$280 Find Cheap Flights from Fort Myers to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Fort Myers to South America departing on 8/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Fort Myers to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Bogotá
Bogotá1 stop$590
Santiago
Santiago2 stops$880
Quito
Quito1 stop$637
Cusco
Cusco2 stops$1,001
Asuncion
Asuncion2 stops$1,597
Bogotá
Bogotá1 stop$590
Santiago
Santiago2 stops$880
Quito
Quito1 stop$637
Cusco
Cusco2 stops$1,001
Asuncion
Asuncion2 stops$1,597

Book Cheap Fort Myers to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Fort Myers to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Fort Myers to South America

Sat, Apr 18 - Thu, Apr 23
Multiple Airlines Logo
9:20 pm - 1:08 pm
RSW
-
MDE
16h 48m
2 stops
Multiple Airlines Logo
4:50 am - 10:17 am
MDE
-
RSW
28h 27m
3 stops
$563Multiple Airlines
Sun, Jul 19 - Fri, Jul 31
American Airlines Logo
7:00 am - 11:58 pm
RSW
-
MDE
17h 58m
2 stops
American Airlines Logo
12:30 am - 1:56 pm
MDE
-
RSW
12h 26m
2 stops
$566American Airlines
Thu, Apr 16 - Thu, Apr 23
Multiple Airlines Logo
9:20 pm - 1:08 pm
RSW
-
MDE
16h 48m
2 stops
Multiple Airlines Logo
4:50 am - 8:35 am
MDE
-
RSW
26h 45m
3 stops
$570Multiple Airlines
Thu, Apr 16 - Thu, Apr 23
Multiple Airlines Logo
9:20 pm - 4:50 pm
RSW
-
MDE
20h 30m
3 stops
Multiple Airlines Logo
4:50 am - 8:35 am
MDE
-
RSW
26h 45m
3 stops
$571Multiple Airlines
Sat, Apr 18 - Thu, Apr 23
Spirit Airlines Logo
9:20 pm - 1:08 pm
RSW
-
MDE
16h 48m
2 stops
Spirit Airlines Logo
2:06 pm - 10:17 am
MDE
-
RSW
19h 11m
2 stops
$582Spirit Airlines
Tue, Apr 7 - Thu, Jun 4
Multiple Airlines Logo
7:24 pm - 10:46 pm
RSW
-
MDE
28h 22m
3 stops
Multiple Airlines Logo
7:05 am - 9:36 am
MDE
-
RSW
25h 31m
3 stops
$583Multiple Airlines
Tue, May 5 - Tue, May 12
United Airlines Logo
4:42 pm - 9:10 pm
RSW
-
MDE
29h 28m
2 stops
United Airlines Logo
9:45 am - 11:16 am
MDE
-
RSW
24h 31m
2 stops
$588United Airlines
Sat, May 16 - Mon, May 18
United Airlines Logo
11:49 am - 4:54 am
RSW
-
BOG
18h 05m
1 stop
United Airlines Logo
8:30 am - 10:41 pm
BOG
-
RSW
13h 11m
1 stop
$591United Airlines
Sat, Jul 18 - Sat, Aug 1
American Airlines Logo
7:41 pm - 12:51 pm
RSW
-
MDE
18h 10m
2 stops
American Airlines Logo
12:30 am - 10:53 pm
MDE
-
RSW
21h 23m
2 stops
$596American Airlines
Fri, May 1 - Sun, May 10
Delta Logo
3:00 pm - 9:45 am
RSW
-
EZE
17h 45m
1 stop
Delta Logo
8:10 pm - 2:40 pm
EZE
-
RSW
19h 30m
1 stop
$1,327Delta
Booking Insights

KAYAK's insights & trends for Fort Myers to South America flights

Get data-powered insights and trends into flights from Fort Myers to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Fort Myers to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Fort Myers to South America were found on American Airlines ($566) and United Airlines ($591).

Good to know

Low seasonSeptember
Cheapest flight$280
Best time to beat the crowds with an average 4% drop in price.
Most popular time to fly and prices are also 1% lower on average.
Flight from Fort Myers to Medellín

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Fort Myers to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Fort Myers to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Fort Myers to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Fort Myers to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Fort Myers to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Fort Myers to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Fort Myers to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Fort Myers to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Fort Myers to South America

 
Need help choosing which airline to fly with from Fort Myers to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8314 reviews
7.8Entertainment
8.1Boarding
7.9Comfort
7.2Food
8.5Crew
Airline reviews

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

10.0 ExcellentDebra, Mar 2026
PBI - ATL
Read more Delta reviews

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

Loved flying First Class. Very comfortable. The seat was amazing. Enjoyed a movie and was able to relax so much better than in coach.

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

An awesome flight crew. FC seat cushion just doesn’t cut it for a 3+ hour flight.

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Totally worth the miles to upgrade to Delta Comfort. Plenty of legroom.

This was my first time flying Delta ever and I had a great experience!

The flight was great as well as the airline staff

Comfort seating was on the tight side. Maybe it was a smaller plane(?)

Excellent flight and got us around tough weather. Only issue was seat TV did not work and crew tried to reboot.

It was great. Smooth flight, comfortable, left on time and landed on time.

Perhaps this is an airport issue, but being in a takeoff queue for over an hour in the taxiing lane is unacceptable. We will definitely be seeking alternative avenues for air travel in the future.

Really good. I accidentally left my duffel on the plane and the reps were so friendly in retrieving it.

After changing the departure gate 5 times making us mo e from one side of the airport to the other and then back the flight was delayed nearly 2 hours. The male flight attendant had a bad attitude with the guest being condescending, disrespectful with people who were already on edge.

There was no beverage service and the only time I saw a crew member walk through the cabin is when we were preparing to land.

Flights were constantly delayed. CRW took 50 minutes to get bags

Appreciate having multiple food options for allergies. Nice to have an extra seat between us for comfort.

Where do I start!! I was delayed with my flight from Dallas to Tampa. On the way back from Tampa to Dallas the flight was delayed over 4 hours+. I was put on another flight that was also delayed but not as long. Traveling on American Airlines is becoming exhausing.

I didn't end up taking this flight. I got up at 4am for a flight that was supposed to board at 6am - at 5:55am you delayed the flight to 10am. The airport is under construction so I switched to a later flight as I wasn't going to sit in the airport for 4 hours. They said the delay was due to the crew needing rest from a flight coming in late the night before - if that was the case then I think you should have delayed the flight much sooner so that passengers wouldn't get up so early and get to the airport to sit and wait.

The flight attendants and the service is getting worse by the day.

Everything you need to know for your flight to South America

Information on your arrival and departure airports