TYS - CHI

$49 Find Cheap Flights from Knoxville to Chicago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Chicago departing on 5/28. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Chicago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Chicago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Chicago, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$210
Typical prices: $457-$244
Allegiant Air
Thu 5/21Sun 5/24
TYS - MDW • Non-stop
Cheapest non-stop
$249
Typical prices: $317-$219
American Airlines
Fri 5/29Tue 6/2
TYS - ORD • Non-stop
Advice from real travelers
AI-powered summary based on content written by travel experts. AI can make mistakes.
United's Economy Plus offers extra legroom on this route.
Allegiant's Legroom+ provides more space and faster exit.
Expert advice
Expert advice
Expert advice
Expert advice
Top airlines
Cheapest • from $216 (round-trip)
Best reviews • 7.4 score
Airline reviews
Airline reviews
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Airline reviews
Airline reviews
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Nonstop flights
You can fly direct with American Airlines, United Airlines and Allegiant Air. Average duration is 2h 01m
Direct flights
Direct flights
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Direct flights
Direct flights
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Top routes
Cheapest • 34% average savings
Most popular
Insights
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Top layover airports
Cheapest • Avg $233 (round-trip)
Shortest trip • 3h 50m (one-way)
Insights
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When to book
in advance
Our data shows that travelers who book at least 4 weeks in advance save around 16% compared to booking last minute.
Insights
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Insights
When to travel
Cheapest • 52% price drop
Most popular
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Flight Deals
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Flight Deals

Cheap Flights from Knoxville to Chicago (TYS-CHI)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Chicago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Chicago

Thu, May 21 - Sun, May 24
Multiple Airlines Logo
1:22 pm - 1:57 pm
TYS
-
MDW
1h 35mnonstop
Multiple Airlines Logo
6:00 am - 8:29 pm
MDW
-
TYS
13h 29m
3 stops
$210Multiple Airlines
Fri, Jun 26 - Sun, Jun 28
Multiple Airlines Logo
12:40 pm - 10:11 pm
TYS
-
MDW
10h 31m
2 stops
Multiple Airlines Logo
2:46 pm - 5:14 pm
MDW
-
TYS
1h 28mnonstop
$211Multiple Airlines
Thu, May 21 - Sun, May 24
Multiple Airlines Logo
1:22 pm - 1:57 pm
TYS
-
MDW
1h 35mnonstop
Multiple Airlines Logo
6:00 am - 8:29 pm
MDW
-
TYS
13h 29m
3 stops
$215Multiple Airlines
Sun, May 24 - Mon, May 25
Allegiant Air Logo
1:22 pm - 1:57 pm
TYS
-
MDW
1h 35mnonstop
Allegiant Air Logo
9:30 pm - 7:31 pm
MDW
-
TYS
21h 01m
1 stop
$216Allegiant Air
Thu, May 21 - Mon, May 25
Multiple Airlines Logo
1:22 pm - 1:57 pm
TYS
-
MDW
1h 35mnonstop
Multiple Airlines Logo
6:00 am - 11:37 pm
MDW
-
TYS
16h 37m
2 stops
$217Multiple Airlines
Fri, Jun 26 - Thu, Jul 2
Multiple Airlines Logo
12:40 pm - 10:11 pm
TYS
-
MDW
10h 31m
2 stops
Multiple Airlines Logo
2:48 pm - 5:18 pm
MDW
-
TYS
1h 30mnonstop
$218Multiple Airlines
Mon, Jun 29 - Thu, Jul 2
Multiple Airlines Logo
12:40 pm - 10:11 pm
TYS
-
MDW
10h 31m
2 stops
Multiple Airlines Logo
2:48 pm - 5:18 pm
MDW
-
TYS
1h 30mnonstop
$222Multiple Airlines
Fri, Jun 26 - Sun, Jul 5
Multiple Airlines Logo
12:40 pm - 10:11 pm
TYS
-
MDW
10h 31m
2 stops
Multiple Airlines Logo
2:48 pm - 5:18 pm
MDW
-
TYS
1h 30mnonstop
$223Multiple Airlines
Fri, May 29 - Tue, Jun 2
American Airlines Logo
7:10 am - 8:20 am
TYS
-
ORD
2h 10mnonstop
American Airlines Logo
7:16 pm - 10:10 pm
ORD
-
TYS
1h 54mnonstop
$249American Airlines
Sat, May 23 - Sun, May 24
American Airlines Logo
7:44 am - 8:54 am
TYS
-
ORD
2h 10mnonstop
American Airlines Logo
2:51 pm - 5:45 pm
ORD
-
TYS
1h 54mnonstop
$250American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Chicago flights

Get data-powered insights and trends into flights from Knoxville to Chicago to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Knoxville to Chicago?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Knoxville to Chicago departing in May.

What is the cheapest Knoxville to Chicago flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest return flight from Knoxville to Chicago costs $122 on the route between Knoxville (TYS) and Chicago Midway Airport (MDW). Over the past month, this route was, on average, 34% cheaper than other Knoxville-Chicago routes. The most popular route is between Knoxville (TYS) and Chicago O'Hare Intl Airport (ORD).

What’s the cheapest day of the week to fly from Knoxville to Chicago?

The average price of all round-trip flights from Knoxville to Chicago clicked on KAYAK for each day over the last 12 months.

Your flight ticket price will generally be cheaper if you fly to Chicago on a Friday and more expensive on a Monday. On your return trip to Knoxville, you should consider flying back on a Saturday, and avoid Fridays for better deals.

What is the cheapest month to fly from Knoxville to Chicago?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Chicago, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Chicago is November, where tickets cost $48 (return) on average. On the other hand, the most expensive months are March and February, where the average cost of round-trip tickets is $189 and $185 respectively.

Can I save money by flying with a layover from Knoxville to Chicago?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $231, prices are generally cheapest when you fly direct.

How far in advance should I book a flight from Knoxville to Chicago?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Knoxville to Chicago, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Knoxville to Chicago, you should book around 4 weeks before departure, which saves you about 16% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 21 weeks before departure.

Expert advice

Expert advice for your flight from Knoxville to Chicago

 
AI-powered summary based on content written by travel experts. AI can make mistakes.
KAYAK teamed up with top travel experts to share the best tips for your journey.
Our travel experts
Harriet Baskas

Harriet Baskas

Expert on American Airlines

Harriet is an award-winning journalist who is happiest in an airport or an unusual museum. Her stories about airports, air travel, and the business of travel have appeared on NBC News, CNBC, USA TODAY, The Points Guy and other outlets. She is the creator of the StuckatTheAirport.com blog and the author of nine books. When not out on the road or exploring the latest airport amenities, she’s home in Seattle getting ready for the next adventure.

Stefanie Waldek

Stefanie Waldek

Expert on United Airlines

Stefanie Waldek is a freelance space, travel, and design writer based in Saratoga Springs, NY. Her words have appeared in Space.com, Travel + Leisure, Condé Nast Traveler, Architectural Digest, and House Beautiful, among other publications. An expert in aviation and expedition cruising, Stefanie is frequently up in the air or on the sea, likely en route to Antarctica or the Arctic.

Daniel Scheffler

Daniel Scheffler

Expert on Allegiant Air

Daniel Scheffler is a travel writer, podcaster, and producer. Born in Africa, bred in Europe and now living in America he has traveled to 140 countries (and all 50 U.S. states). Plus he has stayed at over 2500 hotels across the globe. His original shows Everywhere and Without Maps (available on Spotify) showcase his beliefs, travel is about humanity and sharing that beauty. And thus it reminds you that you shouldn’t believe everything you think.

Good to know

Low seasonJanuary
Cheapest flight$49
Best time to beat the crowds with an average 30% drop in price.
Most popular time to fly and prices are also 8% lower on average.
Flight from Knoxville to Chicago Midway Airport

When to book flights from Knoxville to Chicago

Are your dates flexible? Find out the best times to travel from Knoxville to Chicago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Chicago

  • What parking options are available at the Knoxville McGhee Tyson Airport?

    Knoxville's McGhee Tyson Airport (TYS) offers both short-term and long-term parking options. Short-term parking is available in the hourly lot and can be used for up to 24 hours. This lot is located near the terminal building and features direct access to the terminal via an elevated walkway. Long-term parking is also available at McGhee Tyson Airport and can be used for up to 30 days. The long-term parking lot is located on the east side of the airport. There's valet parking available for those who would like to have their car parked for them while they're traveling.

  • Can I get a rental car at Chicago O'Hare International Airport (ORD)?

    You can choose from a number of car-rental companies, including National, Avis, Enterprise, Hertz, Budget Dollar, and Alamo. If you're looking for a great deal on a rental car, Hertz is the way to go. Hertz has convenient locations at Chicago O'Hare International Airport (ORD). And if you're looking for some extra room or luxury while traveling, then National Car Rental is the way to go. National Car Rental has convenient locations at Chicago O'Hare International Airport (ORD).

  • What check-in options do I have for my flight from Knoxville to Chicago?

    Frontier Airlines requires you to check in online up to 60 minutes before your departure. For the physical check-in at the airport, you should arrive at the airport at least two hours before departure and have your boarding pass printed and validated.

  • Are there kid-friendly facilities at the Knoxville McGhee Tyson Airport?

    If you're traveling through Knoxville's McGhee Tyson Airport, you may be wondering where you can nurse your baby. The McGhee Tyson Airport provides a Mamava pod past the food-concession area. This nursing room is equipped with an electric breast pump, changing table, private sink, and electrical outlets to facilitate electrical breast pumps.

  • What is the cheapest flight from Knoxville to Chicago?

    In the last 3 days, the lowest price for a flight from Knoxville to Chicago was $49 for a one-way ticket and $210 for a round-trip.

  • Do I need a passport to fly between Knoxville and Chicago?

    No

  • Which airports will I be using when flying from Knoxville to Chicago?

    Knoxville is served by only 1 airport and there are 2 airports in Chicago. You will leave Knoxville from Knoxville McGhee Tyson and you will be arriving in Chicago at one of these airports: Chicago Midway or Chicago O'Hare Intl.

  • Which airlines offer Wi-Fi service onboard planes from Knoxville to Chicago?

    American Airlines, and Delta offer inflight Wi-Fi service on the Knoxville to Chicago flight route.

  • Which aircraft models fly most regularly from Knoxville to Chicago?

    The Canadair (Bombardier) Regional Jet 700 is the aircraft model that flies most regularly on the Knoxville to Chicago flight route.

  • Which airline alliances offer flights from Knoxville to Chicago?

    Star Alliance, and oneworld are the airline alliances operating flights between Knoxville and Chicago, with Star Alliance being the most commonly used for this route.

  • On which days can I fly direct from Knoxville to Chicago?

    There are nonstop flights from Knoxville to Chicago on a daily basis.

  • Which is the best airline for flights from Knoxville to Chicago, United Airlines or Allegiant Air?

    The two airlines most popular with KAYAK users for flights from Knoxville to Chicago are United Airlines and Allegiant Air. With an average price for the route of $298 and an overall rating of 7.4, United Airlines is the most popular choice. Allegiant Air is also a great choice for the route, with an average price of $104 and an overall rating of 7.3.

  • How does KAYAK find such low prices on flights from Knoxville to Chicago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Chicago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Chicago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Chicago from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Chicago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Chicago with an airline and back to Knoxville with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Chicago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Chicago from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Knoxville to Chicago

  • Looking for a cheap flight? 25% of our users found flights on this route for $145 or less one-way and $254 or less round-trip.
  • If you love to travel, the Delta Air Lines companion ticket could be a dream come true. You’ll get to take your friend or family member along with you on your next trip. With American Express, there are two individual Delta credit cards that include a companion certificate.
  • If you're looking for a place to relax, unwind, and take your mind off of the hustle and bustle of air travel, look no further than the USO Lounge at Chicago Midway Airport (MDW). Located in the center of Concourse C, this lounge is open to military personnel, veterans, and their families. All guests are welcome to enjoy free Wi-Fi, snacks and drinks, TVs with cable, and a children's play area.
  • Finnair provides passengers with a nice variety of in-flight entertainment options, allowing you to choose from a wide range of movies and TV shows. The entertainment system offers several audio channels, including news, music, and sports channels. There are also several games available for you to play while you're onboard Finnair flights.
  • McGhee Tyson Airport (TYS) offers services for people with disabilities to make their trip as easy as possible. They have handicap parking spaces, restrooms, and seating areas, as well as wheelchair-accessible ramps and elevators in the terminal building.
  • Bensenville, Schiller Park, Franklin Park, and Wood Dale are all suburbs of Chicago near the Chicago O'Hare International Airport (ORD). To get to the suburbs, you can take the Blue Line train.

Prefer to fly direct from Knoxville to Chicago?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Knoxville McGhee Tyson to Chicago.
Find which airlines fly direct from Knoxville McGhee Tyson Airport to Chicago, which days they fly and book direct flights.

Direct departures

Knoxville McGhee Tyson to Chicago

Monday

American Airlines,United Airlines

American Airlines,United Airlines

Tuesday

American Airlines,United Airlines

American Airlines,United Airlines

Wednesday

American Airlines,United Airlines

American Airlines,United Airlines

Thursday

Allegiant Air,American Airlines,United Airlines

Allegiant Air,American Airlines, +1 more

Friday

American Airlines,United Airlines

American Airlines,United Airlines

Saturday

American Airlines,United Airlines

American Airlines,United Airlines

Sunday

Allegiant Air,American Airlines,United Airlines

Allegiant Air,American Airlines, +1 more

See more direct flights

Direct returns

Chicago to Knoxville McGhee Tyson

Monday

American Airlines,United Airlines

American Airlines,United Airlines

Tuesday

American Airlines,United Airlines

American Airlines,United Airlines

Wednesday

American Airlines,United Airlines

American Airlines,United Airlines

Thursday

Allegiant Air,American Airlines,United Airlines

Allegiant Air,American Airlines, +1 more

Friday

American Airlines,United Airlines

American Airlines,United Airlines

Saturday

American Airlines,United Airlines

American Airlines,United Airlines

Sunday

Allegiant Air,American Airlines,United Airlines

Allegiant Air,American Airlines, +1 more

See more direct flights

Reviews of the top 3 airlines serving from Knoxville to Chicago

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Chicago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Chicago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9680 reviews
8.1Crew
7.7Boarding
7.1Entertainment
7.3Comfort
6.6Food
Airline reviews

Standard flight with a drinks and a snack- overall very quick flight. The flight attendants were very strict, bordered on rude.

8.0 ExcellentWendi, Apr 2026
MSP - ORD
Read more United Airlines reviews

Standard flight with a drinks and a snack- overall very quick flight. The flight attendants were very strict, bordered on rude.

Delayed - weather wasn't bad at either end. Also sat on tarmac in ORD.

boarded early to only find out that flight would sit at gate for 45 min to an hour. Landed in chicago and sat on runway for over an hour before got to gate. Total delay was extensive for a 45 min flight door to door.

The flight was significantly delayed. The inbound flight from EWR was delayed departing because of mechanical problems. My original departure from CLT was 5:28 pm but due to the delay of the inbound flight, after arrival, deplaning, cleaning, boarding, we did not push back from the gate until 9:00 pm. Once in the air, the flight was smooth and what was originally supposed to be an arrival in ORD at 7:30 pm local time turned out to be 9:35 pm.

The flight I was supposed to be on was supposed to take off at 1:50 from State College. It was delayed over and over and over again until somehow I had to rebook on a flight that was supposed to have left State College at 8 am that morning but didn't end up taking off until almost 6 pm. Not only was this completely unacceptable, the "token from United" was a 15 dollar meal voucher that has to be used by today. I would personally like some miles added to my account for this inconvenience. I was in transit for 8 hours from the time I arrive at State College Aiport to when I got home. I was supposed to be home at 3 pm and I returned at 8 pm. Unacceptable. I have not been on an on Time united flight in nearly 5 years.

newer aircraft, ability to connect my headset via blue tooth for entertainment.

Very comfortable flight, snacks and drinks were good, good communication from crew. Could have used a little more information on timing of boarding for group 5

Great flight. Got to watch a movie. Smooth flight and early arrival at ORD.

It was better than excellent. The staff in Mason City were great. The young woman that pushed my wheelchair did more than could be expected of her. She came from India 17 years ago. I don't remember her name.

After arriving in Chicago, we were taxiing for 1.5 hours with infrequent and untruthful updates about the amount of time it would take to arrive at the gate. Minimally, the team could have provided timing expectations that were more truthful, especially one their original expectations were not met.

Great. No choice for n/a. No food or entertainment options

No food is available without purchasing it and there is no in-flight entertainment. Both of these are OK because we got an inexpensive flight from Allegiant and, otherwise, our experience was excellent.

just had water and there was plenty of leg & seat room. But then i don't weight 220#s!!

Not totally their fault- screaming kids that had zero parent intervention.

It was cold on the flight. The crew was very pleasant. I didn't order any food. We were delayed due to Captain waiting on maintenance log. He kept us informed though. The flight itself was smooth. I would definitely fly with Allegiant again!

I had a fantastic experience with Allegiant. I had wheelchair assistance and they helped me find my luggage and brought me to my car. Even loaded my luggage. Wonderful service!! Thank you Allegiant!

Superb. Staff great. Great flight. As with other airlines, seating too tight and restrictive.

There is not one likable thing about this airline. It’s starts with the deceptive pricing and continues through the whole flight. The worst staff I’ve ever experienced way over priced bags absolutely no food or drink (unacceptable and you should be embarrassed) the seats are cramped and uncomfortable there is no entertainment there is nothing about this trash airline that constitutes any amount of money. It’s worse than spirit and way more expensive it is disgraceful. Do not travel with Allegiant I repeat do not bother no matter what they say the price is it is never ever going to be the right choice I’m mind blown at how awful the entire experience was I’m embarrassed that I chose so poorly I cannot reiterate enough how beyond horrible this company and its staff are, not one person on this flight or at the airport is qualified to sweep up trash on a city sidewalk they should certainly never be given any job that requires a brain or manners or communication with human beings, what a disgrace to the human race. Your criminal chiselers and should be put out to pasture

Great flight. Friendly staff. Free snacks and drinks would be nice. I would love fewer taxes and fees added on.

My 90 year old father flew with me. He needed wheel chair assistance and is nearly deaf. The staff was amazing with him.

It was good, the staff was great, and the food, was as usual, tea and biscuit. Bathroom was clean, and the plane was clean as well.

Very good I can’t complain one bit. Thank you American Airlines for making my flight enjoyable and safe!

The staff and service on American Airlines were truly outstanding. I had requested wheelchair assistance for my mother due to her knee issues, and the team went above and beyond every step of the way—from boarding in Boston to our arrival in Chicago. Their care, professionalism, and attentiveness made the entire experience smooth and stress-free. I’m very grateful for the support they provided.

The new planes (American Eagle) are beautiful and especially comfortable. The flight attendants are consistently professional and courteous. And, while it may seem inconsequential, the new liquid tube of coffee creamer—in contrast to the powdered coffee creamer—makes all the difference in a cup of coffee.

I'm not sure American is capable of on-time arrivals and departures. When you land at ORD, you almost always get held on the tarmac because your gate is still occupied. I may have missed my connection, but that ended up up being significantly delayed as well. Once again, I finally got home well after midnight.

Crew at the gate was very crabby and not at all polite. The plane was very hot the entire flight. And the seat cushion was very worn out.

The staff are very, very professional. It's what flying should feel like.

Flight was delayed half hour before boarding, but when I checked flight aware the plane that would Pick us up had a delay of more than an hour. AA should let us know in advance to avoid waiting several hours in the airport

Delays with no explanation. It could have been handled better.

Jill was the flight attendant in first class she was fabulous!! Best flight attendant I have had in years.!! And I fly every other week. Other can learn from her!!

Everything you need to know for your flight from Knoxville to Chicago

Information on your arrival and departure airports