MDT - STL

$321 Find Cheap Flights from Harrisburg to St. Louis - Compare and Save

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1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$321
Typical prices: $318-$436
Delta
Wed 12/19Sat 12/29
MDT - STL • 1 stop
Cheapest one-way
$147
Typical prices: $271-$308
Multiple Airlines
Thu 12/6
MDT - STL • 2 stops
Nonstop flights
Not available
There are currently no direct flights between Harrisburg and St. Louis. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
January
Cheapest • 20% price drop
June
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Philadelphia (PHL)
Cheapest • Avg $400 (round-trip)
Detroit Metropolitan Wayne County (DTW)
Shortest trip • 4h 11m (one-way)
Insights
Insights
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Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Harrisburg to St. Louis (MDT-STL)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Harrisburg to St. Louis

Sat, Dec 19 - Tue, Dec 29
Delta Logo
6:15 am - 10:05 amMDT  Harrisburg-STL Lambert-St Louis
4h 50m1 stop Detroit Metropolitan Wayne County
Delta Logo
6:21 pm - 11:15 pmSTL  Lambert-St Louis-MDT Harrisburg
3h 54m1 stop Detroit Metropolitan Wayne County
$321Delta
Thu, Feb 4 - Tue, Feb 9
American Airlines Logo
7:43 am - 12:23 pmMDT  Harrisburg-STL Lambert-St Louis
5h 40m1 stop Philadelphia
American Airlines Logo
5:42 am - 1:52 pmSTL  Lambert-St Louis-MDT Harrisburg
7h 10m1 stop Chicago O'Hare Intl
$330American Airlines
Wed, Dec 2 - Wed, Dec 9
United Airlines Logo
6:17 am - 10:30 amMDT  Harrisburg-STL Lambert-St Louis
5h 13m1 stop Chicago O'Hare Intl
United Airlines Logo
10:50 am - 6:43 pmSTL  Lambert-St Louis-MDT Harrisburg
6h 53m1 stop Chicago O'Hare Intl
$330United Airlines
Tue, Dec 15 - Mon, Dec 21
Delta Logo
12:24 pm - 5:20 pmMDT  Harrisburg-STL Lambert-St Louis
5h 56m1 stop Detroit Metropolitan Wayne County
Delta Logo
6:21 pm - 11:15 pmSTL  Lambert-St Louis-MDT Harrisburg
3h 54m1 stop Detroit Metropolitan Wayne County
$330Delta
Sat, Dec 19 - Mon, Dec 28
Delta Logo
6:15 am - 10:05 amMDT  Harrisburg-STL Lambert-St Louis
4h 50m1 stop Detroit Metropolitan Wayne County
Delta Logo
6:21 pm - 11:15 pmSTL  Lambert-St Louis-MDT Harrisburg
3h 54m1 stop Detroit Metropolitan Wayne County
$330Delta
Thu, Feb 4 - Tue, Feb 9
American Airlines Logo
7:43 am - 12:23 pmMDT  Harrisburg-STL Lambert-St Louis
5h 40m1 stop Philadelphia
American Airlines Logo
5:42 am - 1:52 pmSTL  Lambert-St Louis-MDT Harrisburg
7h 10m1 stop Chicago O'Hare Intl
$335American Airlines
Sun, Dec 6 - Sun, Dec 20
American Airlines Logo
8:20 pm - 12:02 amMDT  Harrisburg-STL Lambert-St Louis
4h 42m1 stop Chicago O'Hare Intl
American Airlines Logo
4:32 pm - 10:22 pmSTL  Lambert-St Louis-MDT Harrisburg
4h 50m1 stop Chicago O'Hare Intl
$339American Airlines
Wed, Feb 3 - Sat, Feb 6
United Airlines Logo
6:20 am - 10:08 amMDT  Harrisburg-STL Lambert-St Louis
4h 48m1 stop Washington, D.C. Dulles Intl
United Airlines Logo
1:17 pm - 8:49 pmSTL  Lambert-St Louis-MDT Harrisburg
6h 32m1 stop Chicago O'Hare Intl
$421United Airlines
Sat, Dec 19 - Tue, Dec 29
Multiple Airlines Logo
4:17 pm - 10:53 amMDT  Harrisburg-STL Lambert-St Louis
43h 36m2 stops Tampa St. Petersburg Atlanta Hartsfield-Jackson
Multiple Airlines Logo
6:20 pm - 8:29 amSTL  Lambert-St Louis-MDT Harrisburg
13h 09m1 stop Orlando
$442Multiple Airlines
Sat, Dec 19 - Mon, Dec 28
Multiple Airlines Logo
9:44 am - 12:41 amMDT  Harrisburg-STL Lambert-St Louis
15h 57m1 stop Orlando Sanford Intl
Multiple Airlines Logo
6:21 pm - 2:55 pmSTL  Lambert-St Louis-MDT Harrisburg
19h 34m2 stops Atlanta Hartsfield-Jackson Orlando
$636Multiple Airlines
Booking Insights

Price, demand and travel trends for Harrisburg to St. Louis flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Harrisburg to St. Louis?

Round-trip flights from Harrisburg to St. Louis typically range from $318 to $436. The lowest price found in the past 5 days was $321, on Delta.

What's the cheapest day of the week to fly from Harrisburg to St. Louis?

Based on deals KAYAK users found in the last 12 months, Thursday is the cheapest day of the week to fly from Harrisburg to St. Louis. It’s 7% cheaper than the average day, while Monday is the most expensive, with prices 53% higher.

What’s the cheapest month to fly from Harrisburg to St. Louis?

•January is the cheapest month to fly from Harrisburg to St. Louis at $304 round-trip.
•October ($741) and November ($685) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 143% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for Harrisburg to St. Louis flights

Low season

December

Cheapest flight

$147
Beat the crowds with an average 40% drop in travelers.
The most popular month to fly with an average 38% increase in travelers.
One-way flight from Harrisburg to St. Louis

When to book flights from Harrisburg to St. Louis

Are your dates flexible? Find out the best times to travel from Harrisburg to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Harrisburg to St. Louis flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Harrisburg to St. Louis?

    Only Economy Class is available on flights from Harrisburg to St. Louis.

  • How long is a flight from Harrisburg to St. Louis?

    A nonstop flight from Harrisburg to St. Louis takes 00m, covering 731 miles.

  • Do I need a passport to fly from Harrisburg to St. Louis?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Harrisburg to St. Louis flight?

    Round-trip flights from Harrisburg to St. Louis range from $318 to $436, with an average of $379 over the past 12 months. Anything below $318 counts as a good deal.

  • Have flight prices from Harrisburg to St. Louis changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $321 to $2,846. That means the highest observed fare was about 9x higher than the lowest one.

  • How are flight prices from Harrisburg to St. Louis looking right now?

    One-way fares from Harrisburg to St. Louis are currently higher than usual. Average one-way flight prices are about $340, which is 16% above the typical average for this route.

  • What car rental options are available at Lambert-St Louis Airport (STL)?

    Lambert-St Louis Airport (STL) hosts 5 major car rental companies, with daily rates averaging $77 for economy cars. Top options include:

    • Hertz
    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Payless

  • Which airports can I use when flying from Harrisburg to St. Louis?

    Flights from Harrisburg to St. Louis usually depart from Harrisburg (MDT) and arrive at Lambert-St Louis (STL).

  • Which airports do connecting flights from Harrisburg to St. Louis pass through?

    One-stop flights from Harrisburg to St. Louis most commonly connect through:

    • Chicago O'Hare Intl (ORD) - 40% of one-stop connections
    • Detroit Metropolitan Wayne County (DTW) - 23% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 14% of one-stop connections
    • Philadelphia (PHL) - 14% of one-stop connections

  • Can I save money by using flexible dates for flights from Harrisburg to St. Louis?

    Yes. Flexible dates can save you up to 40% on flights from Harrisburg to St. Louis. Thursday is the cheapest departure day at $353 round-trip on average, while Monday is the most expensive at $582, a difference of $229.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Harrisburg to St. Louis?

    Flying via Detroit Metropolitan Wayne County (DTW) gives the shortest average 1-stop total travel time at 4h 11m, compared with 5h 02m via Philadelphia (PHL) and 5h 11m via Charlotte Douglas (CLT).

  • What is the time difference between Harrisburg and St. Louis?

    St. Louis is 1 hour behind Harrisburg (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in St. Louis?

    Some of the most popular sights in St. Louis are Busch Stadium, Enterprise Center and America's Center Convention Complex. These are among the most viewed places in St. Louis on KAYAK.

Your guide to booking Harrisburg to St. Louis flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Thursday departure and avoid flying on Monday. On this route, Thursday flights average $353, about $229 less than Monday fares (39% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Harrisburg to St. Louis trip for January. Fares historically average $304 round-trip in that month - typically $437 less than the most expensive month, which is October (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Lambert-St Louis Airport.

    • Renaissance St. Louis Airport Hotel
    • Drury Inn & Suites St. Louis Airport
    • DoubleTree by Hilton St. Louis Airport

More options for your flight from Harrisburg to St. Louis

Complete your trip to St. Louis with a hotel stay or car rental

Car rentals in St. Louis
Hotels in St. Louis
Vacations in St. Louis