GSP - DSM

$138 Find Cheap Flights from Greenville to Des Moines - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Greenville to Des Moines departing on 10/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$297
Typical prices: $338-$426
Multiple Airlines
Thu 9/10Mon 9/14
GSP - DSM • 1 stop
Cheapest one-way
$138
Multiple Airlines
Thu 10/1
GSP - DSM • 1 stop
Top airlines
Cheapest • from $325 (round-trip)
Best reviews • 7.8 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Greenville and Des Moines. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $447 (round-trip)
Shortest trip • 4h 46m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 34% price drop
Most popular
Good to know
Good to know
+1
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Good to know
Good to know
+1
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We hope you love your trip to Des Moines!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Greenville to Des Moines (GSP-DSM)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Greenville to Des Moines that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Greenville to Des Moines

Thu, Sep 10 - Mon, Sep 14
Multiple Airlines Logo
7:59 pm - 10:08 pm
GSP
-
DSM
27h 09m
1 stop
Multiple Airlines Logo
10:24 am - 6:10 pm
DSM
-
GSP
6h 46m
1 stop
$297Multiple Airlines
Wed, Aug 19 - Mon, Aug 24
American Airlines Logo
8:10 am - 12:24 pm
GSP
-
DSM
5h 14m
1 stop
American Airlines Logo
2:21 pm - 9:27 pm
DSM
-
GSP
6h 06m
1 stop
$325American Airlines
Wed, Aug 19 - Sat, Aug 22
American Airlines Logo
5:11 pm - 11:44 pm
GSP
-
DSM
7h 33m
1 stop
American Airlines Logo
8:10 am - 2:47 pm
DSM
-
GSP
5h 37m
1 stop
$325American Airlines
Wed, Aug 26 - Mon, Aug 31
American Airlines Logo
7:39 am - 1:25 pm
GSP
-
DSM
6h 46m
1 stop
American Airlines Logo
8:10 am - 1:05 pm
DSM
-
GSP
3h 55m
1 stop
$325American Airlines
Wed, Aug 19 - Mon, Aug 24
United Airlines Logo
7:00 am - 2:16 pm
GSP
-
DSM
8h 16m
2 stops
United Airlines Logo
1:21 pm - 9:07 pm
DSM
-
GSP
6h 46m
1 stop
$330United Airlines
Wed, Aug 26 - Mon, Aug 31
United Airlines Logo
5:43 pm - 9:23 pm
GSP
-
DSM
4h 40m
1 stop
United Airlines Logo
6:00 am - 2:19 pm
DSM
-
GSP
7h 19m
2 stops
$330United Airlines
Wed, Aug 19 - Mon, Aug 24
Southwest Logo
11:00 am - 9:00 pm
GSP
-
DSM
11h 00m
2 stops
Southwest Logo
5:40 am - 12:30 pm
DSM
-
GSP
5h 50m
2 stops
$335Southwest
Wed, Aug 26 - Mon, Aug 31
Southwest Logo
7:00 am - 1:55 pm
GSP
-
DSM
7h 55m
2 stops
Southwest Logo
5:40 am - 4:05 pm
DSM
-
GSP
9h 25m
2 stops
$335Southwest
Fri, Sep 25 - Mon, Sep 28
Delta Logo
6:25 pm - 10:26 pm
GSP
-
DSM
5h 01m
1 stop
Delta Logo
11:31 am - 5:20 pm
DSM
-
GSP
4h 49m
1 stop
$358Delta
Fri, Sep 25 - Mon, Sep 28
Delta Logo
6:25 pm - 10:26 pm
GSP
-
DSM
5h 01m
1 stop
Delta Logo
11:31 am - 5:20 pm
DSM
-
GSP
4h 49m
1 stop
$378Delta
Booking Insights

KAYAK's insights & trends for Greenville to Des Moines flights

Get data-powered insights and trends into flights from Greenville to Des Moines to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Greenville to Des Moines?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Greenville to Des Moines, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Greenville to Des Moines is October, where tickets cost $326 (return) on average. On the other hand, the most expensive months are March and July, where the average cost of round-trip tickets is $817 and $634 respectively.

Good to know

Low season

January

Cheapest flight

$138
Best time to beat the crowds with an average 21% drop in price.
Most popular time to fly and prices are also 18% lower on average.
Flight from Greenville to Des Moines

When to book flights from Greenville to Des Moines

Are your dates flexible? Find out the best times to travel from Greenville to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Greenville to Des Moines

  • What is the cheapest flight from Greenville to Des Moines?

    In the last 5 days, the lowest price for a flight from Greenville to Des Moines was $138 for a one-way ticket and $297 for a round-trip.

  • Do I need a passport to fly between Greenville and Des Moines?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which airports will I be using when flying from Greenville to Des Moines?

    When flying out of Greenville you will be using Greenville. You will be landing at Des Moines, also known as Des Moines.

  • Which aircraft models fly most regularly from Greenville to Des Moines?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Greenville to Des Moines?

    Star Alliance, oneworld, and SkyTeam are the airline alliances operating flights between Greenville and Des Moines, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from Greenville to Des Moines, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from Greenville to Des Moines are Delta and United Airlines. With an average price for the route of $401 and an overall rating of 7.8, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $541 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from Greenville to Des Moines?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Greenville to Des Moines.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Greenville to Des Moines?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Des Moines from Greenville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Greenville to Des Moines?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Des Moines with an airline and back to Greenville with another airline. Booking your flights between Greenville and DSM can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Greenville to Des Moines?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Des Moines from Greenville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Greenville to Des Moines

 
See real verified KAYAK customer reviews for airlines flying from Greenville to Des Moines. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Greenville to Des Moines? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8497 reviews
7.8Entertainment
8.1Boarding
8.5Crew
7.2Food
7.8Comfort
Airline reviews

Comfortable seats. Nice service online. Short flight, so not a lot of time to enjoy.

8.0 ExcellentMichael, Jul 2026
SEA - SMF
Read more Delta reviews

Comfortable seats. Nice service online. Short flight, so not a lot of time to enjoy.

Awful. There was an unexpected delay of nearly three hours because there were not enough flight attendants. I understand this is likely due to FAA regulations; but in that case, Delta should coordinate with smaller airports such as RDU to have extra flight attendants on the ground and "on call". In addition, this was the second 2-hour+ delay to Boston on this route in one week.

Delta staff was exceptionally helpful and considerate. However, the first two of three flight legs were delayed making connections tentative and stressful.

This wasn't my experience with Delta. It was just the Pegasus flight. Seats were very hard. Staff was kinda rough. Not very nice. Charged me for snacks. For a 4 hour flight I would've expected more.

I had a flight cancel and had it rerouted. When the rerouted they put me at a window seat instead of an isle. It was hard sitting by the window because the couple with masks on were making out. I get motion sickness which is why I need to have the isle seat.

They ended up paying for the bag twice, but the counter wouldn't take my baggage receipt. Left it to me to resolve. Not sure how to resolve the issue.

The plane was old with small storage areas that had problems closing/latching and not enough storage for everyone, and worn, damaged seats. Service was great but feel a little unsafe on such well used planes.

I just can’t understand why are you sell to many tickets ???? We had to wait 2 hours before 13 people from our flight take money and go to next day flight!

The only real hiccups in the flight were things beyond Delta’s control - turbulence which delayed food service and a departure delay caused by some VIP plane which stopped all departures and landings for 30 minutes - and was never explained to us by the crew. Otherwise good flight. I would fly Delta again.

The plane was frigid, and leaked water from the ceiling all over me and my seat.

Even through the flight was delayed due to storms near IAH The flight was great! The crew was so hospitable and professional

A long delay. Don't travel late in the day.

The seat was comfortable. There was a lot of turbulence. If it weren't for that,it would have been okay.

United Airlines is my preferred airlines and I am thankful for Gary who also help support me on the phone to switch my flight literally last min.

The flight was on time. I generally don’t drink or eat on short flights and the seats were good and the flight attendants were friendly. That’s all I expect

It was great, I’m very grateful for the pilots and crew flight attendants for everything.

The attendant were friendly. I suggest you have a medical attendant on board every flight so that in case someone is sick , he/she will help them.

Flight was great. Efficient boarding. Short flight. Early arrival. Friendly flight crew. The entertainment system did not work well. Could not access it until the aircraft reached 10K feet or more. Lots of glitches.

No food service almost missed because of first flight delays

The flight and boarding were easy peasy. I was traveling with my 4-year-old, so a smooth boarding experience was especially appreciated. My only piece of feedback is really about where our gate was in O'Hare. They've shoved four gates into a tiny corner of the B terminal and there isn't early enough room or seating for everyone. Not United's problem, but did dent the overall experience.

Very good I can’t complain one bit. Thank you American Airlines for making my flight enjoyable and safe!

Flight was fine, but not having WiFi was a major negative

Everything was excellent and I enjoyed myself. Thank for everything

One of our group members was struggling to walk. In Charlotte we asked for a wheelchair and she was accompanied by Desmond. I was impressed by his patience and attention. In Boston she received the same service. I didn’t get the name of the helper but she went above and beyond in assisting us. A great AA service

The boarding by groups is pointless. The first two groups worked fine, but almost Noone boarded in goups three thru five leaving the vast majority boarding when group six was called. It defeated the purpose of spreading out the crowd.

I blame kayak for my last trip to dca. Kayak cancelled my direct flight and put on a one stop flight and made lost whole day from my vacation and had not even refunded my ticket.

When my flight was delayed due to weather, I was rebooked to another flight since it showed that I would miss my connection. It was a lot of work to get back onto my originally connecting flight which was also delayed. That part caused a lot of stress and frustration. The ticketing agent at the desk was not very helpful.

delayed multiple times. no resolution on anything from AA customer service. was put on hold in chat to talk to manager. was 6th in line to talk to manager for more than TWELVE HOURS - from sometime around 9AM until well after I had gone to bed that evening. no explanation, no attempt to make it right. just a five hour delay because of repeated maintenance claims

Was the most uncomfortable I ever had in the air. Felt like I was trapped in the seat legs cramped and was just horrible. The flight to DSM was a lot better. Even being on a smaller plane was better. Staff are outstanding. No complaints about the people.

It was exactly as I expected, on time, smooth flight, courteous staff.

Everything you need to know for your flight from Greenville to Des Moines

Information on your arrival and departure airports