GSP - DSM

$169 Find Cheap Flights from Greenville to Des Moines

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Greenville to Des Moines departing on 4/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Des Moines

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Greenville to Des Moines, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Greenville to Des Moines, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$328
Overall average: $386
American Airlines
Sat 5/9Tue 5/12
GSP - DSM • 1 stop
Cheapest one-way
$169
Typical prices: $195-$283
American Airlines
Wed 4/15
GSP - DSM • 1 stop
Top airlines
Cheapest • from $328 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Greenville and Des Moines. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $367 (round-trip)
Shortest trip • 4h 29m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 34% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Des Moines!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Greenville to Des Moines (GSP-DSM)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Greenville to Des Moines that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Greenville to Des Moines

Sat, May 9 - Tue, May 12
American Airlines Logo
6:30 am - 1:20 pm
GSP
-
DSM
7h 50m
1 stop
American Airlines Logo
1:38 pm - 9:13 pm
DSM
-
GSP
6h 35m
1 stop
$328American Airlines
Sat, May 9 - Tue, May 12
American Airlines Logo
6:31 am - 11:10 am
GSP
-
DSM
5h 39m
1 stop
American Airlines Logo
8:56 am - 4:50 pm
DSM
-
GSP
6h 54m
2 stops
$333American Airlines
Sat, May 9 - Tue, May 12
American Airlines Logo
6:30 am - 1:20 pm
GSP
-
DSM
7h 50m
1 stop
American Airlines Logo
2:16 pm - 7:46 pm
DSM
-
GSP
4h 30m
1 stop
$337American Airlines
Sat, May 9 - Tue, May 12
American Airlines Logo
7:02 am - 1:46 pm
GSP
-
DSM
7h 44m
2 stops
American Airlines Logo
8:56 am - 4:50 pm
DSM
-
GSP
6h 54m
2 stops
$338American Airlines
Sat, May 9 - Tue, May 12
American Airlines Logo
7:02 am - 1:46 pm
GSP
-
DSM
7h 44m
2 stops
American Airlines Logo
1:38 pm - 9:13 pm
DSM
-
GSP
6h 35m
1 stop
$342American Airlines
Sat, May 9 - Tue, May 12
American Airlines Logo
7:02 am - 1:46 pm
GSP
-
DSM
7h 44m
2 stops
American Airlines Logo
8:56 am - 4:50 pm
DSM
-
GSP
6h 54m
2 stops
$347American Airlines
Tue, Apr 7 - Tue, Apr 14
American Airlines Logo
5:12 pm - 11:16 pm
GSP
-
DSM
7h 04m
1 stop
American Airlines Logo
11:09 am - 7:46 pm
DSM
-
GSP
7h 37m
1 stop
$356American Airlines
Tue, Apr 7 - Tue, Apr 14
American Airlines Logo
12:35 pm - 8:21 pm
GSP
-
DSM
8h 46m
1 stop
American Airlines Logo
1:25 pm - 9:13 pm
DSM
-
GSP
6h 48m
2 stops
$361American Airlines
Tue, Apr 7 - Tue, Apr 14
Southwest Logo
5:05 pm - 10:10 pm
GSP
-
DSM
6h 05m
2 stops
Southwest Logo
5:30 am - 4:20 pm
DSM
-
GSP
9h 50m
2 stops
$366Southwest
Thu, May 7 - Sun, May 10
Multiple Airlines Logo
7:51 pm - 1:13 pm
GSP
-
DSM
18h 22m
1 stop
Multiple Airlines Logo
2:51 pm - 4:53 pm
DSM
-
GSP
25h 02m
2 stops
$381Multiple Airlines
Booking Insights

KAYAK's insights & trends for Greenville to Des Moines flights

Get data-powered insights and trends into flights from Greenville to Des Moines to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Greenville to Des Moines?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Greenville to Des Moines, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Greenville to Des Moines is October, where tickets cost $296 (return) on average. On the other hand, the most expensive months are March and December, where the average cost of round-trip tickets is $786 and $629 respectively.

Good to know

Low seasonJanuary
Cheapest flight$169
Best time to beat the crowds with an average 14% drop in price.
Most popular time to fly and prices are also 4% lower on average.
Flight from Greenville to Des Moines

When to book flights from Greenville to Des Moines

Are your dates flexible? Find out the best times to travel from Greenville to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Greenville to Des Moines

  • What is the cheapest flight from Greenville to Des Moines?

    In the last 3 days, the lowest price for a flight from Greenville to Des Moines was $169 for a one-way ticket and $328 for a round-trip.

  • Do I need a passport to fly between Greenville and Des Moines?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which airports will I be using when flying from Greenville to Des Moines?

    When flying out of Greenville you will be using Greenville. You will be landing at Des Moines, also known as Des Moines.

  • Which aircraft models fly most regularly from Greenville to Des Moines?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Greenville to Des Moines?

    Star Alliance, oneworld, and SkyTeam are the airline alliances operating flights between Greenville and Des Moines, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from Greenville to Des Moines, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from Greenville to Des Moines are Delta and United Airlines. With an average price for the route of $376 and an overall rating of 7.9, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $571 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from Greenville to Des Moines?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Greenville to Des Moines.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Greenville to Des Moines?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Des Moines from Greenville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Greenville to Des Moines?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Des Moines with an airline and back to Greenville with another airline. Booking your flights between Greenville and DSM can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Greenville to Des Moines?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Des Moines from Greenville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Greenville to Des Moines

 
See real verified KAYAK customer reviews for airlines flying from Greenville to Des Moines. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Greenville to Des Moines? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8288 reviews
8.1Boarding
7.9Comfort
7.8Entertainment
8.5Crew
7.2Food
Airline reviews

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

10.0 ExcellentDebra, Mar 2026
PBI - ATL
Read more Delta reviews

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

First class is comfortable. Enjoyed a movie and was able to relax compared to coach.

Loved flying First Class. Very comfortable. The seat was amazing. Enjoyed a movie and was able to relax so much better than in coach.

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

The WiFi was not working. That made for a long flight.

Absolutely no communication on why there's a delay and multiple flight time reschedules. I would have canceled the flight and drove back home if I known it was going to be rescheduled 3 or 4 times.

Another late night flight and MORE men belligerently drinking and yelling. I had to move from first to economy because they were so obnoxious and disruptive. Crazy to go from a cozy chair to cardboard when you were supposed to be in first. Delta allows was too much drinking which leads to belligerent behavior.

I was in first class and literally the men behind me were so aggressively loud I moved myself to economy. This has become so common on Delta - people using audio without headphones, and men on 12am / late night flights drinking and yelling to talk to each other which prevents anyone around them from resting. Pretty crazy to have to move from first to economy (poorer service, less comfort...). Wild wild. Looking into other airlines.

Love delta smaller commuter plane so no entertainment and paid wifi on MKE-LGA leg was extremely unreliable and slow

Stop changing gates. Stop cancelling flights Stop moving my seat.

United is one airline which regardless of how many separate United tickets in existence, if one flight breaks down, the airline will take care of all the flights.

Both our flights were delayed. Almost didn’t get in the second flight. Staff was rude to the bone.

Both my flight where delayed Had 25min to make it to my transfer flight

Everything was on time and service on the flight was great!

Wifi Bluetooth features for watching in flight movie was horrible. Screen kept blacking out no connection of sound although it said connected. Other than that smooth trip .

The travel company that you have on your site did me so wrong. I don’t know how it happened, but they put my son‘s name on my plane ticket flying to Vietnam. Along with his birthday. They would not have let me fly from Fort Myers to Ho Chi Minh City. I don’t think that I can ever use your service again. I typed my information into the browser along with my passport number and four days before I’m leaving I have to quickly search another ticket to fly out here.

Seats are uncomfortable. This has been a trend in the industry for decades. Trying to fit more seats on each plane to increase profits at the expense of the passenger.

The flight was delayed so we were dead tired, and after that the turbulence was horrible. I was very scared.

It’s always a great time flying with united airlines.

Good flight. Efficient boarding and competent flight crew. No problems until we arrived at our destination gate. We were early so there was an aircraft at the gate that had to move before we could pull in. Then, due to the type of aircraft we flew, the cabin door could not be opened until some luggage from the cargo bay was offloaded to preserve center of gravity characteristics. So, that further delayed deplaning. Despite being 20 minutes early on landing, we ended up being 5 to 10 minutes late after all the delays.

Delay after delay with little communication then AA lost my luggage and at airport would not assist just said scan this QR code to track your luggage and submit a claim. However QR code provided did not work so have to go back to airport

After changing the departure gate 5 times making us mo e from one side of the airport to the other and then back the flight was delayed nearly 2 hours. The male flight attendant had a bad attitude with the guest being condescending, disrespectful with people who were already on edge.

Easy boarding. Rows are smaller but that may be an older and bigger me now :)

It would have been nice if American tried to care.

American Airlines did everything they could with the high Spring Break crowd. I was frustrated to be changed from 1st class to a middle seat at the back of the plane. This has happened before, not sure booking 1st class and paying the extra actually works.

I booked 1st class, my flights were changed and I was sitting in the middle at the back of the plane. A far cry from the 1st class I purchased for my flights. I am grateful I arrived on time.

There was no beverage service and the only time I saw a crew member walk through the cabin is when we were preparing to land.

Our flight was delayed 3 times and this is why I am giving such low reviews. Everything else was okay but being in the airport at 4:30pm for my initial flight at 7pm to not leave until after 9:30pm is insane,

Flights were constantly delayed. CRW took 50 minutes to get bags

Flight has been delayed every time I've ever taken it. Seats uncomfortable. Children behind me yelling the entire flight. Some of this is out of their control but overall just consistently not a great experience.

Everything you need to know for your flight from Greenville to Des Moines

Information on your arrival and departure airports