$607 Find Cheap Flights from Des Moines to Panama - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Des Moines to Panama

Cheapest round-trip prices found by our users on KAYAK in the last 5 days
Sort by: Cheapest
Panama City
7h 20m2 stops
from $607per person
Booking Insights

KAYAK's insights & trends for Des Moines to Panama flights

Get data-powered insights and trends into flights from Des Moines to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Des Moines to Panama?

The cheapest month for flights from Des Moines to Panama is August, when tickets cost $0 (return) on average. On the other hand, the most expensive months are June and December, when the average cost of round-trip tickets is $5,515 and $1,033 respectively.

Good to know

Low season

February

Cheapest flight

$607
Best time to beat the crowds with an average 60% drop in price.
Most popular time to fly and prices are also 60% lower on average.
Flight from Des Moines to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Des Moines to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Des Moines to Panama

 
Need help choosing which airline to fly with from Des Moines to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 10213 reviews
8.1Crew
6.7Food
7.7Boarding
7.1Entertainment
7.3Comfort
Airline reviews

1 flight cancelled Had to fly out of different city Flight at new departure city was delayed 3 hours causing us to miss connecting flights. By the time we did make it to Prague our luggage did not. Had to wait day and a half for luggage to be delivered. Customer service was not good. Agents did not arrive at gate until 5-10 minutes before boarding

2.0 MediocreRuss, Jun 2026
Read more United Airlines reviews

1 flight cancelled Had to fly out of different city Flight at new departure city was delayed 3 hours causing us to miss connecting flights. By the time we did make it to Prague our luggage did not. Had to wait day and a half for luggage to be delivered. Customer service was not good. Agents did not arrive at gate until 5-10 minutes before boarding

It was better than excellent. The staff in Mason City were great. The young woman that pushed my wheelchair did more than could be expected of her. She came from India 17 years ago. I don't remember her name.

Didn't make the flight because the first leg of my flight was canceled and the next leg was already booked.

Same as last comment. Food sucks. Quality. Not surprising most people have no clue about nourishment Clearly

Crew was excellent. This was a relatively long flight though and had very little leg room, and no entertainment.

The food should improve! And The flight should leave on time and not make the traveler wait.

Very rough getting into denver. my kid threw up it was so rough.

I completely missed my flight because the first leg was longer than planned. I had to sleep overnight in the airport because no accommodation was provided and then sent to Trinidad in the morning with an anticipated 7 hour layover before my flight to Georgetown which was now with Caribbean Airlines. I tried twice with customer service to see if they could put me on an earlier flight which had seats available but was told it wasn’t possible.

Liked that we left on time for each flight. Snacks not the best, but we're okay.

I had requested wheelchair assistance prior to flight. The airport staff had no record of it. It was not provided at Cedar Rapids which was a small airport, so I managed on my own. At O'Hare airport the same thing happened. The staff told me they had no record of my request for a wheel chair. But they finally provided it after a delay when I insisted that I needed it.

More options for your flight from Des Moines to Panama

Complete your trip to Panama with a hotel stay or car rental