$290 Find Cheap Flights from Indianapolis to Panama - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Indianapolis to Panama departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Book Cheap Indianapolis to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Indianapolis to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Indianapolis to Panama

Thu, Oct 1 - Mon, Oct 5
Delta Logo
7:05 am - 12:58 pmIND  Indianapolis-PTY Panama City Tocumen Intl
6h 53m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:23 pm - 12:32 amPTY  Panama City Tocumen Intl-IND Indianapolis
9h 09m1 stop Atlanta Hartsfield-Jackson
$577Delta
Wed, Sep 30 - Thu, Oct 1
Delta Logo
6:00 am - 12:58 pmIND  Indianapolis-PTY Panama City Tocumen Intl
7h 58m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:23 pm - 12:32 amPTY  Panama City Tocumen Intl-IND Indianapolis
9h 09m1 stop Atlanta Hartsfield-Jackson
$577Delta
Mon, Oct 5 - Tue, Oct 13
United Airlines Logo
10:51 am - 7:31 pmIND  Indianapolis-PTY Panama City Tocumen Intl
9h 40m1 stop Newark
United Airlines Logo
9:45 am - 9:59 pmPTY  Panama City Tocumen Intl-IND Indianapolis
11h 14m1 stop Newark
$577United Airlines
Wed, Oct 7 - Wed, Oct 14
United Airlines Logo
7:00 am - 2:14 pmIND  Indianapolis-PTY Panama City Tocumen Intl
8h 14m1 stop Houston George Bush Intcntl
United Airlines Logo
10:00 am - 8:29 pmPTY  Panama City Tocumen Intl-IND Indianapolis
9h 29m1 stop Houston George Bush Intcntl
$577United Airlines
Mon, Oct 26 - Tue, Nov 3
American Airlines Logo
7:58 pm - 12:52 pmIND  Indianapolis-PTY Panama City Tocumen Intl
17h 54m2 stops Charlotte Douglas Miami
American Airlines Logo
3:13 pm - 11:34 amPTY  Panama City Tocumen Intl-IND Indianapolis
20h 21m2 stops Miami New York LaGuardia
$581American Airlines
Tue, Oct 6 - Wed, Oct 14
American Airlines Logo
8:27 pm - 1:02 pmIND  Indianapolis-PTY Panama City Tocumen Intl
17h 35m2 stops Washington, D.C. Reagan-National Miami
American Airlines Logo
2:02 pm - 10:22 amPTY  Panama City Tocumen Intl-IND Indianapolis
19h 20m2 stops Miami Dallas/Fort Worth
$581American Airlines
Mon, Sep 28 - Thu, Oct 1
Multiple Airlines Logo
7:48 pm - 8:31 pmIND  Indianapolis-PTY Panama City Tocumen Intl
25h 43m1 stop Atlanta Hartsfield-Jackson
Multiple Airlines Logo
6:36 pm - 6:53 pmPTY  Panama City Tocumen Intl-IND Indianapolis
23h 17m2 stops San Juan Luis Munoz Marin Intl Atlanta Hartsfield-Jackson
$661Multiple Airlines
Fri, Oct 2 - Wed, Oct 7
Multiple Airlines Logo
7:48 pm - 8:31 pmIND  Indianapolis-PTY Panama City Tocumen Intl
25h 43m1 stop Atlanta Hartsfield-Jackson
Multiple Airlines Logo
12:21 pm - 5:46 pmPTY  Panama City Tocumen Intl-IND Indianapolis
28h 25m2 stops San Juan Luis Munoz Marin Intl Orlando
$678Multiple Airlines
Thu, Aug 20 - Sat, Aug 22
Copa Airlines Logo
7:00 am - 6:37 pmIND  Indianapolis-PTY Panama City Tocumen Intl
12h 37m1 stop Houston George Bush Intcntl
Copa Airlines Logo
3:30 pm - 10:48 amPTY  Panama City Tocumen Intl-IND Indianapolis
18h 18m1 stop Houston George Bush Intcntl
$758Copa Airlines
Wed, Dec 16 - Mon, Dec 28
Copa Airlines Logo
9:21 am - 8:37 pmIND  Indianapolis-PTY Panama City Tocumen Intl
11h 16m1 stop Chicago O'Hare Intl
Copa Airlines Logo
10:29 pm - 10:05 amPTY  Panama City Tocumen Intl-IND Indianapolis
11h 36m1 stop Washington, D.C. Dulles Intl
$928Copa Airlines
Booking Insights

KAYAK's insights & trends for Indianapolis to Panama flights

Get data-powered insights and trends into flights from Indianapolis to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Indianapolis to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Indianapolis to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Indianapolis to Panama is February, when tickets cost $559 (return) on average. On the other hand, the most expensive months are December and July, when the average cost of round-trip tickets is $1,052 and $720 respectively.

Good to know

Low season

January

Cheapest flight

$290
Best time to beat the crowds with an average 11% drop in price.
Most popular time to fly with an average 53% increase in price.
Flight from Indianapolis to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from Indianapolis to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Indianapolis to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Indianapolis to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Indianapolis to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Indianapolis to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Indianapolis to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Indianapolis to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Indianapolis to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Indianapolis to Panama

 
Need help choosing which airline to fly with from Indianapolis to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8492 reviews
7.2Food
8.1Boarding
7.8Comfort
8.5Crew
7.8Entertainment
Airline reviews

the flight got cancelled - few hours before the departure time - no time to change

2.0 MediocreWojciech, Aug 2026
Read more Delta reviews

the flight got cancelled - few hours before the departure time - no time to change

This a short easy flight. No food or drink but that was not an issue since we were only in the air for 35 minutes.

The meal tray was not usable it was completely uneven

My experience with Delta started with my luggage being found ripped open with items missing. The baggage office told me to bring the bag, and I wanted them to see how I found it. The agent refused, so I carried my bag into the office myself. The agent was nice enough to fix the zipper and gave me a red card with a number to call. I followed the steps; first one department, then the baggage department took over. This took more than two hours on the phone. The return flight was okay. The flight lead was checking her meals and then asked if we wanted anything before departure. However, throughout the flight, I had to ask for things because she was reading her book;which I have no issue with if she had been more attentive. At the end of the flight, the pilot appeared annoyed with the flight lead for not following his instructions regarding a meal he had requested; a chicken sandwichand said, "I asked for that for the flight." On the positive side, my work event in Vegas went well, and now I'm home relaxing.

WiFi didn’t work on two of four planes. Flight attendants were not overly friendly or welcoming. Planes were extremely slow to board and deplane.

Flight from Fort Wayne to Atlanta was the smallest in terms of cabin space that I've ever seen. A carry on I've used for 20 years BARELY fit in overhead compartment. I'm 5'10" and felt very cramped. Not the best experience.

Extremely dosappoontined and frustrated. Refused entry to lounge in Detroit despite having Delta AMEX Reserve linked in MyDelta phone app as revommended and also having proof of account. No pillows were available for overnight flight to AMS and breakfast was not served in Delta Comfort.

The airplanes were so old and out-dated it was terrifying to fly on them.

Delta flight overall it was goodT!the crew could do more and the food could be better.

Short flight. Perfect crew. Older plane. But clean and comfortable

We where skipped for this flight will not head to Panama until tonight..

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

Very strict carry on rules meant most of the plane had to gate check their luggage. As is often the case had things that were broken because of this, but I appreciated not being charged to gate check. Otherwise good flight and great crew once on the plane

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

Boarding was quick & efficient; they gave boarding groups due priority; staff & air crew were very cordial and helpful, pleasant flight.

Very happy with my flight. I would definitely recommend it.

Did upgrade, travel in business it was great (more room I could sleep)

Placed us in the last rear row of the plane so could not recline seats because of the rear wall, and also made it more of a tight space when the passenger in front reclined their seat. While understand seat assignments, every passenger should be afforded a reclining seat. The odor control scent from the restrooms was overwhelming strong. My wife and I could not deal with it, and she suffered a terrible headache as a result. I kept getting hit by the crew since I was on the ilse seat. No apologies, nothing. They made me feel like I was supposed to take the beating for a 3 hr flight.

There was no individual at the front check in when I arrived. I waited for at least 15 minutes and walked around asking security/janitors if they could help and they did not have a solution. So I had to take my checked bag through security and they threw away some of my items. I ended up making it to the gate only a few minutes before it closed due to my waiting for an agent at check in.

It would have been better if they don't separate families in seating. We were seated in the aile row in the middle of a family of four. It would have been better if they they seat the family of four together than separated.

Not a bad flight but a long delay boarding and taking off due to the pilot not arriving on time.

I would have liked to have been served more food when it came to Panama to Newark

Didn't make the flight because the first leg of my flight was canceled and the next leg was already booked.

Same as last comment. Food sucks. Quality. Not surprising most people have no clue about nourishment Clearly

Crew was excellent. This was a relatively long flight though and had very little leg room, and no entertainment.

The food should improve! And The flight should leave on time and not make the traveler wait.

I completely missed my flight because the first leg was longer than planned. I had to sleep overnight in the airport because no accommodation was provided and then sent to Trinidad in the morning with an anticipated 7 hour layover before my flight to Georgetown which was now with Caribbean Airlines. I tried twice with customer service to see if they could put me on an earlier flight which had seats available but was told it wasn’t possible.

horrible website for checking in- no option just to write the passport number; ludicrous

We flew SEA -Houston-Panama-GYE round trip. The connections were torturing because we had to sleep over in Seattle to board the early morning flight and froze for 11 hours in Hoston for the return flight to SEA. Not United's problem, just the inconvenience of numerous transits. Restaurants and fast foods were closed and all we got was a cookie/coffee for each flight. Finally we waited for a long time for our baggage at carousel 9 as informed by the APP and all reliable sources. Suddenly some fellow passengers found out that our bags showed up on carousal 8.

Flight was great. On time. Pleasant crew and responsible passengers. My only disappointment was that there was no coffee or tea offered. It was a short flight but a coffee would have been appreciated for what the price of tickets are now.

IT issues created a mess had you change my flight and your system never changed it

The ground closures and flight delays were unwelcome. I think the captain did what he could to manage expectations for the delays, but the stress level increasing in the cabin was palpable with every announcement. It may be obvious to those who fly frequently, but if the ground is closed for us to get to a gate, it's also closed for connecting flights to leave. Other passengers were so stressed they were rude. A bit further explanation could have helped.

I’ve been on 8 flights with American Airlines in the last 2 months and 4 have been delayed.

Passenger was too loud for the entire flight crew not once ask them to tame it …. Many passengers are uncomfortable including having headaches

The Mario was so helpful and provided amazing customer service however l have being waiting for a callback for almost a week now and have not heard anything further after l informed them l wanted to change my date of traveling because of my hospital appointment even send them proof and l was unable to use manag your booking on their website is a bit frustrating and l would appreciate an update on My request as soon as possible. And have called them times without numbers no response

There is no room, no gluten free options, or any free internet/entertainment. You have to bring your own tablet or smartphone because there are no screens.

April was the flight attendant in first class and was the most pleasant, cordial and efficient person I have seen on a flight in years. Good example of the type of people AA should hire to increase customer satisfacdtion.

Excellent accommodating crew at gate and on board. Baggage claim and gate checking were flawless.

Delayed 6 times. Eventually rebooked and missed a whole day of my vacation. Hot mess

Unfriendly gate staff and significant delay once we were on the plane.

Everything you need to know for your flight from Indianapolis to Panama

Information on your arrival and departure airports