$204 Find Cheap Flights from Des Moines to Panama

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Panama departing on 3/13. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Book Cheap Des Moines to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Panama

Sat, Dec 13 - Fri, Dec 26
Delta Logo
11:23 am - 7:59 pmDSM-PTY
7h 36m1 stop
Delta Logo
8:00 am - 5:15 pmPTY-DSM
10h 15m1 stop
$462Delta
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Mon, Jan 5 - Mon, Jan 12
American Airlines Logo
2:07 pm - 1:27 pmDSM-PTY
22h 20m2 stops
American Airlines Logo
4:50 pm - 3:15 pmPTY-DSM
23h 25m2 stops
$463American Airlines
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Wed, Jan 7 - Wed, Jan 14
United Airlines Logo
8:10 am - 5:07 pmDSM-PTY
7h 57m1 stop
United Airlines Logo
4:41 pm - 2:33 pmPTY-DSM
22h 52m2 stops
$466United Airlines
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Wed, Jan 7 - Wed, Jan 14
United Airlines Logo
8:10 am - 7:38 pmDSM-PTY
10h 28m1 stop
United Airlines Logo
4:41 pm - 10:30 pmPTY-DSM
30h 49m1 stop
$471United Airlines
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Thu, Jan 8 - Thu, Jan 15
United Airlines Logo
6:48 pm - 7:38 pmDSM-PTY
23h 50m2 stops
United Airlines Logo
4:41 pm - 10:30 pmPTY-DSM
30h 49m1 stop
$475United Airlines
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Thu, Jan 8 - Thu, Jan 15
United Airlines Logo
3:04 pm - 2:45 pmDSM-PTY
22h 41m1 stop
United Airlines Logo
4:41 pm - 10:30 pmPTY-DSM
30h 49m1 stop
$480United Airlines
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Mon, Dec 29 - Mon, Mar 23
United Airlines Logo
6:46 pm - 5:07 pmDSM-PTY
21h 21m2 stops
United Airlines Logo
3:41 pm - 2:27 pmPTY-DSM
22h 46m2 stops
$508United Airlines
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Mon, Jan 5 - Mon, Jan 12
United Airlines Logo
3:14 pm - 2:45 pmDSM-PTY
22h 31m2 stops
United Airlines Logo
4:41 pm - 10:30 pmPTY-DSM
30h 49m1 stop
$518United Airlines
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Thu, Jan 8 - Thu, Jan 15
United Airlines Logo
3:04 pm - 7:38 pmDSM-PTY
27h 34m1 stop
United Airlines Logo
4:41 pm - 10:30 pmPTY-DSM
30h 49m1 stop
$523United Airlines
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Wed, Apr 22 - Sun, Apr 26
American Airlines Logo
2:05 pm - 12:15 pmDSM-PTY
22h 10m2 stops
American Airlines Logo
1:55 pm - 1:17 pmPTY-DSM
23h 22m2 stops
$540American Airlines
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Booking Insights

KAYAK's insights & trends for Des Moines to Panama flights

Get data-powered insights and trends into flights from Des Moines to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Des Moines to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Panama is September, when tickets cost $441 (return) on average. On the other hand, the most expensive months are June and March, when the average cost of round-trip tickets is $1,069 and $861 respectively.

Good to know

Low seasonMarch
Cheapest flight$204
Best time to beat the crowds but there is an average 45% increase in price.
Most popular time to fly and prices are also 7% lower on average.
Flight from Des Moines to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Des Moines to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Panama?

    The cheapest time of day to fly to Panama is generally in the evening, when round-trip flights cost $439 on average. Morning departures are around 23% more expensive than evening flights, on average. The most expensive time of day to fly to Panama is generally in the morning, which is peak travel time and where the average cost of a ticket is $539.

Reviews of the top airlines flying from Des Moines to Panama

 
Need help choosing which airline to fly with from Des Moines to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7999 reviews
8.1Boarding
7.9Entertainment
8.5Crew
7.3Food
7.9Comfort
Airline reviews

First, Delta needs more flights to/from Miami. Second, a 1000pm leaving at 1230pm is unacceptable from their biggest airport world hub. Another aircraft could have been used such as the aircraft scheduled to be used in the morning for that exact same route. Yes, I did get me there but the lack of sleep the next day didn't help me enjoy my entire trip since I was busy with activities during the weekend. This can be and is expected from Spirit (going bankrupt) and Frontier (despite they're nickel and dimers). But from Delta's World Hub? That's totally unacceptable!

2.0 MediocreAnonymous, Nov 2025ATL - TPA
Read more Delta reviews

First, Delta needs more flights to/from Miami. Second, a 1000pm leaving at 1230pm is unacceptable from their biggest airport world hub. Another aircraft could have been used such as the aircraft scheduled to be used in the morning for that exact same route. Yes, I did get me there but the lack of sleep the next day didn't help me enjoy my entire trip since I was busy with activities during the weekend. This can be and is expected from Spirit (going bankrupt) and Frontier (despite they're nickel and dimers). But from Delta's World Hub? That's totally unacceptable!

This flight was straightforward and without difficulty. Service was OK, but I continue to be underwhelmed by level of attention given to Sky Priority passengers.

It would’ve been nice for all that money to have a more substantial snack for free. I remember once upon a time getting a very nice turkey sandwich with Swiss cheese on whole wheat bread for no charge along with a drink. I guess those days are gone. it’s a little insulting being given a cookie or a bag of baked chips Going forward I’ll just bring my own.

Great. Seamless. Check in agent at kiosk international was amazing and extremely helpful.

Our flight from SFO to MSP was right on time on 11/15/2025. No delays. As we approached MSP at about 8 pm, we circled in the air until 8:40 pm so I don't call that efficient for MSP. I think the captain should announce the delay and why. (as if we all don't know that we are just circling around the area, slowing down, speeding up, slowing down.) Thank you. Marilyn Fischer

Service in business class was not impressive. I ordered coffee with dinner and then watched other people get 2 refills before I got my 1 cup of coffee, and only after I pressed the attendant button overhead. Furthermore, the seats in the forward cabin need maintenance on this 737-800: the upholstery is detaching from the seat frame, at least on the backs of seats 1C, 1D.

Plenty of leg room, temperature was great and staff was excellent. Would do it more often.

The ticket agents in West Palm Beach on Friday afternoon Nov. 7th were incredible in getting us on an earlier plane to Atlanta during the government shutdown. Had the taken our original flight we would have missed our connection. She did this on her own, We didn't even have to ask, and she did it all with a smile and showing genuine concern that we would be taken care of. We are very grateful and thankful. We fly often, and now we will be sure to fly Delta.

Flight delayed then cancelled. Misplaced luggage. Still do not have. Rented car 1100 mile drive. I had to buy some overnight Hotels clothes toiletries gas food at my expense. Still not home. Not sure where luggage is. Over 4 hours on hold to Felta

I truly love flying with Delta. They have always treated me with the upmost respect

Very nice flight love the small aircraft. We had a wonderful flight attendant. Nice to see someone that really enjoys her job. Don't have her name but had a southern accent.

This was an older airplane. The cabin was constantly warm to hot throughout the 10 hour flight and there were no vents to personalize air flow. Also since it was an older plane, the material and comfort of the chairs were very uncomfortable. I left my flight with major soreness on my tailbone.

Very thoughtful flight attendant offered me water immediately since I had run to make my connection.

Door to door, the crew and staff were amazing. It was a stressful travel day with delays, but they were focused on customers and doing what they could to get us to our destinations.

Even though we were delayed, we were able to make our connection

Seats in waiting area and on plane hard as rock. Fast internet on the flight was great! Crew was kind.

Starlink wifi on the Embraer E175 is an excellent experience. I was able to connect and work from IAD all the way to approach into BTV.

Older aircraft, no meal, only food was for purchase. Not impressed United.

United needs to step up their game. Delayed flight leaving Seattle, San Francisco. Older aircraft, not very comfortable.

Always wish for more healthy, gluten free options. We have to bring our own.

Everything you need to know for your flight from Des Moines to Panama

Information on your arrival and departure airports