United Airlines
Sat, Feb 7 - Sat, Feb 14
United Airlines Logo
3:04 pm - 5:07 pm
DSM
-
PTY
25h 03m
1 stop
United Airlines Logo
4:41 pm - 10:20 pm
PTY
-
DSM
30h 39m
1 stop
$544United Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to Panama flights

Get data-powered insights and trends into flights from Des Moines to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Des Moines to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Panama is September, when tickets cost $441 (return) on average. On the other hand, the most expensive months are December and March, when the average cost of round-trip tickets is $1,033 and $861 respectively.

Good to know

Low seasonJune
Cheapest flight$209
Best time to beat the crowds with an average 14% drop in price.
Most popular time to fly and prices are also 20% lower on average.
Flight from Des Moines to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Des Moines to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Des Moines to Panama

 
Need help choosing which airline to fly with from Des Moines to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8094 reviews
8.5Crew
8.1Boarding
7.9Comfort
7.2Food
7.8Entertainment
Airline reviews

No WiFi. Comfort plus should have alcohol provided, crew only offered water or tea. Who the heck wants tea?

2.0 MediocreKyle, Jan 2026
GNV - ATL
Read more Delta reviews

No WiFi. Comfort plus should have alcohol provided, crew only offered water or tea. Who the heck wants tea?

The flight was delayed and oversold. I volunteered to give up my seat for compensation. Thinking I could get a good night's sleep instead of arriving home at 2 am. It took over an hour to get the new reservation confirmed, three different gate attendants, and two red coats. It took even longer to confirm the overnight hotel, and when I arrived, the line was 45 minutes long, with two people checking in, and at least 15 people slowly, very slowly—no food except frozen convenience food, no coupon for food from airlines. Slept, headed back to the airport, and that flight had an equipment change and a gate change just as they were about to board. It took an additional hour to board as they cleaned the plane from storage.

There was no wifi available on this flight. And there were no screens, no onboard entertainment, no entertainment options at all. It was like travelling in the 1990s again, except without even a main screen for options. Seats, as usual, were tight and uncomfortable.

Good seat comfort ORF to ATL. Bad seat ATL to SEA (terrible lumbar support, hard, ouch)..

Because I was moved to an exit row, the snacks in economy comfort, the selection of snacks was better.

I upgraded to first. Quick and easy boarding. Comfortable seat with power and a nice IPA.

Probably not the fault of Delta but there was delay after delay after delay and I ended up getting home 4 hours later then I should have at 1:30 in the morning

Easiest airport experience ever in my life at MSP with Delta check-in and flight attendant gave us a bottle of champagne in celebration of our 10-year wedding anniversary, so overall amazing!

No in flight service, no explanation - FC got service, C+ did not, unsure about Economy. No turbulence to speak of, so I guess another way to cut cost, or promote health and well being of Delta employees? Also, boarding in MEM combined zones, and with overhead space already full on both flights after Zone 2/ Diamond, presents a huge challenge to find a space for a bag. Delta, other than point A to B, is no longer reasonable to fly - very poor experiences, not even taking into account the chastising at the gate and rude crews, across the board.

It would have been better if the flight wasn't delayed by 2.5 hours

Unfortunately weather delayed our flight waiting for our plane to arrive and due to a little snow time was needed to deice the plane so departure was very delayed and I missed the connecting flight

Very good. Because of the delays with my previous flight, I missed my connection, but I was able to book another flight through the United app easily.

I wish there were outlets to charge my iPhone. The crew was great; we had a female pilot who was great with explaining what was happening and delays,

The flight crew where really good. Better then the crew from BNE to SFO

Food should be changed in menu Many muslims travels in this airlime they need to add one Halal meal

Delayed, toilets did not flush, pilot parked to far away from Gate

Was happy we finally got upgraded in 1st class. The seat getting old. The cushiness need some improvement.

Yet another flight in which beverage and snack service was skipped. Other that that, firmly mediocre. Landed early, to gate late due to congestion at the gates. Airline's fault or airports fault: unknown.

Ineffective communication with United resulted in lost baggage. Their Baggage Tracing counter at MUC was shut down from 11:00-14:15 on my arrival. Undertrained, underinformed staff had me Running all over MUC to find someone to help me to no avail. Staff was rude, unhelpful, and unable to effectively use the systems they did have operational. They refused to contact United in any way or provide any accommodation or other resources while I waited for my luggage. This has destroyed my downstream itinerary. If they had even the slightest visibility I may have been able to reschedule/plan, but again, their staff provided nothing, and did nothing more than their website, which doesn’t even work on a standard phone browser. Miserable failure at all levels that weren’t associated with the operation of the aircraft.

Miserable. They moved my seat, but canceled the next leg of my flight. I resolved the issue at my transfer, but that resulted in lost luggage that has taken days off my schedule with no resolution. Worse, they fail to interface effectively with Lufthansa, forcing me to bounce between two equally useless help desks. The apps are unable to handle the situation, the bag dropped off the tracker, and while the call centers are polite, they do not provide written information to assist with cross-airline communication.

Everything you need to know for your flight from Des Moines to Panama

Information on your arrival and departure airports