Which airports can I use when flying from Des Moines to Greenville?

Flights from Des Moines to Greenville usually depart from Des Moines (DSM) and arrive at Greenville (GSP).

What cabin classes can I book on flights from Des Moines to Greenville?

Only Economy Class is available on flights from Des Moines to Greenville.

Which airports do connecting flights from Des Moines to Greenville pass through?

One-stop flights from Des Moines to Greenville most commonly connect through: • Charlotte Douglas (CLT) - 40% of one-stop connections • Chicago O'Hare Intl (ORD) - 36% of one-stop connections • Atlanta Hartsfield-Jackson (ATL) - 9% of one-stop connections • Washington, D.C. Reagan-National (DCA) - 9% of one-stop connections

Can I save money by using flexible dates for flights from Des Moines to Greenville?

Yes. Flexible dates can save you up to 49% on flights from Des Moines to Greenville. Saturday is the cheapest departure day at $320 round-trip on average, while Monday is the most expensive at $626, a difference of $306. Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

How long is a flight from Des Moines to Greenville?

A nonstop flight from Des Moines to Greenville takes 00m, covering 771 miles.

Do I need a passport to fly from Des Moines to Greenville?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

Have flight prices from Des Moines to Greenville changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $325 to $1,614. That means the highest observed fare was about 5x higher than the lowest one.

How are flight prices from Des Moines to Greenville looking right now?

One-way fares from Des Moines to Greenville are currently lower than usual. Average one-way flight prices are about $198, which is 14% below the typical average for this route.

How much time can I save by choosing a different layover airport from Des Moines to Greenville?

Flying via Charlotte Douglas (CLT) gives the shortest average 1-stop total travel time at 4h 43m, compared with 4h 57m via Atlanta Hartsfield-Jackson (ATL) and 5h 05m via Chicago O'Hare Intl (ORD).

What is the time difference between Des Moines and Greenville?

Greenville is 1 hour ahead of Des Moines (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

What car rental options are available at Greenville Airport (GSP)?

Greenville Airport (GSP) hosts 5 major car rental companies, with daily rates averaging $67 for economy cars. Top options include: • Budget • Alamo • Thrifty • Enterprise Rent-A-Car • Avis

How much should I expect to pay for a Des Moines to Greenville flight?

Round-trip flights from Des Moines to Greenville range from $386 to $532, with an average of $390 over the past 12 months. Anything below $386 counts as a good deal.

How much is a round-trip flight from Des Moines to Greenville?

Round-trip flights from Des Moines to Greenville typically range from $386 to $532. The lowest price found in the past 5 days was $325, on American Airlines.

What's the cheapest day of the week to fly from Des Moines to Greenville?

Based on deals KAYAK users found in the last 12 months, Saturday is the cheapest day of the week to fly from Des Moines to Greenville. It’s 18% cheaper than the average day, while Monday is the most expensive, with prices 60% higher.

What’s the cheapest month to fly from Des Moines to Greenville?

•October is the cheapest month to fly from Des Moines to Greenville at $344 round-trip. •August ($756) and April ($626) are the most expensive months. •The price difference between flying in the cheapest and most expensive months is 119% on average. This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Which airline is the cheapest to fly from Des Moines to Greenville?

American Airlines ($325) and United Airlines ($330) are the cheapest airlines to fly round-trip from Des Moines to Greenville according to KAYAK data over the last 5 days.

What’s the most popular layover airport when flying from Des Moines to Greenville?

Charlotte Douglas (CLT) is the most popular layover for the Des Moines to Greenville route. 40% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via CLT.

What is the cheapest layover airport when flying from Des Moines to Greenville?

Flights via Dallas/Fort Worth (DFW) offer the most affordable fares, with an average round-trip price of $361. Based on KAYAK data over the past 3 months.

When flying from Des Moines to Greenville which airport offers the shortest layover?

Charlotte Douglas (CLT) had the shortest average connection time for Des Moines to Greenville layovers at 2h 58m over the past 3 months.

$185 CHEAP FLIGHTS from Des Moines to Greenville (DSM - GSP)

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Never overpay with our price tracking tools.

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Cheapest round-trip

$325

Typical prices: $386-$532

American Airlines

Sun 1/21Tue 1/23

DSM - GSP • 1 stop

Cheapest one-way

$185

Typical prices: $213-$243

American Airlines

Mon 12/31

DSM - GSP • 1 stop

Nonstop flights

Not available

There are currently no direct flights between Des Moines and Greenville. You'll need to take a connecting flight to reach the destination.

Insights

When to travel

October

Cheapest • 12% price drop

February

Most popular

Good to know

Top layover airports

Dallas/Fort Worth (DFW)

Cheapest • Avg $361 (round-trip)

Charlotte Douglas (CLT)

Shortest trip • 4h 43m (one-way)

Insights

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KAYAK searches 100s of sites at once to find you the best travel deals.

We hope you love your trip to Greenville!

Flight Deals

Cheap Flights from Des Moines to Greenville (DSM-GSP)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Recent round-trip flight deals from Des Moines to Greenville

Thu, Jan 21 - Sat, Jan 23

10:57 am - 4:51 pmDSM Des Moines-GSP Greenville

4h 54m1 stop Charlotte Douglas

7:10 am - 2:48 pmGSP Greenville-DSM Des Moines

8h 38m1 stop Dallas/Fort Worth

$325American Airlines

Sat, Jan 23 - Sat, Jan 23

8:07 am - 1:15 pmDSM Des Moines-GSP Greenville

4h 08m1 stop Charlotte Douglas

5:21 pm - 11:03 pmGSP Greenville-DSM Des Moines

6h 42m1 stop Charlotte Douglas

$325American Airlines

Thu, Jan 21 - Sat, Jan 23

12:52 pm - 11:34 pmDSM Des Moines-GSP Greenville

9h 42m2 stops Chicago O'Hare Intl Newark

6:30 am - 12:17 pmGSP Greenville-DSM Des Moines

6h 47m1 stop Chicago O'Hare Intl

$330United Airlines

Thu, Dec 10 - Sun, Dec 13

7:14 am - 4:10 pmDSM Des Moines-GSP Greenville

7h 56m1 stop Chicago O'Hare Intl

5:17 pm - 11:05 pmGSP Greenville-DSM Des Moines

6h 48m1 stop Dallas/Fort Worth

$359American Airlines

Thu, Jan 21 - Sat, Jan 23

6:15 am - 2:22 pmDSM Des Moines-GSP Greenville

7h 07m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

12:35 pm - 9:28 pmGSP Greenville-DSM Des Moines

9h 53m2 stops Newark Chicago O'Hare Intl

$370United Airlines

Thu, Dec 24 - Thu, Dec 31

5:30 am - 10:48 amDSM Des Moines-GSP Greenville

4h 18m1 stop Atlanta Hartsfield-Jackson

6:15 am - 12:41 pmGSP Greenville-DSM Des Moines

7h 26m1 stop Atlanta Hartsfield-Jackson

$379Delta

Thu, Dec 10 - Sun, Dec 13

6:00 am - 6:10 pmDSM Des Moines-GSP Greenville

11h 10m2 stops Chicago Midway Nashville Intl

8:15 am - 11:05 pmGSP Greenville-DSM Des Moines

15h 50m2 stops Baltimore/Washington Chicago Midway

$415Southwest

Fri, Dec 18 - Fri, Jan 1

5:10 am - 9:45 pmDSM Des Moines-GSP Greenville

15h 35m2 stops Chicago Midway Baltimore/Washington

2:50 pm - 10:05 pmGSP Greenville-DSM Des Moines

8h 15m2 stops Baltimore/Washington Chicago Midway

$415Southwest

Mon, Dec 7 - Wed, Dec 9

1:15 pm - 8:59 pmDSM Des Moines-GSP Greenville

6h 44m1 stop Chicago O'Hare Intl

6:30 am - 10:37 amGSP Greenville-DSM Des Moines

5h 07m1 stop Chicago O'Hare Intl

$425United Airlines

Sun, Nov 22 - Sun, Nov 29

6:52 pm - 11:38 pmDSM Des Moines-GSP Greenville

3h 46m1 stop Atlanta Hartsfield-Jackson

7:19 pm - 10:35 pmGSP Greenville-DSM Des Moines

4h 16m1 stop Atlanta Hartsfield-Jackson

$633Delta

Booking Insights

Price, demand and travel trends for Des Moines to Greenville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from Des Moines to Greenville? This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Des Moines to Greenville departing in january.
What's the cheapest day of the week to fly from Des Moines to Greenville?: Based on deals KAYAK users found in the last 12 months, Saturday is the cheapest day of the week to fly from Des Moines to Greenville. It’s 18% cheaper than the average day, while Monday is the most expensive, with prices 60% higher.
What’s the cheapest month to fly from Des Moines to Greenville? KAYAK internal proprietary data takes all prices for each month over the last 12 months for round-trip flights from Des Moines to Greenville, removes the top 0.1% to account for outliers and then takes the median of all values for each month.: •October is the cheapest month to fly from Des Moines to Greenville at $344 round-trip.
•August ($756) and April ($626) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 119% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Low season	October
High season	February
Cheapest flight	$185

Beat the crowds with an average 51% drop in travelers.

The most popular month to fly with an average 40% increase in travelers.

One-way flight from Des Moines to Greenville

When to book flights from Des Moines to Greenville

Are your dates flexible? Find out the best times to travel from Des Moines to Greenville based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

What cabin classes can I book on flights from Des Moines to Greenville?
Only Economy Class is available on flights from Des Moines to Greenville.
How long is a flight from Des Moines to Greenville?
A nonstop flight from Des Moines to Greenville takes 00m, covering 771 miles.
Do I need a passport to fly from Des Moines to Greenville?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.
How much should I expect to pay for a Des Moines to Greenville flight?
Round-trip flights from Des Moines to Greenville range from $386 to $532, with an average of $390 over the past 12 months. Anything below $386 counts as a good deal.
Have flight prices from Des Moines to Greenville changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $325 to $1,614. That means the highest observed fare was about 5x higher than the lowest one.
How are flight prices from Des Moines to Greenville looking right now?
One-way fares from Des Moines to Greenville are currently lower than usual. Average one-way flight prices are about $198, which is 14% below the typical average for this route.
What car rental options are available at Greenville Airport (GSP)?
Greenville Airport (GSP) hosts 5 major car rental companies, with daily rates averaging $67 for economy cars. Top options include:

• Budget
• Alamo
• Thrifty
• Enterprise Rent-A-Car
• Avis
Which airports can I use when flying from Des Moines to Greenville?
Flights from Des Moines to Greenville usually depart from Des Moines (DSM) and arrive at Greenville (GSP).
Which airports do connecting flights from Des Moines to Greenville pass through?
One-stop flights from Des Moines to Greenville most commonly connect through:

• Charlotte Douglas (CLT) - 40% of one-stop connections
• Chicago O'Hare Intl (ORD) - 36% of one-stop connections
• Atlanta Hartsfield-Jackson (ATL) - 9% of one-stop connections
• Washington, D.C. Reagan-National (DCA) - 9% of one-stop connections
Can I save money by using flexible dates for flights from Des Moines to Greenville?
Yes. Flexible dates can save you up to 49% on flights from Des Moines to Greenville. Saturday is the cheapest departure day at $320 round-trip on average, while Monday is the most expensive at $626, a difference of $306.

Cheaper weekend fares like these are typical of routes dominated by weekday business travel.
How much time can I save by choosing a different layover airport from Des Moines to Greenville?
Flying via Charlotte Douglas (CLT) gives the shortest average 1-stop total travel time at 4h 43m, compared with 4h 57m via Atlanta Hartsfield-Jackson (ATL) and 5h 05m via Chicago O'Hare Intl (ORD).
What is the time difference between Des Moines and Greenville?
Greenville is 1 hour ahead of Des Moines (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

If your dates are flexible, aim for a Saturday departure and avoid flying on Monday. On this route, Saturday flights average $320, about $306 less than Monday fares (49% savings) based on the last 12 months.
If you can choose when to travel, plan your Des Moines to Greenville trip for October. Fares historically average $344 round-trip in that month - typically $412 less than the most expensive month, which is August (based on the last 12 months).

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DSM - GSP

$185 Find Cheap Flights from Des Moines to Greenville - Compare and Save

Everything you should know

Cheap Flights from Des Moines to Greenville (DSM-GSP)

Recent round-trip flight deals from Des Moines to Greenville

Recent one-way flight deals from Des Moines to Greenville

Recent last minute flight deals from Des Moines to Greenville

Price, demand and travel trends for Des Moines to Greenville flights

How much is a round-trip flight from Des Moines to Greenville?

What's the cheapest day of the week to fly from Des Moines to Greenville?

What’s the cheapest month to fly from Des Moines to Greenville?

Which airline is the cheapest to fly from Des Moines to Greenville?

What’s the most popular layover airport when flying from Des Moines to Greenville?

What is the cheapest layover airport when flying from Des Moines to Greenville?

When flying from Des Moines to Greenville which airport offers the shortest layover?

Key details for Des Moines to Greenville flights

Low season

High season

Cheapest flight

When to book flights from Des Moines to Greenville

Your Des Moines to Greenville flight questions, answered

Your guide to booking Des Moines to Greenville flights

More options for your flight from Des Moines to Greenville

Complete your trip to Greenville with a hotel stay or car rental

Information on your arrival and departure airports

Cabin class types available on flights from Des Moines to Greenville

Find direct flights to and from Des Moines and Greenville

Flights from domestic origins to Greenville

Flights to other popular destinations

Find deals for your return flight