MDT - DSM

$170 Find Cheap Flights from Harrisburg to Des Moines - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$339
Typical prices: $328-$484
Delta
Wed 12/5Fri 12/14
MDT - DSM • 1 stop
Cheapest one-way
$170
Typical prices: $360-$510
American Airlines
Sun 12/30
MDT - DSM • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Harrisburg and Des Moines. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
December
Cheapest • 28% price drop
September
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Philadelphia (PHL)
Cheapest • Avg $390 (round-trip)
Detroit Metropolitan Wayne County (DTW)
Shortest trip • 4h 30m (one-way)
Insights
Insights
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Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Harrisburg to Des Moines (MDT-DSM)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Harrisburg to Des Moines

Sat, Dec 5 - Mon, Dec 14
Delta Logo
6:00 am - 9:50 amMDT  Harrisburg-DSM Des Moines
4h 50m1 stop Detroit Metropolitan Wayne County
Delta Logo
2:58 pm - 11:48 pmDSM  Des Moines-MDT Harrisburg
7h 50m1 stop Atlanta Hartsfield-Jackson
$339Delta
Sat, Nov 21 - Fri, Nov 27
Delta Logo
5:05 pm - 8:43 pmMDT  Harrisburg-DSM Des Moines
4h 38m1 stop Detroit Metropolitan Wayne County
Delta Logo
6:10 am - 11:29 amDSM  Des Moines-MDT Harrisburg
4h 19m1 stop Detroit Metropolitan Wayne County
$339Delta
Fri, Dec 11 - Sun, Dec 13
United Airlines Logo
6:17 am - 10:37 amMDT  Harrisburg-DSM Des Moines
5h 20m1 stop Chicago O'Hare Intl
United Airlines Logo
3:20 pm - 8:54 pmDSM  Des Moines-MDT Harrisburg
4h 34m1 stop Chicago O'Hare Intl
$339United Airlines
Wed, Dec 2 - Sat, Dec 5
United Airlines Logo
8:19 am - 12:39 pmMDT  Harrisburg-DSM Des Moines
5h 20m1 stop Chicago O'Hare Intl
United Airlines Logo
3:20 pm - 8:54 pmDSM  Des Moines-MDT Harrisburg
4h 34m1 stop Chicago O'Hare Intl
$339United Airlines
Sat, Nov 21 - Thu, Nov 26
Delta Logo
5:05 pm - 8:43 pmMDT  Harrisburg-DSM Des Moines
4h 38m1 stop Detroit Metropolitan Wayne County
Delta Logo
5:30 am - 12:52 pmDSM  Des Moines-MDT Harrisburg
6h 22m1 stop Atlanta Hartsfield-Jackson
$339Delta
Thu, Dec 3 - Sun, Dec 6
United Airlines Logo
8:19 am - 2:14 pmMDT  Harrisburg-DSM Des Moines
6h 55m1 stop Chicago O'Hare Intl
United Airlines Logo
1:15 pm - 8:54 pmDSM  Des Moines-MDT Harrisburg
6h 39m1 stop Chicago O'Hare Intl
$339United Airlines
Sat, Dec 5 - Mon, Dec 14
American Airlines Logo
6:08 am - 1:35 pmMDT  Harrisburg-DSM Des Moines
8h 27m2 stops Philadelphia Chicago O'Hare Intl
American Airlines Logo
7:14 am - 1:37 pmDSM  Des Moines-MDT Harrisburg
5h 23m1 stop Chicago O'Hare Intl
$344American Airlines
Wed, Dec 2 - Sat, Dec 5
American Airlines Logo
3:06 pm - 12:33 amMDT  Harrisburg-DSM Des Moines
10h 27m2 stops Philadelphia Chicago O'Hare Intl
American Airlines Logo
2:05 pm - 7:56 pmDSM  Des Moines-MDT Harrisburg
4h 51m1 stop Chicago O'Hare Intl
$344American Airlines
Wed, Dec 23 - Sun, Jan 3
Allegiant Air Logo
4:23 pm - 8:35 pmMDT  Harrisburg-DSM Des Moines
5h 12m1 stop Nashville Intl
Allegiant Air Logo
3:40 pm - 8:59 amDSM  Des Moines-MDT Harrisburg
16h 19m1 stop Orlando Sanford Intl
$504Allegiant Air
Mon, Nov 9 - Wed, Nov 11
Multiple Airlines Logo
12:10 pm - 10:31 pmMDT  Harrisburg-DSM Des Moines
11h 21m1 stop Orlando Sanford Intl
Multiple Airlines Logo
12:46 pm - 9:09 pmDSM  Des Moines-MDT Harrisburg
31h 23m2 stops Orlando Sanford Intl Nashville Intl
$697Multiple Airlines
Booking Insights

Price, demand and travel trends for Harrisburg to Des Moines flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Harrisburg to Des Moines?

Round-trip flights from Harrisburg to Des Moines typically range from $328 to $484. The lowest price found in the past 5 days was $339, on Delta.

What's the cheapest day of the week to fly from Harrisburg to Des Moines?

Based on deals KAYAK users found in the last 12 months, Wednesday is the cheapest day of the week to fly from Harrisburg to Des Moines. It’s 24% cheaper than the average day, while Monday is the most expensive, with prices 71% higher.

What’s the cheapest month to fly from Harrisburg to Des Moines?

•December is the cheapest month to fly from Harrisburg to Des Moines at $308 round-trip.
•April ($788) and September ($511) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 155% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for Harrisburg to Des Moines flights

Low season

January

Cheapest flight

$170
Beat the crowds with an average 54% drop in travelers.
The most popular month to fly with an average 62% increase in travelers.
One-way flight from Harrisburg to Des Moines

When to book flights from Harrisburg to Des Moines

Are your dates flexible? Find out the best times to travel from Harrisburg to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Harrisburg to Des Moines flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Harrisburg to Des Moines?

    Only Economy Class is available on flights from Harrisburg to Des Moines.

  • How long is a flight from Harrisburg to Des Moines?

    A nonstop flight from Harrisburg to Des Moines takes 00m, covering 886 miles.

  • Do I need a passport to fly from Harrisburg to Des Moines?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Harrisburg to Des Moines flight?

    Round-trip flights from Harrisburg to Des Moines range from $328 to $484, with an average of $428 over the past 12 months. Anything below $328 counts as a good deal.

  • Have flight prices from Harrisburg to Des Moines changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $339 to $1,134. That means the highest observed fare was about 3x higher than the lowest one.

  • How are flight prices from Harrisburg to Des Moines looking right now?

    One-way fares from Harrisburg to Des Moines are currently lower than usual. Average one-way flight prices are about $282, which is 33% below the typical average for this route.

  • What car rental options are available at Des Moines Airport (DSM)?

    Des Moines Airport (DSM) hosts 5 major car rental companies, with daily rates averaging $81 for economy cars. Top options include:

    • Hertz
    • Payless
    • Budget
    • Alamo
    • Avis

  • Which airports can I use when flying from Harrisburg to Des Moines?

    Flights from Harrisburg to Des Moines usually depart from Harrisburg (MDT) and arrive at Des Moines (DSM).

  • Which airports do connecting flights from Harrisburg to Des Moines pass through?

    One-stop flights from Harrisburg to Des Moines most commonly connect through:

    • Chicago O'Hare Intl (ORD) - 80% of one-stop connections
    • Detroit Metropolitan Wayne County (DTW) - 16% of one-stop connections
    • Philadelphia (PHL) - 4% of one-stop connections

  • Can I save money by using flexible dates for flights from Harrisburg to Des Moines?

    Yes. Flexible dates can save you up to 56% on flights from Harrisburg to Des Moines. Wednesday is the cheapest departure day at $328 round-trip on average, while Monday is the most expensive at $734, a difference of $406.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Harrisburg to Des Moines?

    Flying via Detroit Metropolitan Wayne County (DTW) gives the shortest average 1-stop total travel time at 4h 30m, compared with 4h 55m via Chicago O'Hare Intl (ORD) and 5h 22m via Philadelphia (PHL).

  • What is the time difference between Harrisburg and Des Moines?

    Des Moines is 1 hour behind Harrisburg (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in Des Moines?

    Some of the most popular sights in Des Moines are UnityPoint Health - Des Moines, Science Center of Iowa and Hy Vee Hall. These are among the most viewed places in Des Moines on KAYAK.

Your guide to booking Harrisburg to Des Moines flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Wednesday departure and avoid flying on Monday. On this route, Wednesday flights average $328, about $406 less than Monday fares (55% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Harrisburg to Des Moines trip for December. Fares historically average $308 round-trip in that month - typically $480 less than the most expensive month, which is April (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Des Moines Airport.

    • Days Inn & Suites by Wyndham Des Moines Airport
    • Quality Inn & Suites Des Moines Airport
    • Homewood Suites by Hilton - Des Moines Airport

More options for your flight from Harrisburg to Des Moines

Complete your trip to Des Moines with a hotel stay or car rental

Car rentals in Des Moines
Hotels in Des Moines
Vacations in Des Moines