$188 Find Cheap Flights from Des Moines to Panama

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Panama departing on 5/24. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Best Panama Flight Deals from Des Moines

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours

Panama City
Panama City2 stops$434
Panama City
Panama City2 stops$434

Cheap Flight Deals from Des Moines to Panama (DSM-PA0)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Panama

Fri, Jun 20 - Fri, Jun 27
KLM Logo
7:00 am - 7:30 pmDSM-PTY
12h 30m2 stops
KLM Logo
2:23 pm - 2:03 pmPTY-DSM
23h 40m2 stops
$434KLM
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Fri, Jun 20 - Fri, Jun 27
KLM Logo
11:24 am - 7:30 pmDSM-PTY
8h 06m1 stop
KLM Logo
2:23 pm - 9:38 amPTY-DSM
19h 15m2 stops
$438KLM
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Sat, May 24 - Sat, May 31
United Airlines Logo
6:07 am - 6:37 pmDSM-PTY
12h 30m1 stop
United Airlines Logo
10:00 am - 10:32 pmPTY-DSM
12h 32m1 stop
$441United Airlines
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Sat, May 24 - Sat, May 31
United Airlines Logo
3:35 pm - 4:12 pmDSM-PTY
24h 37m2 stops
United Airlines Logo
10:00 am - 10:32 pmPTY-DSM
12h 32m1 stop
$446United Airlines
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Sat, May 24 - Sat, May 31
United Airlines Logo
3:01 pm - 4:12 pmDSM-PTY
25h 11m1 stop
United Airlines Logo
10:00 am - 10:32 pmPTY-DSM
12h 32m1 stop
$450United Airlines
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Sun, Jul 27 - Thu, Jul 31
American Airlines Logo
7:47 pm - 2:15 pmDSM-PTY
18h 28m2 stops
American Airlines Logo
1:55 pm - 9:03 amPTY-DSM
19h 08m2 stops
$521American Airlines
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Wed, Jun 18 - Tue, Jun 24
 Logo
10:31 am - 9:10 pmDSM-PTY
34h 39m3 stops
 Logo
3:20 am - 10:37 pmPTY-DSM
43h 17m3 stops
Wed, Jun 18 - Wed, Jun 25
American Airlines Logo
5:58 pm - 1:00 pmDSM-PTY
19h 02m2 stops
American Airlines Logo
1:50 pm - 4:15 pmPTY-DSM
26h 25m2 stops
$608American Airlines
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Wed, Jun 18 - Wed, Jun 25
Delta Logo
5:40 am - 1:08 pmDSM-PTY
7h 28m1 stop
Delta Logo
2:23 pm - 11:03 pmPTY-DSM
8h 40m1 stop
$641Delta
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Fri, Jun 20 - Fri, Jun 27
 Logo
6:30 am - 12:45 amDSM-PTY
18h 15m2 stops
 Logo
9:34 am - 5:16 pmPTY-DSM
31h 42m3 stops
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KAYAK's insights & trends for Des Moines to Panama flights

Get data-powered insights and trends into flights from Des Moines to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Des Moines to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Panama is August, when tickets cost $349 (return) on average. On the other hand, the most expensive months are March and May, when the average cost of round-trip tickets is $843 and $556 respectively.


Good to know

Low seasonAugust
High seasonJanuary
Cheapest flight$188
Best time to beat the crowds with an average 31% drop in price.
Most popular time to fly with an average 4% increase in price.
Flight from Des Moines to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Des Moines to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Panama?

    The cheapest time of day to fly to Panama is generally in the evening, when round-trip flights cost $439 on average. Morning departures are around 23% more expensive than evening flights, on average. The most expensive time of day to fly to Panama is generally in the morning, which is peak travel time and where the average cost of a ticket is $539.

Top 3 airlines serving from Des Moines to Panama

Need help choosing which airline to fly with from Des Moines to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 7944 reviews
7.9Entertainment
7.9Comfort
8.5Crew
8.2Boarding
7.3Food
Airline reviews

Good flights. On time. They had a gluten free snack option which was nice

8.0 ExcellentDenise, May 2025TRI - ATL
Read more Delta reviews

Good flights. On time. They had a gluten free snack option which was nice

Take this flight once or twice a month. Just don’t cut it from the schedule.

737-800 in first class was pretty dumpy. Seat had an uncomfortable angle, storage under the seat was blocked so even my very modest backpack didn't fit, power outlet was flaky. Weird tiny seat pockets that couldn't hold a gallon ziploc bag, emesis bag missing, etc. etc. No in-flight service due to turbulence. Crew was excellent, boarding was smooth despite a full flight.

Food from the flight from Atlanta to Santiago was very poor..

Flight was delayed due to weather. Crew did a nice job of making us comfortable. No complain complaints.

Our bag was lost so that made unnecessary chaos On our trip

Delta is my preferred airline. I've traveled with them for years. On time in most cases, good communication, easy to use app. Most planes are pretty nice. I was on a CRJ 700/900 however, which was pretty badly aged inside and needed a refresh. No infotainment, unreliable wifi, best to download before boarding or bring a book. Food choices are really just snacks on this flight, nice variety but about what you'd expect. Great staff and prompt in departure and early arrival too. Overall quite satisfied.

Crew was friendly Love the entertainment in the seat head rest.

Delta flight was on time, seats were comfortable, and crew was nice.

This had nothing to do with Delta… The flights were on time and flawless. The service was excellent. We purchased seats in (aisle/middle) comfort plus since this was a cross country flight. Unfortunately, the woman seated at the window was 300+ pounds and, as might be expected, covered up about a third of the middle seat also. there was absolutely nothing that Delta could have done about that… I just don’t know what the answer should be. If you purchase a seat, you should should be able to use the entire seat and not just the portion that someone else is not sitting/oozing in. Disappointing…there should be something that could be done….I'm just not sure what solution could be.

The first flight was better in terms of the aircraft.

we were delayed going into and out of Newark Airport by 3-4 hours each way. Excuses/reasons given were misleading. Weather was cited at first when there was NO weather issue. Turns out Newark had a shortage of staff and runway construction. United knew this and should have NOT scheduled flights when they know we would be delayed so long. I will avoid United and EWR airport at all cost going forward. Delta never looked so good.

The seat and leg room was not good. The food and beverage service was good.

Liked fold flat bed. Didn’t like having no window. Didn’t like poor choice of food and being served dinner very late, hours after take off of a 7:40pm flight. Servers not friendly. Food horrible in business class.

Everything is good except the dinner and breakfast. The sandwich is very delicious. Toilet is clean, I only use one of them. Flight attendants are very nice. 👍👍

A bit rush for transit. Food and entertainment are not available

Boarding was a little difficult. The gate area at O'Hare was very small and crowded due to multiple gates in the area. Could not hear the intercom, so had to rely on signage to see when my group was boarding and the signage was blocked by passengers standing in the gate. Flight was great and we arrived in Montreal on time.

Multiple delays and not straight answer from the United team

For economy, it was very good. Staff was great, they even let some of us change seats for more leg room... Put an empty seat between us which was fantastic for a 12hr flight. Onboard entertainment was excellent, I think over 200 choices of movies/tv/etc The bad was the barely/nonfunctional wifi that cost either $16.99 or 1700 miles (full flight). It was atrocious... Definitely the worst of the last 3 long haul major airlines I was on the last few months.

Stewardess spilled orange juice on my clothes/seat no help no apology just threw napkins at me to clean the mess up. Not Happy.

Update departure times in a more timely manner. We are not boarding on time if the plane isn’t arriving until after our scheduled departure time.

Update.us on flight information in a more timely manner. Don’t say we are boarding on time ten minutes before the boarding time when the aircraft isn’t arriving for another forty minutes.

The boarding was pretty easy. However, the first class seats are not lay flat as other airlines (like JetBlue) has and therefore sleeping was a challenge.

It was nobody’s fault - but the plane came 4-hrs late and we were updated randomly in 20-30 mins increments which left us hostage to sit and wait expectantly. It was very long and got very late. Our plane didn’t land until nearly 1 am! Also the toilet wasn’t working. The hosts were nice enough but were clearly “about to pass out” as one told me. Lastly, there was no snack or even time for it. Just a bad experience overall.

Was a normal flight but it was delayed, and there wasn't an explanation.

In flight connectivity (via T-Mobile) was often not working.

Pitch was very small. Knees were on the seat back in front of me.

really bad they refused to check in luggages that I had purchased, even showing them the transaction receipt from british airways app the staff in miami was MEDIOCRE

Several delays. Next flight was worse. Did not arrive home until 2am PT

Very helpful ground crew after an earlier flight delay and being rebooked on a different flight.

Everything you need to know for your flight from Des Moines to Panama

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