GSP - DSM

$141 Find Cheap Flights from Greenville to Des Moines - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$281
Typical prices: $374-$572
American Airlines
Sun 11/25Sun 12/2
GSP - DSM • 1 stop
Cheapest one-way
$141
Typical prices: $202-$410
American Airlines
Sun 11/25
GSP - DSM • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Greenville and Des Moines. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
September
Cheapest • 23% price drop
August
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Chicago O'Hare Intl (ORD)
Cheapest • Avg $410 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 4h 40m (one-way)
Insights
Insights
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Booking Insights
Flight Deals

Cheap Flights from Greenville to Des Moines (GSP-DSM)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Greenville to Des Moines

Wed, Nov 25 - Wed, Dec 2
American Airlines Logo
8:35 pm - 12:26 amGSP  Greenville-DSM Des Moines
4h 51m1 stop Charlotte Douglas
American Airlines Logo
11:09 am - 4:45 pmDSM  Des Moines-GSP Greenville
4h 36m1 stop Charlotte Douglas
$281American Airlines
Wed, Dec 2 - Wed, Dec 2
American Airlines Logo
6:27 am - 10:20 amGSP  Greenville-DSM Des Moines
4h 53m1 stop Charlotte Douglas
American Airlines Logo
3:31 pm - 9:52 pmDSM  Des Moines-GSP Greenville
5h 21m1 stop Dallas/Fort Worth
$281American Airlines
Wed, Dec 2 - Tue, Dec 8
Delta Logo
5:40 am - 10:53 amGSP  Greenville-DSM Des Moines
6h 13m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:30 am - 6:30 pmDSM  Des Moines-GSP Greenville
7h 00m1 stop Detroit Metropolitan Wayne County
$281Delta
Wed, Dec 9 - Sat, Dec 12
United Airlines Logo
6:30 am - 10:37 amGSP  Greenville-DSM Des Moines
5h 07m1 stop Chicago O'Hare Intl
United Airlines Logo
3:20 pm - 8:59 pmDSM  Des Moines-GSP Greenville
4h 39m1 stop Chicago O'Hare Intl
$281United Airlines
Wed, Dec 2 - Tue, Dec 8
United Airlines Logo
5:34 pm - 9:25 pmGSP  Greenville-DSM Des Moines
4h 51m1 stop Chicago O'Hare Intl
United Airlines Logo
11:27 am - 11:40 pmDSM  Des Moines-GSP Greenville
11h 13m2 stops Chicago O'Hare Intl Newark
$286United Airlines
Wed, Dec 9 - Sat, Dec 12
Southwest Logo
2:50 pm - 10:05 pmGSP  Greenville-DSM Des Moines
8h 15m2 stops Baltimore/Washington Chicago Midway
Southwest Logo
7:00 am - 6:10 pmDSM  Des Moines-GSP Greenville
10h 10m2 stops Denver Intl Nashville Intl
$291Southwest
Wed, Dec 2 - Tue, Dec 8
Southwest Logo
2:50 pm - 10:05 pmGSP  Greenville-DSM Des Moines
8h 15m2 stops Baltimore/Washington Chicago Midway
Southwest Logo
7:00 am - 6:10 pmDSM  Des Moines-GSP Greenville
10h 10m2 stops Denver Intl Nashville Intl
$291Southwest
Tue, Nov 24 - Tue, Dec 1
American Airlines Logo
8:35 pm - 12:26 amGSP  Greenville-DSM Des Moines
4h 51m1 stop Charlotte Douglas
American Airlines Logo
3:25 pm - 10:03 pmDSM  Des Moines-GSP Greenville
5h 38m1 stop Dallas/Fort Worth
$325American Airlines
Sat, Nov 21 - Fri, Nov 27
Delta Logo
4:46 pm - 10:35 pmGSP  Greenville-DSM Des Moines
6h 49m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:30 am - 1:15 pmDSM  Des Moines-GSP Greenville
6h 45m1 stop Atlanta Hartsfield-Jackson
$380Delta
Sat, Nov 21 - Fri, Nov 27
Delta Logo
4:46 pm - 10:35 pmGSP  Greenville-DSM Des Moines
6h 49m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:30 am - 1:15 pmDSM  Des Moines-GSP Greenville
6h 45m1 stop Atlanta Hartsfield-Jackson
$440Delta
Booking Insights

Price, demand and travel trends for Greenville to Des Moines flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Greenville to Des Moines?

Round-trip flights from Greenville to Des Moines typically range from $374 to $572. The lowest price found in the past 5 days was $281, on American Airlines.

What’s the cheapest month to fly from Greenville to Des Moines?

•September is the cheapest month to fly from Greenville to Des Moines at $311 round-trip.
•March ($817) and July ($634) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 162% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for Greenville to Des Moines flights

Low season

February

Cheapest flight

$141
Beat the crowds with an average 22% drop in travelers.
The most popular month to fly with an average 33% increase in travelers.
One-way flight from Greenville to Des Moines

When to book flights from Greenville to Des Moines

Are your dates flexible? Find out the best times to travel from Greenville to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Greenville to Des Moines flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Greenville to Des Moines?

    Two cabin classes are available on flights from Greenville to Des Moines:

    • Economy Class
    • First Class

  • How long is a flight from Greenville to Des Moines?

    A nonstop flight from Greenville to Des Moines takes 00m, covering 771 miles.

  • Do I need a passport to fly from Greenville to Des Moines?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Greenville to Des Moines flight?

    Round-trip flights from Greenville to Des Moines range from $374 to $572, with an average of $401 over the past 12 months. Anything below $374 counts as a good deal.

  • Have flight prices from Greenville to Des Moines changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $281 to $1,538. That means the highest observed fare was about 5x higher than the lowest one.

  • How are flight prices from Greenville to Des Moines looking right now?

    One-way fares from Greenville to Des Moines are currently lower than usual. Average one-way flight prices are about $237, which is 11% below the typical average for this route.

  • What car rental options are available at Des Moines Airport (DSM)?

    Des Moines Airport (DSM) hosts 5 major car rental companies, with daily rates averaging $81 for economy cars. Top options include:

    • Hertz
    • Payless
    • Budget
    • Alamo
    • Avis

  • Which airports can I use when flying from Greenville to Des Moines?

    Flights from Greenville to Des Moines usually depart from Greenville (GSP) and arrive at Des Moines (DSM).

  • Which airports do connecting flights from Greenville to Des Moines pass through?

    One-stop flights from Greenville to Des Moines most commonly connect through:

    • Chicago O'Hare Intl (ORD) - 45% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 39% of one-stop connections
    • Charlotte Douglas (CLT) - 12% of one-stop connections
    • Dallas/Fort Worth (DFW) - 2% of one-stop connections

  • Can I save money by using flexible dates for flights from Greenville to Des Moines?

    Yes. Flexible dates can save you up to 51% on flights from Greenville to Des Moines. Saturday is the cheapest departure day at $314 round-trip on average, while Monday is the most expensive at $629, a difference of $315.

    Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

  • How much time can I save by choosing a different layover airport from Greenville to Des Moines?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 40m, compared with 5h 04m via Charlotte Douglas (CLT) and 5h 06m via Chicago O'Hare Intl (ORD).

  • What is the time difference between Greenville and Des Moines?

    Des Moines is 1 hour behind Greenville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in Des Moines?

    Some of the most popular sights in Des Moines are UnityPoint Health - Des Moines, Science Center of Iowa and Hy Vee Hall. These are among the most viewed places in Des Moines on KAYAK.

Your guide to booking Greenville to Des Moines flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Saturday departure and avoid flying on Monday. On this route, Saturday flights average $314, about $315 less than Monday fares (50% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Greenville to Des Moines trip for September. Fares historically average $311 round-trip in that month - typically $506 less than the most expensive month, which is March (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Des Moines Airport.

    • Days Inn & Suites by Wyndham Des Moines Airport
    • Quality Inn & Suites Des Moines Airport
    • Holiday Inn Des Moines-Airport/Conf Center By IHG

More options for your flight from Greenville to Des Moines

Complete your trip to Des Moines with a hotel stay or car rental

Car rentals in Des Moines
Hotels in Des Moines
Vacations in Des Moines