$306 Find Cheap Flights from Des Moines to Panama - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Price, demand and travel trends for Des Moines to Panama flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

What are the cheapest fares from Des Moines to Panama right now?

The cheapest fare from Des Moines to Panama in the last week was $672 round-trip, to Panama City Tocumen Intl (PTY).

Which airport in Panama is the cheapest to fly to from Des Moines?

All flights from Des Moines to Panama arrive at Panama City Tocumen Intl (PTY). On average, round-trip fares are around $613.

What’s the cheapest day to fly from Des Moines to Panama?

Sunday tends to be the cheapest day to fly from Des Moines to Panama, while Friday is the most expensive. Fares run about 56% higher that day, based on the past 12 months of KAYAK data.

What's the cheapest time of day to fly from Des Moines to Panama?

Data from the past 12 months shows it's cheapest to fly to Panama during the afternoon with average prices of $524. The evening is the most expensive time to fly, with average prices of $1,602.

Key details for Des Moines to Panama flights

Low season

September

Cheapest flight

$306
Beat the crowds with an average 87% drop in travelers.
The most popular month to fly with an average 96% increase in travelers.
One-way flight from Des Moines to Panama City

Your Des Moines to Panama flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • Is now a good time to book a flight from Des Moines to Panama?

    Fares from Des Moines to Panama are around their usual level right now. A round-trip under $461 is considered a good deal, so it's worth keeping an eye out, or setting a Price Alert to catch price changes.

  • How much should I budget for a flight from Des Moines to Panama?

    Over the past 12 months, round-trip fares from Des Moines to Panama have ranged from $461 to $779.

  • What airlines fly nonstop from Des Moines to Panama?

    Based on the flight schedule for the next 3 months, no airline regularly operates nonstop flights from Des Moines to Panama. One-stop options include United Airlines and Delta.

  • Which cabin classes are available on flights from Des Moines to Panama?

    On flights from Des Moines to Panama you can book Economy Class or Business Class.

  • What are some popular landmarks in Panama?

    KAYAK travelers' favorite landmarks in Panama include:

    • ATLAPA Conventions Center
    • Panama Old Cathedral
    • Veneto Casino
    • Ancon Hill

Your guide to booking Des Moines to Panama flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your travel dates are flexible, book your trip for February when flights are typically cheapest and avoid May when prices are at their highest.
  • Flying on Sunday is usually the cheapest. Flights on Friday cost about 56% more on average, so being flexible with your travel dates could help you save.
  • Start your trip in Panama City, which is the most popular destination in Panama. From there, it's easy to continue on to other popular destinations such as Bocas del Toro, Río Hato and Boquete.

Reviews of the top airline flying from Des Moines to Panama

 
Need help choosing which airline to fly with from Des Moines to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.3
United AirlinesOverall score based on 10451 reviews
8.1Crew
7.3Comfort
6.7Food
7.7Boarding
7.1Entertainment
Airline reviews

1 flight cancelled Had to fly out of different city Flight at new departure city was delayed 3 hours causing us to miss connecting flights. By the time we did make it to Prague our luggage did not. Had to wait day and a half for luggage to be delivered. Customer service was not good. Agents did not arrive at gate until 5-10 minutes before boarding

2.0 MediocreRuss, Jun 2026
Read more United Airlines reviews

1 flight cancelled Had to fly out of different city Flight at new departure city was delayed 3 hours causing us to miss connecting flights. By the time we did make it to Prague our luggage did not. Had to wait day and a half for luggage to be delivered. Customer service was not good. Agents did not arrive at gate until 5-10 minutes before boarding

It was better than excellent. The staff in Mason City were great. The young woman that pushed my wheelchair did more than could be expected of her. She came from India 17 years ago. I don't remember her name.

Didn't make the flight because the first leg of my flight was canceled and the next leg was already booked.

Same as last comment. Food sucks. Quality. Not surprising most people have no clue about nourishment Clearly

Crew was excellent. This was a relatively long flight though and had very little leg room, and no entertainment.

The food should improve! And The flight should leave on time and not make the traveler wait.

Very rough getting into denver. my kid threw up it was so rough.

I completely missed my flight because the first leg was longer than planned. I had to sleep overnight in the airport because no accommodation was provided and then sent to Trinidad in the morning with an anticipated 7 hour layover before my flight to Georgetown which was now with Caribbean Airlines. I tried twice with customer service to see if they could put me on an earlier flight which had seats available but was told it wasn’t possible.

Liked that we left on time for each flight. Snacks not the best, but we're okay.

I had requested wheelchair assistance prior to flight. The airport staff had no record of it. It was not provided at Cedar Rapids which was a small airport, so I managed on my own. At O'Hare airport the same thing happened. The staff told me they had no record of my request for a wheel chair. But they finally provided it after a delay when I insisted that I needed it.

More options for your flight from Des Moines to Panama

Complete your trip to Panama with a hotel stay or car rental