GSP - DSM

$135 Find Cheap Flights from Greenville to Des Moines - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$322
Typical prices: $357-$506
Multiple Airlines
Mon 10/22Mon 10/29
GSP - DSM • 1 stop
Cheapest one-way
$135
Typical prices: $198-$383
American Airlines
Tue 1/16
GSP - DSM • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Greenville and Des Moines. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
November
Cheapest • 23% price drop
October
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Atlanta Hartsfield-Jackson (ATL)
Cheapest • Avg $397 (round-trip)
Chicago O'Hare Intl (ORD)
Shortest trip • 4h 49m (one-way)
Insights
Insights
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Booking Insights
Flight Deals

Cheap Flights from Greenville to Des Moines (GSP-DSM)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Greenville to Des Moines

Thu, Oct 22 - Thu, Oct 29
Multiple Airlines Logo
8:04 pm - 10:08 pmGSP  Greenville-DSM Des Moines
27h 04m1 stop Fort Myers SW Florida Intl
Multiple Airlines Logo
8:43 am - 2:24 pmDSM  Des Moines-GSP Greenville
28h 41m2 stops Philadelphia Tampa
$322Multiple Airlines
Thu, Nov 5 - Sun, Nov 8
Delta Logo
5:40 am - 10:42 amGSP  Greenville-DSM Des Moines
6h 02m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:03 pm - 9:47 pmDSM  Des Moines-GSP Greenville
5h 44m1 stop Atlanta Hartsfield-Jackson
$362Delta
Thu, Oct 22 - Thu, Oct 29
Multiple Airlines Logo
8:04 pm - 10:08 pmGSP  Greenville-DSM Des Moines
27h 04m1 stop Fort Myers SW Florida Intl
Multiple Airlines Logo
5:52 pm - 8:51 amDSM  Des Moines-GSP Greenville
13h 59m1 stop Fort Lauderdale
$364Multiple Airlines
Thu, Nov 5 - Sun, Nov 8
Delta Logo
5:40 am - 10:42 amGSP  Greenville-DSM Des Moines
6h 02m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:03 pm - 9:47 pmDSM  Des Moines-GSP Greenville
5h 44m1 stop Atlanta Hartsfield-Jackson
$371Delta
Thu, Oct 1 - Sun, Oct 4
American Airlines Logo
5:24 pm - 11:12 pmGSP  Greenville-DSM Des Moines
6h 48m1 stop Dallas/Fort Worth
American Airlines Logo
6:00 am - 3:07 pmDSM  Des Moines-GSP Greenville
8h 07m1 stop Philadelphia
$381American Airlines
Tue, Oct 20 - Tue, Oct 27
American Airlines Logo
4:55 pm - 11:04 pmGSP  Greenville-DSM Des Moines
7h 09m1 stop Washington, D.C. Reagan-National
American Airlines Logo
9:26 am - 6:08 pmDSM  Des Moines-GSP Greenville
7h 42m1 stop Chicago O'Hare Intl
$387American Airlines
Tue, Oct 20 - Tue, Oct 27
United Airlines Logo
5:46 pm - 9:23 pmGSP  Greenville-DSM Des Moines
4h 37m1 stop Chicago O'Hare Intl
United Airlines Logo
11:22 am - 11:00 pmDSM  Des Moines-GSP Greenville
10h 38m2 stops Chicago O'Hare Intl Newark
$392United Airlines
Thu, Oct 22 - Thu, Oct 29
Southwest Logo
6:25 am - 11:10 amGSP  Greenville-DSM Des Moines
5h 45m2 stops Nashville Intl Chicago Midway
Southwest Logo
4:30 pm - 10:50 pmDSM  Des Moines-GSP Greenville
5h 20m2 stops Chicago Midway Nashville Intl
$397Southwest
Tue, Oct 20 - Wed, Oct 21
United Airlines Logo
6:20 am - 10:31 amGSP  Greenville-DSM Des Moines
5h 11m1 stop Chicago O'Hare Intl
United Airlines Logo
1:24 pm - 9:17 pmDSM  Des Moines-GSP Greenville
6h 53m1 stop Chicago O'Hare Intl
$405United Airlines
Thu, Nov 5 - Sun, Nov 8
Delta Logo
5:40 am - 10:42 amGSP  Greenville-DSM Des Moines
6h 02m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:03 pm - 9:47 pmDSM  Des Moines-GSP Greenville
5h 44m1 stop Atlanta Hartsfield-Jackson
$417Delta
Booking Insights

Price, demand and travel trends for Greenville to Des Moines flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Greenville to Des Moines with more confidence.

What's the cheapest day of the week to fly from Greenville to Des Moines?

Saturday is the cheapest day of the week to fly from Greenville to Des Moines, it is 23% cheaper than the average day. Monday is the most expensive day with flight prices 54% higher than average. Based on deals found by KAYAK users in the last 12 months.

What is the cheapest month to fly from Greenville to Des Moines?

  • November is the cheapest month to fly from Greenville to Des Moines at $314 round-trip.
  • March ($817) and July ($634) are the most expensive months.
  • The price difference between flying in the cheapest and most expensive months is 160% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for Greenville to Des Moines flights

Low season

January

Cheapest flight

$135
Best time to beat the crowds with an average 4% drop in price.
Most popular time to fly and prices are also 20% lower on average.
Flight from Greenville to Des Moines

When to book flights from Greenville to Des Moines

Are your dates flexible? Find out the best times to travel from Greenville to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Greenville to Des Moines flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • Which airports can I use when flying from Greenville to Des Moines?

    Flights from Greenville to Des Moines usually depart from Greenville (GSP) and arrive at Des Moines (DSM).

  • What cabin classes can I book on flights from Greenville to Des Moines?

    Two cabin classes are available on flights from Greenville to Des Moines:

    • Economy Class
    • First Class

  • Which airports do connecting flights from Greenville to Des Moines pass through?

    One-stop flights from Greenville to Des Moines most commonly connect through:

    • Atlanta Hartsfield-Jackson (ATL) - 55% of one-stop connections
    • Chicago O'Hare Intl (ORD) - 30% of one-stop connections
    • Charlotte Douglas (CLT) - 10% of one-stop connections
    • Dallas/Fort Worth (DFW) - 3% of one-stop connections

    Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.

  • Can I save money by using flexible dates for flights from Greenville to Des Moines?

    On the Greenville to Des Moines route, being flexible with your departure day can save you up to 51%. Saturday is the cheapest day at $314 round-trip on average, while Monday is the most expensive at $629: a $315 difference. Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

  • What popular places can I visit in Des Moines?

    Some of the most popular sights in Des Moines are Iowa Events Center, UnityPoint Health - Des Moines and Des Moines Civic Center. These are among the most viewed places in Des Moines on KAYAK.

  • How long is a flight from Greenville to Des Moines?

    A nonstop flight from Greenville to Des Moines takes 0h 00m, covering 771 miles.

  • Do I need a passport to fly from Greenville to Des Moines?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

  • Have flight prices from Greenville to Des Moines changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $322 to $1,144. That means the highest observed fare was about 4x higher than the lowest one.

  • How are flight prices from Greenville to Des Moines looking right now?

    One-way fares from Greenville to Des Moines are currently in line with typical prices for this route. Average one-way fares are about $225.

  • How much time can I save by choosing a different layover airport from Greenville to Des Moines?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 40m, compared with 4h 49m via Chicago O'Hare Intl (ORD) and 5h 14m via Charlotte Douglas (CLT).

  • What is the time difference between Greenville and Des Moines?

    Des Moines is 1 hour behind Greenville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

  • What car rental options are available at Des Moines Airport (DSM)?

    Des Moines Airport (DSM) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:
    • Hertz
    • Payless
    • Budget
    • Alamo
    • Avis

  • How much should I expect to pay for a Greenville to Des Moines flight?

    Round-trip flights from Greenville to Des Moines range from $357 to $506, with an average of $406 over the past 12 months. Anything below $357 counts as a good deal.

Your guide to booking Greenville to Des Moines flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Saturday departure instead of Monday. On this route, Saturday flights average $314 - about $315 less than Monday (50% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Greenville to Des Moines trip for November. Fares historically average $314 round-trip in that month - typically $503 less than the most expensive month, which is March (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Des Moines Airport.
    - Days Inn & Suites by Wyndham Des Moines Airport
    - Quality Inn & Suites Des Moines Airport
    - Holiday Inn Des Moines-Airport/Conf Center By IHG

More options for your flight from Greenville to Des Moines

Complete your trip to Des Moines with a hotel stay or car rental

Car rentals in Des Moines
Hotels in Des Moines
Vacations in Des Moines