$244 Find Cheap Flights from Des Moines to Panama

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Panama departing on 4/8. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Book Cheap Des Moines to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Panama

Sat, May 9 - Thu, May 14
American Airlines Logo
12:03 pm - 12:46 pm
DSM
-
PTY
24h 43m
2 stops
American Airlines Logo
1:49 pm - 12:55 pm
PTY
-
DSM
23h 06m
2 stops
$539American Airlines
Fri, Apr 24 - Fri, May 1
American Airlines Logo
5:01 pm - 12:46 pm
DSM
-
PTY
19h 45m
2 stops
American Airlines Logo
1:49 pm - 1:20 pm
PTY
-
DSM
23h 31m
2 stops
$546American Airlines
Sat, Apr 25 - Sat, May 2
American Airlines Logo
5:01 pm - 12:46 pm
DSM
-
PTY
19h 45m
2 stops
American Airlines Logo
1:49 pm - 11:26 am
PTY
-
DSM
21h 37m
2 stops
$547American Airlines
Fri, Apr 10 - Fri, Apr 17
United Airlines Logo
8:20 am - 6:37 pm
DSM
-
PTY
10h 17m
1 stop
United Airlines Logo
10:00 am - 10:43 pm
PTY
-
DSM
12h 43m
1 stop
$553United Airlines
Mon, Apr 27 - Mon, May 4
American Airlines Logo
12:06 pm - 12:46 pm
DSM
-
PTY
24h 40m
2 stops
American Airlines Logo
1:49 pm - 11:26 am
PTY
-
DSM
21h 37m
2 stops
$554American Airlines
Fri, Apr 10 - Fri, Apr 17
United Airlines Logo
3:21 pm - 4:04 am
DSM
-
PTY
12h 43m
2 stops
United Airlines Logo
7:55 am - 10:43 pm
PTY
-
DSM
14h 48m
1 stop
$557United Airlines
Mon, Apr 6 - Thu, Apr 9
United Airlines Logo
8:20 am - 2:14 pm
DSM
-
PTY
29h 54m
1 stop
United Airlines Logo
10:00 am - 10:43 pm
PTY
-
DSM
12h 43m
1 stop
$563United Airlines
Sat, Apr 11 - Sat, Apr 18
Copa Airlines Logo
8:20 am - 4:12 pm
DSM
-
PTY
7h 52m
1 stop
Copa Airlines Logo
3:30 pm - 2:22 pm
PTY
-
DSM
22h 52m
1 stop
$565Copa Airlines
Wed, Apr 22 - Sun, Apr 26
United Airlines Logo
8:20 am - 2:14 pm
DSM
-
PTY
29h 54m
1 stop
United Airlines Logo
3:30 pm - 12:29 pm
PTY
-
DSM
20h 59m
2 stops
$567United Airlines
Fri, Apr 10 - Fri, Apr 17
United Airlines Logo
8:20 am - 4:12 pm
DSM
-
PTY
7h 52m
1 stop
United Airlines Logo
7:55 am - 10:43 pm
PTY
-
DSM
14h 48m
1 stop
$570United Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to Panama flights

Get data-powered insights and trends into flights from Des Moines to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Des Moines to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Panama is April, when tickets cost $436 (return) on average. On the other hand, the most expensive months are December and March, when the average cost of round-trip tickets is $1,033 and $735 respectively.

Good to know

Low seasonJune
Cheapest flight$244
Best time to beat the crowds with an average 15% drop in price.
Most popular time to fly and prices are also 21% lower on average.
Flight from Des Moines to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Des Moines to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Des Moines to Panama

 
Need help choosing which airline to fly with from Des Moines to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8291 reviews
7.2Food
8.1Boarding
7.9Comfort
7.8Entertainment
8.5Crew
Airline reviews

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

2.0 MediocreSusan, Mar 2026
JAX - ATL
Read more Delta reviews

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

The WiFi was not working. That made for a long flight.

With Aeromexico it ended up good but with Delta it was bad because we did everything through Delta... Showed up at the Delta terminal... It was the wrong place! Nothing ever told us to go to the Aeromexico terminal. It said "in partnership with Aeromexico" but I was never instructed to check in with them or go to their terminal. We had to haul @$$ running through the airport and almost didn't make it thanks to this poor communication. 👎🏽

Absolutely no communication on why there's a delay and multiple flight time reschedules. I would have canceled the flight and drove back home if I known it was going to be rescheduled 3 or 4 times.

Another late night flight and MORE men belligerently drinking and yelling. I had to move from first to economy because they were so obnoxious and disruptive. Crazy to go from a cozy chair to cardboard when you were supposed to be in first. Delta allows was too much drinking which leads to belligerent behavior.

I was in first class and literally the men behind me were so aggressively loud I moved myself to economy. This has become so common on Delta - people using audio without headphones, and men on 12am / late night flights drinking and yelling to talk to each other which prevents anyone around them from resting. Pretty crazy to have to move from first to economy (poorer service, less comfort...). Wild wild. Looking into other airlines.

Love delta smaller commuter plane so no entertainment and paid wifi on MKE-LGA leg was extremely unreliable and slow

Stop changing gates. Stop cancelling flights Stop moving my seat.

Extremely disappointed with Delta. They canceled flight last minute and then I rebooked the other flights and with which were delayed as well

Could not get my connecting flight boarding pass until four hrs before departure! Ver annoying especially since the staff could not explain why!

Wifi Bluetooth features for watching in flight movie was horrible. Screen kept blacking out no connection of sound although it said connected. Other than that smooth trip .

The 777’s economy seat’s legroom was more tolerable than expected. I appreciate the reclining mechanism which slides the seat forward to minimize cannibalizing the space behind. The food was terrible: very salty.

The travel company that you have on your site did me so wrong. I don’t know how it happened, but they put my son‘s name on my plane ticket flying to Vietnam. Along with his birthday. They would not have let me fly from Fort Myers to Ho Chi Minh City. I don’t think that I can ever use your service again. I typed my information into the browser along with my passport number and four days before I’m leaving I have to quickly search another ticket to fly out here.

Seats are uncomfortable. This has been a trend in the industry for decades. Trying to fit more seats on each plane to increase profits at the expense of the passenger.

The flight was delayed so we were dead tired, and after that the turbulence was horrible. I was very scared.

It’s always a great time flying with united airlines.

Good flight. Efficient boarding and competent flight crew. No problems until we arrived at our destination gate. We were early so there was an aircraft at the gate that had to move before we could pull in. Then, due to the type of aircraft we flew, the cabin door could not be opened until some luggage from the cargo bay was offloaded to preserve center of gravity characteristics. So, that further delayed deplaning. Despite being 20 minutes early on landing, we ended up being 5 to 10 minutes late after all the delays.

Everything went well except the turbulence what no one have a control of but pilot and crew handled very good!

There was no WiFi available, there were mechanical problems with the plane and we landed at C 124, then the gate was switched to A 26, then all the way back to C126! For a 75 yo woman traveling alone, this was a difficult journey, indeed!

This trip did not start off well. The inbound flight was delayed about 20 minutes. Then, after initial onboarding, the passengers had to deplane due to a mechanical problem. That took about 30 minutes to fix and be cleared. Then, reboarding was chaotic. It took a long time to sort passengers and two passengers on standby were ticketed but there was no seat. So, they had to deplane. One of the flight crew was trying to help passengers figure out a place to put their carry-on bags and that took more time. In the end, our scheduled 10:30 am departure did not actually take off until about 12:05 pm CST. The flight itself was long but we got to Houston. Some passengers missed their connecting flights and had to rebook. Not the best of flights I've had.

Everything you need to know for your flight from Des Moines to Panama

Information on your arrival and departure airports