EYW - SFO

$130 Find Cheap Flights from Key West to San Francisco

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Key West to San Francisco departing on 2/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to San Francisco

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Key West to San Francisco, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Key West to San Francisco, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$264
American Airlines
Fri 2/20Mon 2/23
EYW - SFO • 2 stops
Cheapest one-way
$130
Typical prices: $131-$354
American Airlines
Thu 2/5
EYW - SFO • 1 stop
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to San Francisco!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Key West to San Francisco (EYW-SFO)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Key West to San Francisco that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Key West to San Francisco

Fri, Feb 20 - Mon, Feb 23
American Airlines Logo
1:55 pm - 11:14 pm
EYW
-
SFO
12h 19m
2 stops
American Airlines Logo
7:25 am - 7:15 pm
SFO
-
EYW
8h 50m
1 stop
$264American Airlines
Fri, Feb 20 - Mon, Feb 23
American Airlines Logo
1:55 pm - 11:14 pm
EYW
-
SFO
12h 19m
2 stops
American Airlines Logo
11:35 pm - 2:40 pm
SFO
-
EYW
12h 05m
2 stops
$270American Airlines
Fri, Feb 20 - Mon, Feb 23
American Airlines Logo
4:40 pm - 11:10 pm
EYW
-
SFO
9h 30m
1 stop
American Airlines Logo
9:14 am - 10:37 pm
SFO
-
EYW
10h 23m
1 stop
$304American Airlines
Wed, Feb 25 - Fri, Feb 27
American Airlines Logo
2:45 pm - 10:07 pm
EYW
-
SFO
10h 22m
1 stop
American Airlines Logo
9:14 am - 10:37 pm
SFO
-
EYW
10h 23m
1 stop
$337American Airlines
Tue, Feb 24 - Fri, Feb 27
American Airlines Logo
1:55 pm - 10:40 pm
EYW
-
SFO
11h 45m
2 stops
American Airlines Logo
9:14 am - 10:37 pm
SFO
-
EYW
10h 23m
1 stop
$342American Airlines
Fri, Mar 20 - Mon, Mar 23
United Airlines Logo
4:55 pm - 11:59 pm
EYW
-
SFO
10h 04m
1 stop
United Airlines Logo
9:30 pm - 1:23 pm
SFO
-
EYW
12h 53m
1 stop
$367United Airlines
Thu, Jan 29 - Mon, Feb 2
Delta Logo
7:10 am - 12:55 pm
EYW
-
SFO
8h 45m
1 stop
Delta Logo
11:05 pm - 11:25 am
SFO
-
EYW
9h 20m
1 stop
$375Delta
Wed, Jan 28 - Sun, Feb 1
United Airlines Logo
4:15 pm - 11:00 pm
EYW
-
SFO
9h 45m
1 stop
United Airlines Logo
9:30 pm - 1:03 pm
SFO
-
EYW
12h 33m
1 stop
$389United Airlines
Thu, Jan 29 - Sun, Feb 1
American Airlines Logo
4:01 pm - 10:34 pm
EYW
-
SFO
9h 33m
1 stop
American Airlines Logo
12:17 am - 1:03 pm
SFO
-
EYW
9h 46m
2 stops
$394American Airlines
Wed, Jan 28 - Sun, Feb 1
American Airlines Logo
1:33 pm - 9:26 pm
EYW
-
SFO
10h 53m
1 stop
American Airlines Logo
11:36 pm - 1:03 pm
SFO
-
EYW
10h 27m
2 stops
$400American Airlines
Booking Insights

KAYAK's insights & trends for Key West to San Francisco flights

Get data-powered insights and trends into flights from Key West to San Francisco to help you find the cheapest flights, the best time to fly and much more.

What is the most popular layover airport when flying from Key West to San Francisco?

Percentage of 1-stop round-trip flights from Key West to San Francisco chosen by KAYAK users via each layover airport in the last 12 months (only includes trips with the same layover airport on both legs).

Atlanta (ATL) is the top choice – 67% of KAYAK users who clicked on 1-stop flights from Key West to San Francisco picked an itinerary connecting there.

What is the cheapest layover airport when flying from Key West to San Francisco?

Average round-trip price for 1-stop flights from Key West to San Francisco clicked by KAYAK users in the last 12 months (only includes trips with the same layover airport on both legs).

Flights via Miami (MIA) offer the most affordable fares, with an average round-trip price of $453.

Which layover airport offers the shortest total travel time from Key West to San Francisco?

Shortest average total travel time for 1-stop one-way flights from Key West to San Francisco via different layover airports, based on KAYAK user data from the last 12 months.

Consider flying via Atlanta (ATL) for the shortest journey. The average one-way travel time for flights connecting there is 8h 15m.

Which layover airport has the quickest connection when flying from Key West to San Francisco?

Average layover duration at different layover airports for 1-stop one-way flights from Key West to San Francisco, based on KAYAK user data from the last 12 months.

If you prefer a quick connection, Atlanta (ATL) often has the shortest layovers from Key West to San Francisco, with an average of 1h 37m.

Good to know

Cheapest flight$130
Flight from Key West to San Francisco

When to book flights from Key West to San Francisco

Are your dates flexible? Find out the best times to travel from Key West to San Francisco based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Key West to San Francisco

  • What is the cheapest flight from Key West to San Francisco?

    In the last 3 days, the lowest price for a flight from Key West to San Francisco was $130 for a one-way ticket and $264 for a round-trip.

  • Do I need a passport to fly between Key West and San Francisco?

    No

  • Which aircraft models fly most regularly from Key West to San Francisco?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Key West to San Francisco?

    oneworld is the only airline alliance operating flights between Key West and San Francisco.

  • How does KAYAK find such low prices on flights from Key West to San Francisco?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Key West to San Francisco.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Key West to San Francisco?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco from Key West is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Key West to San Francisco?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back to Key West with another airline. Booking your flights between Key West and SFO can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Key West to San Francisco?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco from Key West up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Key West to San Francisco

 
See real verified KAYAK customer reviews for airlines flying from Key West to San Francisco. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Key West to San Francisco? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11129 reviews
6.9Entertainment
8.0Crew
6.4Food
7.5Boarding
7.2Comfort
Airline reviews

Amazing I love American. I’ll never fly anyone else if I can help it.

10.0 ExcellentRichard, Jan 2026
PHX - ONT
Read more American Airlines reviews

Amazing I love American. I’ll never fly anyone else if I can help it.

Everything about the flight was lovely. My only suggestion would be to offer a few more options of tv series from Apple TV or HBO.

After the door had been closed, the cockpit makes an announcement that catering is running late and it is not the airline's fault. It is their fault in the sense that we had to sit for 2 hours or more when we could have stayed in the terminal. Poor communications between catering and airline. This caused a young man to lose his temper and he went storming out hitting objects. He had complained to the gate agent that he had already waited at the gate 7 hours and when can the airplane leave? Airilnes do a poor job of explaining delays, maintenance issues, etc. whereas being truthful may gain more sympathy or understanding.

We were told the flight was delayed 5 times, then it was moved to the next day.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

Loved the crew . Absolutely no complaints. Except for luggage lost

Wish some foods provided rather than just biscuit/cookie for flight more than 2 hours

We are too tired and frustrated to comment politely at this point

The flight crew was rude. We were in first class and no one even offered water until an hour after we were in the air. Horrible experience

Great. Quick and quiet and east. The breakfast choices were a welcome surprise!

Everything you need to know for your flight from Key West to San Francisco

Information on your arrival and departure airports