DSM - PTY

$349 Find Cheap Flights from Des Moines to Panama City - Compare and Save

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1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$607
Typical prices: $461-$720
United Airlines
Fri 1/19Sat 1/27
DSM - PTY • 1 stop
Cheapest one-way
$349
Typical prices: $253-$462
United Airlines
Fri 11/2
DSM - PTY • 2 stops
Nonstop flights
Not available
There are currently no direct flights between Des Moines and Panama City. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
February
Cheapest • 20% price drop
February
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Houston George Bush Intcntl (IAH)
Cheapest • Avg $598 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 7h 42m (one-way)
Insights
Insights
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Flight Deals

Cheap Flights from Des Moines to Panama City (DSM-PTY)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Panama City

Tue, Dec 8 - Tue, Dec 22
United Airlines Logo
8:00 am - 7:38 pmDSM  Des Moines-PTY Panama City Tocumen Intl
10h 38m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
United Airlines Logo
11:35 am - 10:29 pmPTY  Panama City Tocumen Intl-DSM Des Moines
11h 54m1 stop Houston George Bush Intcntl
$607United Airlines
Mon, Feb 8 - Wed, Feb 24
United Airlines Logo
8:00 am - 5:12 pmDSM  Des Moines-PTY Panama City Tocumen Intl
8h 12m1 stop Houston George Bush Intcntl
United Airlines Logo
11:35 am - 10:30 pmPTY  Panama City Tocumen Intl-DSM Des Moines
11h 55m1 stop Houston George Bush Intcntl
$607United Airlines
Tue, Dec 8 - Tue, Dec 22
United Airlines Logo
8:00 am - 5:12 pmDSM  Des Moines-PTY Panama City Tocumen Intl
8h 12m1 stop Houston George Bush Intcntl
United Airlines Logo
11:35 am - 10:29 pmPTY  Panama City Tocumen Intl-DSM Des Moines
11h 54m1 stop Houston George Bush Intcntl
$607United Airlines
Tue, Jan 19 - Wed, Jan 27
United Airlines Logo
8:00 am - 5:12 pmDSM  Des Moines-PTY Panama City Tocumen Intl
8h 12m1 stop Houston George Bush Intcntl
United Airlines Logo
11:35 am - 10:30 pmPTY  Panama City Tocumen Intl-DSM Des Moines
11h 55m1 stop Houston George Bush Intcntl
$607United Airlines
Tue, Jan 19 - Tue, Jan 26
United Airlines Logo
8:00 am - 7:38 pmDSM  Des Moines-PTY Panama City Tocumen Intl
10h 38m1 stop Houston George Bush Intcntl
United Airlines Logo
8:55 am - 10:30 pmPTY  Panama City Tocumen Intl-DSM Des Moines
14h 35m1 stop Houston George Bush Intcntl
$607United Airlines
Tue, Dec 8 - Tue, Dec 22
United Airlines Logo
6:18 pm - 2:45 pmDSM  Des Moines-PTY Panama City Tocumen Intl
19h 27m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
United Airlines Logo
11:35 am - 7:55 amPTY  Panama City Tocumen Intl-DSM Des Moines
21h 20m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$611United Airlines
Mon, Feb 8 - Wed, Feb 24
United Airlines Logo
8:00 am - 5:12 pmDSM  Des Moines-PTY Panama City Tocumen Intl
8h 12m1 stop Houston George Bush Intcntl
United Airlines Logo
8:55 am - 11:21 pmPTY  Panama City Tocumen Intl-DSM Des Moines
15h 26m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$611United Airlines
Mon, Feb 8 - Wed, Feb 24
United Airlines Logo
3:25 pm - 2:45 pmDSM  Des Moines-PTY Panama City Tocumen Intl
22h 20m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
United Airlines Logo
8:55 am - 9:17 pmPTY  Panama City Tocumen Intl-DSM Des Moines
13h 22m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$611United Airlines
Sat, Jan 9 - Sat, Jan 23
Delta Logo
5:45 am - 1:55 pmDSM  Des Moines-PTY Panama City Tocumen Intl
7h 10m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:20 pm - 10:29 pmPTY  Panama City Tocumen Intl-DSM Des Moines
8h 09m1 stop Atlanta Hartsfield-Jackson
$675Delta
Sun, Nov 22 - Tue, Nov 24
Copa Airlines Logo
8:00 am - 2:45 pmDSM  Des Moines-PTY Panama City Tocumen Intl
29h 45m1 stop Houston George Bush Intcntl
Copa Airlines Logo
4:41 pm - 10:30 pmPTY  Panama City Tocumen Intl-DSM Des Moines
30h 49m1 stop Houston George Bush Intcntl
$679Copa Airlines
Booking Insights

Price, demand and travel trends for Des Moines to Panama City flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Des Moines to Panama City?

Round-trip flights from Des Moines to Panama City typically range from $461 to $720. The lowest price found in the past 5 days was $607, on United Airlines.

What's the cheapest day of the week to fly from Des Moines to Panama City?

Based on deals KAYAK users found in the last 12 months, Sunday is the cheapest day of the week to fly from Des Moines to Panama City. It’s 20% cheaper than the average day, while Friday is the most expensive, with prices 80% higher.

Find deals

Key details for Des Moines to Panama City flights

Low season

May

Cheapest flight

$349
Beat the crowds with an average 80% drop in travelers.
The most popular month to fly with an average 287% increase in travelers.
One-way flight from Des Moines to Panama City

When to book flights from Des Moines to Panama City

Are your dates flexible? Find out the best times to travel from Des Moines to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Des Moines to Panama City flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Des Moines to Panama City?

    Only Economy Class is available on flights from Des Moines to Panama City.

  • How long is a flight from Des Moines to Panama City?

    A nonstop flight from Des Moines to Panama City takes 00m, covering 2,405 miles.

  • Do I need a passport to fly from Des Moines to Panama City?

    Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

  • How much should I expect to pay for a Des Moines to Panama City flight?

    Round-trip flights from Des Moines to Panama City range from $461 to $720, with an average of $573 over the past 12 months. Anything below $461 counts as a good deal.

  • Have flight prices from Des Moines to Panama City changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $607 to $1,748. That means the highest observed fare was about 3x higher than the lowest one.

  • How are flight prices from Des Moines to Panama City looking right now?

    One-way fares from Des Moines to Panama City are currently higher than usual. Average one-way flight prices are about $390, which is 54% above the typical average for this route.

  • What car rental options are available at Panama City Tocumen Intl Airport (PTY)?

    Panama City Tocumen Intl Airport (PTY) hosts 5 major car rental companies, with daily rates starting from around $1 for economy cars. Top options include:

    • Avis
    • Europcar
    • Ace
    • Budget
    • Hertz

  • Which airports can I use when flying from Des Moines to Panama City?

    Flights from Des Moines to Panama City usually depart from Des Moines (DSM) and arrive at Panama City Tocumen Intl (PTY).

  • Which airports do connecting flights from Des Moines to Panama City pass through?

    One-stop flights from Des Moines to Panama City most commonly connect through:

    • Houston George Bush Intcntl (IAH) - 79% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 12% of one-stop connections
    • Miami (MIA) - 9% of one-stop connections

  • Can I save money by using flexible dates for flights from Des Moines to Panama City?

    Yes. Flexible dates can save you up to 56% on flights from Des Moines to Panama City. Sunday is the cheapest departure day at $461 round-trip on average, while Friday is the most expensive at $1,033, a difference of $572.

    Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

  • How much time can I save by choosing a different layover airport from Des Moines to Panama City?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 7h 42m, compared with 8h 51m via Miami (MIA) and 10h 38m via Houston George Bush Intcntl (IAH).

  • What popular places can I visit in Panama City?

    Some of the most popular sights in Panama City are ATLAPA Conventions Center, Panama Old Cathedral and Veneto Casino. These are among the most viewed places in Panama City on KAYAK.

Your guide to booking Des Moines to Panama City flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Sunday departure and avoid flying on Friday. On this route, Sunday flights average $461, about $572 less than Friday fares (55% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Des Moines to Panama City trip for February. Fares historically average $461 round-trip in that month - typically $572 less than the most expensive month, which is December (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Panama City Tocumen Intl Airport.

    • Riande Aeropuerto Hotel & Casino

More options for your flight from Des Moines to Panama City

Complete your trip to Panama City with a hotel stay or car rental

Car rentals in Panama City
Hotels in Panama City
Vacations in Panama City