DSM - PTY

$249 Find Cheap Flights from Des Moines to Panama City

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 5/2. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Panama City

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Panama City, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Panama City, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$564
Typical prices: $532-$556
American Airlines
Mon 5/4Mon 5/11
DSM - PTY • 2 stops
Cheapest one-way
$249
United Airlines
Sat 5/2
DSM - PTY • 1 stop
Top airlines
Cheapest • from $564 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Des Moines and Panama City. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $639 (round-trip)
Shortest trip • 7h 44m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 25% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Panama City!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to Panama City (DSM-PTY)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Panama City

Mon, May 4 - Mon, May 11
American Airlines Logo
5:01 pm - 12:46 pm
DSM
-
PTY
19h 45m
2 stops
American Airlines Logo
1:49 pm - 11:26 am
PTY
-
DSM
21h 37m
2 stops
$564American Airlines
Sun, Apr 12 - Mon, Apr 20
United Airlines Logo
8:20 am - 4:12 pm
DSM
-
PTY
7h 52m
1 stop
United Airlines Logo
7:55 am - 10:43 pm
PTY
-
DSM
14h 48m
1 stop
$573United Airlines
Wed, May 6 - Wed, May 13
American Airlines Logo
6:26 pm - 12:46 pm
DSM
-
PTY
18h 20m
2 stops
American Airlines Logo
1:49 pm - 10:26 am
PTY
-
DSM
20h 37m
2 stops
$575American Airlines
Sat, Apr 11 - Sun, Apr 19
United Airlines Logo
8:04 am - 4:04 am
DSM
-
PTY
20h 00m
2 stops
United Airlines Logo
10:55 pm - 9:32 pm
PTY
-
DSM
22h 37m
2 stops
$577United Airlines
Sun, May 3 - Sun, May 10
American Airlines Logo
6:26 pm - 12:46 pm
DSM
-
PTY
18h 20m
2 stops
American Airlines Logo
1:49 pm - 8:26 am
PTY
-
DSM
18h 37m
2 stops
$580American Airlines
Fri, Apr 24 - Sun, May 3
Delta Logo
6:31 pm - 1:02 pm
DSM
-
PTY
18h 31m
1 stop
Delta Logo
2:27 pm - 10:34 pm
PTY
-
DSM
8h 07m
1 stop
$583Delta
Mon, May 18 - Fri, May 22
United Airlines Logo
8:25 pm - 4:12 pm
DSM
-
PTY
19h 47m
2 stops
United Airlines Logo
3:30 pm - 2:20 pm
PTY
-
DSM
22h 50m
1 stop
$588United Airlines
Fri, Apr 24 - Wed, May 6
Delta Logo
6:31 pm - 1:02 pm
DSM
-
PTY
18h 31m
1 stop
Delta Logo
2:27 pm - 11:08 am
PTY
-
DSM
20h 41m
1 stop
$593Delta
Wed, Apr 8 - Sun, Apr 12
Copa Airlines Logo
6:20 am - 6:37 pm
DSM
-
PTY
12h 17m
2 stops
Copa Airlines Logo
3:30 pm - 9:32 pm
PTY
-
DSM
30h 02m
2 stops
$605Copa Airlines
Thu, May 7 - Thu, May 14
United Airlines Logo
8:15 am - 4:12 pm
DSM
-
PTY
7h 57m
1 stop
United Airlines Logo
10:00 am - 10:45 pm
PTY
-
DSM
12h 45m
1 stop
$607United Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to Panama City flights

Get data-powered insights and trends into flights from Des Moines to Panama City to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Des Moines to Panama City?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Des Moines to Panama City departing in May.

What is the cheapest month to fly from Des Moines to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Panama City is April, where tickets cost $436 (return) on average. On the other hand, the most expensive months are December and March, where the average cost of round-trip tickets is $1,033 and $735 respectively.

Good to know

Low seasonJune
Cheapest flight$249
Best time to beat the crowds with an average 15% drop in price.
Most popular time to fly and prices are also 21% lower on average.
Flight from Des Moines to Panama City

When to book flights from Des Moines to Panama City

Are your dates flexible? Find out the best times to travel from Des Moines to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Panama City

  • What is the cheapest flight from Des Moines to Panama City?

    In the last 3 days, the lowest price for a flight from Des Moines to Panama City was $249 for a one-way ticket and $564 for a round-trip.

  • Do I need a passport to fly between Des Moines and Panama City?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Des Moines and on arrival in Panama City.

  • Which aircraft models fly most regularly from Des Moines to Panama City?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Des Moines to Panama City?

    SkyTeam, and Star Alliance are the airline alliances operating flights between Des Moines and Panama City, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Des Moines to Panama City, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from Des Moines to Panama City are Delta and United Airlines. With an average price for the route of $556 and an overall rating of 7.9, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $483 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from Des Moines to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and PTY can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Des Moines to Panama City

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8319 reviews
7.8Entertainment
7.9Comfort
7.2Food
8.5Crew
8.1Boarding
Airline reviews

Entertainment is ok! Boarding and seat with zone is terrible. I paid for the seats but you didn’t give me what I paid for which is exit isles.

4.0 OkayAnonymous, Mar 2026
BHM - ATL
Read more Delta reviews

Entertainment is ok! Boarding and seat with zone is terrible. I paid for the seats but you didn’t give me what I paid for which is exit isles.

the crew cancel the morning service due to the weather. Then the flight got deverted to Nashville . we were on the ground for over two hours the only gave us water once... no food or any snacks.... the crew should have handled better and offered something to passengers.

My recent experience was excellent on Delta! I flew with Delta Comfort and I was really comfortable in my seat. I enjoyed the in-flight service. The flight attendants were so friendly and hospitable. I love the snack on the flight as well. This was my first time flying on Delta and I will definitely consider flying with them again.

My flight was cencaled due with the bad weather on Sunday the crew was poorly mistaken my luggage supposed depart with my flight instead I didn’t have my luggage for almost 3 days the website is poorly respond to my complain until I have someone to do it my connection smooth their not even respon or email me even the have my luggage

Delta needs to step its game up get a more reliable internet service. Internet service was non-existent for this flight.

Mechanical Delay of over an hour with multiple gate changes. Entertainment system down for rejuvenation.

This was a Latam operated flight. Seats seemed a bit narrow in business class. Older aircraft.

I had a flight cancel and had it rerouted. When the rerouted they put me at a window seat instead of an isle. It was hard sitting by the window because the couple with masks on were making out. I get motion sickness which is why I need to have the isle seat.

NEVER MADE THE FLIGHT BECAUSE DELTA SAID THEY CAN NOT

THEY FAILED ME AND I NEVER GOT ON THE FLIGHT BECAUSE IT WAS SO DELAYED! I ENDED UP HAVING TO PAY OUT OF POCKET FOR A HOTEL AND STAY IN NASHVILLE TO CATCH A FLIGHT FOR THE FOLLOWING DAY. DELTA IS POOR CUSTOMER SERVICE>

ticket agent lady wás very helpful , she arranged wheel chair for my elderly mother

Didn't make the flight because the first leg of my flight was canceled and the next leg was already booked.

My flight was canceled a few hours before boarding. I was rebooked on Copa airlines and missed an important meeting .

Good quick flight on a small but comfortable plane. I'm 6'3 and had plenty of space.

Experience was great - no complaints. Took off on time, landed early. Got to the gate relatively quickly - took a little bit of extra time to deplane but nothing excessive.

Business class seats felt very cramped compared to other airlines.

Economy plus was so cramped I could not use my laptop. It was beyond bad.

OK, we were delayed and had to de plane and reboard.

United is one airline which regardless of how many separate United tickets in existence, if one flight breaks down, the airline will take care of all the flights.

Both our flights were delayed. Almost didn’t get in the second flight. Staff was rude to the bone.

Everything you need to know for your flight from Des Moines to Panama City

Information on your arrival and departure airports