Which airports can I use when flying from Des Moines to Greenville?

Flights from Des Moines to Greenville usually depart from Des Moines (DSM) and arrive at Greenville (GSP).

What cabin classes can I book on flights from Des Moines to Greenville?

Only Economy Class is available on flights from Des Moines to Greenville.

Which airports do connecting flights from Des Moines to Greenville pass through?

One-stop flights from Des Moines to Greenville most commonly connect through: • Charlotte Douglas (CLT) - 35% of one-stop connections • Chicago O'Hare Intl (ORD) - 33% of one-stop connections • Atlanta Hartsfield-Jackson (ATL) - 17% of one-stop connections • Washington, D.C. Reagan-National (DCA) - 8% of one-stop connections

Can I save money by using flexible dates for flights from Des Moines to Greenville?

Yes. Flexible dates can save you up to 49% on flights from Des Moines to Greenville. Saturday is the cheapest departure day at $320 round-trip on average, while Monday is the most expensive at $626, a difference of $306. Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

How long is a flight from Des Moines to Greenville?

A nonstop flight from Des Moines to Greenville takes 00m, covering 771 miles.

Do I need a passport to fly from Des Moines to Greenville?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

Have flight prices from Des Moines to Greenville changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $325 to $1,463. That means the highest observed fare was about 5x higher than the lowest one.

How are flight prices from Des Moines to Greenville looking right now?

One-way fares from Des Moines to Greenville are currently higher than usual. Average one-way flight prices are about $344, which is 51% above the typical average for this route.

How much time can I save by choosing a different layover airport from Des Moines to Greenville?

Flying via Charlotte Douglas (CLT) gives the shortest average 1-stop total travel time at 4h 48m, compared with 4h 51m via Atlanta Hartsfield-Jackson (ATL) and 5h 08m via Chicago O'Hare Intl (ORD).

What is the time difference between Des Moines and Greenville?

Greenville is 1 hour ahead of Des Moines (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

What car rental options are available at Greenville Airport (GSP)?

Greenville Airport (GSP) hosts 5 major car rental companies, with daily rates starting from around $30 for economy cars. Top options include: • Budget • Alamo • Thrifty • Enterprise Rent-A-Car • Avis

How much should I expect to pay for a Des Moines to Greenville flight?

Round-trip flights from Des Moines to Greenville range from $369 to $502, with an average of $387 over the past 12 months. Anything below $369 counts as a good deal.

Which airline is the cheapest to fly from Des Moines to Greenville?

American Airlines ($325) and Allegiant Air ($325) are the cheapest airlines to fly round-trip from Des Moines to Greenville according to KAYAK data over the last 5 days.

What’s the most popular layover airport when flying from Des Moines to Greenville?

Charlotte Douglas (CLT) is the most popular layover for the Des Moines to Greenville route. 35% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via CLT.

What is the cheapest layover airport when flying from Des Moines to Greenville?

Flights via Dallas/Fort Worth (DFW) offer the most affordable fares, with an average round-trip price of $361. Based on KAYAK data over the past 3 months.

When flying from Des Moines to Greenville which airport offers the shortest layover?

Charlotte Douglas (CLT) had the shortest average connection time for Des Moines to Greenville layovers at 3h 04m over the past 3 months.

$229 CHEAP FLIGHTS from Des Moines to Greenville (DSM - GSP)

Save 21% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$325

Typical prices: $369-$502

American Airlines

Sun 12/9Wed 12/12

DSM - GSP • 1 stop

Cheapest one-way

$339

Typical prices: $203-$243

American Airlines

Sat 10/6

DSM - GSP • 1 stop

Nonstop flights

Not available

There are currently no direct flights between Des Moines and Greenville. You'll need to take a connecting flight to reach the destination.

Insights

When to travel

October

Cheapest • 21% price drop

January

Most popular

Good to know

Top layover airports

Dallas/Fort Worth (DFW)

Cheapest • Avg $361 (round-trip)

Charlotte Douglas (CLT)

Shortest trip • 4h 48m (one-way)

Insights

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KAYAK searches 100s of sites at once to find you the best travel deals.

We hope you love your trip to Greenville!

Flight Deals

Cheap Flights from Des Moines to Greenville (DSM-GSP)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Recent round-trip flight deals from Des Moines to Greenville

Wed, Dec 9 - Sat, Dec 12

6:00 am - 2:50 pmDSM Des Moines-GSP Greenville

7h 50m1 stop Washington, D.C. Reagan-National

5:17 pm - 11:30 pmGSP Greenville-DSM Des Moines

7h 13m1 stop Dallas/Fort Worth

$325American Airlines

Mon, Nov 2 - Tue, Nov 3

7:23 am - 4:07 pmDSM Des Moines-GSP Greenville

7h 44m1 stop Chicago O'Hare Intl

7:51 am - 2:39 pmGSP Greenville-DSM Des Moines

7h 48m1 stop Dallas/Fort Worth

$325American Airlines

Fri, Oct 9 - Tue, Oct 13

7:57 pm - 1:40 pmDSM Des Moines-GSP Greenville

16h 43m1 stop Orlando Sanford Intl

10:44 am - 11:55 amGSP Greenville-DSM Des Moines

26h 11m1 stop Orlando Sanford Intl

$325Allegiant Air

Sun, Jan 31 - Thu, Feb 11

2:09 pm - 12:56 pmDSM Des Moines-GSP Greenville

21h 47m1 stop Fort Lauderdale

5:47 pm - 2:39 pmGSP Greenville-DSM Des Moines

21h 52m1 stop Tampa St. Petersburg

$334Allegiant Air

Wed, Dec 9 - Sat, Dec 12

7:00 am - 6:10 pmDSM Des Moines-GSP Greenville

10h 10m2 stops Denver Intl Nashville Intl

10:50 am - 7:40 pmGSP Greenville-DSM Des Moines

9h 50m2 stops Nashville Intl Chicago Midway

$335Southwest

Sun, Jan 31 - Sat, Feb 13

9:37 am - 4:54 pmDSM Des Moines-GSP Greenville

6h 17m1 stop Chicago O'Hare Intl

6:30 am - 10:20 amGSP Greenville-DSM Des Moines

4h 50m1 stop Chicago O'Hare Intl

$371United Airlines

Thu, Dec 17 - Sun, Dec 20

2:58 pm - 7:57 pmDSM Des Moines-GSP Greenville

3h 59m1 stop Atlanta Hartsfield-Jackson

12:44 pm - 5:31 pmGSP Greenville-DSM Des Moines

5h 47m1 stop Atlanta Hartsfield-Jackson

$371Delta

Wed, Dec 16 - Sun, Dec 20

2:58 pm - 10:22 pmDSM Des Moines-GSP Greenville

6h 24m1 stop Atlanta Hartsfield-Jackson

12:44 pm - 5:31 pmGSP Greenville-DSM Des Moines

5h 47m1 stop Atlanta Hartsfield-Jackson

$371Delta

Sun, Jan 31 - Sat, Feb 13

8:00 am - 6:50 pmDSM Des Moines-GSP Greenville

9h 50m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

10:50 am - 2:41 pmGSP Greenville-DSM Des Moines

4h 51m1 stop Chicago O'Hare Intl

$376United Airlines

Wed, Dec 9 - Sat, Dec 12

9:25 am - 6:55 pmDSM Des Moines-GSP Greenville

8h 30m2 stops Chicago O'Hare Intl Charlotte Douglas

7:02 am - 1:28 pmGSP Greenville-DSM Des Moines

7h 26m1 stop Chicago O'Hare Intl

$386American Airlines

Recent last minute flight deals from Des Moines to Greenville

Sat, Sep 26 - Tue, Sep 29

7:05 am - 12:41 pmDSM Des Moines-GSP Greenville

4h 36m1 stop Chicago O'Hare Intl

7:47 am - 12:31 pmGSP Greenville-DSM Des Moines

5h 44m1 stop Philadelphia

$677American Airlines

Sat, Sep 26 - Tue, Sep 29

11:27 am - 5:05 pmDSM Des Moines-GSP Greenville

4h 38m1 stop Chicago O'Hare Intl

11:30 am - 9:23 pmGSP Greenville-DSM Des Moines

10h 53m2 stops Newark Chicago O'Hare Intl

$682United Airlines

Sat, Sep 26 - Tue, Sep 29

6:00 am - 2:16 pmDSM Des Moines-GSP Greenville

7h 16m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

2:16 pm - 10:15 pmGSP Greenville-DSM Des Moines

8h 59m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

$687United Airlines

Sat, Sep 26 - Wed, Sep 30

8:03 am - 1:10 pmDSM Des Moines-GSP Greenville

4h 07m1 stop Charlotte Douglas

11:33 am - 5:26 pmGSP Greenville-DSM Des Moines

6h 53m1 stop Chicago O'Hare Intl

$732American Airlines

Thu, Sep 24 - Wed, Sep 30

5:40 am - 3:08 pmDSM Des Moines-GSP Greenville

8h 28m1 stop Denver Intl

4:25 pm - 11:48 pmGSP Greenville-DSM Des Moines

8h 23m1 stop Denver Intl

$732United Airlines

Sat, Sep 26 - Wed, Sep 30

10:35 am - 8:25 pmDSM Des Moines-GSP Greenville

8h 50m2 stops Chicago O'Hare Intl Charlotte Douglas

5:24 pm - 11:12 pmGSP Greenville-DSM Des Moines

6h 48m1 stop Dallas/Fort Worth

$737American Airlines

Thu, Sep 24 - Wed, Sep 30

5:40 am - 12:30 pmDSM Des Moines-GSP Greenville

5h 50m2 stops Chicago Midway Nashville Intl

7:00 am - 1:55 pmGSP Greenville-DSM Des Moines

7h 55m2 stops Nashville Intl Denver Intl

$742Southwest

Sat, Sep 26 - Mon, Sep 28

9:51 am - 4:34 pmDSM Des Moines-GSP Greenville

5h 43m1 stop Dallas/Fort Worth

6:12 am - 1:43 pmGSP Greenville-DSM Des Moines

8h 31m1 stop Washington, D.C. Reagan-National

$787American Airlines

Sat, Sep 26 - Mon, Sep 28

10:57 am - 9:26 pmDSM Des Moines-GSP Greenville

9h 29m2 stops Minneapolis St Paul Detroit Metropolitan Wayne County

6:25 pm - 10:26 pmGSP Greenville-DSM Des Moines

5h 01m1 stop Atlanta Hartsfield-Jackson

$792Delta

Sat, Sep 26 - Mon, Sep 28

5:30 am - 2:55 pmDSM Des Moines-GSP Greenville

8h 25m2 stops Chicago Midway Nashville Intl

1:05 pm - 9:20 pmGSP Greenville-DSM Des Moines

9h 15m2 stops Nashville Intl Denver Intl

$797Southwest

Booking Insights

Price, demand and travel trends for Des Moines to Greenville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from Des Moines to Greenville?

Round-trip flights from Des Moines to Greenville typically range from $369 to $502. The lowest price found in the past 5 days was $325, on American Airlines.

What's the cheapest day of the week to fly from Des Moines to Greenville?

Based on deals KAYAK users found in the last 12 months, Saturday is the cheapest day of the week to fly from Des Moines to Greenville. It’s 18% cheaper than the average day, while Monday is the most expensive, with prices 61% higher.

What’s the cheapest month to fly from Des Moines to Greenville?

•October is the cheapest month to fly from Des Moines to Greenville at $304 round-trip.
•April ($626) and September ($528) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 105% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Low season	September
High season	January
Cheapest flight	$325

Beat the crowds with an average 21% drop in travelers.

The most popular month to fly with an average 136% increase in travelers.

Round-trip flight from Des Moines to Greenville

When to book flights from Des Moines to Greenville

Are your dates flexible? Find out the best times to travel from Des Moines to Greenville based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

What cabin classes can I book on flights from Des Moines to Greenville?
Only Economy Class is available on flights from Des Moines to Greenville.
How long is a flight from Des Moines to Greenville?
A nonstop flight from Des Moines to Greenville takes 00m, covering 771 miles.
Do I need a passport to fly from Des Moines to Greenville?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.
How much should I expect to pay for a Des Moines to Greenville flight?
Round-trip flights from Des Moines to Greenville range from $369 to $502, with an average of $387 over the past 12 months. Anything below $369 counts as a good deal.
Have flight prices from Des Moines to Greenville changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $325 to $1,463. That means the highest observed fare was about 5x higher than the lowest one.
How are flight prices from Des Moines to Greenville looking right now?
One-way fares from Des Moines to Greenville are currently higher than usual. Average one-way flight prices are about $344, which is 51% above the typical average for this route.
What car rental options are available at Greenville Airport (GSP)?
Greenville Airport (GSP) hosts 5 major car rental companies, with daily rates starting from around $30 for economy cars. Top options include:

• Budget
• Alamo
• Thrifty
• Enterprise Rent-A-Car
• Avis
Which airports can I use when flying from Des Moines to Greenville?
Flights from Des Moines to Greenville usually depart from Des Moines (DSM) and arrive at Greenville (GSP).
Which airports do connecting flights from Des Moines to Greenville pass through?
One-stop flights from Des Moines to Greenville most commonly connect through:

• Charlotte Douglas (CLT) - 35% of one-stop connections
• Chicago O'Hare Intl (ORD) - 33% of one-stop connections
• Atlanta Hartsfield-Jackson (ATL) - 17% of one-stop connections
• Washington, D.C. Reagan-National (DCA) - 8% of one-stop connections
Can I save money by using flexible dates for flights from Des Moines to Greenville?
Yes. Flexible dates can save you up to 49% on flights from Des Moines to Greenville. Saturday is the cheapest departure day at $320 round-trip on average, while Monday is the most expensive at $626, a difference of $306.

Cheaper weekend fares like these are typical of routes dominated by weekday business travel.
How much time can I save by choosing a different layover airport from Des Moines to Greenville?
Flying via Charlotte Douglas (CLT) gives the shortest average 1-stop total travel time at 4h 48m, compared with 4h 51m via Atlanta Hartsfield-Jackson (ATL) and 5h 08m via Chicago O'Hare Intl (ORD).
What is the time difference between Des Moines and Greenville?
Greenville is 1 hour ahead of Des Moines (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

If your dates are flexible, aim for a Saturday departure and avoid flying on Monday. On this route, Saturday flights average $320, about $306 less than Monday fares (49% savings) based on the last 12 months.
If you can choose when to travel, plan your Des Moines to Greenville trip for October. Fares historically average $304 round-trip in that month - typically $322 less than the most expensive month, which is April (based on the last 12 months).

More options for your flight from Des Moines to Greenville

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DSM - GSP

$229 Find Cheap Flights from Des Moines to Greenville - Compare and Save

Everything you should know

Cheap Flights from Des Moines to Greenville (DSM-GSP)

Recent round-trip flight deals from Des Moines to Greenville

Recent one-way flight deals from Des Moines to Greenville

Recent last minute flight deals from Des Moines to Greenville

Price, demand and travel trends for Des Moines to Greenville flights

How much is a round-trip flight from Des Moines to Greenville?

What's the cheapest day of the week to fly from Des Moines to Greenville?

What’s the cheapest month to fly from Des Moines to Greenville?

Which airline is the cheapest to fly from Des Moines to Greenville?

What’s the most popular layover airport when flying from Des Moines to Greenville?

What is the cheapest layover airport when flying from Des Moines to Greenville?

When flying from Des Moines to Greenville which airport offers the shortest layover?

Key details for Des Moines to Greenville flights

Low season

High season

Cheapest flight

When to book flights from Des Moines to Greenville

Your Des Moines to Greenville flight questions, answered

Your guide to booking Des Moines to Greenville flights

More options for your flight from Des Moines to Greenville

Complete your trip to Greenville with a hotel stay or car rental

Information on your arrival and departure airports

Cabin class types available on flights from Des Moines to Greenville

Find direct flights to and from Des Moines and Greenville

Flights from domestic origins to Greenville

Flights to other popular destinations

Find deals for your return flight