EYW - SFO

$186 Find Cheap Flights from Key West to San Francisco - Compare and Save

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Key West to San Francisco departing on 10/6. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$301
Delta
Tue 10/6Sat 10/10
EYW - SFO • 1 stop
Top airlines
Cheapest • from $301 (round-trip)
Best reviews • 7.1 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Key West and San Francisco. You'll need at least 1 connection.
Insights
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Insights
Top layover airports
Cheapest • Avg $348 (round-trip)
Shortest trip • 8h 02m (one-way)
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Flight Deals

Cheap Flights from Key West to San Francisco (EYW-SFO)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Key West to San Francisco that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Key West to San Francisco

Tue, Oct 6 - Sat, Oct 10
Delta Logo
6:10 pm - 11:56 pmEYW  Key West-SFO San Francisco
8h 46m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:30 pm - 10:47 amSFO  San Francisco-EYW Key West
9h 17m1 stop Atlanta Hartsfield-Jackson
$301Delta
Sat, Oct 3 - Sat, Oct 10
Delta Logo
6:19 pm - 11:57 pmEYW  Key West-SFO San Francisco
8h 38m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:30 pm - 10:47 amSFO  San Francisco-EYW Key West
9h 17m1 stop Atlanta Hartsfield-Jackson
$301Delta
Sat, Oct 24 - Fri, Oct 30
American Airlines Logo
5:28 pm - 11:59 pmEYW  Key West-SFO San Francisco
9h 31m1 stop Miami
American Airlines Logo
6:47 am - 4:54 pmSFO  San Francisco-EYW Key West
7h 07m1 stop Dallas/Fort Worth
$340American Airlines
Sat, Sep 5 - Fri, Sep 11
Delta Logo
4:00 pm - 11:58 pmEYW  Key West-SFO San Francisco
10h 58m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:00 pm - 10:46 amSFO  San Francisco-EYW Key West
9h 46m1 stop Atlanta Hartsfield-Jackson
$369Delta
Tue, Oct 6 - Sat, Oct 10
American Airlines Logo
1:43 pm - 7:33 pmEYW  Key West-SFO San Francisco
8h 50m1 stop Miami
American Airlines Logo
10:03 pm - 1:03 pmSFO  San Francisco-EYW Key West
12h 00m2 stops Charlotte Douglas Miami
$388American Airlines
Tue, Aug 25 - Sat, Aug 29
American Airlines Logo
1:40 pm - 8:18 pmEYW  Key West-SFO San Francisco
9h 38m1 stop Miami
American Airlines Logo
7:30 am - 6:40 pmSFO  San Francisco-EYW Key West
8h 10m1 stop Miami
$401American Airlines
Mon, Aug 31 - Tue, Sep 15
American Airlines Logo
4:50 pm - 10:40 pmEYW  Key West-SFO San Francisco
8h 50m1 stop Charlotte Douglas
American Airlines Logo
11:03 pm - 1:11 pmSFO  San Francisco-EYW Key West
11h 08m1 stop Charlotte Douglas
$422American Airlines
Sat, Sep 5 - Fri, Sep 11
American Airlines Logo
1:35 pm - 10:18 pmEYW  Key West-SFO San Francisco
11h 43m2 stops Miami Dallas/Fort Worth
American Airlines Logo
6:12 am - 5:55 pmSFO  San Francisco-EYW Key West
8h 43m1 stop Charlotte Douglas
$427American Airlines
Mon, Aug 31 - Tue, Sep 15
American Airlines Logo
4:50 pm - 10:40 pmEYW  Key West-SFO San Francisco
8h 50m1 stop Charlotte Douglas
American Airlines Logo
10:46 pm - 1:17 pmSFO  San Francisco-EYW Key West
11h 31m2 stops Chicago O'Hare Intl Miami
$427American Airlines
Tue, Aug 25 - Sat, Aug 29
American Airlines Logo
11:30 am - 8:14 pmEYW  Key West-SFO San Francisco
11h 44m2 stops Miami Dallas/Fort Worth
American Airlines Logo
9:35 pm - 9:44 amSFO  San Francisco-EYW Key West
9h 09m1 stop Miami
$438American Airlines
Booking Insights

KAYAK's insights & trends for Key West to San Francisco flights

Get data-powered insights and trends into flights from Key West to San Francisco to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Key West to San Francisco?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 5 days.

In the past 5 days, the cheapest round-trip tickets from Key West to San Francisco were found on Delta ($301) and American Airlines ($340).

Good to know

Cheapest flight

$186
Flight from Key West to San Francisco

When to book flights from Key West to San Francisco

Are your dates flexible? Find out the best times to travel from Key West to San Francisco based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Key West to San Francisco

  • What is the cheapest flight from Key West to San Francisco?

    In the last 5 days, the lowest price for a flight from Key West to San Francisco was $265 for a one-way ticket and $301 for a round-trip.

  • Do I need a passport to fly between Key West and San Francisco?

    No

  • Which aircraft models fly most regularly from Key West to San Francisco?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Key West to San Francisco?

    oneworld is the only airline alliance operating flights between Key West and San Francisco.

  • How does KAYAK find such low prices on flights from Key West to San Francisco?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Key West to San Francisco.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Key West to San Francisco?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco from Key West is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Key West to San Francisco?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back to Key West with another airline. Booking your flights between Key West and SFO can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Key West to San Francisco?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco from Key West up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Key West to San Francisco

 
See real verified KAYAK customer reviews for airlines flying from Key West to San Francisco. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Key West to San Francisco? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11898 reviews
7.9Crew
6.8Entertainment
6.4Food
7.5Boarding
7.2Comfort
Airline reviews

Our experience with American Airlines was extremely disappointing and honestly made an already exhausting international journey much worse. After flying all the way from Melbourne and dealing with significant jet lag, the American Airlines experience at LAX was the last thing we needed. The terminal and boarding area felt very old and uncomfortable, with little to no air conditioning and only old fans running in the area. Boarding was also through outdoor stairs rather than a jet bridge, which felt especially inconvenient after such a long journey. Even though we were traveling First Class, the onboard experience was surprisingly poor. There were no meaningful snack options, no decent coffee available to order, and the aircraft was so small that there was barely enough overhead space for carry-on luggage. The staff experience was also disappointing and lacked the warmth or attentiveness we had experienced on our international flights. To make matters worse, the flight departed late, extending an already very long travel day. Overall, the combination of the outdated terminal, uncomfortable boarding process, limited First Class service, small aircraft, poor staff experience, and delay made this an extremely unpleasant final leg of our journey. It significantly worsened our exhaustion and jet lag rather than making the connection home easier. Unfortunately, this experience was bad enough that I do not plan to travel with American Airlines again in the future.

2.0 MediocreAnonymous, Aug 2026
Read more American Airlines reviews

Our experience with American Airlines was extremely disappointing and honestly made an already exhausting international journey much worse. After flying all the way from Melbourne and dealing with significant jet lag, the American Airlines experience at LAX was the last thing we needed. The terminal and boarding area felt very old and uncomfortable, with little to no air conditioning and only old fans running in the area. Boarding was also through outdoor stairs rather than a jet bridge, which felt especially inconvenient after such a long journey. Even though we were traveling First Class, the onboard experience was surprisingly poor. There were no meaningful snack options, no decent coffee available to order, and the aircraft was so small that there was barely enough overhead space for carry-on luggage. The staff experience was also disappointing and lacked the warmth or attentiveness we had experienced on our international flights. To make matters worse, the flight departed late, extending an already very long travel day. Overall, the combination of the outdated terminal, uncomfortable boarding process, limited First Class service, small aircraft, poor staff experience, and delay made this an extremely unpleasant final leg of our journey. It significantly worsened our exhaustion and jet lag rather than making the connection home easier. Unfortunately, this experience was bad enough that I do not plan to travel with American Airlines again in the future.

Horrible. No AC. No Air inside the plane. We had to deplane twice! It is late almost 5 hrs in total. I almost passed out and about to call 911. I asked the crew to be honest and open the door. The lady next to me was lay down in the floor due to heat and no air inside the plane. I got headaches, can’t wait the replacement flight about midnight Dallas time. I end it up rebook for next day flight and stay overnight using my own pocket in a hotel nearby due to headaches and can’t breath. I still have a headache this morning. Still not decided yes how to file this issue to AA and/or FAA.

Initial flight had an engine overheat - returned to DFW. Had another plane ready, but crew timed out. Had to wait 5h for boarding. Fully boarded and pilot says plane is not flight worthy. Deplane and go to the other end of the terminal. Wait an hour to board third plane because the crew couldn’t leave the second plane because no wheelchairs were brought to remove passengers. Finally take off and there is no catering (in flight service) even in first class. Very much an AA failure.

The flight attendant was very polite and attentive. The food was good.

Was put into a seat right behind the toilet that had no entertainment possible but did have plenty of leg room over noisy part of plane.

Flight: Started on time. Comfortable flight. Arrived on time. Crew: Very cordial and helpful. Drinks and snack was served with a smile. Overall enjoyed the trip. Regards, Hari Doss Chanchala Doss

A first class seat should fit a fat person, and this doesn't. The trays in the armrest are less functional than an ordinary tray in the back of the seat.

Great. Quick and quiet and east. The breakfast choices were a welcome surprise!

This was a horrible experience. For a first class experience, my chair was held together by 3M tape - and I have a photo. The crew weren’t very attentive, somewhat dismissive and forgot my drink and snack, the chair reclined about 3 inches on a 6-hour cross country flight. I was also not informed that there was no lounge available in Newark airport because of renovations, so all around this was one of the worst experiences and I would actively avoid both American and Alaska Air going forward.

Plane felt so crowded and tightly packed. The chair itself was not comfortable.

Everything you need to know for your flight from Key West to San Francisco

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