$78 Find Cheap Flights from Knoxville to Florida Keys - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Florida Keys departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Cheap Flights from Knoxville to Florida Keys

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Miami
Miami1 stop$197
Key West
Key Westnonstop$84
Miami
Miami1 stop$197
Key West
Key Westnonstop$84

Book Cheap Knoxville to Florida Keys Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Florida Keys that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Florida Keys

Fri, Aug 14 - Mon, Aug 17
Allegiant Air Logo
7:30 am - 9:41 am
TYS
-
EYW
2h 11mnonstop
Allegiant Air Logo
10:31 am - 12:46 pm
EYW
-
TYS
2h 15mnonstop
$144Allegiant Air
Fri, Oct 9 - Fri, Oct 16
Allegiant Air Logo
6:20 am - 8:24 am
TYS
-
EYW
2h 04mnonstop
Allegiant Air Logo
10:14 am - 12:27 pm
EYW
-
TYS
2h 13mnonstop
$148Allegiant Air
Mon, Aug 17 - Fri, Aug 21
Multiple Airlines Logo
7:30 am - 9:41 am
TYS
-
EYW
2h 11mnonstop
Multiple Airlines Logo
12:07 pm - 7:05 pm
EYW
-
TYS
6h 58m
1 stop
$151Multiple Airlines
Mon, Aug 17 - Fri, Aug 21
Multiple Airlines Logo
7:30 am - 9:41 am
TYS
-
EYW
2h 11mnonstop
Multiple Airlines Logo
12:07 pm - 7:05 pm
EYW
-
TYS
6h 58m
1 stop
$151Multiple Airlines
Thu, Sep 3 - Sun, Sep 6
Southwest Logo
1:15 pm - 10:10 pm
TYS
-
MIA
8h 55m
1 stop
Southwest Logo
7:55 am - 1:50 pm
MIA
-
TYS
5h 55m
1 stop
$300Southwest
Wed, Sep 9 - Tue, Sep 22
Southwest Logo
8:05 am - 1:35 pm
TYS
-
MIA
5h 30m
1 stop
Southwest Logo
7:10 am - 1:05 pm
MIA
-
TYS
5h 55m
1 stop
$303Southwest
Fri, Dec 4 - Fri, Dec 11
American Airlines Logo
2:55 pm - 9:45 pm
TYS
-
EYW
6h 50m
1 stop
American Airlines Logo
12:00 pm - 4:33 pm
EYW
-
TYS
4h 33m
1 stop
$319American Airlines
Thu, Oct 22 - Sat, Oct 24
Delta Logo
12:06 pm - 5:15 pm
TYS
-
EYW
5h 09m
1 stop
Delta Logo
6:11 pm - 10:22 pm
EYW
-
TYS
4h 11m
1 stop
$319Delta
Tue, Nov 3 - Tue, Nov 17
American Airlines Logo
12:20 pm - 6:01 pm
TYS
-
EYW
5h 41m
1 stop
American Airlines Logo
1:52 pm - 6:44 pm
EYW
-
TYS
4h 52m
1 stop
$333American Airlines
Thu, Oct 22 - Sat, Oct 24
Delta Logo
12:06 pm - 5:15 pm
TYS
-
EYW
5h 09m
1 stop
Delta Logo
6:11 pm - 10:22 pm
EYW
-
TYS
4h 11m
1 stop
$336Delta
Booking Insights

KAYAK's insights & trends for Knoxville to Florida Keys flights

Get data-powered insights and trends into flights from Knoxville to Florida Keys to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest Knoxville to Florida Keys flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to Florida Keys from Knoxville found in the last 5 days was to Key West, at $68 round-trip. The most popular route is from Knoxville (TYS) to Key West (EYW), and the cheapest round-trip airline ticket found on this route in the last 5 days was $68.

What is the cheapest time of day to fly to Florida Keys?

The average price for all round-trip flights from Knoxville to Florida Keys depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to Florida Keys is generally in the evening, when round-trip flights cost $400 on average. Morning departures are around 54% more expensive than evening flights, on average. The most expensive time of day to fly to Florida Keys is generally in the morning, which is peak travel time and where the average cost of a ticket is $617.

Can I save money by flying with a layover from Knoxville to Florida Keys?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $295, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Knoxville to Florida Keys?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Florida Keys, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Florida Keys is February, when tickets cost $297 (return) on average. On the other hand, the most expensive months are March and May, when the average cost of round-trip tickets is $439 and $403 respectively.

What’s the cheapest day of the week to fly from Knoxville to Florida Keys?

The average price of all round-trip flights from Knoxville to Florida Keys clicked on KAYAK for each day over the last 12 months.

Your flight ticket price will generally be cheaper if you fly to Florida Keys on a Friday and more expensive on a Monday. On your return trip to Knoxville, you should consider flying back on a Wednesday, and avoid Sundays for better deals.

How far in advance should I book a flight from Knoxville to Florida Keys?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Knoxville to Florida Keys, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Knoxville to Florida Keys, you should book around 3 weeks before departure, which saves you about 11% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 8 weeks before departure.

Good to know

Low season

September

Cheapest flight

$78
Best time to beat the crowds but there is an average 18% increase in price.
Most popular time to fly and prices are also 3% lower on average.
Flight from Knoxville to Key West

FAQs - booking Florida Keys flights

  • How does KAYAK find such low prices on flights from Knoxville to Florida Keys?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Florida Keys.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Florida Keys?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to Florida Keys is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Florida Keys?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to Florida Keys with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Florida Keys?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to Florida Keys up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • How many flights are there between Knoxville and Florida Keys per day?

    There is a maximum of 1 nonstop flight a day that takes off from Knoxville and lands in Florida Keys, with an average flight time of 2h 11m. The most common departure time is 7:00 am and most flights take off in the morning. Each week, there are 2 flights.

Top tips for finding cheap flights to Florida Keys

  • Looking for a cheap flight? 25% of our users found tickets from Knoxville to the following destinations at these prices or less: Miami $352 one-way - $613 round-trip

Reviews of the top 4 airlines serving from Knoxville to Florida Keys

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Florida Keys. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Florida Keys? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4222 reviews
7.5Entertainment
8.1Boarding
7.0Food
8.6Crew
8.0Comfort
Airline reviews

Red eye from San Diego. Temperature of the cabin was way too warm and the air duct flowed very little air.

6.0 GoodGordon, Jul 2026
SAN - MCO
Read more Southwest reviews

Red eye from San Diego. Temperature of the cabin was way too warm and the air duct flowed very little air.

Over a 3 hour flight. The turbulence was almost imperceptible except for 2 short periods which were not bad and over quickly. The attendants claimed "Safety first" and sat looking at their phones for 3 hours with no drink or snack service. This isn't the first time with Southwest. I thinkit may be there new plan of operation. Oh, and it was June 18, Southwest's Birthday which offered free drinks. NOT.

The flight was okay. The pilots did an amazing job and kept us updated on the flight. The flight attendants were okay. They found time to be chatty with each other rather than focus on the guests. One of the attendants was a little less warm when asking about my bag I had on my lap that I was using during latter part of the mid- flight. Mind you, it was not the departure descent. I’m respectful to each and every attendant, it was the tone in her voice reminding me to place my carryon bag on the floor. I hope to have a better experience next time.

Terrible. Even though there’s assigned seating now, they are still the slowest boarding airline of anyone.

It was canceled. Supposedly weather. But there was no snow in Baltimore. At least we found out before driving to airport

Okay, not wonderful. Short flight. Wi-fi didn't work properly. Stuck waiting for a gate to open upon arrival for 20 or so minutes.

Flight was canceled at 11:50am on my husband’s birthday as if they didn’t have all day to still try to go.

Southwest is going downhill. I'm more apt to fly other airlines now. And I'd appreciate it if your gate agents didn't invent non-existent laws. If Southwest is having issues getting flight crews, you need to go out of your way to accommodate passengers instead of saying it's weather related and not in your hands. We can all see the other carriers are getting their planes off the ground and to/from the cities/regions you claim are weather-impacted.

Landing was kinda fast and my ears were plugged for days after.

Cramped seats. They are like sitting on benches. No lower back support. Very narrow aisles. Bathrooms are getting smaller. I am 5.4 and weigh 150. Barely fit in the bathroom

We were skipped when the snack cart passed and then the attendant said we weren’t . I am disabled and was in a row toward the back of the plane which was very difficult for me to navigate. Disabled people should not be forced to walk the plank.

My flight home from Knoxville, TN, included a layover in Atlanta. I boarded the aircraft in Zone 5 and although there was limited overhead space, I was able to put my 'backpack' style roller-bag above my seat. Unfortunately, due to continued bad weather, we had to deplane. There were many people who would have missed their connection, so they rebooked. When we were re-boarding, the gate agent welcomed zone 5 and then made an announcement: All roller-bags for zone 5 passengers and higher will need to be gate checked. I promptly pushed the telescoping handle in and held my bag like a backpack. I was able to bring it on board, which was a relief. Upon entering the aircraft it became apparent that there was easily 40% open overhead space. There were audible signs of angry passengers who felt duped into checking their bags when in fact there were noticeably LESS passengers on the aircraft and TONS of overhead space. I'm not sure what kinds of parameters are used to determine when to cut off roller-bags from being brought on board, but it seemed deceptive and underhanded to have so many people get stuck checking their bags when clearly there was ample room for at least one more zone.

Flight was delayed and then "they did not have time to load food". No snack or drink at all for 1.5 how flight. Somebody wasn't prepared.

It is usually very pleasant. Good service for the price, international flights are even better

The CRJ-900 was clean but the overhead air vents were broken in our First Class row, making the cabin very hot until about 30 mins into the flight. The flight attendants were both extremely apologetic and accommodating though so that is why I rated the flight as very good. They checked on us many times and truly showed they cared. The snacks for an hour and a half flight could be better. Would be nice if there was a small plated meal over convenient store snacks. WiFi also was not working. And it would be nice if Delta had adjustable headrests on these planes.

New high end luggage ruined/zippers broken, items missing. All happened on return flight from msp to mso. Do better! Not store bought luggage but high end personalized ogio custom embroidered luggage. Total slap in the face ontop of an extra luggage fee that took me 3 hrs on chat to resolve.

Third flight in two months where the crew was not there. Comfort seating does not guarantee overhead bin space. Passengers with children are allowed on the plane first - if you are flying to and from Orlando, this means half the plane has boarded before you get on. And somehow all the bin space is taken up. 3 out of 5 flights have had issues with equipment or procedure. Some of these instances caused the flight to be delayed because of a "nuisance" light. One time it was a bag that had been brought on board but did not belong to anyone so we had to return to the gate. Last night we were told the "AC" on the plane doesn't work well and we're 10th for take off- because the crew was late - and that it will get cool when we're in the air. Not sure if this is usual, but I didn't think flight crew could jump seat in first class. Movie and TV selection has not been refreshed for several months- flying one to two round trips each month easily exhausts the list of content.

Definitely a southern flavor. Cordiality was evident even though no drinks or snacks were served.

No service flight that took 5 hrs and a stop at an unscheduled airport. Crew and pilots did their jobs

From Atlanta to Cabo I would have hoped on a plane that size I would have been able to breathe and wiggle my feet a little! The leg room in that plane is non existent and I am only 5”4’. And the air vent either wasn’t working very well or just could not blow air from the ceiling to the seat area as I was suffocating through the entire flight! And please don’t say I would have been more comfortable in first class because I cannot afford those rates and have always travelled Main Cabin without issues !

It was poor a four hour delay and no explanation for the delay. What’s a 35 dollars going to do. It also made me miss my car rental,

It was on time. Flight was comfortable. Staff was nice. It was the way a flight should always be.

Allegiant canceled the flight. The flight the next day was full. Allegiant did not provide any compensation besides a refund. Last time on Allegiant.

Great. No choice for n/a. No food or entertainment options

just had water and there was plenty of leg & seat room. But then i don't weight 220#s!!

Not totally their fault- screaming kids that had zero parent intervention.

Check in on the web portal was cumbersome! After several attempts I finally got the boarding pass.

I didn’t like it at all. I miss my second flight because of the delay on Allegiant Air now I m stuck in MCO.

My TSA number was missing from my ticket which shouldn’t have happened since it’s in my file. The on board flight attendant who was a male, did not want to help me put my luggage in the overhead bin and made a very rude comment and was very unpleasant. The good… the woman who fixed my ticket with the TSA number was excellent and I had extra legroom which was perfect.

Web site and app most difficult to access. Tel number not accessible. No answer at any time of day.

Bad experience going to DFW with an IT outage then bad on the way back with a nearly 5 hour delay that’s started as maintenance then caused us to wait further due to weather - which would not have happened if we had left on time.

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

During service there was a garbage/beverage spill near our seats that never was cleaned up. On a relatively short flight when we’re fortunate enough to actually have in flight movies available, the flight attendants pitching the AADVANTAGE credit card shouldn’t talk for the last 10 minutes of the flight so that we miss the end of the movie.

I didn’t like anything, being platinum pro get you absolutely nowhere and does not increase the customer service treatment whatsoever anymore. My flight was canceled and they put me on a flight eight hours later that would’ve got me back in the middle of the night. They could’ve easily move me up to an hour Prior on an earlier flight. My second flight was unreasonable to take, the third flight was also canceled due to mechanical issues like the first flight. I don’t know what’s going on with American, but they are falling apart, after seven flight changes I finally got home, Unreasonable.

This was a horrible American Airlines experience, and it discourages me from flying with them again. It may have stemmed from a mechanical delay, but it appeared that the team was unprepared to respond to the delay. After boarding, we waited an hour before finally taking off. After landing at our destination, we waited an additional hour on the tarmac waiting for a gate (at 8:00pm) to be assigned and cleared. The flight crew did their best, but they were clearly tired and also ready to be done for the day. Because of the delay, I missed a connecting flight. It was a very poor experience.

Fantastic! If it had not been for a check-in agent in Knoxville I may have not gotten my passes on British Airways. I couldn’t check-in online because British Airways had messed us the info on my tickets to London & Inverness. AA’s was great! British Airways was a continuous series of delays and frustrations.

Absolutely the worst experience. We were 5 hours delayed due to mechanical issues and a crew timing out. We were not offered any concession. When I asked for a meal voucher, they gave me $12. You can get a bottle of water for that at the airport. Offensive.

Wheelchair was waiting for me,changed to a better seat which was great as it's hard for me to walk

Everything you need to know for your flight to Florida Keys

Information on your arrival and departure airports