DSM - PTY

$198 Find Cheap Flights from Des Moines to Panama City

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 2/8. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Panama City

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Panama City, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Panama City, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$453
Typical prices: $461-$550
United Airlines
Wed 2/4Wed 2/11
DSM - PTY • 2 stops
Cheapest one-way
$198
United Airlines
Sun 2/8
DSM - PTY • 2 stops
Top airlines
United Airlines
Cheapest • from $453 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
September
Cheapest • 29% price drop
February
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Panama City!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to Panama City (DSM-PTY)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Panama City

Wed, Feb 4 - Wed, Feb 11
United Airlines Logo
8:00 am - 7:38 pm
DSM
-
PTY
10h 38m2 stops
United Airlines Logo
8:55 am - 10:30 pm
PTY
-
DSM
14h 35m1 stop
$453United Airlines
Thu, Feb 26 - Sat, Mar 7
United Airlines Logo
7:52 am - 5:07 pm
DSM
-
PTY
8h 15m1 stop
United Airlines Logo
8:55 am - 10:44 pm
PTY
-
DSM
14h 49m1 stop
$462United Airlines
Mon, Feb 2 - Mon, Feb 9
American Airlines Logo
11:42 am - 1:27 pm
DSM
-
PTY
24h 45m2 stops
American Airlines Logo
4:50 pm - 12:46 pm
PTY
-
DSM
20h 56m2 stops
$465American Airlines
Mon, Feb 2 - Mon, Feb 9
United Airlines Logo
8:10 am - 5:07 pm
DSM
-
PTY
7h 57m1 stop
United Airlines Logo
4:41 pm - 10:55 am
PTY
-
DSM
19h 14m2 stops
$466United Airlines
Mon, Feb 2 - Mon, Feb 9
United Airlines Logo
8:10 am - 5:07 pm
DSM
-
PTY
7h 57m1 stop
United Airlines Logo
4:41 pm - 2:22 pm
PTY
-
DSM
22h 41m1 stop
$471United Airlines
Sat, Feb 7 - Tue, Feb 10
United Airlines Logo
3:04 pm - 2:45 pm
DSM
-
PTY
22h 41m1 stop
United Airlines Logo
4:41 pm - 2:33 pm
PTY
-
DSM
22h 52m2 stops
$475United Airlines
Sat, Feb 7 - Tue, Feb 10
United Airlines Logo
3:04 pm - 7:38 pm
DSM
-
PTY
27h 34m1 stop
United Airlines Logo
4:41 pm - 2:22 pm
PTY
-
DSM
22h 41m1 stop
$480United Airlines
Mon, Feb 9 - Sat, Feb 14
United Airlines Logo
8:10 am - 5:07 pm
DSM
-
PTY
7h 57m1 stop
United Airlines Logo
4:41 pm - 2:27 pm
PTY
-
DSM
22h 46m2 stops
$482United Airlines
Tue, Feb 24 - Fri, Mar 6
United Airlines Logo
7:52 am - 5:07 pm
DSM
-
PTY
8h 15m1 stop
United Airlines Logo
8:55 am - 10:44 pm
PTY
-
DSM
14h 49m1 stop
$504United Airlines
Wed, Apr 22 - Sun, Apr 26
United Airlines Logo
1:10 pm - 4:04 am
DSM
-
PTY
14h 54m2 stops
United Airlines Logo
3:30 pm - 12:29 pm
PTY
-
DSM
20h 59m2 stops
$508United Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to Panama City flights

Get data-powered insights and trends into flights from Des Moines to Panama City to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Des Moines to Panama City?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Des Moines to Panama City departing in February.

What is the cheapest month to fly from Des Moines to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Panama City is September, where tickets cost $441 (return) on average. On the other hand, the most expensive months are June and December, where the average cost of round-trip tickets is $1,069 and $1,033 respectively.

Good to know

Low seasonMarch
Cheapest flight$198
Best time to beat the crowds but there is an average 38% increase in price.
Most popular time to fly and prices are also 27% lower on average.
Flight from Des Moines to Panama City

When to book flights from Des Moines to Panama City

Are your dates flexible? Find out the best times to travel from Des Moines to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Panama City

  • What is the cheapest flight from Des Moines to Panama City?

    In the last 3 days, the lowest price for a flight from Des Moines to Panama City was $198 for a one-way ticket and $453 for a round-trip.

  • Do I need a passport to fly between Des Moines and Panama City?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Des Moines and on arrival in Panama City.

  • Which aircraft models fly most regularly from Des Moines to Panama City?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Des Moines to Panama City?

    SkyTeam, and Star Alliance are the airline alliances operating flights between Des Moines and Panama City, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Des Moines to Panama City, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from Des Moines to Panama City are Delta and United Airlines. With an average price for the route of $581 and an overall rating of 7.9, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $485 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from Des Moines to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and PTY can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Des Moines to Panama City

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8021 reviews
8.5Crew
7.9Entertainment
7.9Comfort
8.1Boarding
7.3Food
Airline reviews

Flight delays both to Detroits and return flight . The flight to Detroit was associated with mechanical difficulty

2.0 MediocreGina, Dec 2025
DTW - ELM
Read more Delta reviews

Flight delays both to Detroits and return flight . The flight to Detroit was associated with mechanical difficulty

I am extremely disappointed that delta internal pilot manuals now refer to the Gulf of Mexico as the “gulf of America”. You can bow down to the Orange turd on your own. I will never fly delta again

Wasn't a Delta issue I don't think, but seems there was a Delta flight at each of the 2 Dallas airports at the same exact time, both to Atlanta. I was evidently booked on the one at Love Airport, but the Carey transport shuttle took me to DFW instead and I ended up missing the flight by just a few minutes. Was able to book a Southwest flight from Love Airport, but was a big loss of time and an inconvenience.

Great. I had to modify a flight. That was easy and free. Thank You

I noticed that the planes seem to be outdated. There was no entertainment per se. Also, the waiting area did not have any working electrical outlets

None of the airplane features were available during the flight.

Original flight was cancelled and when i was rebooked by the airline, they couldn't seat me in the same type of seat as I had originally booked (went from window/aisle to middle/middle and one was a bulkhead seat, and other wasn't in the same class)

Lady Pilot was perfect in every way wheels up to wheels down communication, professionalism, excellent on time departure and on time arrival, excellent communication! Fantastic job with Superb attitude!!

The food is terrible. The staff is wonderful. Comfort is good.

Left on time, a bit delayed due to headwinds most of the trip.

The Crew and the food was the worst I ever had in Business Class. First they told us there were no space for carry on. It was plenty of space over our 2 row seats, we had to ask to let us travel with it which was accepted. They were aware that we had to run for the connection due to the previous flight delay. Have us one hour waiting for more customers and not even offer a glass of water. Then started the service and they started to serve other passengers drinks in business and did not offer any drinks until they serve our pre ordered meal and I ask for something to drink. I had to wait until they finished to serve all passengers until Inget something. The crew was the worts I ever had for Business Class in my life.

Very turbulent trip made it pretty bearable, plus the lack of refreshments served and the lack of any air conditioning before takeoff which took an hour or more.

Flight was late - I was downgraded from first class to coach

Not good - outbound flight was delayed and missed my connection even though I got to the gate after running through the airport - the agent would not let me on because the door was closed (flight had not left). There was no notification from United - overall experience was very disappointing. Additionally, I was downgraded from first class to coach on the alternative flight

The flight was on time. I generally don’t drink or eat on short flights and the seats were good and the flight attendants were friendly. That’s all I expect

It was nice to have gotten up upgraded to first class with a meal on a three hour flight

Not great experience - we were super late boarding due to issues with aircraft. Then when we finally all got onboard and seated and they started taxiing out to the runway they just stopped then turned around and went back to the airport. Apparently the crew “ran out of time” to legally fly us. They mentioned that they were about 2 minutes away from taking off. I understand the rules and safety but kinda wonder why they would have bothered boarding us in the first place? Had to go all the way back and de plane and then wait in a HUGE line to get a hotel (this is somewhere around 2:30am) finally got to hotel by Uber (no shuttle after 20min so gave up) and they ended up putting us all back on the same aircraft at 10am next morning so got about 2.5 hours sleep. They did give us. $250 credit, but it was a São Paulo Brazil flight out of Dulles. The flight and everything was fine.

United overall experience is great these days. Airport experience was very organized. Staff on flight were great. App and information as good as it gets.

United have really come back. Airport and boarding process is clear and good, app and information also very good

They charged a fee for 1st bag checked. Others in same party were free.

Everything you need to know for your flight from Des Moines to Panama City

Information on your arrival and departure airports