EYW - SFO

$161 Find Cheap Flights from Key West to San Francisco

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Key West to San Francisco departing on 6/2. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to San Francisco

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Key West to San Francisco, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Key West to San Francisco, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$330
American Airlines
gio 9/3sab 9/12
EYW - SFO • 1 stop
Cheapest one-way
$161
Typical prices: $222-$567
Multiple Airlines
mar 6/2
EYW - SFO • 2 stops
Top airlines
Cheapest • from $330 (round-trip)
Best reviews • 7.1 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Key West and San Francisco. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $348 (round-trip)
Shortest trip • 8h 02m (one-way)
Insights
Insights
Insights
Insights
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to San Francisco!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Key West to San Francisco (EYW-SFO)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Key West to San Francisco that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Key West to San Francisco

gio, set 3 - sab, set 12
American Airlines Logo
8:09 pm - 12:51 am
EYW
-
SFO
7h 42m
1 stop
American Airlines Logo
10:34 pm - 11:21 am
SFO
-
EYW
9h 47m
1 stop
$330American Airlines
gio, set 3 - sab, set 12
American Airlines Logo
11:30 am - 7:25 pm
EYW
-
SFO
10h 55m
2 stops
American Airlines Logo
10:34 pm - 11:21 am
SFO
-
EYW
9h 47m
1 stop
$335American Airlines
gio, mag 14 - sab, mag 23
Delta Logo
1:22 pm - 9:04 pm
EYW
-
SFO
10h 42m
1 stop
Delta Logo
11:59 pm - 10:53 am
SFO
-
EYW
7h 54m
1 stop
$360Delta
mer, giu 3 - mar, giu 9
Delta Logo
6:19 pm - 11:24 pm
EYW
-
SFO
8h 05m
1 stop
Delta Logo
11:59 pm - 11:02 am
SFO
-
EYW
8h 03m
1 stop
$369Delta
gio, set 3 - sab, set 12
American Airlines Logo
11:30 am - 7:25 pm
EYW
-
SFO
10h 55m
2 stops
American Airlines Logo
7:45 pm - 11:21 am
SFO
-
EYW
12h 36m
2 stops
$380American Airlines
mar, mag 5 - sab, mag 9
United Airlines Logo
4:05 pm - 12:50 am
EYW
-
SFO
11h 45m
1 stop
United Airlines Logo
5:00 am - 4:02 pm
SFO
-
EYW
8h 02m
1 stop
$391United Airlines
mar, mag 5 - sab, mag 9
American Airlines Logo
2:29 pm - 10:49 pm
EYW
-
SFO
11h 20m
2 stops
American Airlines Logo
10:45 pm - 10:54 am
SFO
-
EYW
9h 09m
1 stop
$396American Airlines
mar, mag 5 - sab, mag 9
American Airlines Logo
2:29 pm - 10:49 pm
EYW
-
SFO
11h 20m
2 stops
American Airlines Logo
8:00 am - 10:36 pm
SFO
-
EYW
11h 36m
2 stops
$401American Airlines
mer, mag 6 - dom, mag 10
United Airlines Logo
4:47 pm - 11:59 pm
EYW
-
SFO
10h 12m
1 stop
United Airlines Logo
11:05 pm - 1:45 pm
SFO
-
EYW
11h 40m
1 stop
$410United Airlines
mer, giu 3 - mar, giu 9
American Airlines Logo
4:44 pm - 10:49 pm
EYW
-
SFO
9h 05m
1 stop
American Airlines Logo
5:23 am - 7:10 pm
SFO
-
EYW
10h 47m
2 stops
$417American Airlines
Booking Insights

KAYAK's insights & trends for Key West to San Francisco flights

Get data-powered insights and trends into flights from Key West to San Francisco to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Key West to San Francisco?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Key West to San Francisco were found on American Airlines ($330) and Delta ($360).

Good to know

Cheapest flight$161
Flight from Key West to San Francisco

When to book flights from Key West to San Francisco

Are your dates flexible? Find out the best times to travel from Key West to San Francisco based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Key West to San Francisco

  • What is the cheapest flight from Key West to San Francisco?

    In the last 3 days, the lowest price for a flight from Key West to San Francisco was $161 for a one-way ticket and $330 for a round-trip.

  • Do I need a passport to fly between Key West and San Francisco?

    No

  • Which aircraft models fly most regularly from Key West to San Francisco?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Key West to San Francisco?

    oneworld is the only airline alliance operating flights between Key West and San Francisco.

  • How does KAYAK find such low prices on flights from Key West to San Francisco?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Key West to San Francisco.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Key West to San Francisco?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco from Key West is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Key West to San Francisco?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back to Key West with another airline. Booking your flights between Key West and SFO can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Key West to San Francisco?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco from Key West up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Key West to San Francisco

 
See real verified KAYAK customer reviews for airlines flying from Key West to San Francisco. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Key West to San Francisco? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11659 reviews
7.5Boarding
6.9Entertainment
7.2Comfort
7.9Crew
6.4Food
Airline reviews

American delayed the flight for a crew rest period. The delay occurred late in the evening - the earliest i can find is 10:20 pm. With a 6 am flight anyone on the flight would have already have been asleep (unless you are insane, a vampire or on drugs) and at least for me i was already on the way to the airport at 445 am the next morning when i discovered they delayed the flight until 9 am. Given the incoming flight was in the air at 6 pm the evening before this should have been figured out a lot more timely that was there only crew to use. Just frustrating given there is no consideration for customer experience anymore in flying.

4.0 OkayJames, Apr 2026
STL - LAX
Read more American Airlines reviews

American delayed the flight for a crew rest period. The delay occurred late in the evening - the earliest i can find is 10:20 pm. With a 6 am flight anyone on the flight would have already have been asleep (unless you are insane, a vampire or on drugs) and at least for me i was already on the way to the airport at 445 am the next morning when i discovered they delayed the flight until 9 am. Given the incoming flight was in the air at 6 pm the evening before this should have been figured out a lot more timely that was there only crew to use. Just frustrating given there is no consideration for customer experience anymore in flying.

Flight: Started on time. Comfortable flight. Arrived on time. Crew: Very cordial and helpful. Drinks and snack was served with a smile. Overall enjoyed the trip. Regards, Hari Doss Chanchala Doss

To have arrived on time and not 3 hours late after having already spent $100 to change to an earlier flight, only to arrive back home close to the original flight time.

American Airlines is a miserable experience. It is predictably miserable, in the sense that every time I fly American, I brace myself for the certainty that it will be unpleasant and uncomfortable. But it is unpredictable in the sense that I never know if the flight will be on time or delayed nine hours (both happened to me this week). I never know if I will be able to sit in the seat that I selected when I purchased the ticket or if I will be told by Customer Service (!!!) that I must relocate from first class to a seat in the back of the aircraft with no explanation (both happened to me this week). Will the food be frozen and half defrosted, or scalding hot? Will the drinks be warm? Will the flight attendants be surly and mean? Will the toilets be cramped and foul? Will the seats be narrow and uncomfortable? Will there be a real electric outlet at the seat, or just an unreliable USB-2 port? Will there be enough seats in the boarding lounge or just a few? Will the boarding process be smooth and efficient, or will the gate agents mess it up and delay it needlessly for 30 or 40 minutes? Will the catering and cleaning crew be prompt or will they take an extra 30 minutes? Will the brakes on the aircraft work properly, or will the pilot delay takeoff for four hours while the ground crew attends to what can only be described as routine maintenance that should have been done the night before? I've eexperienced every one of these unpleasant things this year, 2026. The only thing I can reliably count on is that American will find a new way to make the experience of flying as miserable as they possibly can.

Wifi was spotty. Tray table was very dirty when I sat down.

The WiFi would not connect enough for me to do my actual work. It permaspooled, disconnected, said it was connected, then wouldn't open an email... it was frustrating. I am not a tall person, 5'4" - and I felt cramped with little room to reach into my bag under the seat in front of me. I feel sorry for anyone taller than me having to fly. the one positive thing I will add, is the overhead bins are roomy enough to manage more bags than other carriers.

Buying ticket from kayak instant booking was a huge mistake, never to be repeated again! The Kayak didn’t book the tickets directly, it handed it off to a third party Underpricer, that booked a code shared American Airlines flight operated by Cathay Pacific!! When managing the booking American Airlines would recognize the itinerary but wouldn’t let me do anything stating, the flight is operated by Cathay Pacific so go to their website. Cathay Pacific would recognize the itinerary, neither by reservation ID or ticket number…asking to reach out to the third party Underpricer….calling Underpricer resulted in no help like seat requests, mileage number or upgrade request, 15hr layover accommodation voucher guidance…so net in net avoid booking through three layers of intermediaries

Going non stop to lax like I paid for. Not stopping in MCI for gas. Too long of delays

I have never been assaulted they way I was today in Charlotte - shame on American

Delayed for mechanical and no updates on what was happening and how long the delay might be.

Everything you need to know for your flight from Key West to San Francisco

Information on your arrival and departure airports